KIM MARIE OLTHOFF

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Outcomes of adult living donor liver transplantation: comparison of the Adult-to-adult Living Donor Liver Transplantation Cohort Study and the national experience
    Kim M Olthoff
    Department of Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA
    Liver Transpl 17:789-97. 2011
  2. pmc Outcomes of 385 adult-to-adult living donor liver transplant recipients: a report from the A2ALL Consortium
    Kim M Olthoff
    Department of Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA
    Ann Surg 242:314-23, discussion 323-5. 2005
  3. ncbi request reprint Summary report of a national conference: Evolving concepts in liver allocation in the MELD and PELD era. December 8, 2003, Washington, DC, USA
    Kim M Olthoff
    Department of Surgery, Division of Transplantation, University of Pennsylvania, Philadelphia, PA, USA
    Liver Transpl 10:A6-22. 2004
  4. doi request reprint Validation of a current definition of early allograft dysfunction in liver transplant recipients and analysis of risk factors
    Kim M Olthoff
    Department of Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA
    Liver Transpl 16:943-9. 2010
  5. ncbi request reprint Combined orthotopic heart and liver transplantation: the need for exception status listing
    Paige M Porrett
    University of Pennsylvania Department of Surgery, Philadelphia, PA 19104 4227, USA
    Liver Transpl 10:1539-44. 2004
  6. ncbi request reprint Allograft survival following adult-to-adult living donor liver transplantation
    Peter L Abt
    Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
    Am J Transplant 4:1302-7. 2004
  7. pmc Survival following liver transplantation from non-heart-beating donors
    Peter L Abt
    Department of Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA
    Ann Surg 239:87-92. 2004
  8. ncbi request reprint Overview of pediatric liver transplantation
    Elizabeth B Rand
    University of Pennsylvania, 3600 Spruce Street, Philadelphia, PA 19104, USA
    Gastroenterol Clin North Am 32:913-29. 2003
  9. doi request reprint Increased incidence of cytomegalovirus infection in high-risk liver transplant recipients receiving valganciclovir prophylaxis versus ganciclovir prophylaxis
    Kevin T Shiley
    Division of Infectious Diseases, University of Pennsylvania, Philadelphia, PA, USA
    Liver Transpl 15:963-7. 2009
  10. ncbi request reprint Survival among pediatric liver transplant recipients: impact of segmental grafts
    Peter L Abt
    Department of Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA
    Liver Transpl 10:1287-93. 2004

Research Grants

  1. THE INTERPLAY BETWEEN HEPATIC GROWTH AND METABOLISM
    Kim Olthoff; Fiscal Year: 2004
  2. Liver Regeneration in the Transplant Setting
    KIM MARIE OLTHOFF; Fiscal Year: 2010

Collaborators

Detail Information

Publications33

  1. pmc Outcomes of adult living donor liver transplantation: comparison of the Adult-to-adult Living Donor Liver Transplantation Cohort Study and the national experience
    Kim M Olthoff
    Department of Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA
    Liver Transpl 17:789-97. 2011
    ..These analyses demonstrate that findings from the A2ALL consortium are relevant to other centers in the U.S. performing LDLT, and conclusions and recommendations from A2ALL may help to guide clinical decision making...
  2. pmc Outcomes of 385 adult-to-adult living donor liver transplant recipients: a report from the A2ALL Consortium
    Kim M Olthoff
    Department of Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA
    Ann Surg 242:314-23, discussion 323-5. 2005
    ....
  3. ncbi request reprint Summary report of a national conference: Evolving concepts in liver allocation in the MELD and PELD era. December 8, 2003, Washington, DC, USA
    Kim M Olthoff
    Department of Surgery, Division of Transplantation, University of Pennsylvania, Philadelphia, PA, USA
    Liver Transpl 10:A6-22. 2004
    ..Recommendations for the transplant community, based on the analysis of the MELD data, were discussed and are presented in the summary document...
  4. doi request reprint Validation of a current definition of early allograft dysfunction in liver transplant recipients and analysis of risk factors
    Kim M Olthoff
    Department of Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA
    Liver Transpl 16:943-9. 2010
    ..This definition can be used as an endpoint in translational studies aiming to identify mechanistic pathways leading to a subgroup of liver grafts with clinical expression of suboptimal function...
  5. ncbi request reprint Combined orthotopic heart and liver transplantation: the need for exception status listing
    Paige M Porrett
    University of Pennsylvania Department of Surgery, Philadelphia, PA 19104 4227, USA
    Liver Transpl 10:1539-44. 2004
    ..Providing exception status listing to these patients would ensure more expeditious transplantation and potentially contribute to improved survival...
  6. ncbi request reprint Allograft survival following adult-to-adult living donor liver transplantation
    Peter L Abt
    Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
    Am J Transplant 4:1302-7. 2004
    ..Analysis of this early experience with AALDLT suggests that allograft failure may be higher than among recipients of a cadaveric liver...
  7. pmc Survival following liver transplantation from non-heart-beating donors
    Peter L Abt
    Department of Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA
    Ann Surg 239:87-92. 2004
    ..To determine whether patient and graft survival following transplantation with non-heart-beating donor (NHBD) hepatic allografts is equivalent to heart-beating-donor (HBD) allografts...
  8. ncbi request reprint Overview of pediatric liver transplantation
    Elizabeth B Rand
    University of Pennsylvania, 3600 Spruce Street, Philadelphia, PA 19104, USA
    Gastroenterol Clin North Am 32:913-29. 2003
    ..Future advances in transplant immunobiology, organ availability and infection control are likely to lead to still greater improvements in short and long-term outcome [34]...
  9. doi request reprint Increased incidence of cytomegalovirus infection in high-risk liver transplant recipients receiving valganciclovir prophylaxis versus ganciclovir prophylaxis
    Kevin T Shiley
    Division of Infectious Diseases, University of Pennsylvania, Philadelphia, PA, USA
    Liver Transpl 15:963-7. 2009
    ..The 4-fold higher incidence of CMV disease in our study supports the avoidance of valganciclovir for prophylaxis in high-risk OLT patients. Liver Transpl 15:963-967, 2009. (c) 2009 AASLD...
  10. ncbi request reprint Survival among pediatric liver transplant recipients: impact of segmental grafts
    Peter L Abt
    Department of Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA
    Liver Transpl 10:1287-93. 2004
    ..Much of the difference in graft survival could be attributed to events in the perioperative period. In conclusion, LD liver transplantation provides improved graft survival in children 2 years of age or less...
  11. ncbi request reprint Serum protein electrophoresis abnormalities in adult solid organ transplant patients with post-transplant lymphoproliferative disorder
    Donald E Tsai
    Hematologic Malignancies Program, University of Pennsylvania Cancer Center, Philadelphia, PA 19104, USA
    Clin Transplant 19:644-52. 2005
    ..68 wk, p = 0.003). Persistence of MG after complete response of the PTLD did not predict relapse. There is a high incidence of MG and gammaglobulin abnormalities in patients with PTLD...
  12. ncbi request reprint Liver transplantation for hepatocellular carcinoma validation of present selection criteria in predicting outcome
    Kirti Shetty
    Division of Gastroenterology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Liver Transpl 10:911-8. 2004
    ..e., vascular invasion and multifocality. Present UNOS selection criteria for HCC based on tumor burden appear to provide adequate discriminatory power in predicting outcome of OLT...
  13. ncbi request reprint Effects of sirolimus vs. calcineurin inhibitors on renal dysfunction after orthotopic liver transplantation
    Mical S Campbell
    Division of Gastroenterology, Penn Liver Transplant Center, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    Clin Transplant 21:377-84. 2007
    ..The effect of sirolimus on renal function will need to be prospectively evaluated in a prospective, randomized trial...
  14. ncbi request reprint Hepatic regeneration in living donor liver transplantation
    Kim M Olthoff
    Department of Surgery, Division of Transplantation, Liver Transplant Program, University of Pennsylvania, Philadelphia, PA 19104, USA
    Liver Transpl 9:S35-41. 2003
  15. ncbi request reprint Use of EBV PCR for the diagnosis and monitoring of post-transplant lymphoproliferative disorder in adult solid organ transplant patients
    Donald E Tsai
    Hematologic Malignancies Program, University of Pennsylvania Cancer Center, Philadelphia, Pennsylvania 19104, USA
    Am J Transplant 2:946-54. 2002
    ..We conclude that peripheral blood EBV PCR may have a role in the diagnosis and monitoring of post-transplant lymphoproliferative disorder in adult solid organ transplant patients...
  16. pmc Donor morbidity after living donation for liver transplantation
    Rafik M Ghobrial
    Department of Surgery, University of California Los Angeles, Los Angeles, California, USA
    Gastroenterology 135:468-76. 2008
    ..The rate and severity of complications in living donors were investigated in the 9-center Adult-to-Adult Living Donor Liver Transplantation Cohort Study (A2ALL)...
  17. ncbi request reprint Toward further expansion of the organ pool for adult liver recipients: splitting the cadaveric liver into right and left lobes
    Gideon Zamir
    Department of Surgery, Division of Transplantation Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA
    Transplantation 74:1757-61. 2002
    ....
  18. doi request reprint Live donor adult liver transplantation
    Heidi Yeh
    Division of Transplantation, Massachusetts General Hospital, Boston, Massachusetts, USA
    Curr Opin Organ Transplant 13:241-6. 2008
    ..Because the gap between liver organ supply and demand continues to increase, adult living-donor liver transplantation continues to represent a significant pool of organs...
  19. ncbi request reprint The outcome of liver grafts procured from hepatitis C-positive donors
    Ergun Velidedeoglu
    Department of Surgery, University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104, USA
    Transplantation 73:582-7. 2002
    ..The survival of grafts from HCV+ donors has not been studied in detail...
  20. ncbi request reprint Molecular pathways of regeneration and repair after liver transplantation
    Kim M Olthoff
    Department of Surgery, University of Pennsylvania, 4 Silverstein, 3400 Spruce Street, Philadelphia, Pennsylvania 19104, USA
    World J Surg 26:831-7. 2002
    ..Further defining the role of these immune cells and their products during the initiation of cellular recovery is essential for developing strategies to improve hepatocellular function after injury...
  21. ncbi request reprint Renal function after orthotopic liver transplantation is predicted by duration of pretransplantation creatinine elevation
    Mical S Campbell
    Division of Gastroenterology, University of Pennsylvania Health System, Philadelphia, PA 19104, USA
    Liver Transpl 11:1048-55. 2005
    ..01) after transplantation. In conclusion, duration, but not cause, of renal dysfunction predicts renal outcome in OLTa recipients. Prospective studies may use duration of renal dysfunction to help identify CKLT candidates...
  22. ncbi request reprint Early kidney dysfunction post liver transplantation predicts late chronic kidney disease
    Ergun Velidedeoglu
    Department of Surgery, University of Pennsylvania Health System, Philadelphia, PA, USA
    Transplantation 77:553-6. 2004
    ..Acute and chronic renal dysfunction (ARD, CRD) are common complications after liver transplantation and are associated with poor outcome...
  23. pmc Hospitalization rates before and after adult-to-adult living donor or deceased donor liver transplantation
    Robert M Merion
    Department of Surgery, University of Michigan, Ann Arbor, MI, USA
    Ann Surg 251:542-9. 2010
    ..To compare rates of hospitalization before and after adult-to-adult living donor liver transplant (LDLT) and deceased donor liver transplant (DDLT)...
  24. ncbi request reprint Pattern of ischemia reperfusion injury in a mouse orthotopic liver transplant model
    Xingyi Que
    Department of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Surg Res 116:262-8. 2004
    ..The aim of this study was to establish a model of cold ischemia and reperfusion injury in mOLT and describe the pattern of the regenerative response to various lengths of cold storage...
  25. pmc Genes involved in viral carcinogenesis and tumor initiation in hepatitis C virus-induced hepatocellular carcinoma
    Valeria R Mas
    Division of Transplantation, Department of Surgery, Virginia Commonwealth University, Richmond, Virginia, USA
    Mol Med 15:85-94. 2009
    ..Characteristic gene signatures were identified at different stages of HCV-HCC progression. A set of genes were identified to predict whether the cirrhotic tissue was associated with HCC...
  26. ncbi request reprint Sequential liver and bone marrow transplantation for treatment of erythropoietic protoporphyria
    Elizabeth B Rand
    Department of Pediatrics, University of Pennsylvania, Children s Hospital of Philadelphia, 324 S 34th St, Philadelphia, PA 19104, USA
    Pediatrics 118:e1896-9. 2006
    ..This combination corrected the severe phenotype, resolving the severe photosensitivity and halting erythropoietic protoporphyria associated liver graft injury. Splenectomy seemed to facilitate the successful bone marrow transplant...
  27. ncbi request reprint Appendicitis among liver transplant recipients
    Peter L Abt
    Department of Surgery, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Liver Transpl 11:1282-4. 2005
    ..Four patients experienced perforation, three of whom presented three days after the development of abdominal pain. All patients recovered after surgery without untoward sequela...
  28. ncbi request reprint Severe preservation injury induces Il-6/STAT3 activation with lack of cell cycle progression after partial liver graft transplantation
    Fotini Debonera
    Department of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Am J Transplant 4:1964-71. 2004
    ..Partial grafts with severe injury fail to achieve cellular proliferation despite the early initiating signals. This failure could be attributed to the impaired ability of the parenchyma to respond to initiating signals for regeneration...
  29. ncbi request reprint Interleukin-6 from intrahepatic cells of bone marrow origin is required for normal murine liver regeneration
    Xavier Aldeguer
    Department of Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA
    Hepatology 35:40-8. 2002
    ..This investigation demonstrates a paracrine mechanism by which cells of bone marrow origin, most likely Kupffer cells, regulate the regenerative capacity of the hepatocyte through IL-6 expression...
  30. ncbi request reprint Dexamethasone inhibits early regenerative response of rat liver after cold preservation and transplantation
    Fotini Debonera
    Department of Surgery, University of Pennsylvania, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Hepatology 38:1563-72. 2003
    ..This may be particularly relevant for transplantation of partial liver grafts in the living donor setting...
  31. ncbi request reprint Selective neutralization of the chemokine TCA3 reduces the increased injury of partial versus whole liver transplants induced by cold preservation
    Jin Fu Xie
    Department of Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA
    Transplantation 82:1501-9. 2006
    ....
  32. ncbi request reprint A matched comparison study of medical and psychiatric complications and anesthesia and analgesia requirements in methadone-maintained liver transplant recipients
    Robert M Weinrieb
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA
    Liver Transpl 10:97-106. 2004
    ..Posttransplant, 20% of patients receiving MMT used alcohol or illicit drugs. Data do not support withholding the provision of liver transplantation to patients receiving MMT, but larger, well-controlled studies are warranted...
  33. ncbi request reprint Patterns of transgene expression and viral clearance from the transplanted liver following ex vivo adenovirus-mediated gene transfer
    Gideon Zamir
    Department of Surgery, University of Pennsylvania, Ground Gates, 3400 Spruce Street, Philadelphia, PA 19104, USA
    J Hepatol 41:714-20. 2004
    ....

Research Grants6

  1. THE INTERPLAY BETWEEN HEPATIC GROWTH AND METABOLISM
    Kim Olthoff; Fiscal Year: 2004
    ..The applicant will assess basic parameters of glucose metabolism in IGFBP-1 null mice and determine the basis for any abnormalities. ..
  2. Liver Regeneration in the Transplant Setting
    KIM MARIE OLTHOFF; Fiscal Year: 2010
    ..Understanding the mechanistic biology of graft recovery and pathways of liver regeneration will provide important data for designing treatment modalities that will prevent injury and enhance recovery and regeneration. ..