Genomes and Genes
Michal A Olszewski
Affiliation: University of Michigan
- Macrophage M1/M2 polarization dynamically adapts to changes in cytokine microenvironments in Cryptococcus neoformans infectionMichael J Davis
Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, Michigan, USA
MBio 4:e00264-13. 2013..Collectively, these data indicate that M1/M2 macrophage polarization phenotypes are highly plastic to external signals, and interventions which therapeutically repolarize macrophages could be beneficial for treatment of cryptococcosis...
- Immune modulation mediated by cryptococcal laccase promotes pulmonary growth and brain dissemination of virulent Cryptococcus neoformans in miceYafeng Qiu
Research Service, Veterans Administration Ann Arbor Health System, Michigan, United States of America
PLoS ONE 7:e47853. 2012..Furthermore, our data support the hypothesis that laccase-induced changes in polarization of CD4+ T cells contribute to CNS dissemination...
- Mechanisms of cryptococcal virulence and persistenceMichal A Olszewski
Ann Arbor Veterans Administration Health System 11R, 2215 Fuller Road, Ann Arbor, MI 48105, USA
Future Microbiol 5:1269-88. 2010..We also review cryptococcal strategies of survival in the CNS and briefly discuss adaptations developing in response to medical treatment...
- Cryptococcal urease promotes the accumulation of immature dendritic cells and a non-protective T2 immune response within the lungJohn J Osterholzer
Veterans Affairs Ann Arbor Health System, Ann Arbor, 2215 Fuller Rd, Ann Arbor, MI 48105, USA
Am J Pathol 174:932-43. 2009..These findings provide new insights into mechanisms by which microbial factors contribute to the immunopathology associated with invasive fungal disease...
- Effect of laparotomy on clearance and cytokine induction in Staphylococcus aureus infected lungsMichal A Olszewski
The Veterans Administration Ann Arbor Healthcare System, Ann Arbor, Michigan 48105 2303, USA
Am J Respir Crit Care Med 176:921-9. 2007..Staphylococcus aureus is a major pathogen complicating postsurgical care...
- Urease expression by Cryptococcus neoformans promotes microvascular sequestration, thereby enhancing central nervous system invasionMichal A Olszewski
Veteran s Administration Medical Center Ann Arbor, Ann Arbor, Michigan, USA
Am J Pathol 164:1761-71. 2004..neoformans...
- Implicating exudate macrophages and Ly-6C(high) monocytes in CCR2-dependent lung fibrosis following gene-targeted alveolar injuryJohn J Osterholzer
Pulmonary Section, Medical Service, Veterans Affairs Ann Arbor Healthcare System, Department of Veterans Affairs Health System, Ann Arbor, MI 48105, USA
J Immunol 190:3447-57. 2013..Together, these results implicate CCR2 and the accumulation of ExM and Ly-6C(high) monocytes as critical determinants of pulmonary fibrosis induced by selective type II AEC injury...
- Th2 but not Th1 immune bias results in altered lung functions in a murine model of pulmonary Cryptococcus neoformans infectionAditya V Jain
Department of Veteran s Affairs Ann Arbor Healthcare System, Ann Arbor, Michigan 48105, USA
Infect Immun 77:5389-99. 2009..Taken together, the data show that C. neoformans can significantly affect airflow physiology, particularly in the context of a Th2 immune response with possible involvement of IgE as an important factor...
- Interleukin-17A enhances host defense against cryptococcal lung infection through effects mediated by leukocyte recruitment, activation, and gamma interferon productionBenjamin J Murdock
Pulmonary Section, VA Ann Arbor Healthcare System, Michigan, USA
Infect Immun 82:937-48. 2014..neoformans through effects on leukocyte recruitment, IFN-γ production by CD4 and CD8 T cells, and the activation of lung myeloid cells...
- Robust Th1 and Th17 immunity supports pulmonary clearance but cannot prevent systemic dissemination of highly virulent Cryptococcus neoformans H99Yanmei Zhang
VA Ann Arbor Health System, Ann Arbor, Michigan 48105, USA
Am J Pathol 175:2489-500. 2009..These data indicate that the Th2 immune bias is a crucial mechanism for pulmonary virulence of H99, whereas other mechanisms are largely responsible for its central nervous system tropism and systemic dissemination...
- Early induction of CCL7 downstream of TLR9 signaling promotes the development of robust immunity to cryptococcal infectionYafeng Qiu
Department of Research Service, Veterans Administration Ann Arbor Health System, Ann Arbor, MI 48105, USA
J Immunol 188:3940-8. 2012....
- Virulence factors identified by Cryptococcus neoformans mutant screen differentially modulate lung immune responses and brain disseminationXiumiao He
VA Ann Arbor Health System, Research Service, University of Michigan Medical School, Ann Arbor, Michigan 48105, USA
Am J Pathol 181:1356-66. 2012..Thus, cryptococcal PIK1, RUB1, and ENA1 differentially contribute to cryptococcal virulence, in correlation with their differential capacity to modulate immune responses...
- Effect of cytokine interplay on macrophage polarization during chronic pulmonary infection with Cryptococcus neoformansShikha Arora
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109 0642, USA
Infect Immun 79:1915-26. 2011..This cytokine interplay modulates Mac differentiation, including generation of an intermediate caMac/aaMac phenotype, which in turn may support chronic "steady-state" fungal infection and the resultant ABPM pathology...
- Dual roles of CD40 on microbial containment and the development of immunopathology in response to persistent fungal infection in the lungGwo Hsiao Chen
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, 6220 MSRB III, Box 0624, 1150 W Medical Center Dr, Ann Arbor, MI 48109, USA
Am J Pathol 177:2459-71. 2010..CD40 also promotes some, but not all, elements of Th2-mediated immunopathology in response to persistent fungal infection in the lung...
- Accumulation of CD11b+ lung dendritic cells in response to fungal infection results from the CCR2-mediated recruitment and differentiation of Ly-6Chigh monocytesJohn J Osterholzer
Pulmonary Section, Medical Service, Ann Arbor Veterans Affairs Health System, Department of Veterans Affairs Health System, Ann Arbor, MI 48105, USA
J Immunol 183:8044-53. 2009..We conclude that the CCR2-mediated accumulation of CD11b(+) DC in the lungs of Cryptococcus-infected mice is primarily attributable to the continuous recruitment and differentiation of Ly-6C(high) monocytes...
- Chemokine receptor 2-mediated accumulation of fungicidal exudate macrophages in mice that clear cryptococcal lung infectionJohn J Osterholzer
Pulmonary Section, Medical Service, Ann Arbor Veterans Affairs Health System, Ann Arbor, Michigan, USA
Am J Pathol 178:198-211. 2011..We conclude that clearance of cryptococcal lung infection requires the CCR2-mediated massive accumulation of fungicidal ExMs derived from circulating Ly-6C(high) monocytes...
- CD11c+ cells are required to prevent progression from local acute lung injury to multiple organ failure and deathJami E Milam
VA Ann Arbor Healthcare System, Ann Arbor, MI 48105, USA
Am J Pathol 176:218-26. 2010..These data demonstrate that CD11c(+) cells play a critical role in protecting the organs from systemic injury caused by a pulmonary endotoxin challenge...
- Role of dendritic cells and alveolar macrophages in regulating early host defense against pulmonary infection with Cryptococcus neoformansJohn J Osterholzer
Pulmonary Section, VA Ann Arbor Healthcare System, Ann Arbor, Michigan 48105, USA
Infect Immun 77:3749-58. 2009..neoformans. These findings provide important insight into the cellular mechanisms which coordinate early host defense against an invasive fungal pathogen in the lung...
- Role of granulocyte macrophage colony-stimulating factor in host defense against pulmonary Cryptococcus neoformans infection during murine allergic bronchopulmonary mycosisGwo Hsiao Chen
Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 0642, USA
Am J Pathol 170:1028-40. 2007..Production of both Th1 and Th2 cytokines was impaired in the absence of GM-CSF, consistent with both reduced C. neoformans clearance and absence of allergic lung pathology...
- Scavenger receptor A modulates the immune response to pulmonary Cryptococcus neoformans infectionYafeng Qiu
Veterans Administration Ann Arbor Health System, Ann Arbor, MI 48105, USA
J Immunol 191:238-48. 2013..This results in amplification of Th2 arm of the immune response and subsequently impaired adaptive control of C. neoformans in the infected lungs...
- Inheritance of immune polarization patterns is linked to resistance versus susceptibility to Cryptococcus neoformans in a mouse modelGwo Hsiao Chen
VA Medical Center Ann Arbor, Ann Arbor, MI 48105, USA
Infect Immun 76:2379-91. 2008..The enhanced pulmonary lymphocyte recruitment could be responsible for a gradual shutdown of the undesirable Th2 arm of the immune response and subsequently improved anticryptococcal resistance in F1 mice...
- TLR9 signaling is required for generation of the adaptive immune protection in Cryptococcus neoformans-infected lungsYanmei Zhang
Veterans Affairs Ann Arbor Health System, Ann Arbor, Michigan, USA
Am J Pathol 177:754-65. 2010....
- PAI-1 promotes the accumulation of exudate macrophages and worsens pulmonary fibrosis following type II alveolar epithelial cell injuryJohn J Osterholzer
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA
J Pathol 228:170-80. 2012..Copyright © 2012 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd...
- Early or late IL-10 blockade enhances Th1 and th17 effector responses and promotes fungal clearance in mice with cryptococcal lung infectionBenjamin J Murdock
Research Service, Veterans Affairs Ann Arbor Healthcare System, Department of Veterans Affairs Health System, Ann Arbor, MI 48105 Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109
J Immunol 193:4107-16. 2014..Collectively, this study identifies early and late cellular and molecular mechanisms through which IL-10 impairs fungal clearance and highlights the therapeutic potential of IL-10 blockade in the treatment of fungal lung infections...
- Role of CC chemokine receptor 4 in natural killer cell activation during acute cigarette smoke exposureValerie R Stolberg
Department of Pathology and Laboratory Medicine, VA Ann Arbor Healthcare System, Ann Arbor, Michigan
Am J Pathol 184:454-63. 2014..These findings demonstrate that acute CS exposure elicits NK cell responses and suggest that CCR4 promotes NK cell priming/activation by mediating contacts with sentinel cells in the lung. ..
- Development of immune response that protects mice from viral pneumonitis after a single intranasal immunization with influenza A virus and nanoemulsionAndrzej Myc
Department of Internal Medicine, Division of Allergy, Center of Biologic Nanotechnology, University of Michigan, 9240 MSRB III, Ann Arbor, MI 48109 0666, USA
Vaccine 21:3801-14. 2003..This paper demonstrates that nanoemulsion can be employed as a non-toxic mucosal adjuvant for influenza virus vaccine...