Maynard Olson

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. doi request reprint Human genetics: Dr Watson's base pairs
    Maynard V Olson
    Nature 452:819-20. 2008
  2. pmc Large-insert genome analysis technology detects structural variation in Pseudomonas aeruginosa clinical strains from cystic fibrosis patients
    Hillary S Hayden
    Genome Center, University of Washington, Seattle, WA 98195, USA
    Genomics 91:530-7. 2008
  3. doi request reprint Human genetic individuality
    Maynard V Olson
    Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA 98195, USA
    Annu Rev Genomics Hum Genet 13:1-27. 2012
  4. pmc Comparison of Francisella tularensis genomes reveals evolutionary events associated with the emergence of human pathogenic strains
    Laurence Rohmer
    Department of Genome Sciences, University of Washington, Campus Box 357710, 1705 NE Pacific Street Seattle, Washington 98195, USA
    Genome Biol 8:R102. 2007
  5. ncbi request reprint Genomics. The chimpanzee genome--a bittersweet celebration
    Maynard V Olson
    University of Washington Genome Center, Departments of Medicine and Genome Sciences, Seattle, WA 98195, USA
    Science 305:191-2. 2004
  6. pmc Hypervariability, suppressed recombination and the genetics of individuality
    M V Olson
    University of Washington Genome Center, Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Philos Trans R Soc Lond B Biol Sci 359:129-40. 2004
  7. ncbi request reprint Sequencing the chimpanzee genome: insights into human evolution and disease
    Maynard V Olson
    University of Washington Genome Center, Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    Nat Rev Genet 4:20-8. 2003
  8. ncbi request reprint Genome mosaicism is conserved but not unique in Pseudomonas aeruginosa isolates from the airways of young children with cystic fibrosis
    Robert K Ernst
    Department of Microbiology, University of Washington, Health Sciences Building, K 140, Box 357710, Seattle, WA 98195, USA
    Environ Microbiol 5:1341-9. 2003
  9. pmc Ancient haplotypes of the HLA Class II region
    Christopher K Raymond
    University of Washington Genome Center, Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    Genome Res 15:1250-7. 2005
  10. pmc Whole-genome sequence variation among multiple isolates of Pseudomonas aeruginosa
    David H Spencer
    The University of Washington Genome Center, Department of Medicine, University of Washington Children s Hospital and Regional Medical Center, Seattle, Washington 98195, USA
    J Bacteriol 185:1316-25. 2003

Research Grants

  1. METHODS FOR SINGLE NUCLEOTIDE POLYMORPHISMS
    Maynard Olson; Fiscal Year: 2001
  2. Center for the Study of Natural Genetic Variation
    Maynard Olson; Fiscal Year: 2005
  3. UW Genome Center Large-scale Sequencing Program
    Maynard Olson; Fiscal Year: 2006

Collaborators

Detail Information

Publications25

  1. doi request reprint Human genetics: Dr Watson's base pairs
    Maynard V Olson
    Nature 452:819-20. 2008
  2. pmc Large-insert genome analysis technology detects structural variation in Pseudomonas aeruginosa clinical strains from cystic fibrosis patients
    Hillary S Hayden
    Genome Center, University of Washington, Seattle, WA 98195, USA
    Genomics 91:530-7. 2008
    ..aeruginosa and validates a technology that complements emerging, short-read sequencing methods that are better suited to characterizing single-nucleotide polymorphisms than structural variation...
  3. doi request reprint Human genetic individuality
    Maynard V Olson
    Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA 98195, USA
    Annu Rev Genomics Hum Genet 13:1-27. 2012
    ..However, it appears to be a combination of mutation-selection balance and founder effects that largely accounts for genetic individuality. If true, this inference has major implications for future research programs in human genetics...
  4. pmc Comparison of Francisella tularensis genomes reveals evolutionary events associated with the emergence of human pathogenic strains
    Laurence Rohmer
    Department of Genome Sciences, University of Washington, Campus Box 357710, 1705 NE Pacific Street Seattle, Washington 98195, USA
    Genome Biol 8:R102. 2007
    ....
  5. ncbi request reprint Genomics. The chimpanzee genome--a bittersweet celebration
    Maynard V Olson
    University of Washington Genome Center, Departments of Medicine and Genome Sciences, Seattle, WA 98195, USA
    Science 305:191-2. 2004
  6. pmc Hypervariability, suppressed recombination and the genetics of individuality
    M V Olson
    University of Washington Genome Center, Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Philos Trans R Soc Lond B Biol Sci 359:129-40. 2004
    ..We examine characteristic features of these allele families and explore the possibility that genetic loci with similar characteristics can be recognized in a whole-genome scan of human genetic variation...
  7. ncbi request reprint Sequencing the chimpanzee genome: insights into human evolution and disease
    Maynard V Olson
    University of Washington Genome Center, Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    Nat Rev Genet 4:20-8. 2003
    ..Second, chimpanzee-human comparisons are likely to yield molecular insights into how new biological characteristics evolve--findings that might be relevant throughout the tree of life...
  8. ncbi request reprint Genome mosaicism is conserved but not unique in Pseudomonas aeruginosa isolates from the airways of young children with cystic fibrosis
    Robert K Ernst
    Department of Microbiology, University of Washington, Health Sciences Building, K 140, Box 357710, Seattle, WA 98195, USA
    Environ Microbiol 5:1341-9. 2003
    ..Further characterization of P. aeruginosa diversity within the airways of individual CF patients may reveal common adaptations, perhaps mediated by gene loss, that suggest new opportunities for therapy...
  9. pmc Ancient haplotypes of the HLA Class II region
    Christopher K Raymond
    University of Washington Genome Center, Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    Genome Res 15:1250-7. 2005
    ....
  10. pmc Whole-genome sequence variation among multiple isolates of Pseudomonas aeruginosa
    David H Spencer
    The University of Washington Genome Center, Department of Medicine, University of Washington Children s Hospital and Regional Medical Center, Seattle, Washington 98195, USA
    J Bacteriol 185:1316-25. 2003
    ..aeruginosa backbone sequence while the strains addressed in this study possess additional genetic material that accounts for at least 10% of their genomes. Approximately half of these additional sequences are novel...
  11. pmc Mapping and sequencing of structural variation from eight human genomes
    Jeffrey M Kidd
    Department of Genome Sciences and Howard Hughes Medical Institute, University of Washington, Seattle, Washington 98195, USA
    Nature 453:56-64. 2008
    ..These data provide the first high-resolution sequence map of human structural variation--a standard for genotyping platforms and a prelude to future individual genome sequencing projects...
  12. pmc IFRD1 is a candidate gene for SMNA on chromosome 7q22-q23
    Zoran Brkanac
    Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98104, USA
    Am J Hum Genet 84:692-7. 2009
    ..Mutation analysis of IFRD1 in additional patients with similar phenotypes is needed for demonstration of causality and further evaluation of its importance in neurological diseases...
  13. pmc Genetic adaptation by Pseudomonas aeruginosa to the airways of cystic fibrosis patients
    Eric E Smith
    Genome Center, Program in Molecular and Cellular Biology, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 103:8487-92. 2006
    ..aeruginosa strains present in advanced CF infections differ systematically from those of "wild-type" P. aeruginosa and that these differences may offer new opportunities for treatment of this chronic disease...
  14. ncbi request reprint Targeted, haplotype-resolved resequencing of long segments of the human genome
    Christopher K Raymond
    University of Washington Genome Center, Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Genomics 86:759-66. 2005
    ..We illustrate its implementation with a detailed example of more than 400 kbp from the human CFTR region, across 15 individuals, and summarize our experience applying it to many other human loci...
  15. pmc Detecting disease-causing mutations in the human genome by haplotype matching
    David H Spencer
    Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA
    Am J Hum Genet 79:958-64. 2006
    ..We also define a reference data resource that would allow efficient application of this strategy to large critical intervals across the genome...
  16. ncbi request reprint Fine-scale structural variation of the human genome
    Eray Tuzun
    Department of Genome Sciences, University of Washington School of Medicine, 1705 NE Pacific Street, Seattle, Washington 98195, USA
    Nat Genet 37:727-32. 2005
    ..These data provide a fine-scale structural variation map of the human genome and the requisite sequence precision for subsequent genetic studies of human disease...
  17. pmc Genetic variation at the O-antigen biosynthetic locus in Pseudomonas aeruginosa
    Christopher K Raymond
    University of Washington Genome Center, Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Bacteriol 184:3614-22. 2002
    ..The overall pattern underscores the plasticity of the P. aeruginosa genome, in which a specific site in a well-conserved genomic region can be occupied by any of numerous islands of functionally related DNA with diverse sequences...
  18. pmc Linker-mediated recombinational subcloning of large DNA fragments using yeast
    Christopher K Raymond
    The University of Washington Genome Center, Department of Medicine, University of Washington, Seattle, Washington 98115, USA
    Genome Res 12:190-7. 2002
    ..This technology may find broad application in the final stages of completing the Human Genome Sequencing Project and in applications of BAC clones to the functional analysis of complex genomes...
  19. pmc Comprehensive transposon mutant library of Pseudomonas aeruginosa
    Michael A Jacobs
    Department of Medicine, University of Washington Genome Center, Box 352145, Seattle, WA 98195 2145, USA
    Proc Natl Acad Sci U S A 100:14339-44. 2003
    ..The transposons used to generate the mutant collection have added features that should facilitate downstream studies of gene expression, protein localization, epistasis, and chromosome engineering...
  20. pmc Evidence for diversifying selection at the pyoverdine locus of Pseudomonas aeruginosa
    Eric E Smith
    Program of Molecular and Cellular Biology, University of Washington, Seattle, WA 98195, USA
    J Bacteriol 187:2138-47. 2005
    ..The pyoverdine region shows evidence of horizontal transfer; we propose that some alleles in the region were introduced from other soil bacteria and have been subsequently maintained by diversifying selection...
  21. ncbi request reprint Closing gaps in the human genome with fosmid resources generated from multiple individuals
    Donald Bovee
    Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    Nat Genet 40:96-101. 2008
    ....
  22. ncbi request reprint High-throughput genotyping of intermediate-size structural variation
    Tera L Newman
    Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA
    Hum Mol Genet 15:1159-67. 2006
    ..The approach we describe may be used to characterize a large number of individuals in a cost-effective manner once the sequence organization of ISVs is known...
  23. ncbi request reprint The Human Genome Project: a player's perspective
    Maynard V Olson
    Department of Medicine, UW Genome Center, University of Washington, Box 352145, Seattle, WA 98195, USA
    J Mol Biol 319:931-42. 2002
  24. ncbi request reprint The DNA sequence of human chromosome 7
    Ladeana W Hillier
    Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA
    Nature 424:157-64. 2003
    ..Of genes confirmed by transcript sequences, some are polymorphic for mutations that disrupt the reading frame...
  25. ncbi request reprint Planning the genome institute's future
    Wendy R Uhlmann
    Science 299:1515; author reply 1515. 2003

Research Grants7

  1. METHODS FOR SINGLE NUCLEOTIDE POLYMORPHISMS
    Maynard Olson; Fiscal Year: 2001
    ..We will evaluate a scoring technology (TDI) that has the potential to be arrayed. And we will develop software to facilitate the process of cSNP discovery, marker creation, and TDI scoring. ..
  2. Center for the Study of Natural Genetic Variation
    Maynard Olson; Fiscal Year: 2005
    ..abstract_text> ..
  3. UW Genome Center Large-scale Sequencing Program
    Maynard Olson; Fiscal Year: 2006
    ..Other capabilities of the UWGC such as its automated finishing capacity will be made available to the NHGRI network on an as-needed basis. ..