E N Olson

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi request reprint The transcriptional coactivator CAMTA2 stimulates cardiac growth by opposing class II histone deacetylases
    Kunhua Song
    Department of Molecular Biology, The University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Blvd, Dallas, TX 75390, USA
    Cell 125:453-66. 2006
  2. pmc CREST--a large and diverse superfamily of putative transmembrane hydrolases
    Jimin Pei
    Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390, USA
    Biol Direct 6:37. 2011
  3. ncbi request reprint Cardiac hypertrophy: the good, the bad, and the ugly
    N Frey
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
    Annu Rev Physiol 65:45-79. 2003
  4. ncbi request reprint Sizing up the heart: development redux in disease
    Eric N Olson
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
    Genes Dev 17:1937-56. 2003
  5. ncbi request reprint Gene regulatory networks in the evolution and development of the heart
    Eric N Olson
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA
    Science 313:1922-7. 2006
  6. ncbi request reprint A decade of discoveries in cardiac biology
    Eric N Olson
    Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Blvd, Dallas, Texas 75390 9148, USA
    Nat Med 10:467-74. 2004
  7. ncbi request reprint Coronary artery disease and the MEF2A transcription factor
    Eric N Olson
    Department of Molecular Biology, University of Texas, Southwestern Medical Center, Dallas, TX 75390, USA
    Sci Aging Knowledge Environ 2003:pe33. 2003
  8. ncbi request reprint The combinatorial activities of Nkx2.5 and dHAND are essential for cardiac ventricle formation
    H Yamagishi
    Department of Pediatrics, Division of Cardiology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, Texas 75390 9148, USA
    Dev Biol 239:190-203. 2001
  9. ncbi request reprint Failure of Myf5 to support myogenic differentiation without myogenin, MyoD, and MRF4
    M R Valdez
    Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Dallas, Texas, 75235 9148, USA
    Dev Biol 219:287-98. 2000
  10. ncbi request reprint Regulation of cardiac growth and development by SRF and its cofactors
    D Wang
    Department of Molecular Biology, University of Texas, Southwestern Medical Center at Dallas, Dallas, Texas 75390 9148, USA
    Cold Spring Harb Symp Quant Biol 67:97-105. 2002

Collaborators

Detail Information

Publications150 found, 100 shown here

  1. ncbi request reprint The transcriptional coactivator CAMTA2 stimulates cardiac growth by opposing class II histone deacetylases
    Kunhua Song
    Department of Molecular Biology, The University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Blvd, Dallas, TX 75390, USA
    Cell 125:453-66. 2006
    ..These findings reveal a transcriptional regulatory mechanism that modulates cardiac growth and gene expression by linking hypertrophic signals to the cardiac genome...
  2. pmc CREST--a large and diverse superfamily of putative transmembrane hydrolases
    Jimin Pei
    Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390, USA
    Biol Direct 6:37. 2011
    ..Recently, a group of putative transmembrane receptors called progestin and adipoQ receptors (PAQRs) were found to be distantly related to alkaline ceramidases, raising the possibility that they may also function as membrane enzymes...
  3. ncbi request reprint Cardiac hypertrophy: the good, the bad, and the ugly
    N Frey
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
    Annu Rev Physiol 65:45-79. 2003
    ..In this review, we summarize recent insights into hypertrophic signaling and consider several novel antihypertrophic strategies...
  4. ncbi request reprint Sizing up the heart: development redux in disease
    Eric N Olson
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
    Genes Dev 17:1937-56. 2003
  5. ncbi request reprint Gene regulatory networks in the evolution and development of the heart
    Eric N Olson
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA
    Science 313:1922-7. 2006
    ..The consequences of such mutations reveal the logic of organogenesis and the evolutionary origins of morphological complexity...
  6. ncbi request reprint A decade of discoveries in cardiac biology
    Eric N Olson
    Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Blvd, Dallas, Texas 75390 9148, USA
    Nat Med 10:467-74. 2004
    ..These discoveries have provided new therapeutic approaches for prevention and palliation of cardiac disease and have raised new questions, challenges and opportunities for the future...
  7. ncbi request reprint Coronary artery disease and the MEF2A transcription factor
    Eric N Olson
    Department of Molecular Biology, University of Texas, Southwestern Medical Center, Dallas, TX 75390, USA
    Sci Aging Knowledge Environ 2003:pe33. 2003
    ..These findings reveal a new function for this regulator of cardiovascular development and raise intriguing questions about the underlying mechanisms of CAD...
  8. ncbi request reprint The combinatorial activities of Nkx2.5 and dHAND are essential for cardiac ventricle formation
    H Yamagishi
    Department of Pediatrics, Division of Cardiology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, Texas 75390 9148, USA
    Dev Biol 239:190-203. 2001
    ..5 and dHAND. These studies provide the first demonstration of gene mutations that result in ablation of the entire ventricular segment of the mammalian heart, and reveal essential transcriptional pathways for ventricular formation...
  9. ncbi request reprint Failure of Myf5 to support myogenic differentiation without myogenin, MyoD, and MRF4
    M R Valdez
    Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Dallas, Texas, 75235 9148, USA
    Dev Biol 219:287-98. 2000
    ....
  10. ncbi request reprint Regulation of cardiac growth and development by SRF and its cofactors
    D Wang
    Department of Molecular Biology, University of Texas, Southwestern Medical Center at Dallas, Dallas, Texas 75390 9148, USA
    Cold Spring Harb Symp Quant Biol 67:97-105. 2002
  11. pmc The transcriptional corepressor MITR is a signal-responsive inhibitor of myogenesis
    C L Zhang
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390 9148, USA
    Proc Natl Acad Sci U S A 98:7354-9. 2001
    ..These results reveal a role for MITR as a signal-dependent regulator of muscle differentiation...
  12. ncbi request reprint Dual role of the basic helix-loop-helix transcription factor scleraxis in mesoderm formation and chondrogenesis during mouse embryogenesis
    D Brown
    Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75235 9148, USA
    Development 126:4317-29. 1999
    ..These results reveal an essential early role for scleraxis in mesoderm formation, as well as a later role in formation of somite-derived chondrogenic lineages, and suggest that scleraxis target genes mediate these processes...
  13. pmc MyoR: a muscle-restricted basic helix-loop-helix transcription factor that antagonizes the actions of MyoD
    J Lu
    Department of Molecular Biology and Oncology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75235 9148, USA
    Proc Natl Acad Sci U S A 96:552-7. 1999
    ..These results suggest a role for MyoR as a lineage-restricted transcriptional repressor of the muscle differentiation program...
  14. ncbi request reprint Regulation of skeletal myogenesis by association of the MEF2 transcription factor with class II histone deacetylases
    J Lu
    Department of Molecular Biology, University of Texas, Southwestern Medical Center at Dallas, 75235, USA
    Mol Cell 6:233-44. 2000
    ..These findings reveal central roles for HDACs in chromatin remodeling during myogenesis and as intranuclear targets for signaling pathways controlled by IGF and CaM kinase...
  15. ncbi request reprint A GATA-dependent right ventricular enhancer controls dHAND transcription in the developing heart
    D G McFadden
    Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, 75390 9148, USA
    Development 127:5331-41. 2000
    ..Since GATA factors are not chamber-restricted, these findings suggest the existence of positive and/or negative coregulators that cooperate with GATA factors to control right ventricular-specific gene expression in the developing heart...
  16. pmc Role of Dlx6 in regulation of an endothelin-1-dependent, dHAND branchial arch enhancer
    J Charite
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75239 9148, USA
    Genes Dev 15:3039-49. 2001
    ..These results suggest that Dlx6 acts as an intermediary between ET-1 signaling and dHAND transcription during craniofacial morphogenesis...
  17. ncbi request reprint Antisocial, an intracellular adaptor protein, is required for myoblast fusion in Drosophila
    E H Chen
    Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, 75390, USA
    Dev Cell 1:705-15. 2001
    ..These findings suggest that ANTS functions as an intracellular adaptor protein that relays signals from Dumbfounded to the cytoskeleton during myoblast fusion...
  18. ncbi request reprint Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation
    T A McKinsey
    Department of Molecular Biology, The University of Texas Southwestern Medical Center at Dallas, 75390 9148, USA
    Nature 408:106-11. 2000
    ....
  19. pmc The basic helix-loop-helix transcription factor, dHAND, is required for vascular development
    H Yamagishi
    Department of Pediatrics, Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA
    J Clin Invest 105:261-70. 2000
    ..These results suggest that dHAND is required for vascular development and regulates angiogenesis, possibly through a VEGF signaling pathway...
  20. ncbi request reprint Transcription of the myogenic regulatory gene Mef2 in cardiac, somatic, and visceral muscle cell lineages is regulated by a Tinman-dependent core enhancer
    R M Cripps
    Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Dallas, Texas 75235 9148, USA
    Dev Biol 215:420-30. 1999
    ....
  21. ncbi request reprint Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND
    D Srivastava
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas 75235 9148, USA
    Nat Genet 16:154-60. 1997
    ....
  22. ncbi request reprint Transcriptional activity of MEF2 during mouse embryogenesis monitored with a MEF2-dependent transgene
    F J Naya
    Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Blvd, Dallas, TX 75235 9148, USA
    Development 126:2045-52. 1999
    ..The discordance between MEF2 mRNA expression and MEF2 transcriptional activity in nonmuscle cell types of embryos and adults also supports the notion that post-transcriptional mechanisms regulate the expression of MEF2 proteins...
  23. pmc Activation of MEF2 by muscle activity is mediated through a calcineurin-dependent pathway
    H Wu
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    EMBO J 20:6414-23. 2001
    ....
  24. ncbi request reprint Molecular mechanisms of ventricular hypoplasia
    D Srivastava
    Departments of Pediatrics and Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
    Cold Spring Harb Symp Quant Biol 67:121-5. 2002
    ....
  25. ncbi request reprint Heart and extra-embryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand1
    A B Firulli
    Department of Molecular Biology, The University of Texas Southwestern Medical Center at Dallas, 75235 9148, USA
    Nat Genet 18:266-70. 1998
    ..Heart development was also perturbed and did not progress beyond the cardiac-looping stage. Our results demonstrate important roles for Hand1 in extraembryonic mesodermal and heart development...
  26. ncbi request reprint Control of early cardiac-specific transcription of Nkx2-5 by a GATA-dependent enhancer
    C L Lien
    Departments of Molecular Biology and Oncology and Pathology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75235 9148, USA
    Development 126:75-84. 1999
    ....
  27. ncbi request reprint Twist is required for muscle template splitting during adult Drosophila myogenesis
    R M Cripps
    Department of Molecular Biology and Oncology, Hamon Center for Basic Cancer Research, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas, 75235 9148, USA
    Dev Biol 203:106-15. 1998
    ....
  28. ncbi request reprint CHAMP, a novel cardiac-specific helicase regulated by MEF2C
    Z P Liu
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, Texas 75390 9148, USA
    Dev Biol 234:497-509. 2001
    ..These findings suggest that CHAMP acts downstream of MEF2C in a cardiac-specific regulatory pathway for RNA processing and/or transcriptional control...
  29. pmc Activated MEK5 induces serial assembly of sarcomeres and eccentric cardiac hypertrophy
    R L Nicol
    Department of Molecular Biology, University of Texas, Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Dallas, TX 75390 9148, USA
    EMBO J 20:2757-67. 2001
    ..These findings reveal a specific role for MEK5-ERK5 in the induction of eccentric cardiac hypertrophy and in transduction of cytokine signals that regulate serial sarcomere assembly...
  30. pmc Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling
    O Nakagawa
    Departments of Molecular Biology and Pediatrics, The University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Dallas, Texas 75390 9148, USA
    Proc Natl Acad Sci U S A 97:13655-60. 2000
    ..These findings identify HRT genes as downstream targets for Notch signaling and reveal a negative autoregulatory loop whereby HRT proteins repress their own expression through interference with Notch signaling...
  31. ncbi request reprint Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C
    Q Lin
    Department of Molecular Biology and Oncology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235 9148, USA
    Science 276:1404-7. 1997
    ..Thus, MEF2C is an essential regulator of cardiac myogenesis and right ventricular development...
  32. ncbi request reprint The bHLH factors, dHAND and eHAND, specify pulmonary and systemic cardiac ventricles independent of left-right sidedness
    T Thomas
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas 75235 9148, USA
    Dev Biol 196:228-36. 1998
    ....
  33. pmc Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5
    T A McKinsey
    Department of Molecular Biology, The University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 97:14400-5. 2000
    ..Our studies suggest that 14-3-3 binding to HDAC5 is required for CaMK-dependent disruption of MEF2-HDAC complexes and nuclear export of HDAC5, and implicate 14-3-3 as a signal-dependent regulator of muscle cell differentiation...
  34. ncbi request reprint Muscle minus myoD
    E N Olson
    Department of Molecular Biology and Oncology, University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Dallas, Texas 75235 9148, USA
    Dev Biol 202:153-6. 1998
  35. ncbi request reprint Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor
    D Wang
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA
    Cell 105:851-62. 2001
    ..Myocardin is the founding member of a class of muscle transcription factors and provides a mechanism whereby SRF can convey myogenic activity to cardiac muscle genes...
  36. ncbi request reprint A signaling cascade involving endothelin-1, dHAND and msx1 regulates development of neural-crest-derived branchial arch mesenchyme
    T Thomas
    Department of Pediatrics, Division of Cardiology and Department of Molecular Biology and Oncology, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9148, USA edu
    Development 125:3005-14. 1998
    ..Complete disruption of this molecular pathway results in growth failure of the branchial arches from apoptosis, while partial disruption leads to defects of branchial arch derivatives, similar to those seen in CATCH-22 syndrome...
  37. pmc Myocyte-enriched calcineurin-interacting protein, MCIP1, inhibits cardiac hypertrophy in vivo
    B A Rothermel
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 98:3328-33. 2001
    ..The future development of measures to increase expression or activity of MCIP proteins selectively within the heart may have clinical value for prevention of heart failure...
  38. pmc The myogenic regulatory gene Mef2 is a direct target for transcriptional activation by Twist during Drosophila myogenesis
    R M Cripps
    Department of Molecular Biology and Oncology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235 9148, USA
    Genes Dev 12:422-34. 1998
    ..These findings define a novel transcriptional pathway required for skeletal muscle development and identify Twist as an essential and direct regulator of Mef2 expression in the somatic mesoderm...
  39. ncbi request reprint Muscle specificity encoded by specific serum response factor-binding sites
    P S Chang
    Department of Molecular Biology, University of Texas, Southwestern Medical Center, Dallas, Texas 75390-9148, USA
    J Biol Chem 276:17206-12. 2001
    ..We conclude that sequence variations among CArG boxes influence cell type specificity of expression and account, at least in part, for the ability of SRF to distinguish between growth factor-inducible and muscle-specific genes in vivo...
  40. ncbi request reprint The Mef2c gene is a direct transcriptional target of myogenic bHLH and MEF2 proteins during skeletal muscle development
    D Z Wang
    Department of Molecular Biology, Department of Pathology, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX 75390 9148, USA
    Development 128:4623-33. 2001
    ..Our findings reveal the existence of a regulatory circuit between these two classes of transcription factors that induces, amplifies and maintains their expression during skeletal muscle development...
  41. ncbi request reprint Control of muscle development by dueling HATs and HDACs
    T A McKinsey
    Department of Molecular Biology, The University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Blvd, Dallas, Texas 75390 9148, USA
    Curr Opin Genet Dev 11:497-504. 2001
    ..We describe the molecules and mechanisms involved in chromatin remodeling during skeletal muscle development...
  42. ncbi request reprint Development. The path to the heart and the road not taken
    E N Olson
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Science 291:2327-8. 2001
  43. ncbi request reprint Requirement of the MADS-box transcription factor MEF2C for vascular development
    Q Lin
    Department of Molecular Biology and Oncology and Pathology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75235 9148, USA
    Development 125:4565-74. 1998
    ..These results reveal multiple roles for MEF2C in vascular development and suggest that MEF2-dependent target genes mediate endothelial cell organization and SMC differentiation...
  44. ncbi request reprint Divergent roles for NK-2 class homeobox genes in cardiogenesis in flies and mice
    G Ranganayakulu
    Department of Molecular Biology and Oncology, The University of Texas Southwestern Medical Center, Dallas, TX 75235 9148, USA
    Development 125:3037-48. 1998
    ..The distinct cardiogenic programs in vertebrates and flies may be built upon a common and perhaps more ancient program for specification of visceral muscle...
  45. ncbi request reprint The bHLH transcription factor dHAND controls Sonic hedgehog expression and establishment of the zone of polarizing activity during limb development
    J Charite
    Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9148, USA
    Development 127:2461-70. 2000
    ..Together, these findings identify dHAND as an upstream activator of Shh expression and important transcriptional regulator of limb development...
  46. pmc Signal-dependent activation of the MEF2 transcription factor by dissociation from histone deacetylases
    J Lu
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75235 9148, USA
    Proc Natl Acad Sci U S A 97:4070-5. 2000
    ....
  47. ncbi request reprint Association of COOH-terminal-binding protein (CtBP) and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor
    C L Zhang
    Department of Molecular Biology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
    J Biol Chem 276:35-9. 2001
    ..These findings reveal CtBP-dependent and -independent mechanisms for transcriptional repression by MITR and show that MITR represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs...
  48. pmc Calsarcins, a novel family of sarcomeric calcineurin-binding proteins
    N Frey
    Departments of Molecular Biology and Pathology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390 9148, USA
    Proc Natl Acad Sci U S A 97:14632-7. 2000
    ..Calsarcins represent a novel family of sarcomeric proteins that link calcineurin with the contractile apparatus, thereby potentially coupling muscle activity to calcineurin activation...
  49. ncbi request reprint HRT1, HRT2, and HRT3: a new subclass of bHLH transcription factors marking specific cardiac, somitic, and pharyngeal arch segments
    O Nakagawa
    Department of Molecular Biology, The University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Dallas, Texas, 75235 9148, USA
    Dev Biol 216:72-84. 1999
    ..The unique and complementary expression patterns of this novel subfamily of bHLH proteins suggest a previously unrecognized role for Hairy-related pathways in segmental patterning of the heart and pharyngeal arches, among other organs...
  50. pmc The basic helix-loop-helix transcription factor capsulin controls spleen organogenesis
    J Lu
    Departments of Molecular Biology and Pathology, University of Texas Southwestern Medical Center at Dallas, 75235 9148, USA
    Proc Natl Acad Sci U S A 97:9525-30. 2000
    ....
  51. ncbi request reprint Transcriptional control of muscle development by myocyte enhancer factor-2 (MEF2) proteins
    B L Black
    Department of Molecular Biology and Oncology, University of Texas Southwestern Medical Center, Dallas 75235 9148, USA
    Annu Rev Cell Dev Biol 14:167-96. 1998
    ..We discuss the diverse functions of this family of transcription factors, the ways in which they are regulated, and their mechanisms of action...
  52. pmc Identification of a signal-responsive nuclear export sequence in class II histone deacetylases
    T A McKinsey
    Department of Molecular Biology, The University of Texas Southwestern Medical Center at Dallas, 75390 9148, USA
    Mol Cell Biol 21:6312-21. 2001
    ..These findings provide molecular insight into the mechanism by which extracellular cues alter chromatin structure to promote muscle differentiation and other MEF2-regulated processes...
  53. pmc Regulation of microtubule dynamics and myogenic differentiation by MURF, a striated muscle RING-finger protein
    J A Spencer
    Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235 9148, USA
    J Cell Biol 150:771-84. 2000
    ..These results identify MURF as a myogenic regulator of the microtubule network of striated muscle cells and reveal a link between microtubule organization and myogenesis...
  54. pmc FOG-2, a heart- and brain-enriched cofactor for GATA transcription factors
    J R Lu
    Departments of Molecular Biology and Oncology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235 9148, USA
    Mol Cell Biol 19:4495-502. 1999
    ..The properties of FOG-2 suggest its involvement in the control of cardiac and neural gene expression by GATA transcription factors...
  55. ncbi request reprint Myocardin and ternary complex factors compete for SRF to control smooth muscle gene expression
    Zhigao Wang
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, Texas 75390 9148, USA
    Nature 428:185-9. 2004
    ..We conclude that growth and developmental signals modulate smooth muscle gene expression by regulating the association of SRF with antagonistic cofactors...
  56. ncbi request reprint Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy
    Chun Li Zhang
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas 75390, USA
    Cell 110:479-88. 2002
    ..Thus, class II HDACs act as signal-responsive suppressors of the transcriptional program governing cardiac hypertrophy and heart failure...
  57. ncbi request reprint A genetic blueprint for growth and development of the heart
    Eric N Olson
    Department of Molecular Biology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
    Harvey Lect 98:41-64. 2002
  58. ncbi request reprint The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner
    David G McFadden
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390 9148, USA
    Development 132:189-201. 2005
    ..These findings demonstrate that Hand factors play pivotal and partially redundant roles in cardiac morphogenesis, cardiomyocyte differentiation and cardiac-specific transcription...
  59. ncbi request reprint EVEC, a novel epidermal growth factor-like repeat-containing protein upregulated in embryonic and diseased adult vasculature
    R C Kowal
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9148, USA
    Circ Res 84:1166-76. 1999
    ..These data suggest that EVEC may play an important role in the regulation of vascular growth and maturation during development and in lesions of injured vessels...
  60. pmc Activated notch inhibits myogenic activity of the MADS-Box transcription factor myocyte enhancer factor 2C
    J Wilson-Rawls
    Department of Molecular Biology and Oncology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235 9148, USA
    Mol Cell Biol 19:2853-62. 1999
    ..These findings reveal a novel mechanism for Notch-mediated inhibition of myogenesis and demonstrate that the Notch signaling pathway can discriminate between different members of the MEF2 family...
  61. ncbi request reprint Cooperative transcriptional activation by the neurogenic basic helix-loop-helix protein MASH1 and members of the myocyte enhancer factor-2 (MEF2) family
    B L Black
    Department of Molecular Biology and Oncology, Hamon Center for Basic Cancer Research, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA
    J Biol Chem 271:26659-63. 1996
    ..These results suggest that members of the MEF2 family perform similar roles in synergistic activation of transcription in myogenic and neurogenic lineages by serving as cofactors for cell type-specific bHLH proteins...
  62. pmc Abnormalities of the genitourinary tract in female mice lacking GATA5
    J D Molkentin
    Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9148, USA
    Mol Cell Biol 20:5256-60. 2000
    ..These results reveal a specific role of GATA5 in development of the female genitourinary system and suggest that other GATA factors may have functions overlapping those of GATA5 in other tissues...
  63. ncbi request reprint Myocardin is a direct transcriptional target of Mef2, Tead and Foxo proteins during cardiovascular development
    Esther E Creemers
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX 75390, USA
    Development 133:4245-56. 2006
    ....
  64. ncbi request reprint Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis
    J D Molkentin
    Department of Molecular Biology and Oncology, University of Texas Southwestern Medical Center at Dallas, 75235 9148, USA
    Genes Dev 11:1061-72. 1997
    ..We propose that GATA4 is required for the migration or folding morphogenesis of the precardiogenic splanchnic mesodermal cells at the level of the AIP...
  65. ncbi request reprint Wingless signaling induces nautilus expression in the ventral mesoderm of the Drosophila embryo
    G Ranganayakulu
    Department of Molecular Biology and Oncology, Hamon Center for Basic Cancer Research, The University of Texas Southwestern Medical Center, Dallas, Texas 75235 9148, USA
    Dev Biol 176:143-8. 1996
    ..Our results, combined with recent studies from chick, suggest a conserved role for Wg signaling pathways during muscle development...
  66. ncbi request reprint Oracle, a novel PDZ-LIM domain protein expressed in heart and skeletal muscle
    R Passier
    Department of Molecular Biology, Hamon Center for Basic Cancer Research, The University of Texas, Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75235 9148, USA
    Mech Dev 92:277-84. 2000
    ..5. From E9.5 low expression of Oracle mRNA was detectable in myotomes. These data suggest a role for Oracle in the early development and function of heart and skeletal muscle...
  67. ncbi request reprint Overlapping functions of the myogenic bHLH genes MRF4 and MyoD revealed in double mutant mice
    A Rawls
    Department of Molecular Biology and Oncology, Department of Pathology, UT Southwestern Medical Center at Dallas, Dallas, Texas 75235, USA
    Development 125:2349-58. 1998
    ....
  68. ncbi request reprint Capsulin: a novel bHLH transcription factor expressed in epicardial progenitors and mesenchyme of visceral organs
    J Lu
    Department of Molecular Biology and Oncology, The University of Texas, Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75235 9148, USA
    Mech Dev 73:23-32. 1998
    ....
  69. ncbi request reprint Remodeling muscles with calcineurin
    E N Olson
    Department of Molecular Biology, University of Texas, Southwestern Medical Center at Dallas, Texas
    Bioessays 22:510-9. 2000
    ..BioEssays 22:510-519, 2000...
  70. pmc An intragenic MEF2-dependent enhancer directs muscle-specific expression of microRNAs 1 and 133
    Ning Liu
    Departments of Molecular Biology and Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    Proc Natl Acad Sci U S A 104:20844-9. 2007
    ....
  71. ncbi request reprint Stem cells and their derivatives can bypass the requirement of myocardin for smooth muscle gene expression
    G C Teg Pipes
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX 75390, USA
    Dev Biol 288:502-13. 2005
    ....
  72. ncbi request reprint Control of stress-dependent cardiac growth and gene expression by a microRNA
    Eva van Rooij
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    Science 316:575-9. 2007
    ..Thus, the alphaMHC gene, in addition to encoding a major cardiac contractile protein, regulates cardiac growth and gene expression in response to stress and hormonal signaling through miR-208...
  73. ncbi request reprint Transcriptional regulation of cardiac progenitor cell populations
    Amanda M Masino
    Department of Internal Medicine, University of Texas Southwestern Medical Center Dallas, Dallas, TX 75390 8573, USA
    Circ Res 95:389-97. 2004
    ..These results define the transcriptional profile of mammalian cardiac progenitor cells and provide insight into the molecular regulation of the earliest periods of heart development...
  74. pmc Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice
    Rusty L Montgomery
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    J Clin Invest 118:3588-97. 2008
    ..These findings reveal a unique role for Hdac3 in maintenance of cardiac function and regulation of myocardial energy metabolism...
  75. pmc Control of endothelial cell proliferation and migration by VEGF signaling to histone deacetylase 7
    Shusheng Wang
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9148
    Proc Natl Acad Sci U S A 105:7738-43. 2008
    ..These results demonstrate that phosphorylation of HDAC7 serves as a molecular switch to mediate VEGF signaling and endothelial function...
  76. pmc Myocardin-related transcription factor-a controls myofibroblast activation and fibrosis in response to myocardial infarction
    Eric M Small
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Circ Res 107:294-304. 2010
    ..Myocardin-related transcription factors (MRTFs) are serum response factor (SRF) cofactors that promote a smooth muscle phenotype and are emerging as components of stress-responsive signaling...
  77. pmc Modulation of smooth muscle gene expression by association of histone acetyltransferases and deacetylases with myocardin
    Dongsun Cao
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390 9148, USA
    Mol Cell Biol 25:364-76. 2005
    ..These findings point to myocardin as a nexus for positive and negative regulation of smooth muscle gene expression by changes in chromatin acetylation...
  78. pmc Muscle-specific signaling mechanism that links actin dynamics to serum response factor
    Koichiro Kuwahara
    Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Blvd, Dallas, TX 75390, USA
    Mol Cell Biol 25:3173-81. 2005
    ....
  79. pmc Association of class II histone deacetylases with heterochromatin protein 1: potential role for histone methylation in control of muscle differentiation
    Chun Li Zhang
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
    Mol Cell Biol 22:7302-12. 2002
    ....
  80. pmc The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis
    Shusheng Wang
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Dev Cell 15:261-71. 2008
    ..These findings have important therapeutic implications for a variety of disorders involving abnormal angiogenesis and vascular leakage...
  81. ncbi request reprint MEF2C transcription factor controls chondrocyte hypertrophy and bone development
    Michael A Arnold
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Dev Cell 12:377-89. 2007
    ..These findings reveal unexpected commonalities in the mechanisms governing muscle, cardiovascular, and bone development with respect to their regulation by MEF2 and class II HDACs...
  82. pmc FoxO4 regulates tumor necrosis factor alpha-directed smooth muscle cell migration by activating matrix metalloproteinase 9 gene transcription
    Hao Li
    Department of Internal Medicine, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX 75390 9148, USA
    Mol Cell Biol 27:2676-86. 2007
    ....
  83. ncbi request reprint Control of cardiac growth by histone acetylation/deacetylation
    Johannes Backs
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    Circ Res 98:15-24. 2006
    ..Manipulation of histone modifying enzymes and the signaling pathways that impinge on them in the settings of pathological cardiac growth, remodeling, and heart failure represents an auspicious therapeutic approach...
  84. pmc Requirement of protein kinase D1 for pathological cardiac remodeling
    Jens Fielitz
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9148, USA
    Proc Natl Acad Sci U S A 105:3059-63. 2008
    ..We conclude that PKD1 functions as a key transducer of stress stimuli involved in pathological cardiac remodeling in vivo...
  85. pmc Histone deacetylase degradation and MEF2 activation promote the formation of slow-twitch myofibers
    Matthew J Potthoff
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
    J Clin Invest 117:2459-67. 2007
    ..These findings provide what we believe are new insights into the molecular basis of skeletal muscle function and have important implications for possible therapeutic interventions into muscular diseases...
  86. ncbi request reprint Hairy-related transcription factors inhibit GATA-dependent cardiac gene expression through a signal-responsive mechanism
    Irfan S Kathiriya
    Department of Molecular Biology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
    J Biol Chem 279:54937-43. 2004
    ..These results suggest that HRT proteins may regulate specific sets of cardiac genes by modulating the function of GATA proteins and other cardiac transcriptional activators in a signal-dependent manner...
  87. pmc Activated glycogen synthase-3 beta suppresses cardiac hypertrophy in vivo
    Christopher L Antos
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390 9148, USA
    Proc Natl Acad Sci U S A 99:907-12. 2002
    ....
  88. pmc Potentiation of serum response factor activity by a family of myocardin-related transcription factors
    Da Zhi Wang
    Department of Molecular Biology, University of Texas, Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas 75390 9148, USA
    Proc Natl Acad Sci U S A 99:14855-60. 2002
    ..Myocardin and MRTFs comprise a previously uncharacterized family of SRF cofactors with the potential to modulate SRF target genes in a wide range of tissues...
  89. ncbi request reprint Misexpression of dHAND induces ectopic digits in the developing limb bud in the absence of direct DNA binding
    David G McFadden
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX 75390 9148, USA
    Development 129:3077-88. 2002
    ..These findings suggest that dHAND may act via novel transcriptional mechanisms mediated by protein-protein interactions independent of direct DNA binding...
  90. ncbi request reprint Control of facial muscle development by MyoR and capsulin
    Jian Rong Lu
    Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Dallas, TX 75390 9148, USA
    Science 298:2378-81. 2002
    ..These findings identify MyoR and capsulin as unique transcription factors for the development of specific head muscles...
  91. ncbi request reprint Cardiac-specific activity of an Nkx2-5 enhancer requires an evolutionarily conserved Smad binding site
    Ching Ling Lien
    Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Dallas, Texas 75390, USA
    Dev Biol 244:257-66. 2002
    ....
  92. pmc Requirement of myocardin-related transcription factor-B for remodeling of branchial arch arteries and smooth muscle differentiation
    Jiyeon Oh
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    Proc Natl Acad Sci U S A 102:15122-7. 2005
    ..The phenotype of MRTF-B mutant mice is distinct from that of mice lacking myocardin, revealing unique roles for these serum response factor coactivators in the development of different subsets of smooth muscle cells in vivo...
  93. pmc Defective erythroid differentiation in miR-451 mutant mice mediated by 14-3-3zeta
    David M Patrick
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Genes Dev 24:1614-9. 2010
    ..These findings reveal an essential role of 14-3-3zeta as a mediator of the proerythroid differentiation actions of miR-451, and highlight the therapeutic potential of miR-451 inhibitors...
  94. ncbi request reprint Mice lacking calsarcin-1 are sensitized to calcineurin signaling and show accelerated cardiomyopathy in response to pathological biomechanical stress
    Norbert Frey
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9148, USA
    Nat Med 10:1336-43. 2004
    ..These findings show important roles for calsarcins as modulators of calcineurin signaling and the transmission of a specific subset of stress signals leading to cardiac remodeling in vivo...
  95. pmc Regulation of HDAC9 gene expression by MEF2 establishes a negative-feedback loop in the transcriptional circuitry of muscle differentiation
    Michael Haberland
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA
    Mol Cell Biol 27:518-25. 2007
    ..HDAC9 can associate with MEF2 proteins and suppress their transcriptional activity. The transcriptional repressor HDAC9 thus forms a negative-feedback loop in the transcriptional circuitry of muscle differentiation...
  96. pmc MicroRNA-218 regulates vascular patterning by modulation of Slit-Robo signaling
    Eric M Small
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas TX, USA
    Circ Res 107:1336-44. 2010
    ....
  97. ncbi request reprint Hand, an evolutionarily conserved bHLH transcription factor required for Drosophila cardiogenesis and hematopoiesis
    Zhe Han
    Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, TX 75390, USA
    Development 133:1175-82. 2006
    ..These findings demonstrate evolutionarily conserved functions of HAND transcription factors in Drosophila and mammalian cardiogenesis, and reveal a previously unrecognized requirement of Hand genes in hematopoiesis...
  98. pmc Histone deacetylases 1 and 2 redundantly regulate cardiac morphogenesis, growth, and contractility
    Rusty L Montgomery
    Department of Molecular Biology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    Genes Dev 21:1790-802. 2007
    ....
  99. pmc Activation of the MEF2 transcription factor in skeletal muscles from myotonic mice
    Hai Wu
    Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas 75390 9148, USA
    J Clin Invest 109:1327-33. 2002
    ..These findings provide new molecular targets for potential treatment of congenital myotonia...
  100. pmc Modulation of adverse cardiac remodeling by STARS, a mediator of MEF2 signaling and SRF activity
    Koichiro Kuwahara
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    J Clin Invest 117:1324-34. 2007
    ..These findings suggest that STARS modulates the responsiveness of the heart to stress signaling by functioning as a cytoskeletal intermediary between MEF2 and SRF...
  101. pmc CaM kinase II selectively signals to histone deacetylase 4 during cardiomyocyte hypertrophy
    Johannes Backs
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
    J Clin Invest 116:1853-64. 2006
    ..These findings reveal a central role for HDAC4 in CaMKII signaling pathways and have implications for the control of gene expression by calcium signaling in a variety of cell types...

Research Grants22

  1. MicroRNA Control of Cardiac Gene Expression, Function and Disease
    Eric N Olson; Fiscal Year: 2010
    ....
  2. TRANSCRIPTIONAL CONTROL OF CARDIAC MUSCLE DEVELOPMENT
    Eric Olson; Fiscal Year: 2007
    ..These studies will provide insights into fundamental mechanisms for muscle development and disease. ..
  3. Control of Cardiac Gene Expression Through Regulated Transcriptional Coactivators
    Eric N Olson; Fiscal Year: 2010
    ..abstract_text> ..
  4. Genetic Dissection of Cardiogenesis
    Eric N Olson; Fiscal Year: 2010
    ..Understanding the function of these proteins will reveal new insights into the fundamental circuitry of cardiac development and provide approaches to combat congenital heart disease. ..
  5. Genetic Dissection of Cardiogenesis
    Eric Olson; Fiscal Year: 2007
    ..abstract_text> ..
  6. Control of Cardiac Gene Expression Through Regulated Transcriptional Coactivators
    Eric Olson; Fiscal Year: 2007
    ....
  7. TRANSCRIPTIONAL CONTROL OF CARDIAC HYPERTROPHY
    Eric Olson; Fiscal Year: 2002
    ..End of Abstract) ..
  8. Laser Microdissection System
    Eric Olson; Fiscal Year: 2004
    ....