B M Olivera

Summary

Affiliation: University of Utah
Country: USA

Publications

  1. pmc Elucidation of the molecular envenomation strategy of the cone snail Conus geographus through transcriptome sequencing of its venom duct
    Hao Hu
    Eccles Institute of Human Genetics, University of Utah, and School of Medicine, Salt Lake City, UT 84112, USA
    BMC Genomics 13:284. 2012
  2. pmc Adaptive radiation of venomous marine snail lineages and the accelerated evolution of venom peptide genes
    Baldomero M Olivera
    Biology Department, University of Utah, Salt Lake City, Utah, USA
    Ann N Y Acad Sci 1267:61-70. 2012
  3. pmc Characterization of the Conus bullatus genome and its venom-duct transcriptome
    Hao Hu
    Eccles Institute of Human Genetics, University of Utah, and School of Medicine, Salt Lake City, UT 84112, USA
    BMC Genomics 12:60. 2011
  4. ncbi request reprint Speciation of cone snails and interspecific hyperdivergence of their venom peptides. Potential evolutionary significance of introns
    B M Olivera
    Department of Biology, University of Utah, Salt Lake City 84112, USA
    Ann N Y Acad Sci 870:223-37. 1999
  5. ncbi request reprint Diversity of the neurotoxic Conus peptides: a model for concerted pharmacological discovery
    Baldomero M Olivera
    Department of Biology, University of Utah, Salt Lake City, UT 84112, USA
    Mol Interv 7:251-60. 2007
  6. ncbi request reprint Conus peptides: biodiversity-based discovery and exogenomics
    Baldomero M Olivera
    Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA
    J Biol Chem 281:31173-7. 2006
  7. ncbi request reprint A novel alpha-conotoxin, PeIA, cloned from Conus pergrandis, discriminates between rat alpha9alpha10 and alpha7 nicotinic cholinergic receptors
    J Michael McIntosh
    Department of Psychiatry, University of Utah, Salt Lake City, Utah 84112, USA
    J Biol Chem 280:30107-12. 2005
  8. ncbi request reprint Characterization and three-dimensional structure determination of psi-conotoxin Piiif, a novel noncompetitive antagonist of nicotinic acetylcholine receptors
    Ryan M Van Wagoner
    Department of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, USA
    Biochemistry 42:6353-62. 2003
  9. ncbi request reprint Post-translational amino acid isomerization: a functionally important D-amino acid in an excitatory peptide
    Olga Buczek
    Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA
    J Biol Chem 280:4247-53. 2005
  10. ncbi request reprint Conantokin-G precursor and its role in gamma-carboxylation by a vitamin K-dependent carboxylase from a Conus snail
    P K Bandyopadhyay
    Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA
    J Biol Chem 273:5447-50. 1998

Research Grants

  1. CONUS PEPTIDES AND THEIR RECEPTOR TARGETS
    Baldomero Olivera; Fiscal Year: 2007

Detail Information

Publications101 found, 100 shown here

  1. pmc Elucidation of the molecular envenomation strategy of the cone snail Conus geographus through transcriptome sequencing of its venom duct
    Hao Hu
    Eccles Institute of Human Genetics, University of Utah, and School of Medicine, Salt Lake City, UT 84112, USA
    BMC Genomics 13:284. 2012
    ....
  2. pmc Adaptive radiation of venomous marine snail lineages and the accelerated evolution of venom peptide genes
    Baldomero M Olivera
    Biology Department, University of Utah, Salt Lake City, Utah, USA
    Ann N Y Acad Sci 1267:61-70. 2012
    ....
  3. pmc Characterization of the Conus bullatus genome and its venom-duct transcriptome
    Hao Hu
    Eccles Institute of Human Genetics, University of Utah, and School of Medicine, Salt Lake City, UT 84112, USA
    BMC Genomics 12:60. 2011
    ..Thus the genomics analyses presented here provide the first step toward a better understanding the enigmatic Textilia clade...
  4. ncbi request reprint Speciation of cone snails and interspecific hyperdivergence of their venom peptides. Potential evolutionary significance of introns
    B M Olivera
    Department of Biology, University of Utah, Salt Lake City 84112, USA
    Ann N Y Acad Sci 870:223-37. 1999
    ..Plausible mechanisms that could underlie differing mutational frequency in the different exons of a gene are discussed...
  5. ncbi request reprint Diversity of the neurotoxic Conus peptides: a model for concerted pharmacological discovery
    Baldomero M Olivera
    Department of Biology, University of Utah, Salt Lake City, UT 84112, USA
    Mol Interv 7:251-60. 2007
    ..The Conus peptides thus serve as a model system for reaping the pharmacological potential of biodiverse animal lineages...
  6. ncbi request reprint Conus peptides: biodiversity-based discovery and exogenomics
    Baldomero M Olivera
    Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA
    J Biol Chem 281:31173-7. 2006
  7. ncbi request reprint A novel alpha-conotoxin, PeIA, cloned from Conus pergrandis, discriminates between rat alpha9alpha10 and alpha7 nicotinic cholinergic receptors
    J Michael McIntosh
    Department of Psychiatry, University of Utah, Salt Lake City, Utah 84112, USA
    J Biol Chem 280:30107-12. 2005
    ..Alpha-conotoxin PeIA represents a novel probe to differentiate responses mediated either through alpha9alpha10 or alpha7 nAChRs in those tissues where both receptors are expressed...
  8. ncbi request reprint Characterization and three-dimensional structure determination of psi-conotoxin Piiif, a novel noncompetitive antagonist of nicotinic acetylcholine receptors
    Ryan M Van Wagoner
    Department of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, USA
    Biochemistry 42:6353-62. 2003
    ..The third loop, which contains no charged residues in either peptide, is the prime determinant of potency in these psi-conotoxins...
  9. ncbi request reprint Post-translational amino acid isomerization: a functionally important D-amino acid in an excitatory peptide
    Olga Buczek
    Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA
    J Biol Chem 280:4247-53. 2005
    ....
  10. ncbi request reprint Conantokin-G precursor and its role in gamma-carboxylation by a vitamin K-dependent carboxylase from a Conus snail
    P K Bandyopadhyay
    Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA
    J Biol Chem 273:5447-50. 1998
    ..However, the role of propeptide in enhancing the efficiency of carboxylation is maintained...
  11. pmc Structure and sodium channel activity of an excitatory I1-superfamily conotoxin
    Olga Buczek
    Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA
    Biochemistry 46:9929-40. 2007
    ..Thus, there is a convergence of structure and function in iota-RXIA, as its disulfide pairing and structure resemble those of funnel web spider toxins that also target sodium channels...
  12. ncbi request reprint Delta-conotoxin structure/function through a cladistic analysis
    G Bulaj
    Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA
    Biochemistry 40:13201-8. 2001
    ....
  13. ncbi request reprint Novel excitatory Conus peptides define a new conotoxin superfamily
    Elsie C Jimenez
    Department of Biology, University of Utah, Salt Lake City, Utah 84112 0840, USA
    J Neurochem 85:610-21. 2003
    ..Thus, the I-superfamily conotoxins promise to provide a significant new technology platform for dissecting the molecular components of axons...
  14. ncbi request reprint The A-superfamily of conotoxins: structural and functional divergence
    Ameurfina D Santos
    Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA
    J Biol Chem 279:17596-606. 2004
    ..Patterns of sequence divergence and Cys codon usage define the major superfamily branches and suggest how these separate branches arose...
  15. ncbi request reprint Structural and functional diversities among mu-conotoxins targeting TTX-resistant sodium channels
    Min Min Zhang
    Departments of Biology, University of Utah, Salt Lake City 84112, USA
    Biochemistry 45:3723-32. 2006
    ..This is the most comprehensive characterization to date of the structural and functional diversities of an emerging group of mu-conotoxins targeting TTX-r sodium channels...
  16. pmc Specificity, affinity and efficacy of iota-conotoxin RXIA, an agonist of voltage-gated sodium channels Na(V)1.2, 1.6 and 1.7
    Brian Fiedler
    Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA
    Biochem Pharmacol 75:2334-44. 2008
    ..6 at nodes of Ranvier as well as in unmyelinated axons. Sixteen peptides homologous to iota-RXIA have been identified from a single species of Conus, so these peptides represent a rich family of novel sodium channel-targeting ligands...
  17. pmc Synergistic and antagonistic interactions between tetrodotoxin and mu-conotoxin in blocking voltage-gated sodium channels
    Min Min Zhang
    Department of Biology, University of Utah, Salt Lake City, UT 84112, USA
    Channels (Austin) 3:32-8. 2009
    ..The results lead us to postulate that in the bi-liganded NaV complex, TTX is bound between the peptide and the selectivity filter. These observations refine our view of Site 1 and open new possibilities in NaV pharmacology...
  18. doi request reprint Structurally minimized mu-conotoxin analogues as sodium channel blockers: implications for designing conopeptide-based therapeutics
    Tiffany S Han
    Department of Biology, University of Utah, 257 S 1400 E, Salt Lake City, UT 84112, USA
    ChemMedChem 4:406-14. 2009
    ....
  19. ncbi request reprint Mu-conotoxin SmIIIA, a potent inhibitor of tetrodotoxin-resistant sodium channels in amphibian sympathetic and sensory neurons
    Peter J West
    Interdepartmental Program in Neuroscience and Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA
    Biochemistry 41:15388-93. 2002
    ....
  20. ncbi request reprint Alpha-conotoxin PIA is selective for alpha6 subunit-containing nicotinic acetylcholine receptors
    Cheryl Dowell
    Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA
    J Neurosci 23:8445-52. 2003
    ..Exploiting the unusual intron conservation of conotoxin genes may represent a more general approach for defining conotoxin ligand scaffolds to discriminate among closely related receptor populations...
  21. ncbi request reprint Isolation and characterization of a novel conus peptide with apparent antinociceptive activity
    J M McIntosh
    Departments of Psychiatry and Biology, University of Utah, Salt Lake City, Utah 84112, Cognetix, Inc, Salt Lake City, Utah, 84108, USA
    J Biol Chem 275:32391-7. 2000
    ..This disulfide linkage is unprecedented among conotoxins and defines a new family of Conus peptides...
  22. ncbi request reprint Alpha-conotoxin BuIA, a novel peptide from Conus bullatus, distinguishes among neuronal nicotinic acetylcholine receptors
    Layla Azam
    Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA
    J Biol Chem 280:80-7. 2005
    ..Thus, alpha-conotoxin BuIA also represents a novel probe for distinguishing between beta 2- and beta 4-containing nAChRs...
  23. ncbi request reprint AlphaC-conotoxin PrXA: a new family of nicotinic acetylcholine receptor antagonists
    Elsie C Jimenez
    Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA
    Biochemistry 46:8717-24. 2007
    ..AlphaC-PrXA is strikingly different from the many conopeptides shown to be nicotinic antagonists; it is most similar in its general biochemical features to the snake toxins known as Waglerins...
  24. ncbi request reprint AlphaA-Conotoxin OIVA defines a new alphaA-conotoxin subfamily of nicotinic acetylcholine receptor inhibitors
    Russell W Teichert
    Department of Biology, University of Utah, 254 South 1400 East, Salt Lake City, UT 84112, USA
    Toxicon 44:207-14. 2004
    ..These results indicate that the alphaA-conotoxin family is both more structurally diverse and broadly distributed than previously believed...
  25. ncbi request reprint Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels
    Min Min Zhang
    Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA
    J Biol Chem 282:30699-706. 2007
    ..2 and that further engineering of micro-conopeptides belonging to the KIIIA group may provide subtype-selective pharmacological compounds for mammalian neuronal sodium channels and potential therapeutics for the treatment of pain...
  26. ncbi request reprint Contryphans from Conus textile venom ducts
    E C Jimenez
    Department of Biology, University of Utah, Salt Lake City, UT 84112, USA
    Toxicon 39:803-8. 2001
    ..Both the sequences and in vivo effects of all contryphans isolated suggest that there are two major branches of the contryphan family...
  27. ncbi request reprint Conantokin-L, a new NMDA receptor antagonist: determinants for anticonvulsant potency
    Elsie C Jimenez
    Department of Biology, University of Utah, 257 South 1400 East 201, Salt Lake City, UT 84112 0840, USA
    Epilepsy Res 51:73-80. 2002
    ..2 in the audiogenic mouse model. The results suggest that the C-terminal sequences of conantokin-R and conantokin-L are a major determinant of their anticonvulsant potency...
  28. ncbi request reprint Definition of the M-conotoxin superfamily: characterization of novel peptides from molluscivorous Conus venoms
    Gloria P Corpuz
    Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA
    Biochemistry 44:8176-86. 2005
    ..A notable feature of the superfamily is that two distinct structural frameworks have been generated by changing the disulfide connectivity on an otherwise conserved Cys pattern...
  29. ncbi request reprint Conus peptides targeted to specific nicotinic acetylcholine receptor subtypes
    J M McIntosh
    Department of Biology, University of Utah, Salt Lake City 84112 0840, USA
    Annu Rev Biochem 68:59-88. 1999
    ..As a group the nicotinic acetylcholine receptor-targeted Conus peptides represent an increasingly well-defined set of tools for probing the structure, function, and physiological role of nicotinic acetylcholine receptors...
  30. ncbi request reprint On a potential global role for vitamin K-dependent gamma-carboxylation in animal systems. Evidence for a gamma-glutamyl carboxylase in Drosophila
    C S Walker
    Department of Biology, University of Utah, Salt Lake City, Utah 84112 0840, USA
    J Biol Chem 276:7769-74. 2001
    ..e. Conus), and Drosophila and the apparently strong homology between the three systems suggest that this is a highly conserved and widely distributed post-translational modification in biological systems...
  31. pmc μ-conotoxin KIIIA derivatives with divergent affinities versus efficacies in blocking voltage-gated sodium channels
    Min Min Zhang
    Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA
    Biochemistry 49:4804-12. 2010
    ....
  32. doi request reprint Peptide-toxin tools for probing the expression and function of fetal and adult subtypes of the nicotinic acetylcholine receptor
    Russell W Teichert
    Department of Biology, University of Utah, Salt Lake City, Utah, USA
    Ann N Y Acad Sci 1132:61-70. 2008
    ....
  33. ncbi request reprint Characterization of D-amino-acid-containing excitatory conotoxins and redefinition of the I-conotoxin superfamily
    Olga Buczek
    Department of Biology, University of Utah, Salt Lake City, UT 84112, USA
    FEBS J 272:4178-88. 2005
    ..Our results indicate that neither the chemical nature of the side chain nor the precise vicinal sequence around the modified residue seem to be critical, but there may be favored loci for isomerization to a d-amino acid...
  34. pmc Conantokin-P, an unusual conantokin with a long disulfide loop
    Konkallu Hanumae Gowd
    Department of Biology, University of Utah, Salt Lake City, UT 84112, USA
    Toxicon 52:203-13. 2008
    ..Our results suggest that different branches of the phylogenetic tree of cone snails have evolved distinct groups of conantokins, each with its own unique biochemical features...
  35. ncbi request reprint Conotoxins containing nonnatural backbone spacers: cladistic-based design, chemical synthesis, and improved analgesic activity
    Brad R Green
    Department of Biology, University of Utah, Salt Lake City, UT 84112, USA
    Chem Biol 14:399-407. 2007
    ..The resulting polytides provide a promising strategy for transforming disulfide-rich peptides into therapeutics...
  36. pmc NMR-based mapping of disulfide bridges in cysteine-rich peptides: application to the mu-conotoxin SxIIIA
    Aleksandra Walewska
    Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA
    J Am Chem Soc 130:14280-6. 2008
    ..These results suggest that differential incorporation of isotope-labeled cysteine residues is an efficient strategy to map disulfides and should facilitate the discovery and structure-function studies of many bioactive peptides...
  37. pmc Alpha-RgIA, a novel conotoxin that blocks the alpha9alpha10 nAChR: structure and identification of key receptor-binding residues
    Michael Ellison
    Department of Biology, University of Utah, Salt Lake City, UT 84112, USA
    J Mol Biol 377:1216-27. 2008
    ..Our findings contribute to a better understanding of the molecular basis for antagonism of the alpha9alpha10 nAChR subtype, which is a target for the development of analgesics for the treatment of chronic neuropathic pain...
  38. ncbi request reprint Conus venoms - a rich source of peptide-based therapeutics
    Tiffany S Han
    Department of Biology, University of Utah, Salt Lake City, Utah 84108, USA
    Curr Pharm Des 14:2462-79. 2008
    ..This review summarizes recent efforts in the discovery of conopeptides, and their preclinical and clinical development...
  39. doi request reprint Role of hydroxyprolines in the in vitro oxidative folding and biological activity of conotoxins
    Estuardo Lopez-Vera
    Department of Biology, University of Utah, Salt Lake City, Utah 84108, USA
    Biochemistry 47:1741-51. 2008
    ..Taken together, our data suggest that proline hydroxylation is important for both in vitro oxidative folding and the bioactivity of conotoxins...
  40. ncbi request reprint Novel conantokins from Conus parius venom are specific antagonists of N-methyl-D-aspartate receptors
    Russell W Teichert
    Department of Biology, University of Utah, Salt Lake City, Utah 84112 0840, USA
    J Biol Chem 282:36905-13. 2007
    ..Conus parius conantokins allow for a better definition of structural and functional features of conantokins as ligands targeting NMDA receptors...
  41. ncbi request reprint Multiple 6-bromotryptophan residues in a sleep-inducing peptide
    Elsie C Jimenez
    Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA
    Biochemistry 43:12343-8. 2004
    ..The pattern of posttranslational bromination in the light sleeper peptide suggests that tryptophan residues at N- and C-termini may be preferential sites for posttranslational bromination...
  42. ncbi request reprint A novel alpha conotoxin (alpha-PIB) isolated from C. purpurascens is selective for skeletal muscle nicotinic acetylcholine receptors
    Estuardo Lopez-Vera
    Department of Biology, University of Utah, 257 South 1400 East, Salt Lake City, UT 84112, USA
    Toxicon 49:1193-9. 2007
    ..Testing of alpha-PIB against other receptors indicated that the inhibitory effect is specific for skeletal muscle nAChRs. alpha-PIB shares the key biochemical and pharmacological characteristics of the alpha-conotoxin family...
  43. pmc Efficient oxidative folding of conotoxins and the radiation of venomous cone snails
    Grzegorz Bulaj
    Department of Biology, University of Utah, Salt Lake City, UT 84112, USA
    Proc Natl Acad Sci U S A 100:14562-8. 2003
    ..Almost certainly, additional specialized adaptations for efficient microprotein folding are required...
  44. pmc gamma -Glutamyl carboxylation: An extracellular posttranslational modification that antedates the divergence of molluscs, arthropods, and chordates
    Pradip K Bandyopadhyay
    Department of Biology, University of Utah, 257 South 1400 East, Salt Lake City, UT 84112 and Cognetix, Inc, 401 Wakara Way no 201, Salt Lake City, UT 84108
    Proc Natl Acad Sci U S A 99:1264-9. 2002
    ..The data raise the possibility that most introns in the genes of both mammals and molluscs antedate the divergence of these phyla...
  45. ncbi request reprint The augertoxins: biochemical characterization of venom components from the toxoglossate gastropod Terebra subulata
    Julita S Imperial
    Department of Biology, University of Utah, 257 South 1400 East, Salt Lake City, UT 84112 0840, USA
    Toxicon 42:391-8. 2003
    ..The results suggest that Conus peptide gene superfamilies probably do not extend to the Terebridae, suggesting that distinctive venom gene superfamilies may be expressed in each major division of Conacean gastropods...
  46. ncbi request reprint Autoradiographic localization of N-type VGCCs in gerbil hippocampus and failure of omega-conotoxin MVIIA to attenuate neuronal injury after transient cerebral ischemia
    A Azimi-Zonooz
    Department of Pediatrics, Oregon Health Sciences University, Portland, OR 97201, USA
    Brain Res 907:61-70. 2001
    ..Possible reasons are discussed. Lastly, we show that the peptide can be used as a synaptic marker in assessing short and long-term changes that occur in hippocampus after ischemic injury...
  47. doi request reprint Characterization of conantokin Rl-A: molecular phylogeny as structure/function study
    Konkallu H Gowd
    Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA
    J Pept Sci 16:375-82. 2010
    ..Thus, incorporating phylogeny in the discovery of novel ligands for the given family of ion channels or receptors is an efficient means of exploring the megadiverse group of peptides from the genus Conus...
  48. pmc Discovery and characterization of the short kappaA-conotoxins: a novel subfamily of excitatory conotoxins
    Russell W Teichert
    Department of Biology, University of Utah, 257 South 1400 East, Salt Lake City, UT 84112, USA
    Toxicon 49:318-28. 2007
    ..In contrast, the kappaA(S)-and kappaA(L)-conotoxins that diverge in several biochemical characteristics are clearly more similar in their physiological effects...
  49. pmc Tyrosine-rich conopeptides affect voltage-gated K+ channels
    Julita S Imperial
    Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA
    J Biol Chem 283:23026-32. 2008
    ..This is the first report of tyrosine-rich bioactive peptides in Conus venom...
  50. ncbi request reprint Solution conformation of alphaA-conotoxin EIVA, a potent neuromuscular nicotinic acetylcholine receptor antagonist from Conus ermineus
    Seung Wook Chi
    Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA
    J Biol Chem 278:42208-13. 2003
    ....
  51. ncbi request reprint Alpha-conotoxins ImI and ImII. Similar alpha 7 nicotinic receptor antagonists act at different sites
    Michael Ellison
    Department of Biology, University of Utah, Salt Lake City 84112, USA
    J Biol Chem 278:757-64. 2003
    ..Like alpha-CTx ImI, the block by alpha-CTx ImII is voltage-independent. Thus, alpha-CTx ImII represents a probe for a novel antagonist binding site, or microsite, on the alpha7 nAChR...
  52. pmc The mitochondrial genome of Conus textile, coxI-coxII intergenic sequences and Conoidean evolution
    Pradip K Bandyopadhyay
    Department of Biology, University of Utah, Salt Lake City, UT 84112, USA
    Mol Phylogenet Evol 46:215-23. 2008
    ..Thus, the coxI-coxII intergenic region can be used both to define evolutionary relationships between species in a clade, and to understand broad evolutionary patterns across the large superfamily Conoidea...
  53. ncbi request reprint Alpha-conotoxin GIC from Conus geographus, a novel peptide antagonist of nicotinic acetylcholine receptors
    J Michael McIntosh
    Department of Psychiatry, University of Utah, 257 S 1400 East, Salt Lake City, UT 84112, USA
    J Biol Chem 277:33610-5. 2002
    ....
  54. ncbi request reprint I(1)-superfamily conotoxins and prediction of single D-amino acid occurrence
    Olga Buczek
    Department of Biology, University of Utah, 257 South 1400 East, Salt Lake City, UT 84112, USA
    Toxicon 51:218-29. 2008
    ..We apply the rule to other members of the I(1)-superfamily, to determine a priori which are probably modified...
  55. ncbi request reprint Alpha4/3 conotoxins: phylogenetic distribution, functional properties, and structure-function insights
    Michael Ellison
    Department of Biology, University of Utah, Salt Lake City, Utah, 84112, USA
    Chem Rec 7:341-53. 2007
    ..The chemical diversity produced by the closely related animals in Stephanoconus is thus functionally differentiated, although structurally homologous...
  56. doi request reprint Purification and characterization of a novel excitatory peptide from Conus distans venom that defines a novel gene superfamily of conotoxins
    Ping Chen
    Department of Biology, University of Utah, 257 South, 1400 East, Salt Lake City, UT 84112, USA
    Toxicon 52:139-45. 2008
    ..The peptide defines both a previously uncharacterized gene superfamily of conopeptides, and a new Cys pattern with three vicinal Cys residues...
  57. ncbi request reprint A novel conotoxin inhibitor of Kv1.6 channel and nAChR subtypes defines a new superfamily of conotoxins
    Julita S Imperial
    Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA
    Biochemistry 45:8331-40. 2006
    ..This is the first conotoxin shown to affect the activity of both voltage-gated and ligand-gated ion channels...
  58. ncbi request reprint Alpha S-conotoxin RVIIIA: a structurally unique conotoxin that broadly targets nicotinic acetylcholine receptors
    Russell W Teichert
    Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA
    Biochemistry 44:7897-902. 2005
    ..Our working hypothesis is that the particular group of fish-hunting Conus species that includes Conus radiatus uses the alphaS-conotoxin family to target the muscle nAChR and paralyze prey...
  59. ncbi request reprint Folding of conotoxins: formation of the native disulfide bridges during chemical synthesis and biosynthesis of Conus peptides
    Grzegorz Bulaj
    Department of Medicinal Chemistry, College of Pharmacy, Salt Lake City, Utah 84108, USA
    Antioxid Redox Signal 10:141-55. 2008
    ....
  60. ncbi request reprint Alpha-RgIA: a novel conotoxin that specifically and potently blocks the alpha9alpha10 nAChR
    Michael Ellison
    Department of Biology, University of Utah, Salt Lake City, Utah 84112 0840, USA
    Biochemistry 45:1511-7. 2006
    ....
  61. pmc Pruning nature: Biodiversity-derived discovery of novel sodium channel blocking conotoxins from Conus bullatus
    MANDE HOLFORD
    Department of Biology, University of Utah, 257 S 1400 E Rm 114, Salt Lake City, UT 84112, USA
    Toxicon 53:90-8. 2009
    ..The discovery of BuIIIA, BuIIIB and BuIIIC Na channel blockers expands the diversity of ligands useful in determining the structure-activity relationship of voltage-gated sodium channels...
  62. pmc Integrated oxidative folding of cysteine/selenocysteine containing peptides: improving chemical synthesis of conotoxins
    Aleksandra Walewska
    Department of Biology, University of Utah, Salt Lake City, Utah 84108, USA
    Angew Chem Int Ed Engl 48:2221-4. 2009
    ....
  63. doi request reprint Conantokin-Br from Conus brettinghami and selectivity determinants for the NR2D subunit of the NMDA receptor
    Vernon D Twede
    Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA
    Biochemistry 48:4063-73. 2009
    ....
  64. ncbi request reprint A uniquely selective inhibitor of the mammalian fetal neuromuscular nicotinic acetylcholine receptor
    Russell W Teichert
    Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA
    J Neurosci 25:732-6. 2005
    ..In addition to its potential as a research tool, alphaA-OIVB may have some direct biomedical applications...
  65. ncbi request reprint Alpha-conotoxins ImI and ImII target distinct regions of the human alpha7 nicotinic acetylcholine receptor and distinguish human nicotinic receptor subtypes
    Michael Ellison
    Department of Biology and Psychiatry, University of Utah, Salt Lake City, Utah 84112, USA
    Biochemistry 43:16019-26. 2004
    ..Collectively, the data show that while alpha-ImI targets the classical competitive ligand binding site in a subtype selective manner, alpha-ImII is a probe of a novel inhibitory site in homomeric alpha7 nAChRs...
  66. ncbi request reprint Synthetic muO-conotoxin MrVIB blocks TTX-resistant sodium channel NaV1.8 and has a long-lasting analgesic activity
    Grzegorz Bulaj
    Department of Biology, The University of Utah, Salt Lake City, Utah 84112, USA
    Biochemistry 45:7404-14. 2006
    ..Our work provides the first example of analgesia produced by a conotoxin that blocks sodium channels. The emerging diversity of antinociceptive mechanisms targeted by different classes of conotoxins is discussed...
  67. ncbi request reprint Novel conotoxins from Conus striatus and Conus kinoshitai selectively block TTX-resistant sodium channels
    Grzegorz Bulaj
    Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA
    Biochemistry 44:7259-65. 2005
    ..Taken together, structural and functional differences among mu-conotoxins SmIIIA, SIIIA, and KIIIA offer a unique insight into the "evolutionary engineering" of conotoxin activity...
  68. ncbi request reprint Definition and characterization of the short alphaA-conotoxins: a single residue determines dissociation kinetics from the fetal muscle nicotinic acetylcholine receptor
    Russell W Teichert
    Department of Biology, University of Utah, Salt Lake City, Utah, 84112, USA
    Biochemistry 45:1304-12. 2006
    ..The rapidly reversible peptides may be most suitable for electrophysiological studies, while the relatively irreversible peptides should be most useful for binding and localization studies...
  69. ncbi request reprint Effects of Conus peptides on the behavior of mice
    B M Olivera
    Department of Biology, University of Utah, Salt Lake City 84112 0840, USA
    Curr Opin Neurobiol 9:772-7. 1999
    ..Recent studies have advanced our understanding of the mechanisms by which four conopeptides produce different behaviors in mice...
  70. ncbi request reprint Conolysin-Mt: a conus peptide that disrupts cellular membranes
    Jason S Biggs
    Department of Biology, University of Utah, Salt Lake City, Utah 84108, USA
    Biochemistry 46:12586-93. 2007
    ..aureus of 25-50 microM. The specificity of conolysin-Mt for native eukaryotic membranes is a novel feature of the peptide compared to other well-characterized cytolytic peptides such as melittin...
  71. ncbi request reprint Genes expressed in a turrid venom duct: divergence and similarity to conotoxins
    Maren Watkins
    Department of Pathology, University of Utah, Salt Lake City, 84112, USA
    J Mol Evol 62:247-56. 2006
    ..This is only 1 of >10,000 different turrid venoms that needs to be characterized. From this study, a common origin with Conus for one family of putative turrid toxins is indicated...
  72. ncbi request reprint Venomous auger snail Hastula (Impages) hectica (Linnaeus, 1758): molecular phylogeny, foregut anatomy and comparative toxinology
    Julita S Imperial
    Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA
    J Exp Zool B Mol Dev Evol 308:744-56. 2007
    ..The results suggest that different major lineages of venomous molluscs have strikingly divergent toxinological and venom-delivery strategies...
  73. pmc Microhabitats within venomous cone snails contain diverse actinobacteria
    Olivier Peraud
    Department of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, USA
    Appl Environ Microbiol 75:6820-6. 2009
    ..This suggests that cone snails may represent an underexplored reservoir of novel actinomycetes of potential interest for drug discovery...
  74. ncbi request reprint Complete mitochondrial DNA sequence of a Conoidean gastropod, Lophiotoma (Xenuroturris) cerithiformis: gene order and gastropod phylogeny
    Pradip K Bandyopadhyay
    Department of Biology, University of Utah, 257 South 1400 East, Salt Lake City, UT 84112, USA
    Toxicon 48:29-43. 2006
    ..cerithiformis mtDNA from mtDNAs of H. rubra, K. tunicata and O. vulgaris is shared by mtDNA of a littorinomorph gastropod Littorina saxitalis, suggesting a close relationship of conoidean and littorinomorph gastropods...
  75. ncbi request reprint Oxidative folding of conotoxins sharing an identical disulfide bridging framework
    Erika Fuller
    Cognetix Inc, Salt Lake City, UT 84112, USA
    FEBS J 272:1727-38. 2005
    ....
  76. ncbi request reprint Conotoxins and the posttranslational modification of secreted gene products
    O Buczek
    Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA
    Cell Mol Life Sci 62:3067-79. 2005
    ..Although the database of modified conotoxins is growing rapidly, there are far more questions raised than answers provided about possible mechanisms and functions of posttranslational modifications in Conus...
  77. ncbi request reprint Nicotine-evoked transmitter release from synaptosomes: functional association of specific presynaptic acetylcholine receptors and voltage-gated calcium channels
    J M Kulak
    Departments of Biology and Psychiatry, University of Utah, Salt Lake City, Utah 84112-0840, USA
    J Neurochem 77:1581-9. 2001
    ..Thus, these data indicate that different presynaptic termini can have distinctive functional associations of specific nAChRs and voltage-gated calcium channels...
  78. pmc DNA ligase and the pyridine nucleotide cycle in Salmonella typhimurium
    U E Park
    Department of Biology, University of Utah, Salt Lake City 84112
    J Bacteriol 171:2173-80. 1989
    ..We suggest that most intracellular pyridine nucleotide breakdown occurs in a process that protects the cell against oxygen damage but involves a biochemical mechanism other than DNA ligation...
  79. ncbi request reprint Conophysin-R, a Conus radiatus venom peptide belonging to the neurophysin family
    M Lirazan
    Department of Biology, University of Utah, 257 South 1400 East, Salt Lake City 84112 0840, USA
    Toxicon 40:901-8. 2002
    ..In addition, conophysin-R is the first neurophysin family member isolated and biochemically characterized from an invertebrate source...
  80. ncbi request reprint Biochemical characterization of Drosophila gamma-glutamyl carboxylase and its role in fly development
    P K Bandyopadhyay
    Department of Biology, University of Utah, Salt Lake City, 84112, USA
    Insect Mol Biol 15:147-56. 2006
    ..Inactivation of Drosophila gamma-glutamyl carboxylase by non-sense mutations or insertional mutagenesis by P-element insertion have no apparent effects on growth and fertility under laboratory conditions...
  81. pmc Characterization of a novel psi-conotoxin from Conus parius Reeve
    Arturo O Lluisma
    Marine Science Institute, University of the Philippines, Quezon City, Philippines
    Toxicon 51:174-80. 2008
    ..purpurascens belongs, suggests that greater structural and functional diversity of psi-conotoxins remains to be discovered from the members of this subgenus...
  82. doi request reprint Structure, dynamics, and selectivity of the sodium channel blocker mu-conotoxin SIIIA
    Shenggen Yao
    Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Biochemistry 47:10940-9. 2008
    ....
  83. ncbi request reprint muO conotoxins inhibit NaV channels by interfering with their voltage sensors in domain-2
    Enrico Leipold
    Center for Molecular Biomedicine, Department of Biophysics, Friedrich Schiller University, Jena, Germany
    Channels (Austin) 1:253-62. 2007
    ..They "block" Na(+) flow most likely by hindering the voltage sensor in domain-2 from activating and, hence, the channel from opening...
  84. doi request reprint The rescue of developing avian motoneurons from programmed cell death by a selective inhibitor of the fetal muscle-specific nicotinic acetylcholine receptor
    Ronald W Oppenheim
    Department of Neurobiology and Anatomy and the Neuroscience Program, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Dev Neurobiol 68:972-80. 2008
    ..We conclude that selective inhibition of the embryonic/fetal form of the chicken muscle nAChR is sufficient to rescue MNs from PCD without any involvement of neuronal nAChRs...
  85. ncbi request reprint A novel conus peptide ligand for K+ channels
    Michael Ferber
    AG Molekulare und Zelluläre Neuropharmakologie, Max Planck Institut fur experimentelle Medizin, Hermann Rein Str 3, D 37075 Gottingen, Germany
    J Biol Chem 278:2177-83. 2003
    ..Binding of kappaM-conotoxin RIIIK is state-dependent, with an IC(50) of 20 nm for the closed state and 60 nm at 0 mV for the open state of TSha1 channels...
  86. ncbi request reprint Structural basis for tetrodotoxin-resistant sodium channel binding by mu-conotoxin SmIIIA
    David W Keizer
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    J Biol Chem 278:46805-13. 2003
    ....
  87. pmc The binding of kappa-Conotoxin PVIIA and fast C-type inactivation of Shaker K+ channels are mutually exclusive
    E Dietlind Koch
    Max Planck Institute for Experimental Medicine, Molecular and Cellular Neuropharmacology Group, Gottingen, Germany
    Biophys J 86:191-209. 2004
    ....
  88. pmc Solution conformation of alpha-conotoxin GIC, a novel potent antagonist of alpha3beta2 nicotinic acetylcholine receptors
    Seung Wook Chi
    Laboratory of Protein Analysis and Design, Division of Drug Discovery, Korea Research Institute of Bioscience and Biotechnology, Yusong P O Box 115, Daejon, Korea
    Biochem J 380:347-52. 2004
    ....
  89. ncbi request reprint Identification of a mammalian target of kappaM-conotoxin RIIIK
    Michael Ferber
    AG Molekulare und Zelluläre Neuropharmakologie, Max Planck Institut fur experimentelle Medizin, Hermann Rein Strasse 3, D 37075 Gottingen, Germany
    Toxicon 43:915-21. 2004
    ..kappaM-conotoxin RIIIK is the first conotoxin described to block human Kv1.2 potassium channels...
  90. ncbi request reprint Identification of a novel pharmacophore for peptide toxins interacting with K+ channels
    Laurent Verdier
    Department of NMR Based Structural Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, D 37077 Gottingen, Germany
    J Biol Chem 280:21246-55. 2005
    ....
  91. ncbi request reprint Molecular interaction of delta-conotoxins with voltage-gated sodium channels
    Enrico Leipold
    Institute of Molecular Cell Biology, Research Unit Molecular and Cellular Biophysics, Friedrich Schiller University Jena, Drackendorfer Strasse 1, D 07747 Jena, Germany
    FEBS Lett 579:3881-4. 2005
    ..Delta-SVIE functionally competes with Lqh-2, but exhibits strong cooperativity with Lqh-3, presumably by synergistically trapping the voltage sensor in its "on" position...
  92. ncbi request reprint A novel conotoxin from Conus delessertii with posttranslationally modified lysine residues
    Manuel B Aguilar
    Laboratory of Marine Neuropharmacology, Institute of Neurobiology, Universidad Nacional Autonoma de Mexico, Juriquilla, Qro 76230, Mexico
    Biochemistry 44:11130-6. 2005
    ..This peptide thus defines a novel class of conotoxins, with a new posttranslational modification not previously found in other Conus peptide families...
  93. ncbi request reprint Solution structure of alpha-conotoxin PIA, a novel antagonist of alpha6 subunit containing nicotinic acetylcholine receptors
    Seung Wook Chi
    Protein Analysis and Design Laboratory, Division of Drug Discovery, Korea Research Institute of Bioscience and Biotechnology, Yusong P O Box 115, Daejon, Republic of Korea
    Biochem Biophys Res Commun 338:1990-7. 2005
    ..By comparing the structure of alpha-conotoxin PIA with other functionally related alpha-conotoxins we suggest structural features in alpha-conotoxin PIA that may be associated with its unique receptor recognition profile...
  94. ncbi request reprint The muO-conotoxin MrVIA inhibits voltage-gated sodium channels by associating with domain-3
    Stefan Zorn
    Institute of Molecular Cell Biology, Research Unit Molecular and Cellular Biophysics, Medical Faculty of the Friedrich Schiller University Jena, Drackendorfer Str 1, D 07747 Jena, Germany
    FEBS Lett 580:1360-4. 2006
    ..2 channels. muO-conotoxins therefore show an interaction pattern with Na(V) channels that is clearly different from the related mu- and delta-conotoxins, indicative of a distinct molecular mechanism of channel inhibition...
  95. ncbi request reprint Solution conformation of a neuronal nicotinic acetylcholine receptor antagonist alpha-conotoxin OmIA that discriminates alpha3 vs. alpha6 nAChR subtypes
    Seung Wook Chi
    Molecular Anti Cancer Research Center, Division of Molecular Therapeutics, Korea Research Institute of Bioscience and Biotechnology, Yusong P O Box 115, Daejon, Republic of Korea
    Biochem Biophys Res Commun 345:248-54. 2006
    ..Reduced size of the hydrophilic area in alpha-conotoxin OmIA seems to be associated with the reduced affinity towards the alpha6beta2 nAChR subtype...
  96. ncbi request reprint NMR structure determination of alpha-conotoxin BuIA, a novel neuronal nicotinic acetylcholine receptor antagonist with an unusual 4/4 disulfide scaffold
    Seung Wook Chi
    Molecular Cancer Research Center, Division of Molecular Therapeutics, KRIBB, Daejeon 305 806, Republic of Korea
    Biochem Biophys Res Commun 349:1228-34. 2006
    ....
  97. pmc Molecular mechanism for analgesia involving specific antagonism of alpha9alpha10 nicotinic acetylcholine receptors
    Michelle Vincler
    Department of Anesthesiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Proc Natl Acad Sci U S A 103:17880-4. 2006
    ..Our findings not only suggest a molecular mechanism for the treatment of neuropathic pain but also demonstrate the involvement of alpha9alpha10 nAChRs in the pathophysiology of peripheral nerve injury...
  98. ncbi request reprint Conkunitzin-S1 is the first member of a new Kunitz-type neurotoxin family. Structural and functional characterization
    Monika Bayrhuber
    Department for NMR based Structural Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Gottingen, Germany
    J Biol Chem 280:23766-70. 2005
    ..The affinity of Conk-S1 can be enhanced by a pore mutation within the Shaker channel pore indicating an interaction of Conk-S1 with the vestibule of potassium channels...
  99. ncbi request reprint Discovery, synthesis, and structure activity of a highly selective alpha7 nicotinic acetylcholine receptor antagonist
    Paul Whiteaker
    Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80309, USA
    Biochemistry 46:6628-38. 2007
    ..The peptide was also shown to be highly selective in competition binding assays in rat brain membranes. alpha-CtxArIB[V11L,V16D] is the most selective ligand yet reported for alpha7 nAChRs...
  100. pmc Conorfamide-Sr2, a gamma-carboxyglutamate-containing FMRFamide-related peptide from the venom of Conus spurius with activity in mice and mollusks
    Manuel B Aguilar
    Laboratorio de Neurofarmacología Marina, Departamento de Neurobiologia Celular y Molecular, Instituto de Neurobiologia, Universidad Nacional Autonoma de Mexico, Campus Juriquilla, Queretaro 76230, Mexico
    Peptides 29:186-95. 2008
    ..The biological activities of CNF-Sr2 in mollusks and mice make it a potential tool to study molecular targets in these and other organisms...
  101. ncbi request reprint Structure of a novel P-superfamily spasmodic conotoxin reveals an inhibitory cystine knot motif
    Luke A Miles
    The Walter and Eliza Hall Institute of Medical Research, NMR Laboratory, 381 Royal Parade, Parkville 3052, Australia
    J Biol Chem 277:43033-40. 2002
    ....

Research Grants2

  1. CONUS PEPTIDES AND THEIR RECEPTOR TARGETS
    Baldomero Olivera; Fiscal Year: 2007
    ....