Research Topics
Species | M F OliveSummaryAffiliation: University of California Country: USA Publications
| Collaborators
|
Detail Information
Publications
Microdialysis in the mouse nucleus accumbens: a method for detection of monoamine and amino acid neurotransmitters with simultaneous assessment of locomotor activityM F Olive
Ernest Gallo Clinic and Research Center, Department of Neurology, University of California at San Francisco, San Francisco, CA 94110, USA
Brain Res Brain Res Protoc 5:16-24. 2000....
The mGluR5 antagonist 6-methyl-2-(phenylethynyl)pyridine decreases ethanol consumption via a protein kinase C epsilon-dependent mechanismM Foster Olive
Ernest Gallo Clinic and Research Center, Department of Neurology, University of California at San Francisco, 5858 Horton St, Suite 200, Emeryville, CA 94608, USA
Mol Pharmacol 67:349-55. 2005..Our data indicate that mGluR5 is coupled to PKCepsilon via a PI3K-dependent pathway and that PKCepsilon is required for the ability of the mGluR5 antagonist MPEP to reduce ethanol consumption...
Interactions between taurine and ethanol in the central nervous systemM F Olive
Department of Neurology, University of California at San Francisco, Emeryville, California, USA
Amino Acids 23:345-57. 2002....
A role for corticotropin releasing factor (CRF) in ethanol consumption, sensitivity, and reward as revealed by CRF-deficient miceM Foster Olive
Ernest Gallo Clinic and Research Center, University of California at San Francisco, 5858 Horton Street, Suite 200, Emeryville, CA 94608, USA
Psychopharmacology (Berl) 165:181-7. 2003..Corticotropin-releasing factor (CRF) plays an integral role in mediating stress responses and anxiety. However, little is known regarding the role of CRF in ethanol consumption, a behavior often associated with stress and anxiety in humans...
Protein kinase C isozymes and addictionM Foster Olive
Ernest Gallo Clinic and Research Center, Department of Neurology, University of California at San Francisco, Emeryville, CA 94608, USA
Mol Neurobiol 29:139-54. 2004..In addition, we summarize recent studies utilizing mice with targeted deletions of the genes for PKCgamma and PKCepsilon. These studies suggest that individual PKC isozymes play a role in the development of drug dependence and addiction...
Elevated extracellular CRF levels in the bed nucleus of the stria terminalis during ethanol withdrawal and reduction by subsequent ethanol intakeM Foster Olive
Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, 5858 Horton Street, Suite 200, Emeryville, CA 94608, USA
Pharmacol Biochem Behav 72:213-20. 2002..These data demonstrate that extracellular CRF levels are increased in the BNST during ethanol withdrawal, and that these increases are reduced by subsequent ethanol intake...
Effects of acute acamprosate and homotaurine on ethanol intake and ethanol-stimulated mesolimbic dopamine releaseM Foster Olive
Ernest Gallo Clinic and Research Center, UCSF Department of Neurology, 5858 Horton Street, Suite 200, Emeryville, CA 94608, USA
Eur J Pharmacol 437:55-61. 2002....
Stimulation of endorphin neurotransmission in the nucleus accumbens by ethanol, cocaine, and amphetamineM F Olive
Department of Neurology, University of California at San Francisco, Emeryville, California 94608, USA
J Neurosci 21:RC184. 2001..We hypothesize that this drug-induced release of endorphins may contribute to the positive reinforcing and motivating properties of ethanol and psychostimulants...
Modulation of extracellular neurotransmitter levels in the nucleus accumbens by a taurine uptake inhibitorM F Olive
Ernest Gallo Clinic and Research Center, UCSF Department of Neurology, 5858 Horton Street, Suite 200, Emeryville, CA 94608, USA
Eur J Pharmacol 409:291-4. 2000..These results indicate that guanidinoethyl sulfonate can modulate extracellular amino acid levels in the nucleus accumbens...
Reduced operant ethanol self-administration and in vivo mesolimbic dopamine responses to ethanol in PKCepsilon-deficient miceM F Olive
Department of Neurology, Ernest Gallo Clinic and Research Center, University of California San Francisco, 5858 Horton Street, Suite 200, Emeryville, CA 94608, USA
Eur J Neurosci 12:4131-40. 2000....
The discriminative stimulus properties of self-administered ethanol are mediated by GABA(A) and NMDA receptors in ratsC W Hodge
Department of Neurology, Ernest Gallo Clinic and Research Center, University of California at San Francisco, 94608, USA
Psychopharmacology (Berl) 154:13-22. 2001..The neurobiological systems that mediate the discriminative stimulus effects of self-administered drugs are largely unknown. The present study examined the discriminative stimulus effects of self-administered ethanol...
Reduced ethanol withdrawal severity and altered withdrawal-induced c-fos expression in various brain regions of mice lacking protein kinase C-epsilonM F Olive
Department of Neurology and Ernest Gallo Clinic and Research Center, University of California at San Francisco, 5858 Horton Street, Emeryville, CA 94608, USA
Neuroscience 103:171-9. 2001..These data also provide insight into potential brain regions involved in generation or suppression of ethanol withdrawal seizures...
Alcohol addictionM Foster Olive
Department of Neurology, Ernest Gallo Clinic and Research Center, University of California, San Francisco, Emeryville, USA
Methods Mol Biol 233:555-70. 2003
The mGluR5 antagonist MPEP reduces the conditioned rewarding effects of cocaine but not other drugs of abuseAndrew J McGeehan
Department of Neurology, University of California at San Francisco, Emeryville, California 94608, USA
Synapse 47:240-2. 2003..When tested alone at the doses effective in reducing CPP, MPEP produced neither a place preference nor aversion. These data provide further support for a role of the mGluR5 receptor in the rewarding effects of cocaine...
The anti-relapse compound acamprosate inhibits the development of a conditioned place preference to ethanol and cocaine but not morphineAndrew J McGeehan
Ernest Gallo Clinic and Research Center, Department of Neurology, University of California at San Francisco, 5858 Horton Street, Emeryville, CA 94608, U.S.A
Br J Pharmacol 138:9-12. 2003..These data suggest that acamprosate can suppress the conditioned rewarding effects of ethanol and certain classes of abused substances...
A microdialysis study of extracellular levels of acamprosate and naltrexone in the rat brain following acute and repeated administrationCostanza Burattini
University of California, San Francisco, USA
Addict Biol 13:70-9. 2008....
Acamprosate attenuates cocaine- and cue-induced reinstatement of cocaine-seeking behavior in ratsM Scott Bowers
Ernest Gallo Clinic and Research Center, Department of Neurology, University of California at San Francisco, Emeryville, CA 94608, USA
Psychopharmacology (Berl) 195:397-406. 2007..Acamprosate (calcium acetylhomotaurinate) is a glutamatergic neuromodulator used for the treatment of alcoholism, but its potential efficacy in the treatment of psychostimulant addiction has not been explored...
Anxiogenic and aversive effects of corticotropin-releasing factor (CRF) in the bed nucleus of the stria terminalis in the rat: role of CRF receptor subtypesLacey L Sahuque
Ernest Gallo Clinic and Research Center, Department of Neurology, University of California at San Francisco, Emeryville, CA 94608, USA
Psychopharmacology (Berl) 186:122-32. 2006..CONCLUSIONS: CRF1 receptors in the BNST mediate the anxiogenic-like effects of CRF in this region, whereas both CRF1 and CRF2 receptor subtypes mediate the conditioned aversive effects of this peptide within the BNST...
The glucocorticoid receptor antagonist mifepristone reduces ethanol intake in rats under limited access conditionsHeather N Koenig
Ernest Gallo Clinic and Research Center, Department of Neurology, University of California at San Francisco, 5858 Horton Street, Suite 200, Emeryville, CA 94608, USA
Psychoneuroendocrinology 29:999-1003. 2004..p.) was without effect on ethanol intake, and neither compound had an effect on water intake. These data confirm an active role of GRs in modulating voluntary ethanol consumption, particularly under conditions of limited access...
Effect of the mGluR5 antagonist 6-methyl-2-(phenylethynyl)pyridine (MPEP) on the acute locomotor stimulant properties of cocaine, D-amphetamine, and the dopamine reuptake inhibitor GBR12909 in miceAndrew J McGeehan
Department of Neurology, Ernest Gallo Clinic and Research Center, University of California at San Francisco, 5858 Horton Street, Suite 200, Emeryville, CA 94608, USA
Psychopharmacology (Berl) 174:266-73. 2004....
The anti-craving taurine derivative acamprosate: failure to extinguish morphine conditioned place preferenceM Foster Olive
Ernest Gallo Clinic and Research Center, Department of Neurology, University of California at San Francisco, California, USA
Adv Exp Med Biol 526:481-4. 2003
Decreased anxiety-like behavior, reduced stress hormones, and neurosteroid supersensitivity in mice lacking protein kinase CepsilonClyde W Hodge
Ernest Gallo Clinic and Research Center, Department of Neurology, University of California San Francisco, Emeryville, California 94608, USA
J Clin Invest 110:1003-10. 2002..The findings also suggest PKCepsilon as a possible therapeutic target for development of anxiolytics...
Ethanol consumption patterns and conditioned place preference in mice lacking preproenkephalinHeather N Koenig
Department of Neurology, Ernest Gallo Clinic and Research Center, University of California at San Francisco, 5858 Horton Street, Suite 200, Emeryville, CA 94608, USA
Neurosci Lett 325:75-8. 2002..In addition, both genotypes displayed a similar conditioned place preference to ethanol. These data suggest that the preproenkephalin system is not involved in voluntary ethanol consumption patterns or ethanol reward...
Inhibition of aldehyde dehydrogenase-2 suppresses cocaine seeking by generating THP, a cocaine use-dependent inhibitor of dopamine synthesisLina Yao
Gilead Sciences, Palo Alto, California, USA
Nat Med 16:1024-8. 2010..Selective inhibition of ALDH-2 may have therapeutic potential for treating human cocaine addiction and preventing relapse...
Reinstatement of ethanol-seeking behavior following intravenous self-administration in Wistar ratsJustin T Gass
Center for Drug and Alcohol Programs, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Alcohol Clin Exp Res 31:1441-5. 2007..However, no studies to date have examined reinstatement of ethanol-seeking behavior in animals with a history of IV ethanol self-administration...
Effects of adolescent exposure to cocaine on locomotor activity and extracellular dopamine and glutamate levels in nucleus accumbens of DBA/2J miceRosana Camarini
Department of Pharmacology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil
Brain Res 1193:34-42. 2008....
Role of the endogenous opioid system on the neuropsychopharmacological effects of ethanol: new insights about an old questionCarles Sanchis-Segura
Howard Florey Institute, University of Melbourne, Australia
Alcohol Clin Exp Res 29:1522-7. 2005..Grisel, Amanda J. Roberts, and George F. Koob; and () The mu-Opioid Receptor Modulates Acute Ethanol Sensitivity and Ethanol Withdrawal Severity by Sandra Ghozland...
Transcriptional profiling of the rat frontal cortex following administration of the mGlu5 receptor antagonists MPEP and MTEPJustin T Gass
Center for Drug and Alcohol Programs, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, 29425, USA
Eur J Pharmacol 584:253-62. 2008....
Effects of the mGluR2/3 agonist LY379268 and the mGluR5 antagonist MPEP on handling-induced convulsions during ethanol withdrawal in miceM Foster Olive
Center for Drug and Alcohol Programs, Department of Psychiatry and Behavioral Sciences Medical University of South Carolina, Charleston, SC 29425 USA
Alcohol 42:191-7. 2008....
The corticotropin-releasing factor/urocortin system and alcoholAndrey E Ryabinin
Department of Behavioral Neuroscience, Oregon Health and Sciences University, Portland 97201 3098, USA
Alcohol Clin Exp Res 26:714-22. 2002..Mehmert, R. Camarini, Joseph A. Kim, Heather N. Koenig, Michelle A. Nannini, and Clyde W. Hodge; and (5) Selective sensitivity of urocortin-containing neurons to alcohol self-administration, by Andrey E. Ryabinin and Ryan K. Bachtell...
Glutamatergic substrates of drug addiction and alcoholismJustin T Gass
Center for Drug and Alcohol Programs, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
Biochem Pharmacol 75:218-65. 2008..Nonetheless, manipulation of glutamatergic neurotransmission appears to be a promising avenue of research in developing improved therapeutic agents for the treatment of drug addiction and alcoholism...
The safety of disulfiram for the treatment of alcohol and cocaine dependence in randomized clinical trials: guidance for clinical practiceRobert Malcolm
Medical University of South Carolina, Institute of Psychiatry, 67 President Street, MSC 861, Charleston, SC 29425, USA
Expert Opin Drug Saf 7:459-72. 2008..Disulfiram has demonstrated efficacy in six randomized clinical trials for the treatment of cocaine dependence, but is rarely used in clinical settings because of safety concerns...
