Affiliation: University of Colorado Denver
- Inhibition of the P50 cerebral evoked response to repeated auditory stimuli: results from the Consortium on Genetics of SchizophreniaAnn Olincy
Department of Psychiatry, Veterans Affairs Denver Medical Center VISN 19 MIRECC, CO 80045, USA
Schizophr Res 119:175-82. 2010....
- Effects of an alpha 7-nicotinic agonist on default network activity in schizophreniaJason R Tregellas
Department of Psychiatry, Denver VA Medical Center, VISN19 MIRECC, Colorado, USA
Biol Psychiatry 69:7-11. 2011..This study examined the effects of DMXB-A on default network activity as a biomarker for drug effects on pathologic brain function associated with schizophrenia...
- Genome-wide linkage analyses of 12 endophenotypes for schizophrenia from the Consortium on the Genetics of SchizophreniaTiffany A Greenwood
Department of Psychiatry, University of California San Diego, La Jolla, Calif, USA
Am J Psychiatry 170:521-32. 2013..The authors previously demonstrated the heritability of these endophenotypes; in the present study, genetic linkage was evaluated...
- Abnormal auditory N100 amplitude: a heritable endophenotype in first-degree relatives of schizophrenia probandsBruce I Turetsky
Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Biol Psychiatry 64:1051-9. 2008..We report initial results from the COGS dataset of auditory N100 amplitude and gating as candidate endophenotypes...
- Initial heritability analyses of endophenotypic measures for schizophrenia: the consortium on the genetics of schizophreniaTiffany A Greenwood
Department of Psychiatry, University of California San Diego, La Jolla, USA
Arch Gen Psychiatry 64:1242-50. 2007..Exploration of the genetic architecture of specific endophenotypes may be a powerful strategy for understanding the genetic basis of schizophrenia...
- Physiology of schizophrenia, bipolar disorder, and schizoaffective disorderLaura F Martin
Department of Psychiatry, University of Colorado at Denver and Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
Am J Psychiatry 164:1900-6. 2007..A second aim was to determine whether subjects with schizoaffective disorder, bipolar type, were neurophysiologically more similar to subjects with schizophrenia or subjects with bipolar disorder...
- Comparison of polymorphisms in the alpha7 nicotinic receptor gene and its partial duplication in schizophrenic and control subjectsJudith Gault
Department of Psychiatry, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Am J Med Genet B Neuropsychiatr Genet 123:39-49. 2003..Twenty-one variants were found in the exons, but non-synonymous changes were rare. Although the expression of CHRNA7 is decreased in schizophrenia, the general structure of the remaining receptors is likely to be normal...
- Multi-site studies of acoustic startle and prepulse inhibition in humans: initial experience and methodological considerations based on studies by the Consortium on the Genetics of SchizophreniaNeal R Swerdlow
Department of Psychiatry, University of California San Diego, San Diego, California, USA
Schizophr Res 92:237-51. 2007..Genetic studies now often employ multiple, geographically dispersed test sites to accommodate the need for large and complex study samples. Here, we assessed the feasibility of using PPI in multi-site studies...
- Initial phase 2 trial of a nicotinic agonist in schizophreniaRobert Freedman
Department of Psychiatry, Denver VA Medical Center and University of Colorado, Denver, CO 80262, USA
Am J Psychiatry 165:1040-7. 2008..The agent 3-(2,4-dimethoxybenzylidene) anabaseine (DMXB-A) is a partial alpha(7)-nicotinic agonist and can be taken orally. A phase 1 trial showed evidence for cognitive enhancement in schizophrenia...
- Neurophysiological endophenotypes of schizophrenia: the viability of selected candidate measuresBruce I Turetsky
Department of Psychiatry, 10th Floor, Gates Building, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
Schizophr Bull 33:69-94. 2007..We conclude with a discussion of the few studies thus far that have employed a multivariate approach with these candidates...
- Analysis of 94 candidate genes and 12 endophenotypes for schizophrenia from the Consortium on the Genetics of SchizophreniaTiffany A Greenwood
Department of Psychiatry, University of California at San Diego, La Jolla, CA 92093 0804, USA
Am J Psychiatry 168:930-46. 2011....
- The Consortium on the Genetics of Endophenotypes in Schizophrenia: model recruitment, assessment, and endophenotyping methods for a multisite collaborationMonica E Calkins
Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania, 10 Gates, 3400 Spruce St, Philadelphia, PA 19104, USA
Schizophr Bull 33:33-48. 2007..The purpose of this article is to provide a description of the COGS structure and methods, including participant recruitment and assessment...
- Multiple genes in the 15q13-q14 chromosomal region are associated with schizophreniaSarah H Stephens
Department of Psychiatry, University of Colorado Denver, Colorado 80045, USA
Psychiatr Genet 22:1-14. 2012..This study fine-mapped genes at 15q13-q14 to determine whether the association is unique to CHRNA7...
- Sensory gating and alpha-7 nicotinic receptor gene allelic variants in schizoaffective disorder, bipolar typeLaura F Martin
Department of Psychiatry, Denver Veterans Affairs Medical Center, Denver, Colorado 80262, USA
Am J Med Genet B Neuropsychiatr Genet 144:611-4. 2007..The purpose of this study was to determine if CHRNA7 promoter allelic variants are also associated with abnormal P50 ratios in persons with schizoaffective disorder, bipolar type...
- Cerebellar hyperactivity during smooth pursuit eye movements in bipolar disorderLaura Frances Martin
University of Colorado Denver School of Medicine, Pscyhiatry, Mail Stop F546, 13001 E 17th Place, Aurora, CO 80045, USA
J Psychiatr Res 45:670-7. 2011..The underlying neurobiology of SPEM deficits in bipolar disorder is unknown...
- Functional magnetic resonance imaging of effects of a nicotinic agonist in schizophreniaJason R Tregellas
Department of Psychiatry, Denver VA Medical Center VISN19 MIRECC and University of Colorado Denver, Aurora, CO 80045, USA
Neuropsychopharmacology 35:938-42. 2010..Imaging of drug response is useful in planning future clinical tests of this compound and other nicotinic agonists for schizophrenia...
- Differential effects of cigarette smoking on performance of a smooth pursuit and a saccadic eye movement task in schizophreniaAnn Olincy
Department of Psychiatry, University of Colorado Health Sciences Center, 4200 E 9th Ave, Box C 268 71, Denver, CO 80262, USA
Psychiatry Res 117:223-36. 2003..However, premature saccades and large anticipatory saccades, although measures of inhibitory dysfunction in schizophrenia, appear to be unrelated to the nicotinic system...
- Admixture analysis of smooth pursuit eye movements in probands with schizophrenia and their relatives suggests gain and leading saccades are potential endophenotypesRandal G Ross
Department of Psychiatry, Denver Veterans Administration Medical Center, Colorado, USA
Psychophysiology 39:809-19. 2002..Relatives of childhood-onset and adult-onset probands had similar impairments. Gain and frequency of leading saccades may be genetic endophenotypes in childhood-onset and adult-onset schizophrenia...
- Treating schizophrenia symptoms with an alpha7 nicotinic agonist, from mice to menAnn Olincy
Department of Psychiatry, University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA
Biochem Pharmacol 74:1192-201. 2007..These data suggest that therapeutic agents selected for alpha7 nicotinic activity may have utility in treating certain symptoms of schizophrenia...
- Association of promoter variants in the alpha7 nicotinic acetylcholine receptor subunit gene with an inhibitory deficit found in schizophreniaSherry Leonard
Department of Psychiatry, Campus Box C 268 71, University of Colorado Health Sciences Center, 4200 E Ninth Ave, Denver, CO 80262, USA
Arch Gen Psychiatry 59:1085-96. 2002..This study presents DNA sequence analysis of the core promoter region for CHRNA7 in schizophrenic and control subjects...
- Sensory gating impairment associated with schizophrenia persists into REM sleepMichael A Kisley
Department of Psychiatry, University of Colorado Health Sciences Center and Denver Veteran s Affairs Medical Center, Denver, Colorado, USA
Psychophysiology 40:29-38. 2003..These results suggest that REM sleep is an appropriate state during which to assess P50 gating in order to disentangle the effects of state and trait on sensory gating impairment in other clinical populations...
- Early sensory processing deficits predict sensitivity to distraction in schizophreniaJason Smucny
Department of Psychiatry, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
Schizophr Res 147:196-200. 2013..The observed relationship between noise effects on reaction time and P50 auditory gating supports the hypothesis that early inhibitory processing deficits may contribute to susceptibility to distraction in the illness...