Ann Olincy

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. pmc Treating schizophrenia symptoms with an alpha7 nicotinic agonist, from mice to men
    Ann Olincy
    Department of Psychiatry, University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA
    Biochem Pharmacol 74:1192-201. 2007
  2. ncbi request reprint Proof-of-concept trial of an alpha7 nicotinic agonist in schizophrenia
    Ann Olincy
    Department of Veterans Affairs Schizophrenia Research Center, Denver, Colorado, USA
    Arch Gen Psychiatry 63:630-8. 2006
  3. pmc Effects of an alpha 7-nicotinic agonist on default network activity in schizophrenia
    Jason R Tregellas
    Department of Psychiatry, Denver VA Medical Center, VISN19 MIRECC, Colorado, USA
    Biol Psychiatry 69:7-11. 2011
  4. pmc Genome-wide linkage analyses of 12 endophenotypes for schizophrenia from the Consortium on the Genetics of Schizophrenia
    Tiffany A Greenwood
    Department of Psychiatry, University of California San Diego, La Jolla, Calif, USA
    Am J Psychiatry 170:521-32. 2013
  5. pmc Abnormal auditory N100 amplitude: a heritable endophenotype in first-degree relatives of schizophrenia probands
    Bruce I Turetsky
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Psychiatry 64:1051-9. 2008
  6. pmc Inhibition of the P50 cerebral evoked response to repeated auditory stimuli: results from the Consortium on Genetics of Schizophrenia
    Ann Olincy
    Department of Psychiatry, Veterans Affairs Denver Medical Center VISN 19 MIRECC, CO 80045, USA
    Schizophr Res 119:175-82. 2010
  7. ncbi request reprint Physiology of schizophrenia, bipolar disorder, and schizoaffective disorder
    Laura F Martin
    Department of Psychiatry, University of Colorado at Denver and Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Am J Psychiatry 164:1900-6. 2007
  8. pmc Multi-site studies of acoustic startle and prepulse inhibition in humans: initial experience and methodological considerations based on studies by the Consortium on the Genetics of Schizophrenia
    Neal R Swerdlow
    Department of Psychiatry, University of California San Diego, San Diego, California, USA
    Schizophr Res 92:237-51. 2007
  9. pmc Initial phase 2 trial of a nicotinic agonist in schizophrenia
    Robert Freedman
    Department of Psychiatry, Denver VA Medical Center and University of Colorado, Denver, CO 80262, USA
    Am J Psychiatry 165:1040-7. 2008
  10. ncbi request reprint Initial heritability analyses of endophenotypic measures for schizophrenia: the consortium on the genetics of schizophrenia
    Tiffany A Greenwood
    Department of Psychiatry, University of California San Diego, La Jolla, USA
    Arch Gen Psychiatry 64:1242-50. 2007

Research Grants

Collaborators

Detail Information

Publications35

  1. pmc Treating schizophrenia symptoms with an alpha7 nicotinic agonist, from mice to men
    Ann Olincy
    Department of Psychiatry, University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA
    Biochem Pharmacol 74:1192-201. 2007
    ..These data suggest that therapeutic agents selected for alpha7 nicotinic activity may have utility in treating certain symptoms of schizophrenia...
  2. ncbi request reprint Proof-of-concept trial of an alpha7 nicotinic agonist in schizophrenia
    Ann Olincy
    Department of Veterans Affairs Schizophrenia Research Center, Denver, Colorado, USA
    Arch Gen Psychiatry 63:630-8. 2006
    ....
  3. pmc Effects of an alpha 7-nicotinic agonist on default network activity in schizophrenia
    Jason R Tregellas
    Department of Psychiatry, Denver VA Medical Center, VISN19 MIRECC, Colorado, USA
    Biol Psychiatry 69:7-11. 2011
    ..This study examined the effects of DMXB-A on default network activity as a biomarker for drug effects on pathologic brain function associated with schizophrenia...
  4. pmc Genome-wide linkage analyses of 12 endophenotypes for schizophrenia from the Consortium on the Genetics of Schizophrenia
    Tiffany A Greenwood
    Department of Psychiatry, University of California San Diego, La Jolla, Calif, USA
    Am J Psychiatry 170:521-32. 2013
    ..The authors previously demonstrated the heritability of these endophenotypes; in the present study, genetic linkage was evaluated...
  5. pmc Abnormal auditory N100 amplitude: a heritable endophenotype in first-degree relatives of schizophrenia probands
    Bruce I Turetsky
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Psychiatry 64:1051-9. 2008
    ..We report initial results from the COGS dataset of auditory N100 amplitude and gating as candidate endophenotypes...
  6. pmc Inhibition of the P50 cerebral evoked response to repeated auditory stimuli: results from the Consortium on Genetics of Schizophrenia
    Ann Olincy
    Department of Psychiatry, Veterans Affairs Denver Medical Center VISN 19 MIRECC, CO 80045, USA
    Schizophr Res 119:175-82. 2010
    ....
  7. ncbi request reprint Physiology of schizophrenia, bipolar disorder, and schizoaffective disorder
    Laura F Martin
    Department of Psychiatry, University of Colorado at Denver and Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Am J Psychiatry 164:1900-6. 2007
    ..A second aim was to determine whether subjects with schizoaffective disorder, bipolar type, were neurophysiologically more similar to subjects with schizophrenia or subjects with bipolar disorder...
  8. pmc Multi-site studies of acoustic startle and prepulse inhibition in humans: initial experience and methodological considerations based on studies by the Consortium on the Genetics of Schizophrenia
    Neal R Swerdlow
    Department of Psychiatry, University of California San Diego, San Diego, California, USA
    Schizophr Res 92:237-51. 2007
    ..Genetic studies now often employ multiple, geographically dispersed test sites to accommodate the need for large and complex study samples. Here, we assessed the feasibility of using PPI in multi-site studies...
  9. pmc Initial phase 2 trial of a nicotinic agonist in schizophrenia
    Robert Freedman
    Department of Psychiatry, Denver VA Medical Center and University of Colorado, Denver, CO 80262, USA
    Am J Psychiatry 165:1040-7. 2008
    ..The agent 3-(2,4-dimethoxybenzylidene) anabaseine (DMXB-A) is a partial alpha(7)-nicotinic agonist and can be taken orally. A phase 1 trial showed evidence for cognitive enhancement in schizophrenia...
  10. ncbi request reprint Initial heritability analyses of endophenotypic measures for schizophrenia: the consortium on the genetics of schizophrenia
    Tiffany A Greenwood
    Department of Psychiatry, University of California San Diego, La Jolla, USA
    Arch Gen Psychiatry 64:1242-50. 2007
    ..Exploration of the genetic architecture of specific endophenotypes may be a powerful strategy for understanding the genetic basis of schizophrenia...
  11. pmc Sex differences in familiality effects on neurocognitive performance in schizophrenia
    Monica E Calkins
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Biol Psychiatry 73:976-84. 2013
    ..In view of these findings, the current investigation tested the hypothesis that neurocognitive performance of schizophrenia probands can predict the neurocognitive performance of their unaffected family members...
  12. ncbi request reprint Comparison of polymorphisms in the alpha7 nicotinic receptor gene and its partial duplication in schizophrenic and control subjects
    Judith Gault
    Department of Psychiatry, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Med Genet B Neuropsychiatr Genet 123:39-49. 2003
    ..Twenty-one variants were found in the exons, but non-synonymous changes were rare. Although the expression of CHRNA7 is decreased in schizophrenia, the general structure of the remaining receptors is likely to be normal...
  13. pmc Neurophysiological endophenotypes of schizophrenia: the viability of selected candidate measures
    Bruce I Turetsky
    Department of Psychiatry, 10th Floor, Gates Building, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Schizophr Bull 33:69-94. 2007
    ..We conclude with a discussion of the few studies thus far that have employed a multivariate approach with these candidates...
  14. ncbi request reprint Improved p50 auditory gating with ondansetron in medicated schizophrenia patients
    Lawrence E Adler
    Denver VA Medical Center, 1055 Clermont St, Denver, CO 80220, USA
    Am J Psychiatry 162:386-8. 2005
    ..This study examined the effects of ondansetron, a highly selective 5-HT3 antagonist, on the P50 auditory evoked potential...
  15. pmc Functional magnetic resonance imaging of effects of a nicotinic agonist in schizophrenia
    Jason R Tregellas
    Department of Psychiatry, Denver VA Medical Center VISN19 MIRECC and University of Colorado Denver, Aurora, CO 80045, USA
    Neuropsychopharmacology 35:938-42. 2010
    ..Imaging of drug response is useful in planning future clinical tests of this compound and other nicotinic agonists for schizophrenia...
  16. pmc Analysis of 94 candidate genes and 12 endophenotypes for schizophrenia from the Consortium on the Genetics of Schizophrenia
    Tiffany A Greenwood
    Department of Psychiatry, University of California at San Diego, La Jolla, CA 92093 0804, USA
    Am J Psychiatry 168:930-46. 2011
    ....
  17. pmc Multiple genes in the 15q13-q14 chromosomal region are associated with schizophrenia
    Sarah H Stephens
    Department of Psychiatry, University of Colorado Denver, Colorado 80045, USA
    Psychiatr Genet 22:1-14. 2012
    ..This study fine-mapped genes at 15q13-q14 to determine whether the association is unique to CHRNA7...
  18. ncbi request reprint The genetics of sensory gating deficits in schizophrenia
    Robert Freedman
    Departments of Psychiatry and Pharmacology, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, C 268 71, Denver, CO 80262, USA
    Curr Psychiatry Rep 5:155-61. 2003
    ..Polymorphisms in the core promoter of the gene are associated with schizophrenia and also with diminished inhibition of the P50 response. These genetic data may identify a new pathophysiologic target for drug discovery...
  19. pmc Sensory gating and alpha-7 nicotinic receptor gene allelic variants in schizoaffective disorder, bipolar type
    Laura F Martin
    Department of Psychiatry, Denver Veterans Affairs Medical Center, Denver, Colorado 80262, USA
    Am J Med Genet B Neuropsychiatr Genet 144:611-4. 2007
    ..The purpose of this study was to determine if CHRNA7 promoter allelic variants are also associated with abnormal P50 ratios in persons with schizoaffective disorder, bipolar type...
  20. ncbi request reprint Paternal age of schizophrenia probands and endophenotypic differences from unaffected siblings
    James Schmeidler
    Department of Psychiatry, Icahn School of Medicine at Mount Sinai School, One Gustave L Levy Place, Box 1230, New York, NY, USA
    Psychiatry Res 219:67-71. 2014
    ..A possible explanation is that the identification of heritable endophenotypes was based on samples for which schizophrenia was attributable to inherited rather than de novo/non-inherited causes. ..
  21. pmc Early sensory processing deficits predict sensitivity to distraction in schizophrenia
    Jason Smucny
    Department of Psychiatry, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
    Schizophr Res 147:196-200. 2013
    ..The observed relationship between noise effects on reaction time and P50 auditory gating supports the hypothesis that early inhibitory processing deficits may contribute to susceptibility to distraction in the illness...
  22. ncbi request reprint Varied effects of atypical neuroleptics on P50 auditory gating in schizophrenia patients
    Lawrence E Adler
    Box C268 26, Psychiatry, University of Colorado Health Science Ctr, 4200 East 9th Ave, Denver, CO 80262, USA
    Am J Psychiatry 161:1822-8. 2004
    ..This study sought to determine whether other atypical neuroleptics improve P50 ratios...
  23. ncbi request reprint Differential effects of cigarette smoking on performance of a smooth pursuit and a saccadic eye movement task in schizophrenia
    Ann Olincy
    Department of Psychiatry, University of Colorado Health Sciences Center, 4200 E 9th Ave, Box C 268 71, Denver, CO 80262, USA
    Psychiatry Res 117:223-36. 2003
    ..However, premature saccades and large anticipatory saccades, although measures of inhibitory dysfunction in schizophrenia, appear to be unrelated to the nicotinic system...
  24. ncbi request reprint Sensory gating impairment associated with schizophrenia persists into REM sleep
    Michael A Kisley
    Department of Psychiatry, University of Colorado Health Sciences Center and Denver Veteran s Affairs Medical Center, Denver, Colorado, USA
    Psychophysiology 40:29-38. 2003
    ..These results suggest that REM sleep is an appropriate state during which to assess P50 gating in order to disentangle the effects of state and trait on sensory gating impairment in other clinical populations...
  25. pmc Early biomarkers of psychosis
    Robert Freedman
    Department of Psychiatry C 268 71, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Dialogues Clin Neurosci 7:17-29. 2005
    ..Examples are given from work on the role of the alpha(T)nicotinic receptor and its gene CHRNA7 on chromosome 15 in the neurobiology and genetic transmission of schizophrenia...
  26. ncbi request reprint Association of promoter variants in the alpha7 nicotinic acetylcholine receptor subunit gene with an inhibitory deficit found in schizophrenia
    Sherry Leonard
    Department of Psychiatry, Campus Box C 268 71, University of Colorado Health Sciences Center, 4200 E Ninth Ave, Denver, CO 80262, USA
    Arch Gen Psychiatry 59:1085-96. 2002
    ..This study presents DNA sequence analysis of the core promoter region for CHRNA7 in schizophrenic and control subjects...
  27. ncbi request reprint Neurobiology of smooth pursuit eye movement deficits in schizophrenia: an fMRI study
    Jason R Tregellas
    Department of Pharmacology, University of Colorado Health Sciences Center, Denver 80262, USA
    Am J Psychiatry 161:315-21. 2004
    ..The investigators used functional magnetic resonance imaging (fMRI) to compare brain hemodynamic response during a smooth pursuit eye movement task in patients with schizophrenia and healthy comparison subjects...
  28. pmc The Consortium on the Genetics of Endophenotypes in Schizophrenia: model recruitment, assessment, and endophenotyping methods for a multisite collaboration
    Monica E Calkins
    Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania, 10 Gates, 3400 Spruce St, Philadelphia, PA 19104, USA
    Schizophr Bull 33:33-48. 2007
    ..The purpose of this article is to provide a description of the COGS structure and methods, including participant recruitment and assessment...
  29. ncbi request reprint Admixture analysis of smooth pursuit eye movements in probands with schizophrenia and their relatives suggests gain and leading saccades are potential endophenotypes
    Randal G Ross
    Department of Psychiatry, Denver Veterans Administration Medical Center, Colorado, USA
    Psychophysiology 39:809-19. 2002
    ..Relatives of childhood-onset and adult-onset probands had similar impairments. Gain and frequency of leading saccades may be genetic endophenotypes in childhood-onset and adult-onset schizophrenia...
  30. ncbi request reprint Input dysfunction, schizotypy, and genetic models of schizophrenia
    Robert Freedman
    Department of Psychiatry and Pharmacology, University of Colorado Health Sciences Center, Campus Box C 268 71, 4200 E Ninth Avenue, Denver, CO 80262, USA
    Schizophr Res 54:25-32. 2002
    ..Thus, as predicted by Venables, the substrates of schizotypy and schizophrenia may arise from variants in normal brain function...
  31. ncbi request reprint Successful multi-site measurement of antisaccade performance deficits in schizophrenia
    Allen D Radant
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, United States
    Schizophr Res 89:320-9. 2007
    ..These results confirm previous findings of antisaccade deficits in schizophrenia subjects and support the use of the antisaccade task as a potential schizophrenia endophenotype in multi-site genetic studies...
  32. ncbi request reprint Diminished suppression of the P50 auditory evoked potential in bipolar disorder subjects with a history of psychosis
    Ann Olincy
    Department of Veterans Affairs and University of Colorado Health Sciences Center, Denver 80262, USA
    Am J Psychiatry 162:43-9. 2005
    ..This study addresses whether diminished P50 auditory evoked potential suppression represents a phenotype associated with psychosis in bipolar illness...
  33. pmc Verbal working memory impairments in individuals with schizophrenia and their first-degree relatives: findings from the Consortium on the Genetics of Schizophrenia
    William P Horan
    Department of Psychiatry and Biobehavioral Sciences, Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90095 6968, USA
    Schizophr Res 103:218-28. 2008
    ....
  34. pmc Genomewide linkage scan of 409 European-ancestry and African American families with schizophrenia: suggestive evidence of linkage at 8p23.3-p21.2 and 11p13.1-q14.1 in the combined sample
    Brian K Suarez
    Department of Psychiatry and Genetics, Washington University, St Louis, MO, USA
    Am J Hum Genet 78:315-33. 2006
    ..3-p15.2, 5p15.2-q13.3, 10p15.3-p14, 10q25.3-q26.3, and 11p13-q23.3. The highest increase in Z(lr) scores was observed for 5p14.1-q12.1, where the maximum Z(lr) increased from 2.77 initially to 3.80 after fine mapping in the EA families...
  35. doi request reprint No significant association of 14 candidate genes with schizophrenia in a large European ancestry sample: implications for psychiatric genetics
    Alan R Sanders
    Department of Psychiatry and Behavioural Sciences, Evanston Northwestern Healthcare Research Institute, Evanston, IL 60201 3137, USA
    Am J Psychiatry 165:497-506. 2008
    ....

Research Grants5

  1. The Genetics of Endophenotypes and Schizophrenia
    Ann Olincy; Fiscal Year: 2003
    ..Findings of heritable deficits in specific measures will be used to guide the next generation of studies of the genetics of schizophrenia. ..
  2. The Genetics of Endophenotypes and Schizophrenia
    Ann Olincy; Fiscal Year: 2004
    ..Findings of heritable deficits in specific measures will be used to guide the next generation of studies of the genetics of schizophrenia. ..
  3. The Genetics of Endophenotypes and Schizophrenia
    Ann Olincy; Fiscal Year: 2005
    ..Findings of heritable deficits in specific measures will be used to guide the next generation of studies of the genetics of schizophrenia. ..
  4. The Genetics of Endophenotypes and Schizophrenia
    Ann Olincy; Fiscal Year: 2006
    ..Findings of heritable deficits in specific measures will be used to guide the next generation of studies of the genetics of schizophrenia. ..
  5. The Genetics of Endophenotypes and Schizophrenia
    Ann Olincy; Fiscal Year: 2007
    ..Findings of heritable deficits in specific measures will be used to guide the next generation of studies of the genetics of schizophrenia. ..