I M Olfert

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Muscle-specific VEGF deficiency greatly reduces exercise endurance in mice
    I Mark Olfert
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0623, USA
    J Physiol 587:1755-67. 2009
  2. ncbi Skeletal muscle capillarity and angiogenic mRNA levels after exercise training in normoxia and chronic hypoxia
    I M Olfert
    Department of Physiology and Pharmacology, Loma Linda University, Loma Linda, California 92350, USA
    J Appl Physiol 91:1176-84. 2001
  3. pmc Does gender affect human pulmonary gas exchange during exercise?
    I Mark Olfert
    Department of Medicine, University of California, San Diego, CA 92093 0623, USA
    J Physiol 557:529-41. 2004
  4. ncbi Effect of 60 degrees head-down tilt on peripheral gas mixing in the human lung
    I Mark Olfert
    Department of Medicine, University of California, San Diego, La Jolla, California 92093 0623, USA
    J Appl Physiol 97:827-34. 2004
  5. ncbi Temporal thrombospondin-1 mRNA response in skeletal muscle exposed to acute and chronic exercise
    I Mark Olfert
    Division of Physiology, Department of Medicine, University of California San Diego, La Jolla, CA 92093 0623, USA
    Growth Factors 24:253-9. 2006
  6. ncbi Oxygen consumption during maximal exercise in Fischer 344 x Brown Norway F1 hybrid rats
    I Mark Olfert
    Department of Medicine, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0623, USA
    J Gerontol A Biol Sci Med Sci 59:801-8. 2004
  7. ncbi Chronic hypoxia attenuates resting and exercise-induced VEGF, flt-1, and flk-1 mRNA levels in skeletal muscle
    I M Olfert
    Department of Physiology and Pharmacology, Loma Linda University, Loma Linda, California 92350, USA
    J Appl Physiol 90:1532-8. 2001
  8. ncbi Effect of prolonged, heavy exercise on pulmonary gas exchange in athletes
    S R Hopkins
    Division of Physiology, Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    J Appl Physiol 85:1523-32. 1998
  9. pmc Myocyte vascular endothelial growth factor is required for exercise-induced skeletal muscle angiogenesis
    I Mark Olfert
    Department of Medicine, University of California, San Diego, La Jolla, USA
    Am J Physiol Regul Integr Comp Physiol 299:R1059-67. 2010
  10. pmc Loss of skeletal muscle HIF-1alpha results in altered exercise endurance
    Steven D Mason
    Molecular Biology Section, Division of Biology, School of Medicine, University of California, San Diego, USA
    PLoS Biol 2:e288. 2004

Collaborators

Detail Information

Publications21

  1. pmc Muscle-specific VEGF deficiency greatly reduces exercise endurance in mice
    I Mark Olfert
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0623, USA
    J Physiol 587:1755-67. 2009
    ..Furthermore, VEGF is essential in regulating postnatal muscle capillarity, and that adult mice, deficient in cardiac and skeletal muscle VEGF, exhibit a major intolerance to aerobic exercise...
  2. ncbi Skeletal muscle capillarity and angiogenic mRNA levels after exercise training in normoxia and chronic hypoxia
    I M Olfert
    Department of Physiology and Pharmacology, Loma Linda University, Loma Linda, California 92350, USA
    J Appl Physiol 91:1176-84. 2001
    ....
  3. pmc Does gender affect human pulmonary gas exchange during exercise?
    I Mark Olfert
    Department of Medicine, University of California, San Diego, CA 92093 0623, USA
    J Physiol 557:529-41. 2004
    ..Possibly fitness level and lung size are more important in determining whether or not pulmonary gas exchange impairment occurs during exercise than sex per se...
  4. ncbi Effect of 60 degrees head-down tilt on peripheral gas mixing in the human lung
    I Mark Olfert
    Department of Medicine, University of California, San Diego, La Jolla, California 92093 0623, USA
    J Appl Physiol 97:827-34. 2004
    ..These findings support the notion that changes in thoracic fluid volume alter ventilation distribution in the lung periphery but also demonstrate that the effect during HDT does not wholly mimic that observed in microG...
  5. ncbi Temporal thrombospondin-1 mRNA response in skeletal muscle exposed to acute and chronic exercise
    I Mark Olfert
    Division of Physiology, Department of Medicine, University of California San Diego, La Jolla, CA 92093 0623, USA
    Growth Factors 24:253-9. 2006
    ....
  6. ncbi Oxygen consumption during maximal exercise in Fischer 344 x Brown Norway F1 hybrid rats
    I Mark Olfert
    Department of Medicine, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0623, USA
    J Gerontol A Biol Sci Med Sci 59:801-8. 2004
    ..The underlying mechanism responsible for increasing O2 consumption in aged F344BNF1 rats during exercise, although partly explained by mechanical inefficiencies of locomotion, still remains to be determined...
  7. ncbi Chronic hypoxia attenuates resting and exercise-induced VEGF, flt-1, and flk-1 mRNA levels in skeletal muscle
    I M Olfert
    Department of Physiology and Pharmacology, Loma Linda University, Loma Linda, California 92350, USA
    J Appl Physiol 90:1532-8. 2001
    ..These findings may provide an explanation for the lack of mammalian skeletal muscle angiogenesis that is observed after chronic hypoxia...
  8. ncbi Effect of prolonged, heavy exercise on pulmonary gas exchange in athletes
    S R Hopkins
    Division of Physiology, Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    J Appl Physiol 85:1523-32. 1998
    ..97, P < 0.005 at 60 min). These data are compatible with interstitial edema as a mechanism and suggest that lung size is an important determinant of the efficiency of gas exchange during exercise...
  9. pmc Myocyte vascular endothelial growth factor is required for exercise-induced skeletal muscle angiogenesis
    I Mark Olfert
    Department of Medicine, University of California, San Diego, La Jolla, USA
    Am J Physiol Regul Integr Comp Physiol 299:R1059-67. 2010
    ..However, skeletal muscle metabolic adaptation to exercise training takes place independent of myocyte VEGF expression...
  10. pmc Loss of skeletal muscle HIF-1alpha results in altered exercise endurance
    Steven D Mason
    Molecular Biology Section, Division of Biology, School of Medicine, University of California, San Diego, USA
    PLoS Biol 2:e288. 2004
    ..Thus, these results demonstrate an important role for the HIF-1 pathway in the metabolic control of muscle function...
  11. ncbi Pulmonary gas exchange during exercise in women: effects of exercise type and work increment
    S R Hopkins
    Division of Physiology, Department of Medicine, University of California, San Diego, La Jolla 92093, USA
    J Appl Physiol 89:721-30. 2000
    ..The Pa(O(2)) responses to R and C exercise in our 17 subjects do not differ significantly from those previously observed in men...
  12. ncbi HIF-1alpha in endurance training: suppression of oxidative metabolism
    Steven D Mason
    Div of Biologicay, University of California, San Diego, La Jolla, CA 92093 0377, USA
    Am J Physiol Regul Integr Comp Physiol 293:R2059-69. 2007
    ..These data demonstrate that removal of HIF-1alpha causes an adaptive response in skeletal muscle akin to endurance training and provides evidence for the suppression of mitochondrial biogenesis by HIF-1alpha in normal tissue...
  13. pmc Steep head-down tilt has persisting effects on the distribution of pulmonary blood flow
    A Cortney Henderson
    Univ of California, San Diego, Dept of Medicine, 9500 Gilman Dr, 0931, La Jolla, CA 92093 0931, USA
    J Appl Physiol 101:583-9. 2006
    ..05). We speculate that the mechanism most likely responsible for our findings is that increased pulmonary capillary pressures and fluid efflux in the lung resulting from head-down tilt alters regional blood flow distribution...
  14. pmc Rapid intravenous infusion of 20 ml/kg saline does not impair resting pulmonary gas exchange in the healthy human lung
    G Kim Prisk
    Dept of Medicine, Univ of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0931, USA
    J Appl Physiol 108:53-9. 2010
    ..05] with similar effects on ventilation in the face of unchanged (.)VA and (.)Q. These results suggest active control of blood flow to regions of decreased ventilation during air breathing, thus minimizing the gas exchange consequences...
  15. doi Detraining losses of skeletal muscle capillarization are associated with vascular endothelial growth factor protein expression in rats
    Moh H Malek
    University of California, San Diego, School of Medicine, Division of Physiology, 9500 Gilman Drive, DEPT 0623A, La Jolla, CA 92093 0623A, USA
    Exp Physiol 95:359-68. 2010
    ..The results indicated that training-induced angiogenic remodelling was reversible following 1 week of detraining and may be modulated by VEGF...
  16. doi Global deletion of thrombospondin-1 increases cardiac and skeletal muscle capillarity and exercise capacity in mice
    Moh H Malek
    University of California, San Diego, School of Medicine, Department of Medicine, Division of Physiology, La Jolla, CA 92093 0623A, USA
    Exp Physiol 94:749-60. 2009
    ..The increased capillarity alone was sufficient to increase (P < 0.05) exercise capacity. These data demonstrate that the capillary-to-muscle interface is a critical factor that limits oxygen transport during exercise...
  17. ncbi Arteriolar and venular capillary distribution in skeletal muscles of old rats
    Li Cui
    Department of Medicine, 0623A, University of California, San Diego, La Jolla, CA 92093 0623, USA
    J Gerontol A Biol Sci Med Sci 63:928-35. 2008
    ..These data suggest that age-associated increases in skeletal muscle capillarity may be due to the venular portion of capillaries and that the increase occurs primarily in muscles that demonstrate increased oxidative potential with age...
  18. ncbi Tidal volume dependency of gas exchange in bronchoconstricted pig lungs
    Axel Kleinsasser
    Department of Medicine, Division of Physiology, University of California San Diego, La Jolla, California 92093 0623, USA
    J Appl Physiol 103:148-55. 2007
    ..However, our data do not allow exclusion of other mechanisms that may lead to improved ventilatory distribution when tidal volume is increased...
  19. pmc Effect of acetazolamide on pulmonary and muscle gas exchange during normoxic and hypoxic exercise
    Amy M Jonk
    Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0623, USA
    J Physiol 579:909-21. 2007
    ..05). In summary, ACZ improved arterial oxygenation during exercise, due to both greater ventilation and more efficient pulmonary gas exchange. However, muscle gas exchange was unaffected...
  20. ncbi Muscle-targeted deletion of VEGF and exercise capacity in mice
    Peter D Wagner
    Division of Physiology, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, DEPT 0623A, La Jolla, CA 92093, USA
    Respir Physiol Neurobiol 151:159-66. 2006
    ..Because VEGF deletion is embryonically lethal, its study requires conditional and/or organ-targeted strategies. We inactivated the muscle VEGF gene in two ways:..
  21. ncbi The effect of incomplete acetylene washout on cardiac output measurement using open circuit acetylene uptake
    Jamal Balouch
    Department of Medicine, Division of Physiology, University of California, San Diego, La Jolla, California 92093 0623, USA
    Respir Physiol Neurobiol 155:177-83. 2007
    ....