Research Topics
Genomes and GenesSpecies | JERROLD MICHAEL OLEFSKYSummaryAffiliation: University of California Country: USA Publications
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Publications
Fat talks, liver and muscle listenJerrold M Olefsky
University of California San Diego, La Jolla, CA 92093 0673, USA
Cell 134:914-6. 2008..Cao et al. (2008) now take this concept a step further by identifying a fatty acid metabolite generated in adipose tissue that regulates insulin sensitivity in liver and muscle...
Increased malonyl-CoA levels in muscle from obese and type 2 diabetic subjects lead to decreased fatty acid oxidation and increased lipogenesis; thiazolidinedione treatment reverses these defectsGautam K Bandyopadhyay
Department of Medicine, Division of Endocrinology and Metabolism, University of California at San Diego, 9500 Gilman Dr, La Jolla, 92093, USA
Diabetes 55:2277-85. 2006....
Restoration of Euglycemia After Duodenal Bypass Surgery Is Reliant on Central and Peripheral Inputs in Zucker fa/fa RatsJian Jiao
Corresponding authors Jerrold M Olefsky
Diabetes 62:1074-83. 2013..The present data highlight and support the significance of vagal inputs and intestinal hormone peptides toward normalization of glucose and lipid homeostasis after duodenal bypass surgery...- Prospects for research in diabetes mellitusJ M Olefsky
Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Diego, La Jolla, CA 92093, USA
JAMA 285:628-32. 2001..Also, the link between obesity and type 2 diabetes mandates a redoubled effort to understand the genetic and behavioral contributions to obesity... - Cell signaling. A new way to burn fatJaap G Neels
Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0673, USA
Science 312:1756-8. 2006 - Novel liver-specific TORC2 siRNA corrects hyperglycemia in rodent models of type 2 diabetesMaziyar Saberi
Univ of California San Diego, Dept of Medicine, 9500 Gilman Dr, SCR225, La Jolla CA 92093, USA
Am J Physiol Endocrinol Metab 297:E1137-46. 2009..In conclusion, these results demonstrate the importance of TORC2 in modulating HGP in vivo and highlight a novel, liver-specific siRNA approach for the potential treatment of hyperglycemia and type 2 diabetes... - IKKepsilon: a bridge between obesity and inflammationJerrold M Olefsky
Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
Cell 138:834-6. 2009..Chiang et al. (2009) now show that the IkappaB kinase IKKepsilon is an important link between obesity and inflammation and may be a new therapeutic target for treating obesity-related metabolic diseases... - Macrophages, inflammation, and insulin resistanceJerrold M Olefsky
Department of Medicine, University of California San Diego, La Jolla, CA 92093 0651, USA
Annu Rev Physiol 72:219-46. 2010..Strategies focused on inhibiting the inflammation/insulin resistance axis that otherwise preserve essential innate immune functions may hold promise for therapeutic intervention... - Increased macrophage migration into adipose tissue in obese miceDa Young Oh
Department of Medicine, University of California, San Diego, La Jolla, California, USA
Diabetes 61:346-54. 2012..Monocytes from obese mice are not programmed to become inflammatory ATMs but rather the increased proinflammatory ATM accumulation in obesity is in response to tissue signals... - The US's changing competitiveness in the biomedical sciencesJerrold M Olefsky
University of California at San Diego, Department of Medicine, La Jolla, CA 92093-0673, USA
J Clin Invest 117:270-6. 2007 - Decreased susceptibility to fatty acid-induced peripheral tissue insulin resistance in womenJ P Frias
Department of Endocrinology and Metabolism, University of California-San Diego, Veterans Affairs Medical Center, 3350 La Jolla Village Dr, La Jolla, CA 92093, USA
Diabetes 50:1344-50. 2001..In summary, our findings suggest that although the effects on EGP appear comparable, the inhibitory effects of NEFA on peripheral tissue insulin sensitivity are observed in men but cannot be demonstrated in women... - Improved insulin-sensitivity in mice heterozygous for PPAR-gamma deficiencyP D Miles
Department of Surgery, University of California San Diego, San Diego, California 92103, USA
J Clin Invest 105:287-92. 2000.... - Cellular insulin resistance in adipocytes from obese polycystic ovary syndrome subjects involves adenosine modulation of insulin sensitivityT P Ciaraldi
Department of Medicine, University of California San Diego, La Jolla 92093, USA
J Clin Endocrinol Metab 82:1421-5. 1997..In addition, this insulin resistance involves an impairment of the system by which adenosine acts to modulate insulin signal transduction... - TNF-alpha-induced insulin resistance in vivo and its prevention by troglitazoneP D Miles
Department of Surgery, University of California, San Diego 92103, USA
Diabetes 46:1678-83. 1997..If TNF-alpha plays a role in the development of the obesity/NIDDM syndrome, troglitazone may prove useful in its treatment... - Troglitazone prevents hyperglycemia-induced but not glucosamine-induced insulin resistanceP D Miles
Department of Surgery, University of California, San Diego, USA
Diabetes 47:395-400. 1998.... - Exercise-stimulated glucose turnover in the rat is impaired by glucosamine infusionP D Miles
Department of Surgery, University of California San Diego, USA
Diabetes 50:139-42. 2001..In conclusion, the infusion of glucosamine, which is known to cause insulin resistance, also impaired exercise-induced glucose uptake. This inhibition was independent of hyperglycemia and FFA levels... - Insulin resistance and diabetes due to different mutations in the tyrosine kinase domain of both insulin receptor gene allelesJ Kusari
Department of Medicine, University of California, La Jolla 92093
J Biol Chem 266:5260-7. 1991.... - Synthesis of an organoinsulin molecule that can be activated by antibody catalysisD S Worrall
Department of Medicine (0673, Division of Endocrinology and Metabolism, University of California at San Diego, La Jolla, CA 92093, USA
Proc Natl Acad Sci U S A 98:13514-8. 2001..We propose that these results are the foundation for an in vivo regulated system of insulin activation using the prohormone insulin(D) and catalytic antibody 38C2 with potential therapeutic application... - Variance-modeled posterior inference of microarray data: detecting gene-expression changes in 3T3-L1 adipocytesA Hsiao
Department of Bioengineering, UC San Diego, La Jolla, CA 92093, USA
Bioinformatics 20:3108-27. 2004..In addition, the statistical framework developed here can be readily applied to understand the implicit assumptions made in traditional fold-change approaches to array analysis... - A functional assessment of insulin/insulin-like growth factor-I hybrid receptorsB L Seely
Department of Medicine, University of California San Diego, La Jolla 92093
Endocrinology 136:1635-41. 1995..In conclusion, IGF-I-stimulated insulin/IGF-I hybrid receptors function like IGF-I receptors, rather than like insulin receptors... - Analysis of the gene sequences of the insulin receptor and the insulin-sensitive glucose transporter (GLUT-4) in patients with common-type non-insulin-dependent diabetes mellitusJ Kusari
Department of Medicine, University of California, San Diego, La Jolla 92093
J Clin Invest 88:1323-30. 1991..Possibly, a subpopulation of NIDDM patients exists displaying variation in the GLUT-4 gene... - Insulin and insulin-like growth factor I receptors utilize different G protein signaling componentsS Dalle
Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Diego, La Jolla, California 92093-0673, USA
J Biol Chem 276:15688-95. 2001..These results suggest that insulin receptors and IGF-IRs can function as G protein-coupled receptors and engage different G protein partners for downstream signaling... - Chronic endothelin-1 treatment leads to heterologous desensitization of insulin signaling in 3T3-L1 adipocytesK I Ishibashi
Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Diego, La Jolla, California 92093-0673, USA
J Clin Invest 107:1193-202. 2001.... - Insulin stimulates the tyrosine dephosphorylation of pp125 focal adhesion kinaseT S Pillay
Department of Medicine, University of California San Diego, La Jolla 92093 0673
J Biol Chem 270:991-4. 1995.... - beta -Arrestin-mediated recruitment of the Src family kinase Yes mediates endothelin-1-stimulated glucose transportT Imamura
Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Diego, La Jolla, California 92093 0673, USA
J Biol Chem 276:43663-7. 2001.... - Insulin can regulate GLUT4 internalization by signaling to Rab5 and the motor protein dyneinJ Huang
Department of Medicine, Division of Endocrinology and Metabolism, University of California at San Diego, La Jolla, CA 92093-0673, USA
Proc Natl Acad Sci U S A 98:13084-9. 2001.... - Protein tyrosine phosphatase 1B interacts with the activated insulin receptorB L Seely
Department of Medicine, University of California, San Diego, La Jolla, USA
Diabetes 45:1379-85. 1996..We conclude that PTP1B can associate directly with the activated insulin receptor at multiple different phosphotyrosine sites and that dephosphorylation by PTP1B may play a significant role in insulin receptor signal transduction... - Insulin disrupts beta-adrenergic signalling to protein kinase A in adipocytesJin Zhang
Department of Pharmacology, University of California at San Diego, La Jolla, California 92093, USA
Nature 437:569-73. 2005..Chronically high insulin levels may disrupt the close apposition of beta-adrenergic receptors and PKA, identifying a new mechanism for crosstalk between heterologous signal transduction pathways... - Topiramate treatment causes skeletal muscle insulin sensitization and increased Acrp30 secretion in high-fat-fed male Wistar ratsJason J Wilkes
Division of Endocrinology and Metabolism, Department of Medicine, University of California San Diego, 0673 UCSD, 9500 Gilman Drive, La Jolla, CA 92093, USA
Am J Physiol Endocrinol Metab 289:E1015-22. 2005.... - Lentiviral short hairpin ribonucleic acid-mediated knockdown of GLUT4 in 3T3-L1 adipocytesWei Liao
Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Diego, La Jolla, 92093, USA
Endocrinology 147:2245-52. 2006..These studies indicate that lentiviral shRNA constructs provide an excellent approach to deliver functional siRNAs into 3T3-L1 adipocytes for studying insulin signaling and adipocyte biology... - PPARdelta regulates glucose metabolism and insulin sensitivityChih Hao Lee
Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 103:3444-9. 2006..The combined hepatic and peripheral actions of PPARdelta suggest new therapeutic approaches to treat type II diabetes... - Suppression of Egr-1 transcription through targeting of the serum response factor by oncogenic H-RasSoon Young Shin
Division of Molecular and Life Science, College of Science and Technology, Hanyang University, Ansan, Korea
EMBO J 25:1093-103. 2006..Our findings suggest a novel signaling mechanism by which prolonged activation of oncogenic H-Ras can trigger the loss of tumor suppressor Egr-1 through the PI3K pathway in NIH3T3 fibroblast model cell lines... - Stressed out about obesity and insulin resistanceCarl De Luca
Nat Med 12:41-2; discussion 42. 2006 - Inflamed fat: what starts the fire?Jaap G Neels
Department of Medicine, Division of Endocrinology and Metabolism, UCSD, La Jolla, California 92093 0673, USA
J Clin Invest 116:33-5. 2006..In this issue of the JCI, Weisberg et al. show the importance of C-C motif chemokine receptor 2 (CCR2) in macrophage recruitment to adipose tissue and the development of obesity and its complications... - JNK and tumor necrosis factor-alpha mediate free fatty acid-induced insulin resistance in 3T3-L1 adipocytesM T Audrey Nguyen
Division of Endocrinology Metabolism, University of California, San Diego, La Jolla, California 92093 0673, USA
J Biol Chem 280:35361-71. 2005.... - Disruption of microtubules ablates the specificity of insulin signaling to GLUT4 translocation in 3T3-L1 adipocytesJie Huang
Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Diego, La Jolla, California 92093-0673, USA
J Biol Chem 280:42300-6. 2005.... - Bone marrow-specific Cap gene deletion protects against high-fat diet-induced insulin resistanceLisa A Lesniewski
Department of Endocrinology and Metabolism, University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
Nat Med 13:455-62. 2007..These studies show that macrophages are an important cell type in the induction of insulin resistance and that Cap has a modulatory role in this function... - Insulin sensitivity: modulation by nutrients and inflammationSimon Schenk
Department of Medicine, Division of Endocrinology and Metabolism, UCSD, La Jolla, California 92093, USA
J Clin Invest 118:2992-3002. 2008..Overall, we provide our integrative perspective regarding how nutrients and obesity interact to regulate insulin sensitivity... - Beta-Arrestin-1 mediates glucagon-like peptide-1 signaling to insulin secretion in cultured pancreatic beta cellsNoriyuki Sonoda
Department of Medicine, Division of Endocrinology and Metabolism, University of California at San Diego, La Jolla, CA 92093, USA
Proc Natl Acad Sci U S A 105:6614-9. 2008..Taken together, these studies indicate that beta-arrestin-1 plays a role in GLP-1 signaling leading to insulin secretion, defining a previously undescribed mechanism for GLP-1 action... - Blockade of alpha4 integrin signaling ameliorates the metabolic consequences of high-fat diet-induced obesityChloe C Feral
Department of Medicine, University of California, San Diego, La Jolla, California, USA
Diabetes 57:1842-51. 2008..Thus, we hypothesized that mice bearing an alpha4(Y991A) mutation, which blocks signaling, would be protected from development of high-fat diet-induced insulin resistance... - Phosphoinositide signalling links O-GlcNAc transferase to insulin resistanceXiaoyong Yang
Howard Hughes Medical Institute and Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
Nature 451:964-9. 2008..These findings identify a molecular mechanism by which nutritional cues regulate insulin signalling through O-GlcNAc, and underscore the contribution of this modification to the aetiology of insulin resistance and type 2 diabetes... - JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesityGiovanni Solinas
Department of Medicine, University of Fribourg, Chemin du Musee 5, CH 1700 Fribourg, Switzerland
Cell Metab 6:386-97. 2007..By contrast, Jnk1 removal from hematopoietic cells has no effect on adiposity but confers protection against HFD-induced insulin resistance by decreasing obesity-induced inflammation... - Selective modulation of promoter recruitment and transcriptional activity of PPARgammaDOROTHY D SEARS
Department of Medicine, University of California, San Diego, 9500 Gilman Drive, MC0673, La Jolla, CA 92093, USA
Biochem Biophys Res Commun 364:515-21. 2007..Selective modulation of PPARgamma by TZDs resulted in distinct expression profiles and transcription kinetics which may be due to differential promoter activation and chromatin remodeling of target genes... - A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathwaysM T Audrey Nguyen
Division of Endocrinology Metabolism, University of California, San Diego, La Jolla, California 92093, USA
J Biol Chem 282:35279-92. 2007..Together our results show that FFAs can activate CD11c(+) myeloid proinflammatory cells via TLR2/4 and JNK signaling pathways, thereby promoting inflammation and subsequent cellular insulin resistance... - Tumor necrosis factor receptor-1 can function through a G alpha q/11-beta-arrestin-1 signaling complexYuji Kawamata
Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Diego, La Jolla, California 92093 0673, USA
J Biol Chem 282:28549-56. 2007.... - Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinedionesAndrea L Hevener
Department of Medicine, Division of Endocrinology and Metabolism, UCSD, La Jolla, California, USA
J Clin Invest 117:1658-69. 2007..These findings reveal an essential role of PPAR gamma in macrophages for the maintenance of whole-body insulin action and in mediating the antidiabetic actions of TZDs... - Myosin 5a is an insulin-stimulated Akt2 (protein kinase Bbeta) substrate modulating GLUT4 vesicle translocationTakeshi Yoshizaki
Department of Medicine 0673, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0673, USA
Mol Cell Biol 27:5172-83. 2007..Taken together, these data indicate that myosin 5a is a newly identified direct substrate of Akt2 and, upon insulin stimulation, phosphorylated myosin 5a facilitates anterograde movement of GLUT4 vesicles along actin to the cell surface... - Suppression of PPAR-gamma attenuates insulin-stimulated glucose uptake by affecting both GLUT1 and GLUT4 in 3T3-L1 adipocytesWei Liao
Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Diego, La Jolla, CA 92093, USA
Am J Physiol Endocrinol Metab 293:E219-27. 2007.... - Impaired insulin secretion in a mouse model of ataxia telangiectasiaPhilip D Miles
Division of Endocrinology and Metabolism, Department of Medicine, University of California San Diego, La Jolla, CA, USA
Am J Physiol Endocrinol Metab 293:E70-4. 2007..Our findings support a role for ATM in metabolic function and point toward impaired insulin secretion as the primary cause of DM in A-T... - Regulation of receptor tyrosine kinase signaling by GRKs and beta-arrestinsChristopher J Hupfeld
Department of Medicine, Division of Endocrinology and Metabolism, University of California San Diego, La Jolla, California 92093, USA
Annu Rev Physiol 69:561-77. 2007..In this review of RTK signaling, we describe the role of cross talk between RTKs and 7TMRs, focusing specifically on the role played in this process by beta-arrestins and by G proteins... - Adenovirus-mediated adiponectin expression augments skeletal muscle insulin sensitivity in male Wistar ratsHiroaki Satoh
Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0673, USA
Diabetes 54:1304-13. 2005..These results indicate that chronic adiponectin treatment enhances insulin sensitivity and could serve as a therapy for human insulin resistance... - Effects of peroxisome proliferator-activated receptor delta on placentation, adiposity, and colorectal cancerYaacov Barak
Gene Expression Laboratory, Howard Hughes Medical Institute, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 99:303-8. 2002..Together, these observations reveal specific roles for PPARdelta in embryo development and adipocyte physiology, but not cancer... - G protein-coupled receptor kinase 2 mediates endothelin-1-induced insulin resistance via the inhibition of both Galphaq/11 and insulin receptor substrate-1 pathways in 3T3-L1 adipocytesIsao Usui
Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Diego, La Jolla, California 92093 0673, USA
Mol Endocrinol 19:2760-8. 2005.... - Inhibition of mitochondrial Na+-Ca2+ exchanger increases mitochondrial metabolism and potentiates glucose-stimulated insulin secretion in rat pancreatic isletsBumsup Lee
Division of Metabolic Diseases, MitoKor, San Diego, California 92121, USA
Diabetes 52:965-73. 2003..These results illustrate the potential utility of agents that affect mitochondrial metabolism as novel insulin secretagogues... - Effect of obesity on susceptibility to fatty acid-induced peripheral tissue insulin resistanceYolanta T Kruszynska
Department of Endocrinology and Metabolism, University of California San Diego and the Whittier Institute for Diabetes, La Jolla, CA, USA
Metabolism 52:233-8. 2003..11, NS). In summary, the effect of a short term elevation of plasma NEFA levels on insulin stimulated GDR and suppression of HGO is comparable in lean and moderately obese subjects... - Cdc42 is a Rho GTPase family member that can mediate insulin signaling to glucose transport in 3T3-L1 adipocytesIsao Usui
Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Diego, La Jolla 92093, USA
J Biol Chem 278:13765-74. 2003..Taken together, these data indicate that cdc42 can mediate insulin signaling to GLUT4 translocation and lies downstream of G alpha(q/11) and upstream of PI3-kinase and PKC lambda in this stimulatory pathway... - Effect of heterozygous PPARgamma deficiency and TZD treatment on insulin resistance associated with age and high-fat feedingPhilip D G Miles
Department of Surgery, University of California, San Diego, USA
Am J Physiol Endocrinol Metab 284:E618-26. 2003..In conclusion, PPARgamma deficiency partially protects against age-related insulin resistance but does not protect against HF diet-induced insulin resistance... - Beta -Arrestin 1 down-regulation after insulin treatment is associated with supersensitization of beta 2 adrenergic receptor Galpha s signaling in 3T3-L1 adipocytesChristopher J Hupfeld
Department of Medicine, Division of Endocrinology and Metabolism, University of California at San Diego, La Jolla 92093, USA
Proc Natl Acad Sci U S A 100:161-6. 2003.... - Profiling gene transcription in vivo reveals adipose tissue as an immediate target of tumor necrosis factor-alpha: implications for insulin resistanceHong Ruan
Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
Diabetes 51:3176-88. 2002..TNF-alpha later alters systemic energy homeostasis that closely resembles the insulin resistance phenotype. Our data suggest that blockade of TNF-alpha action in adipose tissue may prevent TNF-alpha-induced insulin resistance in vivo... - The effect of thiazolidinediones on plasma adiponectin levels in normal, obese, and type 2 diabetic subjectsJoseph G Yu
Department of Medicine, Division of Endocrinology and Metabolism, University of California San Diego, La Jolla 92093, USA
Diabetes 51:2968-74. 2002..We have confirmed these results in normal rats. These findings suggest that adiponectin can be regulated by obesity, diabetes, TZDs, and insulin, and it may play a physiologic role in enhancing insulin sensitivity... - Insulin induces heterologous desensitization of G-protein-coupled receptor and insulin-like growth factor I signaling by downregulating beta-arrestin-1Stephane Dalle
Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Diego, La Jolla, California 92093 0673, USA
Mol Cell Biol 22:6272-85. 2002.... - Phosphatidylinositol 3-kinase is required for insulin-stimulated tyrosine phosphorylation of Shc in 3T3-L1 adipocytesSatoshi Ugi
Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Diego, La Jolla, California 92093-0673, USA
J Biol Chem 277:18592-7. 2002..2) PI 3-kinase-stimulated generation of membrane phospholipids can localize Shc to the plasma membrane through the Shc PTB domain facilitating phosphorylation by the insulin receptor... - Protein phosphatase 2A forms a molecular complex with Shc and regulates Shc tyrosine phosphorylation and downstream mitogenic signalingSatoshi Ugi
Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, La Jolla, California 92093 0673, USA
Mol Cell Biol 22:2375-87. 2002.... - GnRH activates ERK1/2 leading to the induction of c-fos and LHbeta protein expression in LbetaT2 cellsFujun Liu
Department of Medicine, University of California, San Diego, California 92093, USA
Mol Endocrinol 16:419-34. 2002..These results also demonstrate that the nuclear translocation of ERK by GnRH requires PKC signaling... - The effects of intracellular calcium depletion on insulin signaling in 3T3-L1 adipocytesDorothy Sears Worrall
Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Diego, La Jolla, California 92093, USA
Mol Endocrinol 16:378-89. 2002.... - Fatty acid-induced insulin resistance: decreased muscle PI3K activation but unchanged Akt phosphorylationYolanta T Kruszynska
Department of Endocrinology and Metabolism, University of California San Diego, Veterans Administration Center, La Jolla, California 92093, USA
J Clin Endocrinol Metab 87:226-34. 2002..This in turn may lead to impaired glucose transport through an Akt-independent pathway because Akt phosphorylation was unaffected by elevated NEFA levels... - Insulin-induced GLUT4 translocation involves protein kinase C-lambda-mediated functional coupling between Rab4 and the motor protein kinesinTakeshi Imamura
Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA
Mol Cell Biol 23:4892-900. 2003.... - Cellular effects of small molecule PTP1B inhibitors on insulin signalingLaiping Xie
Department of Molecular Pharmacology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
Biochemistry 42:12792-804. 2003.... - Regulation of the insulin receptor by protein kinase C isoenzymes: preferential interaction with beta isoenzymes and interaction with the catalytic domain of betaIITahir S Pillay
Division of Endocrinology and Metabolism, Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0673, USA
Cell Signal 16:97-104. 2004.... - Deletion of Gab1 in the liver leads to enhanced glucose tolerance and improved hepatic insulin actionEmilie A Bard-Chapeau
Signal Transduction Program, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
Nat Med 11:567-71. 2005..Thus, Gab1 acts to attenuate, through promotion of the Erk pathway, insulin-elicited signals flowing through IRS and Akt proteins, which represents a novel balancing mechanism for control of insulin signal strength in the liver... - Topiramate is an insulin-sensitizing compound in vivo with direct effects on adipocytes in female ZDF ratsJason J Wilkes
Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, USA
Am J Physiol Endocrinol Metab 288:E617-24. 2005..Thus the in vivo effects of TPM treatment appear to be exerted through adipose tissue... - Insulin-induced beta-arrestin1 Ser-412 phosphorylation is a mechanism for desensitization of ERK activation by Galphai-coupled receptorsChristopher J Hupfeld
Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Diego, La Jolla 92093, USA
J Biol Chem 280:1016-23. 2005..These findings provide a new mechanism for insulin-induced desensitization of ERK activation by Galphai-coupled receptors... - Mechanism of SHIP-mediated inhibition of insulin- and platelet-derived growth factor-stimulated mitogen-activated protein kinase activity in 3T3-L1 adipocytesPrem M Sharma
Department of Medicine 0673, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 0673, USA
Mol Endocrinol 19:421-30. 2005.... - beta-arrestin-1 competitively inhibits insulin-induced ubiquitination and degradation of insulin receptor substrate 1Isao Usui
Department of Medicine 0673, University of California, San Diego, Stein Bldg, Room 210, 9500 Gilman Dr, La Jolla, CA 92093 0673, USA
Mol Cell Biol 24:8929-37. 2004.... - Protein phosphatase 2A negatively regulates insulin's metabolic signaling pathway by inhibiting Akt (protein kinase B) activity in 3T3-L1 adipocytesSatoshi Ugi
Division of Endocrinology and Metabolism, Department of Medicine, Shiga University of Medical Science, Otsu, Japan
Mol Cell Biol 24:8778-89. 2004.... - Adiposity, dyslipidemia, and insulin resistance in mice with targeted deletion of phospholipid scramblase 3 (PLSCR3)Therese Wiedmer
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 101:13296-301. 2004.... - Adenovirus-mediated chronic "hyper-resistinemia" leads to in vivo insulin resistance in normal ratsHiroaki Satoh
Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Diego, La Jolla 92093 0673, USA
J Clin Invest 114:224-31. 2004..Thus elevated resistin levels in normal rats fed a regular chow diet produce many of the features of human syndrome X... - GRK2 is an endogenous protein inhibitor of the insulin signaling pathway for glucose transport stimulationIsao Usui
Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Diego, La Jolla, CA 92093 0673, USA
EMBO J 23:2821-9. 2004..Furthermore, inhibitors of GRK2 can lead to enhanced insulin sensitivity... - Protein phosphatase-2C alpha as a positive regulator of insulin sensitivity through direct activation of phosphatidylinositol 3-kinase in 3T3-L1 adipocytesTakeshi Yoshizaki
Department of Medicine, Shiga University of Medical Science, Otsu, Shiga 520 2192, Japan
J Biol Chem 279:22715-26. 2004..In conclusion, PP2Calpha is a new positive regulator of insulin sensitivity that acts through a direct activation of PI3K in 3T3-L1 adipocytes... - Annexin II is a thiazolidinedione-responsive gene involved in insulin-induced glucose transporter isoform 4 translocation in 3T3-L1 adipocytesJie Huang
Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Diego 92093 0673, USA
Endocrinology 145:1579-86. 2004..In summary, our results show that annexin II is a newly described thiazolidinedione response gene involved in insulin-induced GLUT4 translocation in 3T3-L1 adipocytes... - Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivityUtpal B Pajvani
Department of Cell Biology, Division of Endocrinology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
J Biol Chem 279:12152-62. 2004..These observations suggest that the HMW adiponectin complex is the active form of this protein, which we directly demonstrate in vivo by its ability to depress serum glucose levels in a dose-dependent manner... - Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscleWeimin He
Departments of Medicine and Biology, University of California at San Diego, La Jolla, CA 92093, USA
Proc Natl Acad Sci U S A 100:15712-7. 2003..These results suggest that syndrome X may be comprised of separable PPARgamma-dependent components whose origins and therapeutic sites may reside in distinct tissues... - Involvement of both G(q/11) and G(s) proteins in gonadotropin-releasing hormone receptor-mediated signaling in L beta T2 cellsFujun Liu
Department of Medicine, University of California, San Diego, California 92093, USA
J Biol Chem 277:32099-108. 2002..Taken together, these results indicate that the GnRH receptor activates both G(q) and G(s) signaling to regulate gene expression in L beta T2 cells... - The effect of oral glucosamine sulfate on insulin sensitivity in human subjectsJoseph G Yu
Diabetes Care 26:1941-2. 2003 - Synthesis and evaluation of photolabile insulin prodrugsLian-Sheng Li
The Skaggs Institute for Chemical Biology and Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Bioorg Med Chem Lett 15:3917-20. 2005..Using 2-deoxyglucose uptake assays, both di- and tri-protected compounds were less active than native insulin in the protected state, and showed comparable activity to native insulin upon photoactivation...
Research Grants
- TRAINING PROGRAM IN DIABETES RESEARCHJerrold Olefsky; Fiscal Year: 2007..bring together various activities encompassing the training and education of postdoctoral fellows in the fields of diabetes, metabolism and signal transduction at the University of California, San Diego School of Medicine ..
- INSULIN RECEPTORS AND THE GLUCOSE TRANSPORT SYSTEMJerrold Olefsky; Fiscal Year: 2007..abstract_text> ..
- Estrogens and Insulin Resistance in WomenJerrold Olefsky; Fiscal Year: 2006..abstract_text> ..
- Estrogen Effects in Insulin Target and Granulosa CellsJerrold Olefsky; Fiscal Year: 2004..These studies should also highlight the role of inflammatory pathway activation in these pathophysiologic events and this may have potential therapeutic implications for new treatment approaches. ..
- INSULIN RECEPTORS AND THE GLUCOSE TRANSPORT SYSTEMJERROLD MICHAEL OLEFSKY; Fiscal Year: 2010..These studies should lead to an improved understanding of the basic causes of Type 2 diabetes mellitus and hold the potential for new therapeutic modalities. ..