DANIEL S O'LEARY
Affiliation: University of Iowa
- Effects of smoking marijuana on brain perfusion and cognitionDANIEL S O'LEARY
Mental Health Clinical Research Center, University of Iowa College of Medicine, Iowa City, IA 52242 1057, USA
Neuropsychopharmacology 26:802-16. 2002..There was no significant rCBF change in the nucleus accumbens or other reward-related brain regions, nor in basal ganglia or hippocampus, which have a high density of cannabinoid receptors...
- Marijuana alters the human cerebellar clockDANIEL S O'LEARY
Department of Psychiatry, University of Iowa Hospital and Clinic, Iowa City, IA 52242, USA
Neuroreport 14:1145-51. 2003..Smoking marijuana appears to accelerate a cerebellar clock altering self-paced behaviors...
- Effects of smoking marijuana on focal attention and brain blood flowDANIEL S O'LEARY
Department of Psychiatry, Roy J and Lucille A Carver College of Medicine, The University of Iowa, Iowa 52242, USA
Hum Psychopharmacol 22:135-48. 2007..These data indicate that marijuana has dramatic direct effects on rCBF, but causes relatively little change in the normal pattern of task-related rCBF on this auditory focused attention task...
- Theory of mind and schizophrenia: a positron emission tomography study of medication-free patientsNancy C Andreasen
Department of Psychiatry, The University of Iowa Carver College of Medicine, 200 Hawkins Drive, Room W278GH, Iowa City, IA 52242 1057, USA
Schizophr Bull 34:708-19. 2008..This capacity, critical for social competence, is impaired in schizophrenia. We undertook a study of TOM in a group of patients with schizophrenia and healthy controls...
- Effects of frequent marijuana use on memory-related regional cerebral blood flowRobert I Block
Department of Anesthesia, University of Iowa, Room 5140, Westlawn Building, Iowa City, IA 52242, USA
Pharmacol Biochem Behav 72:237-50. 2002..These findings indicate altered memory-related brain function in marijuana users...
- Cognitive and magnetic resonance imaging brain morphometric correlates of brain-derived neurotrophic factor Val66Met gene polymorphism in patients with schizophrenia and healthy volunteersBeng Choon Ho
Department of Psychiatry, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, USA
Arch Gen Psychiatry 63:731-40. 2006..Its role in determining cognitive deficits in schizophrenia has also not been systematically studied...
- Emotions in unmedicated patients with schizophrenia during evaluation with positron emission tomographySergio Paradiso
Mental Health Clinical Research Center, Dapartment of Psychiatry, Univeristy of Iowa College of Medicine, Iowa City, IA 52242 1057, USA
Am J Psychiatry 160:1775-83. 2003..The authors measured regional cerebral blood flow (rCBF) during performance of a task that required unmedicated patients to recognize the emotional valence of visual images and to determine whether they were pleasant or unpleasant...
- Cerebral blood flow changes associated with Schneiderian first-rank symptoms in schizophreniaNicolas Franck
Mental Health Clinical Research Center, Department of Psychiatry, University of Iowa College of Medicine, Iowa City, Iowa, USA
J Neuropsychiatry Clin Neurosci 14:277-82. 2002..The results of this study demonstrate a cerebral pattern of activation related to Schneiderian symptoms and reinforce the hypothesis of an involvement of cortical areas that mediate space and body representation in such phenomena...
- The neural correlates of implicit sequence learning in schizophreniaCherie L Marvel
Department of Psychiatry, Roy J and Lucille A Carver College of Medicine, University of Iowa, USA
Neuropsychology 21:761-77. 2007..This adaptive strategy facilitated sequence learning but may have interfered with conventional implicit learning of the overall stimulus pattern...
- Age and regional cerebral blood flow in schizophrenia: age effects in anterior cingulate, frontal, and parietal cortexSusan K Schultz
Department of Radiology, University of Iowa College of Medicine, Iowa City, Iowa 52242 1000, USA
J Neuropsychiatry Clin Neurosci 14:19-24. 2002..In contrast, the reduced flow observed in the frontal and parietal regions may be unique to schizophrenia...
- Untreated initial psychosis: relation to cognitive deficits and brain morphology in first-episode schizophreniaBeng Choon Ho
Mental Health Clinical Research Center, Department of Psychiatry, University of Iowa College of Medicine and the University of Iowa College of Public Health, Iowa City, IA 52242, USA
Am J Psychiatry 160:142-8. 2003..This study investigated the relationships between duration of untreated initial psychosis and neurocognitive functioning and high-resolution imaging brain measurements...
- Effects of chronic marijuana use on brain activity during monetary decision-makingJatin G Vaidya
Department of Psychiatry, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA
Neuropsychopharmacology 37:618-29. 2012..Thus, chronic MJ users tend to strongly recruit neural circuitry involved in decision-making and reward processing (vmPFC), and probabilistic learning (cerebellum) when performing the IGT...
- Neural sensitivity to absolute and relative anticipated reward in adolescentsJatin G Vaidya
Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States of America
PLoS ONE 8:e58708. 2013..Thus, ventral striatal activity in anticipation of absolute and relative rewards develops with age. Absolute reward processing is also linked to individual differences in Impulsivity...
- Structural MR image processing using the BRAINS2 toolboxVincent A Magnotta
Mental Health Clinical Research Center, The University of Iowa Hospitals and Clinics, Room 2911 JPP, 200 Hawkins Drive, Iowa City, IA 52242, USA
Comput Med Imaging Graph 26:251-64. 2002..These features are described in detail, as well as the reliability of these procedures...
- Eyeblink conditioning in healthy adults: a positron emission tomography studyKrystal L Parker
Department of Psychiatry, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA
Cerebellum 11:946-56. 2012..Specifically, large peaks were noted in cerebellar lobules IV/V, the frontal lobes, and cingulate gyri...
- ACUTE MARIJUANA EFFECTS ON REGIONAL CEREBRAL BLOOD FLOWDANIEL O LEARY; Fiscal Year: 2000..It will also be the first study to provide information about whether the acute changes in rCBF and cognitive function caused by smoking marijuana become more severe following chronic use of this substance. ..
- ACUTE MARIJUANA EFFECTS ON REGIONAL CEREBRAL BLOOD FLOWDANIEL O LEARY; Fiscal Year: 2007..Finally, cognitive tasks requiring self-paced timing and other putative cerebellar functions will be used to assess the functional consequences of cerebellar hypoperfusion in chronic users of marijuana. ..
- Brain Development in Adolescents with Genetic Risk Factors for AlcoholismDANIEL S O LEARY; Fiscal Year: 2010....