Michael C Oldham

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Functional organization of the transcriptome in human brain
    Michael C Oldham
    Interdepartmental Program for Neuroscience, University of California Los Angeles, Los Angeles, California 90095, USA
    Nat Neurosci 11:1271-82. 2008
  2. ncbi Human-specific transcriptional networks in the brain
    Genevieve Konopka
    Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Neuron 75:601-17. 2012
  3. ncbi Is human blood a good surrogate for brain tissue in transcriptional studies?
    Chaochao Cai
    Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    BMC Genomics 11:589. 2010
  4. ncbi Functional genomic analyses identify pathways dysregulated by progranulin deficiency, implicating Wnt signaling
    Ezra Y Rosen
    Interdepartmental Program for Neuroscience, University of California Los Angeles, Los Angeles, CA 90095, USA
    Neuron 71:1030-42. 2011
  5. ncbi The organization of the transcriptional network in specific neuronal classes
    Kellen D Winden
    Interdepartmental Program for Neuroscience, University of California Los Angeles, Los Angeles, CA, USA
    Mol Syst Biol 5:291. 2009
  6. ncbi Is my network module preserved and reproducible?
    Peter Langfelder
    Department of Human Genetics, University of California, Los Angeles, Los Angeles, California, United States of America
    PLoS Comput Biol 7:e1001057. 2011
  7. ncbi Conservation and evolution of gene coexpression networks in human and chimpanzee brains
    Michael C Oldham
    Interdepartmental Program for Neuroscience, Program in Neurogenetics, and Semel Institute, David Geffen School of Medicine, Los Angeles, CA 90095-6814, USA
    Proc Natl Acad Sci U S A 103:17973-8. 2006
  8. ncbi A systems level analysis of transcriptional changes in Alzheimer's disease and normal aging
    Jeremy A Miller
    Center for Neurobehavioral Genetics, University of California, Los Angeles, Los Angeles, California 90095 1769, USA
    J Neurosci 28:1410-20. 2008

Collaborators

Detail Information

Publications8

  1. ncbi Functional organization of the transcriptome in human brain
    Michael C Oldham
    Interdepartmental Program for Neuroscience, University of California Los Angeles, Los Angeles, California 90095, USA
    Nat Neurosci 11:1271-82. 2008
    ..Our findings provide a new foundation for neurogenetic inquiries by revealing a robust and previously unrecognized organization to the human brain transcriptome...
  2. ncbi Human-specific transcriptional networks in the brain
    Genevieve Konopka
    Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Neuron 75:601-17. 2012
    ..These data demonstrate that transcriptional networks have undergone evolutionary remodeling even within a given brain region, providing a window through which to view the foundation of uniquely human cognitive capacities...
  3. ncbi Is human blood a good surrogate for brain tissue in transcriptional studies?
    Chaochao Cai
    Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    BMC Genomics 11:589. 2010
    ..We tested this hypothesis by relating three human brain expression data sets (from cortex, cerebellum and caudate nucleus) to two large human blood expression data sets (comprised of 1463 individuals)...
  4. ncbi Functional genomic analyses identify pathways dysregulated by progranulin deficiency, implicating Wnt signaling
    Ezra Y Rosen
    Interdepartmental Program for Neuroscience, University of California Los Angeles, Los Angeles, CA 90095, USA
    Neuron 71:1030-42. 2011
    ..Together, these in vitro and in vivo data point to an adaptive role for altered Wnt signaling in GRN deficiency-mediated FTD, representing a potential therapeutic target...
  5. ncbi The organization of the transcriptional network in specific neuronal classes
    Kellen D Winden
    Interdepartmental Program for Neuroscience, University of California Los Angeles, Los Angeles, CA, USA
    Mol Syst Biol 5:291. 2009
    ..These analyses provide a basis for understanding how specific aspects of neuronal phenotypic diversity are organized at the transcriptional level...
  6. ncbi Is my network module preserved and reproducible?
    Peter Langfelder
    Department of Human Genetics, University of California, Los Angeles, Los Angeles, California, United States of America
    PLoS Comput Biol 7:e1001057. 2011
    ..Data, R software and accompanying tutorials can be downloaded from the following webpage: http://www.genetics.ucla.edu/labs/horvath/CoexpressionNetwork/ModulePreservation...
  7. ncbi Conservation and evolution of gene coexpression networks in human and chimpanzee brains
    Michael C Oldham
    Interdepartmental Program for Neuroscience, Program in Neurogenetics, and Semel Institute, David Geffen School of Medicine, Los Angeles, CA 90095-6814, USA
    Proc Natl Acad Sci U S A 103:17973-8. 2006
    ..Our results provide insights into the molecular bases of primate brain organization and demonstrate the general utility of weighted gene coexpression network analysis...
  8. ncbi A systems level analysis of transcriptional changes in Alzheimer's disease and normal aging
    Jeremy A Miller
    Center for Neurobehavioral Genetics, University of California, Los Angeles, Los Angeles, California 90095 1769, USA
    J Neurosci 28:1410-20. 2008
    ..Finally, we found that presenilin 1 (PSEN1) is highly coexpressed with canonical myelin proteins, suggesting a role for PSEN1 in aspects of glial-neuronal interactions related to neurodegenerative processes...