Michael C Oldham
Affiliation: University of California
- Functional organization of the transcriptome in human brainMichael C Oldham
Interdepartmental Program for Neuroscience, University of California Los Angeles, Los Angeles, California 90095, USA
Nat Neurosci 11:1271-82. 2008..Our findings provide a new foundation for neurogenetic inquiries by revealing a robust and previously unrecognized organization to the human brain transcriptome...
- Human-specific transcriptional networks in the brainGenevieve Konopka
Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
Neuron 75:601-17. 2012..These data demonstrate that transcriptional networks have undergone evolutionary remodeling even within a given brain region, providing a window through which to view the foundation of uniquely human cognitive capacities...
- Is human blood a good surrogate for brain tissue in transcriptional studies?Chaochao Cai
Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
BMC Genomics 11:589. 2010..We tested this hypothesis by relating three human brain expression data sets (from cortex, cerebellum and caudate nucleus) to two large human blood expression data sets (comprised of 1463 individuals)...
- Functional genomic analyses identify pathways dysregulated by progranulin deficiency, implicating Wnt signalingEzra Y Rosen
Interdepartmental Program for Neuroscience, University of California Los Angeles, Los Angeles, CA 90095, USA
Neuron 71:1030-42. 2011..Together, these in vitro and in vivo data point to an adaptive role for altered Wnt signaling in GRN deficiency-mediated FTD, representing a potential therapeutic target...
- The organization of the transcriptional network in specific neuronal classesKellen D Winden
Interdepartmental Program for Neuroscience, University of California Los Angeles, Los Angeles, CA, USA
Mol Syst Biol 5:291. 2009..These analyses provide a basis for understanding how specific aspects of neuronal phenotypic diversity are organized at the transcriptional level...
- Is my network module preserved and reproducible?Peter Langfelder
Department of Human Genetics, University of California, Los Angeles, Los Angeles, California, United States of America
PLoS Comput Biol 7:e1001057. 2011..Data, R software and accompanying tutorials can be downloaded from the following webpage: http://www.genetics.ucla.edu/labs/horvath/CoexpressionNetwork/ModulePreservation...
- Conservation and evolution of gene coexpression networks in human and chimpanzee brainsMichael C Oldham
Interdepartmental Program for Neuroscience, Program in Neurogenetics, and Semel Institute, David Geffen School of Medicine, Los Angeles, CA 90095-6814, USA
Proc Natl Acad Sci U S A 103:17973-8. 2006..Our results provide insights into the molecular bases of primate brain organization and demonstrate the general utility of weighted gene coexpression network analysis...
- A systems level analysis of transcriptional changes in Alzheimer's disease and normal agingJeremy A Miller
Center for Neurobehavioral Genetics, University of California, Los Angeles, Los Angeles, California 90095 1769, USA
J Neurosci 28:1410-20. 2008..Finally, we found that presenilin 1 (PSEN1) is highly coexpressed with canonical myelin proteins, suggesting a role for PSEN1 in aspects of glial-neuronal interactions related to neurodegenerative processes...