Paul Okunieff

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi Is there a favorable subset of patients with prostate cancer who develop oligometastases?
    Deepinder Singh
    Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY 14642 8647, USA
    Int J Radiat Oncol Biol Phys 58:3-10. 2004
  2. ncbi Long-term management of patients with multiple brain metastases after shaped beam radiosurgery. Case report and review of the literature
    Paul Okunieff
    Department of Radiation Oncology, James P Wilmot Cancer Center at the University of Rochester Medical Center, NY 14642, USA
    J Neurosurg 101:406-12. 2004
  3. ncbi Pentoxifylline in the treatment of radiation-induced fibrosis
    Paul Okunieff
    University of Rochester School of Medicine, 601 Elmwood Ave, Box 647, Rochester, NY 14642, USA
    J Clin Oncol 22:2207-13. 2004
  4. pmc Report from the Radiation Therapy Committee of the Southwest Oncology Group (SWOG): Research Objectives Workshop 2008
    Paul Okunieff
    University of Rochester Medical Center, Rochester, New York 14642, USA
    Clin Cancer Res 15:5663-70. 2009
  5. ncbi Report from the Radiation Oncology Committee of the Southwest Oncology Group (SWOG): Research Objectives Workshop 2003
    Paul Okunieff
    Department of Radiation Oncology, JP Wilmot Cancer Center, University of Rochester, Rochester, NY 14642, USA
    Am J Clin Oncol 26:522-9. 2003
  6. ncbi Curcumin protects against radiation-induced acute and chronic cutaneous toxicity in mice and decreases mRNA expression of inflammatory and fibrogenic cytokines
    Paul Okunieff
    Department of Radiation Oncology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Int J Radiat Oncol Biol Phys 65:890-8. 2006
  7. ncbi Stereotactic Body Radiation Therapy (SBRT) for lung metastases
    Paul Okunieff
    Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY, USA
    Acta Oncol 45:808-17. 2006
  8. pmc Molecular markers of radiation-related normal tissue toxicity
    Paul Okunieff
    Department of Radiation Oncology, James P Wilmot Cancer Center, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 647, Rochester, NY 14642, USA
    Cancer Metastasis Rev 27:363-74. 2008
  9. ncbi Celecoxib reduces skin damage after radiation: selective reduction of chemokine and receptor mRNA expression in irradiated skin but not in irradiated mammary tumor
    Li Liang
    Department of Radiation Oncology, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Am J Clin Oncol 26:S114-21. 2003
  10. doi Central thoracic lesions treated with hypofractionated stereotactic body radiotherapy
    Michael T Milano
    Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Radiother Oncol 91:301-6. 2009

Collaborators

  • Michael T Milano
  • Mei Zhang
  • Ivan Ding
  • Wei Wang
  • Yuhchyau Chen
  • Jacqueline P Williams
  • Alan W Katz
  • Bruce M Fenton
  • Louis S Constine
  • Hong Zhang
  • Lei Zhang
  • Philip Rubin
  • Lisa A Kachnic
  • Charles R Thomas
  • G R Morrow
  • Benjamin Movsas
  • Shanmin Yang
  • Liangjie Yin
  • Zhenyu Xiao
  • Bo Lu
  • Weimin Liu
  • Kunzhong Zhang
  • Sheema Chawla
  • Ying Su
  • Amy Zhang
  • Zhenhuan Zhang
  • David Maguire
  • Chun Chen
  • Bingrong Zhang
  • Sadasivan Vidyasagar
  • Yeping Tian
  • Tithi Biswas
  • Li Yan Khor
  • Jane T Hickok
  • Deping Han
  • Ann G Muhs
  • Steven Bingrong Zhang
  • YongBing Cao
  • Jonathan Li
  • Chihray Liu
  • Kathryn Mittauer
  • Darren Kahler
  • Dongping Hu
  • Feng Ming Spring Kong
  • Praveena Cheruvu
  • Steven G Swarts
  • Clifton D Fuller
  • Lois B Travis
  • Li Liang
  • Chaomei Liu
  • Abraham Philip
  • Weimin Sun
  • Anitha Priya Krishnan
  • Andrea L DiCarlo
  • Walter J Curran
  • Jianzhong Sun
  • Peng Wang
  • Therese Smudzin
  • Robert S Bakos
  • Michael C Schell
  • Won Sam Yi
  • Michelle DeSilvio
  • Peter Keng
  • WALTER G O'DELL
  • Alan Pollack
  • Joseph A Roscoe
  • Karen Mustian
  • Amy H Moore
  • Feng Gao
  • William Sause
  • Deepinder Singh
  • Luis Souhami
  • Jianhui Zhong
  • Haisong Liu
  • Carl J Johnston
  • Arvind B Soni
  • Dhruv B Pateder
  • Xiaohui Wang
  • Luqiang Huang
  • Jinsheng Hong
  • Wenlong Lv
  • Jingshen Hong
  • Jun Ma
  • Steven Swarts
  • Yansong Guo
  • Roi Dagan
  • Sanjiv Samant
  • Joop C Duppen
  • Timothy Ritter
  • Anna M Harris

Detail Information

Publications88

  1. ncbi Is there a favorable subset of patients with prostate cancer who develop oligometastases?
    Deepinder Singh
    Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY 14642 8647, USA
    Int J Radiat Oncol Biol Phys 58:3-10. 2004
    ....
  2. ncbi Long-term management of patients with multiple brain metastases after shaped beam radiosurgery. Case report and review of the literature
    Paul Okunieff
    Department of Radiation Oncology, James P Wilmot Cancer Center at the University of Rochester Medical Center, NY 14642, USA
    J Neurosurg 101:406-12. 2004
    ..The authors present the management and a methodology for rational treatment of a patient with breast cancer who has harbored 24 brain metastases during a 3-year period...
  3. ncbi Pentoxifylline in the treatment of radiation-induced fibrosis
    Paul Okunieff
    University of Rochester School of Medicine, 601 Elmwood Ave, Box 647, Rochester, NY 14642, USA
    J Clin Oncol 22:2207-13. 2004
    ..Tumor necrosis factor alpha and fibroblast growth factor 2 (FGF2), which are abnormally elevated in irradiated tissues, may mediate radiation fibrovascular injury...
  4. pmc Report from the Radiation Therapy Committee of the Southwest Oncology Group (SWOG): Research Objectives Workshop 2008
    Paul Okunieff
    University of Rochester Medical Center, Rochester, New York 14642, USA
    Clin Cancer Res 15:5663-70. 2009
    ..The Committee concluded that the future research opportunities are among the most exciting to have developed in the last decade, and work is in progress to embark on these plans...
  5. ncbi Report from the Radiation Oncology Committee of the Southwest Oncology Group (SWOG): Research Objectives Workshop 2003
    Paul Okunieff
    Department of Radiation Oncology, JP Wilmot Cancer Center, University of Rochester, Rochester, NY 14642, USA
    Am J Clin Oncol 26:522-9. 2003
    ..This hypothesis is ready for testing in cancers of the breast, prostate, colon, and in sarcomas. Enlarging the therapeutic window is a major goal that would allow for an increasingly favorable therapeutic gain...
  6. ncbi Curcumin protects against radiation-induced acute and chronic cutaneous toxicity in mice and decreases mRNA expression of inflammatory and fibrogenic cytokines
    Paul Okunieff
    Department of Radiation Oncology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Int J Radiat Oncol Biol Phys 65:890-8. 2006
    ....
  7. ncbi Stereotactic Body Radiation Therapy (SBRT) for lung metastases
    Paul Okunieff
    Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY, USA
    Acta Oncol 45:808-17. 2006
    ..Median survival time and progression-free survival both appear better than that achieved with standard care alone. Long-term progression-free survival can be seen in a subset of patients when all tumors are targeted...
  8. pmc Molecular markers of radiation-related normal tissue toxicity
    Paul Okunieff
    Department of Radiation Oncology, James P Wilmot Cancer Center, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 647, Rochester, NY 14642, USA
    Cancer Metastasis Rev 27:363-74. 2008
    ..Genomics and proteomics are still in nascent stages and are actively being studied and developed...
  9. ncbi Celecoxib reduces skin damage after radiation: selective reduction of chemokine and receptor mRNA expression in irradiated skin but not in irradiated mammary tumor
    Li Liang
    Department of Radiation Oncology, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Am J Clin Oncol 26:S114-21. 2003
    ..The differential effects of celecoxib on inflammation help to explain the selective protection by celecoxib of irradiated cutaneous tissues without a concurrent protection of MCa-35 tumors...
  10. doi Central thoracic lesions treated with hypofractionated stereotactic body radiotherapy
    Michael T Milano
    Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Radiother Oncol 91:301-6. 2009
    ..To investigate the toxicity and outcome after moderately hypofractionated stereotactic body radiotherapy (SBRT) for central thoracic lesions...
  11. pmc Mitigation effect of an FGF-2 peptide on acute gastrointestinal syndrome after high-dose ionizing radiation
    Lurong Zhang
    Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY 14642 8647, USA
    Int J Radiat Oncol Biol Phys 77:261-8. 2010
    ..Currently, no satisfactory agent exists for mitigation of AGS. A peptide derived from the receptor binding domain of fibroblast growth factor 2 (FGF-P) was synthesized and its mitigation effect on AGS was examined...
  12. doi Alteration of the inflammatory molecule network after irradiation of soft tissue
    Zhenyu Xiao
    Department of Radiation Oncology, University of Florida, Gainesville, FL 32610, USA
    Adv Exp Med Biol 765:335-41. 2013
    ....
  13. doi Descriptive analysis of oligometastatic lesions treated with curative-intent stereotactic body radiotherapy
    Michael T Milano
    Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY, USA
    Int J Radiat Oncol Biol Phys 72:1516-22. 2008
    ..To characterize oligometastases in patients enrolled on two prospective pilot studies, treating oligometastases with hypofractionated stereotactic body radiotherapy and stereotactic radiosurgery to cranial lesions...
  14. doi Antioxidant properties of quercetin
    Mei Zhang
    Department of Radiation Oncology, University of Florida, 2033 Mowry Road, 103633, Gainesville, FL 32610, USA
    Adv Exp Med Biol 701:283-9. 2011
    ..These data provide a physico-chemical basis for comparing antioxidants, with potential benefits individually or in combination...
  15. doi Oligometastases treated with stereotactic body radiotherapy: long-term follow-up of prospective study
    Michael T Milano
    Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Int J Radiat Oncol Biol Phys 83:878-86. 2012
    ..To analyze the long-term survival and tumor control outcomes after stereotactic body radiotherapy (SBRT) for metastases limited in number and extent...
  16. doi Anti-cancer effect of resveratrol is associated with induction of apoptosis via a mitochondrial pathway alignment
    Weimin Sun
    Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Adv Exp Med Biol 614:179-86. 2008
    ....
  17. doi Oligometastatic breast cancer treated with curative-intent stereotactic body radiation therapy
    Michael T Milano
    Department of Radiation Oncology, University of Rochester Medical Center, 601 Elmwood Ave, P O Box 647, Rochester, NY 14642, USA
    Breast Cancer Res Treat 115:601-8. 2009
    ..Prospective pilot study to assess patient outcome after stereotactic body radiation therapy (SBRT) for limited metastases from breast cancer...
  18. ncbi Enhanced antitumor effect of combined triptolide and ionizing radiation
    Wei Wang
    Department of Radiation Oncology, University of Rochester Medical Center, Rochester, New York 14642 8647, USA
    Clin Cancer Res 13:4891-9. 2007
    ..This study explores the enhancement of the therapeutic effect on human pancreatic cancer via the combination of triptolide and ionizing radiation (IR)...
  19. pmc Normal tissue toxicity after small field hypofractionated stereotactic body radiation
    Michael T Milano
    Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Radiat Oncol 3:36. 2008
    ..While clinical data has shown SBRT to be safe in most circumstances, more data is needed to refine the ideal dose-volume metrics...
  20. pmc B1 sequence-based real-time quantitative PCR: a sensitive method for direct measurement of mouse plasma DNA levels after gamma irradiation
    Hengshan Zhang
    Department of Radiation Oncology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642 8647, USA
    Int J Radiat Oncol Biol Phys 74:1592-9. 2009
    ..We have identified a new technique with the advantage of directly measuring circulating DNA by amplifying inter-B1 regions in the mouse genome, providing a sensitive method for quantitating plasma DNA...
  21. ncbi FGF1 and VEGF mediated angiogenesis in KHT tumor-bearing mice
    Ivan Ding
    Department of Radiation Oncology, University of Rochester, Box 647, Rochester, NY 14642, USA
    Adv Exp Med Biol 530:603-9. 2003
    ..In summary, alteration of tumor oxygenation by local administration of angiogenic growth factors may be mediated by cytokine/chemokine production in the tumor...
  22. ncbi Radiation affects the responsiveness of bone marrow to G-CSF
    Zhenhuan Zhang
    Department of Radiation Oncology, UF Shands Cancer Center, University of Florida, Gainesville, FL, 32610, USA
    Adv Exp Med Biol 789:273-80. 2013
    ..The radiation-induced increase in plasma IL-6 in vivo could be enhanced by the administration of G-CSF. The data suggest that radiation potentiates the response of bone marrow cells to G-CSF treatment. ..
  23. doi Response patterns of cytokines/chemokines in two murine strains after irradiation
    Mei Zhang
    Department of Radiation Oncology, Shands Cancer Center, University of Florida, Gainesville, Gainesville, FL 32610 0385, USA
    Cytokine 58:169-77. 2012
    ..To determine the plasma concentrations of acute responding cytokines/chemokines following 9-Gy ionizing radiation in C57BL/6 (radiation tolerant) and C3H/HeN (radiation sensitive) murine strains...
  24. ncbi Triptolide alters mitochondrial functions
    Ying Su
    Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Adv Exp Med Biol 599:139-46. 2007
    ..It is likely that by impairment of mitochondrial function, TPL exerts its inhibitory effect on growth of tumor and progression of inflammatory disease...
  25. ncbi Interleukin 1beta (IL1B) signaling is a critical component of radiation-induced skin fibrosis
    Weimin Liu
    Department of Radiation Oncology, James P Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York 14642, USA
    Radiat Res 165:181-91. 2006
    ..In conclusion, these data suggest that IL1B plays a critical role in radiation-induced fibrosis and that the increased MMPs fail to block the IL1-related collagen accumulation...
  26. ncbi Combination of radiation and celebrex (celecoxib) reduce mammary and lung tumor growth
    Weimin Liu
    Department of Radiation Oncology, University of Rochester, Rochester, New York 14642, USA
    Am J Clin Oncol 26:S103-9. 2003
    ....
  27. ncbi Protective effect of esculentoside A on radiation-induced dermatitis and fibrosis
    Zhenyu Xiao
    Department of Radiation Oncology, James P Wilmot Cancer Center at the University of Rochester Medical Center, Rochester, NY, USA
    Int J Radiat Oncol Biol Phys 65:882-9. 2006
    ..To investigate the effect of esculentoside A (EsA) on radiation-induced cutaneous and fibrovascular toxicity and its possible molecular mechanisms, both in vivo and in vitro...
  28. pmc Fibroblast growth factor-peptide improves barrier function and proliferation in human keratinocytes after radiation
    Kunzhong Zhang
    Department of Radiation Oncology, University of Rochester Medical Center, Rochester, New York 14642, USA
    Int J Radiat Oncol Biol Phys 81:248-54. 2011
    ..We tested fibroblast growth factor-peptide (FGF-P), a small peptide derived from the receptor-binding domain of FGF-2, as a potential mitigator of radiation effects via proliferation and the barrier function of keratinocytes...
  29. doi Antioxidant properties of select radiation mitigators based on semicarbazone and pyrazole derivatives of curcumin
    Steven G Swarts
    Department of Radiation Oncology, University of Florida, 2033 Mowry Road, 103633, Gainesville, FL 32610, USA
    Adv Exp Med Biol 701:291-7. 2011
    ....
  30. doi A new flavonoid regulates angiogenesis and reactive oxygen species production
    Mei Zhang
    Department of Radiation Oncology, University of Florida, Cancer Genetics Research Complex, 2033 Mowry Road, Suite 145, 103633, Gainesville, FL, 32610, USA
    Adv Exp Med Biol 812:149-55. 2014
    ..CM-H2DCFDA staining indicated that intracellular ROS production increased with the R24 dose. In summary, we found that R24 exhibits potent antiangiogenic and antiproliferative effects, induces apoptosis, and promotes ROS production. ..
  31. doi A patient alignment solution for lung SBRT setups based on a deformable registration technique
    Bo Lu
    Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL, USA
    Med Phys 39:7379-89. 2012
    ....
  32. doi Alteration of circulating mitochondrial DNA concentration after irradiation
    Mei Zhang
    Department of Radiation Oncology, University of Florida, Gainesville, FL 32610, USA
    Adv Exp Med Biol 765:371-7. 2013
    ..The alteration of mtDNA was not dose-dependent or time-dependent; hence, it is unlikely to be an effective biodosimeter...
  33. doi Stereotactic body radiotherapy for treatment of adrenal metastases
    Sheema Chawla
    Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Int J Radiat Oncol Biol Phys 75:71-5. 2009
    ..To investigate the dosimetry and outcomes of patients undergoing stereotactic body radiotherapy (SBRT) for metastases to the adrenal glands...
  34. pmc Replication of murine mitochondrial DNA following irradiation
    Hengshan Zhang
    Department of Radiation Oncology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Adv Exp Med Biol 645:43-8. 2009
    ..In conclusion, we found that radiation increased the ratio of mtDNA:nDNA and that this effect seems to be tissue independent and seems to increase with radiation dose and duration following radiation exposure...
  35. ncbi Effect of administration of lovastatin on the development of late pulmonary effects after whole-lung irradiation in a murine model
    Jacqueline P Williams
    Department of Radiation Oncology, James P Wilmot Cancer Center, University of Rochester, Rochester, NY 14642, USA
    Radiat Res 161:560-7. 2004
    ..Additional experiments are needed to assess whether statins offer a potential treatment for the amelioration of late effects in breast and lung cancer patients undergoing radiation therapy...
  36. ncbi Interleukin (IL)-1A and IL-6: applications to the predictive diagnostic testing of radiation pneumonitis
    Yuhchyau Chen
    Department of Radiation Oncology, James P Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY 14642, USA
    Int J Radiat Oncol Biol Phys 62:260-6. 2005
    ..To explore the application of interleukin (IL)-1alpha and IL-6 measurements in the predictive diagnostic testing for symptomatic radiation pneumonitis (RP)...
  37. ncbi Fibroblast growth factors (FGFS) increase breast tumor growth rate, metastases, blood flow, and oxygenation without significant change in vascular density
    Paul Okunieff
    Department of Radiation Oncology, University of Rochester, Rochester, NY, USA
    Adv Exp Med Biol 530:593-601. 2003
    ..We found that angiogenic factors preserve and augment neovascular function, thus facilitating tumor growth and progression...
  38. doi Patterns and timing of recurrence after temozolomide-based chemoradiation for glioblastoma
    Michael T Milano
    Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Int J Radiat Oncol Biol Phys 78:1147-55. 2010
    ..To determine recurrence patterns of glioblastoma treated with temozolomide-based chemoradiation...
  39. ncbi Maternal bias in mouse radiosensitivity: the role of the mitochondrial PTP
    Steven Bingrong Zhang
    Department of Radiation Oncology, UF Shands Cancer Center, University of Florida, 2033 Mowry Road, Gainesville, FL, 32610, USA
    Adv Exp Med Biol 789:251-6. 2013
    ..We propose that a genetic change in ANT and a postirradiation change involving either mtDNA-encoded protein replacement or altered mtDNA association fit these data. ..
  40. doi In vitro Sirius Red collagen assay measures the pattern shift from soluble to deposited collagen
    Chun Chen
    Department of Radiation Oncology, University of Florida, Gainesville, FL 32610, USA
    Adv Exp Med Biol 765:47-53. 2013
    ....
  41. pmc Comparison of outcomes in patients with stage III versus limited stage IV non-small cell lung cancer
    Praveena Cheruvu
    Department of Radiation Oncology, University of Rochester Medical Center, Rochester, New York, USA
    Radiat Oncol 6:80. 2011
    ..We hypothesized that patients treated with SBRT for limited metastases have comparable outcomes with those treated with curative-intent radiation for Stage III NSCLC...
  42. doi Analysis of patients with oligometastases undergoing two or more curative-intent stereotactic radiotherapy courses
    Michael T Milano
    Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Int J Radiat Oncol Biol Phys 73:832-7. 2009
    ..We hypothesized that these patients would remain amenable to curative-intent treatment with additional RT courses...
  43. ncbi Radiation pneumonitis and early circulatory cytokine markers
    Yuhchyau Chen
    Department of Radiation Oncology, James P Wilmot Cancer Center, University of Rochester, Rochester, NY 14642, USA
    Semin Radiat Oncol 12:26-33. 2002
    ..Analysis of a panel of circulating cytokines with different putative functions in radiation pulmonary injury identified IL-1alpha and IL-6 as early circulating cytokine markers for radiation pneumonitis...
  44. ncbi A new intrinsic hypoxia marker in esophageal cancer
    Ivan Ding
    University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Adv Exp Med Biol 540:227-33. 2003
  45. pmc Antioxidants reduce consequences of radiation exposure
    Paul Okunieff
    Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Adv Exp Med Biol 614:165-78. 2008
    ..In this review we discuss what is known about the radioprotective properties of antioxidants, and what those properties tell us about the DNA and other cellular targets of radiation...
  46. doi Decreasing the adverse effects of cancer therapy: National Cancer Institute guidance for the clinical development of radiation injury mitigators
    Benjamin Movsas
    Department of Radiation Oncology, Henry Ford Hospital, Detroit, Michigan 48202, USA
    Clin Cancer Res 17:222-8. 2011
    ..Ultimately, the goal is to be able to apply such promising agents to improve the quality of life for patients receiving radiotherapy or chemoradiotherapy for cancer...
  47. pmc Stereotactic radiosurgery for glioblastoma: retrospective analysis
    Tithi Biswas
    Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Radiat Oncol 4:11. 2009
    ..This retrospective study was done to better understand the conditions for which stereotactic radiosurgery (SRS) for glioblastoma may be efficacious...
  48. ncbi The biological basis of a comprehensive grading system for the adverse effects of cancer treatment
    Jacqueline Williams
    Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Semin Radiat Oncol 13:182-8. 2003
    ..It also provides insights into potential targets and strategies for modulating response, which may in turn lead to effective interventions for altering the therapeutic ratio...
  49. ncbi Primary spinal cord glioma: a Surveillance, Epidemiology, and End Results database study
    Michael T Milano
    Department of Radiation Oncology, University of Rochester Medical Center, 601 Elmwood Ave, Box 647, Rochester, NY 14642, USA
    J Neurooncol 98:83-92. 2010
    ..Given the retrospective nature of this study, specific recommendations about which situations warrant radiotherapy cannot be determined...
  50. ncbi Immunohistochemical identification and localization of endogenous endostatin and its related peptides in murine tumors
    Jianzhong Sun
    Department of Radiation Oncology, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Adv Exp Med Biol 599:147-53. 2007
    ..3) Staining patterns and localization of endostatin and thrombospondin-1 were similar in these tumor sections...
  51. doi Patterns of recurrence after curative-intent radiation for oligometastases confined to one organ
    Michael T Milano
    Department of Radiation Oncology, University of Rochester Medical Center, Rochester, New York 14642, USA
    Am J Clin Oncol 33:157-63. 2010
    ....
  52. ncbi Mechanism and modification of gastrointestinal soft tissue response to radiation: role of growth factors
    Paul Okunieff
    Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Int J Radiat Oncol Biol Phys 62:273-8. 2005
    ..The purpose of the present study was to measure mRNA levels of inflammatory cytokines in abdominally irradiated mouse bowel...
  53. ncbi A prospective pilot study of curative-intent stereotactic body radiation therapy in patients with 5 or fewer oligometastatic lesions
    Michael T Milano
    Department of Radiation Oncology, University of Rochester Medical Center, Rochester, New York 14642, USA
    Cancer 112:650-8. 2008
    ..It is hypothesized that oligometastatic disease represents a state of potentially curable, limited metastases. Stereotactic body radiation therapy (SBRT) is an option for patients who are not amenable to or do not want resection...
  54. ncbi Hypofractionated stereotactic body radiation therapy (SBRT) for limited hepatic metastases
    Alan W Katz
    Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Int J Radiat Oncol Biol Phys 67:793-8. 2007
    ..To evaluate the feasibility and efficacy of hypofractionated stereotactic body radiation therapy (SBRT) for the treatment of liver metastases...
  55. ncbi Normal tissue tolerance dose metrics for radiation therapy of major organs
    Michael T Milano
    Department of Radiation Oncology and James P Wilmot Cancer Center, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Semin Radiat Oncol 17:131-40. 2007
    ..This review summarizes the published clinical data on the risk of late toxicity as a function of quantitative dose metrics and attempts to offer suggested dose constraints for radiation treatment planning...
  56. ncbi Phase I/II clinical study of pulsed paclitaxel radiosensitization for thoracic malignancy: a therapeutic approach on the basis of preclinical research of human cancer cell lines
    Yuhchyau Chen
    Department of Radiation, James P Wilmot Cancer Center, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Clin Cancer Res 9:969-75. 2003
    ..The study was based on preclinical research of the effects of paclitaxel on apoptosis and the cell cycle in human cancer cell lines...
  57. ncbi Intratumoral VEGF and FGF1 administration alters tumor growth, vascular density, oxygenation, and expression of MCP-1 and interleukins
    Paul Okunieff
    Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Adv Exp Med Biol 599:109-16. 2007
    ..This improved vascular function occurs without an increase in vascular density...
  58. doi Tumor oxygen measurements and personalized medicine
    Paul Okunieff
    Department of Radiation Oncology, University of Florida, Gainesville, FL 32610, USA
    Adv Exp Med Biol 765:195-201. 2013
    ..Therapies aimed at reversing hypoxia-related treatment resistance or normalizing hypoxia are proven effective with level 1 evidence. The weak link remains the lack of satisfactory methods of measurement of tumor oxygenation...
  59. doi The role of mitochondrial proteomic analysis in radiological accidents and terrorism
    David Maguire
    Department of Radiation Oncology, University of Florida, Gainesville, FL 32610, USA
    Adv Exp Med Biol 765:139-45. 2013
    ..We discuss the implications of this finding both in terms of possible mechanisms and potential applications in bio-radiation monitoring...
  60. doi Elevated mitochondrial DNA copy number and POL-γ expression but decreased expression of TFAM in murine intestine following therapeutic dose irradiation
    Hengshan Zhang
    Department of Radiation Oncology, University of Florida, 2033 Mowry Road, 103633, Gainesville, FL 32610, USA
    Adv Exp Med Biol 701:201-6. 2011
    ..Paradoxically, transcription factor A (TFAM), exhibited the directly opposite response...
  61. doi Stereotactic radiosurgery for spinal metastases: case report and review of treatment options
    Sheema Chawla
    University of Rochester Medical Center, Department of Radiation Oncology, 601 Elmwood Ave Box 647, Rochester, NY 14642, USA
    Bone 45:817-21. 2009
    ..We also review the literature on treatment of spinal metastases using SRS, SBRT, and other modalities...
  62. ncbi Occurrence, severity, and longitudinal course of twelve common symptoms in 1129 consecutive patients during radiotherapy for cancer
    Jane T Hickok
    Department of Radiation Oncology and James P Wilmot Cancer Center, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Pain Symptom Manage 30:433-42. 2005
    ..Improved understanding about the time course and dose response of radiation-induced toxicity will permit more accurate presentation of side effect risk at the time patient consent is obtained...
  63. pmc Bcl-2 and bax expression and prostate cancer outcome in men treated with radiotherapy in Radiation Therapy Oncology Group protocol 86-10
    Li Yan Khor
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Radiat Oncol Biol Phys 66:25-30. 2006
    ..In this study we examined bcl-2 and bax expression as predictive markers in men treated with radiotherapy +/- androgen deprivation on Radiation Therapy Oncology Group (RTOG) protocol 86-10...
  64. pmc Testicular cancer survivorship: research strategies and recommendations
    Lois B Travis
    Department of Radiation Oncology, James P Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Natl Cancer Inst 102:1114-30. 2010
    ..Just as testicular cancer once served as the paradigm of a curable malignancy, comprehensive follow-up studies of testicular cancer survivors can pioneer new methodologies in survivorship research for all adult-onset cancer...
  65. ncbi Lung metastases detection in CT images using 3D template matching
    Peng Wang
    Department of Biomedical Engineering, University of Rochester, Rochester, New York 14642, USA
    Med Phys 34:915-22. 2007
    ..This study demonstrates that an automatic and straightforward 3D template-matching method, without any complex training or postprocessing, can be used to detect small lung metastases quickly and reliably in the clinical setting...
  66. doi Evidence that MR diffusion tensor imaging (tractography) predicts the natural history of regional progression in patients irradiated conformally for primary brain tumors
    Anitha Priya Krishnan
    Department of Biomedical Engineering, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Int J Radiat Oncol Biol Phys 71:1553-62. 2008
    ....
  67. ncbi Translational research in lung cancer
    Yuhchyau Chen
    Department of Radiation Oncology, University of Rochester Medical Center, Rochester, New York 14642, USA
    Semin Surg Oncol 21:205-19. 2003
    ..We believe that knowledge of lung cancer biology will continue to provide the foundation for future improvements in lung cancer treatment...
  68. pmc Prospective randomized double-blind pilot study of site-specific consensus atlas implementation for rectal cancer target volume delineation in the cooperative group setting
    Clifton D Fuller
    Department of Radiation Oncology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Int J Radiat Oncol Biol Phys 79:481-9. 2011
    ..Variations in target volume delineation represent a significant hurdle in clinical trials involving conformal radiotherapy. We sought to determine the effect of a consensus guideline-based visual atlas on contouring the target volumes...
  69. pmc Consideration of dose limits for organs at risk of thoracic radiotherapy: atlas for lung, proximal bronchial tree, esophagus, spinal cord, ribs, and brachial plexus
    Feng Ming Spring Kong
    Department of Radiation Oncology, University of Michigan and Ann Arbor Veteran Affairs Medical System, Ann Arbor, MI 48109, USA
    Int J Radiat Oncol Biol Phys 81:1442-57. 2011
    ....
  70. ncbi Low-dose radiosurgery for benign intracranial lesions
    Tithi Biswas
    Department of Radiation Oncology, University of Rochester Medical Center Rochester, New York 14642 8647, USA
    Am J Clin Oncol 26:325-31. 2003
    ..If lower, more homogeneous radiation doses produce responses as durable as higher doses, then toxicity might be further reduced...
  71. ncbi Radiation and third-generation chemotherapy
    Yuhchyau Chen
    Department of Radiation Oncology, University of Rochester Medical Center, 600 Elmwood Avenue, Box 647, Rochester, NY 14642, USA
    Hematol Oncol Clin North Am 18:55-80. 2004
    ..The challenge of targeting distant disease control for locally advanced NSCLC continues...
  72. ncbi Regulation of prostaglandin E2 synthesis after brain irradiation
    Amy H Moore
    Department of Neurobiology and Anatomy, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Int J Radiat Oncol Biol Phys 62:267-72. 2005
    ..Previous work suggested that cyclooxygenase (COX)-2 activity was important for changes in gene expression associated with neuroinflammation as well as increased prostaglandin E2 (PGE2) levels seen after radiation treatment...
  73. ncbi Optimal marker placement in photogrammetry patient positioning system
    Haisong Liu
    Department of Radiation Oncology, University of Rochester, Rochester, New York 14642, USA
    Med Phys 30:103-10. 2003
    ..A 50% reduction in TRE has been achieved by using the optimal configuration compared to the random configuration. This result demonstrates that the optimization of a fiducial configuration can result in improved tumor targeting ability...
  74. pmc Animal models for medical countermeasures to radiation exposure
    Jacqueline P Williams
    Department of Radiation Oncology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 647, Rochester, NY 14642, USA
    Radiat Res 173:557-78. 2010
    ..Discussions covered the most appropriate species and strains available as well as other factors that may affect differential findings between groups and institutions. This report provides the workshop findings...
  75. ncbi Comparison and modulation of angiogenic responses by FGFs, VEGF and SCF in murine and human fibrosarcomas
    Ivan Ding
    Department of Radiation Oncology, Box 647, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Comp Biochem Physiol A Mol Integr Physiol 132:17-25. 2002
    ..The SK-LMS-1 cells, in contrast, only responded to exogenous FGF1, FGF7 and FGF10, but did not respond to VEGF...
  76. ncbi Frequency, severity, clinical course, and correlates of fatigue in 372 patients during 5 weeks of radiotherapy for cancer
    Jane T Hickok
    Department of Radiation Oncology, James P Wilmot Cancer Center, University of Rochester, Rochester, New York 14642, USA
    Cancer 104:1772-8. 2005
    ..Patients often describe fatigue as the most distressing of the symptoms they experienced during their cancer treatment. Fatigue may increase from initial levels experienced during cancer treatment with the addition of radiotherapy (RT)...
  77. ncbi Benefits of external beam irradiation for peripheral arterial bypass: preliminary report on a phase I study
    Arvind B Soni
    Department of Radiation Oncology, University of Rochester Medical Center, 601 ElmwoodAvenue, Rochester, NY 14642, USA
    Int J Radiat Oncol Biol Phys 54:1174-9. 2002
    ..To perform a Phase I study to determine the safety and feasibility of using external beam radiotherapy to prevent neointimal hyperplasia in patients after surgical bypass of occluded infrainguinal arteries...
  78. doi An approach for online evaluations of dose consequences caused by small rotational setup errors in intracranial stereotactic radiation therapy
    Bo Lu
    Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL 32607, USA
    Med Phys 38:6203-15. 2011
    ....
  79. ncbi Role of pentoxifylline in preventing radiation damage to epiphyseal growth plate chondrocytes
    Dhruv B Pateder
    Department of Orthopaedic Surgery, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Radiat Res 157:62-8. 2002
    ....
  80. ncbi Radiation-induced pulmonary fibrosis: examination of chemokine and chemokine receptor families
    Carl J Johnston
    University of Rochester, Department of Pediatrics, Environmental Medicine, and Radiation Oncology, Rochester, New York 14642, USA
    Radiat Res 157:256-65. 2002
    ..These studies suggest that monocyte/macrophage and lymphocyte recruitment and activation are key components of radiation-induced fibrosis...
  81. ncbi fMRI for monitoring dynamic changes in tissue oxygenation/blood flow: potential applications for tumor response to carbogen treatment
    Jianhui Zhong
    Department of Radiology, Biomedical Engineering, University of Rochester, Rochester, NY, USA
    Adv Exp Med Biol 530:449-59. 2003
    ....
  82. ncbi Evidence for and against hypoxia as the primary cause of tumor aggressiveness
    Paul Okunieff
    University of Rochester, Rochester, New York 14642, USA
    Adv Exp Med Biol 510:69-75. 2003
  83. ncbi MDM2 as a predictor of prostate carcinoma outcome: an analysis of Radiation Therapy Oncology Group Protocol 8610
    Li Yan Khor
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer 104:962-7. 2005
    ....
  84. ncbi Randomized comparison of stereotactic radiosurgery followed by conventional radiotherapy with carmustine to conventional radiotherapy with carmustine for patients with glioblastoma multiforme: report of Radiation Therapy Oncology Group 93-05 protocol
    Luis Souhami
    Department of Oncology, Division of Radiation Oncology, McGill University, Montreal, Quebec, Canada
    Int J Radiat Oncol Biol Phys 60:853-60. 2004
    ..We investigated the effect of stereotactic radiosurgery (SRS) added to conventional external beam radiation therapy (EBRT) with carmustine (BCNU) on the survival of patients with GBM...
  85. ncbi Hypoxia-induced alterations in hyaluronan and hyaluronidase
    Feng Gao
    Adv Exp Med Biol 566:249-56. 2005
    ..This study demonstrates that hypoxia can stimulate the production of HA and the activity of hyaluronidase, which may promote angiogenesis as a compensation mechanism for hypoxia...
  86. ncbi Design of multi-institutional and cooperative group studies of SBRT
    Paul Okunieff
    Acta Oncol 45:775-8. 2006
  87. doi Medical countermeasures for radiation combined injury: radiation with burn, blast, trauma and/or sepsis. report of an NIAID Workshop, March 26-27, 2007
    Andrea L DiCarlo
    Division of Allergy, Immunology and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Radiat Res 169:712-21. 2008
    ....
  88. ncbi Past, present, and future of oxygen in cancer research
    Paul Okunieff
    Adv Exp Med Biol 566:213-22. 2005
    ..ISOTT scientists are responsible for much of the elucidation of the specific effects of O2, ADP/ATP ratios, hypoglycemia, and acidosis on tumor responses to radiation and hyperthermia. Many questions still remain...