M S Okun

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. ncbi request reprint Visual-spatial ability in Parkinson's disease
    Gregory P Crucian
    University of Florida Department of Neurology, P O Box 100236, Gainesville, FL 32610 0236, USA
    Front Biosci 8:s992-7. 2003
  2. ncbi request reprint Americo Negrette (1924 to 2003): diagnosing Huntington disease in Venezuela
    Michael S Okun
    Department of Neurology, University of Florida, McKnight Brain Institute, Movement Disorders Center, P O Box 100236, Gainesville, FL 32610, USA
    Neurology 63:340-3. 2004
  3. ncbi request reprint Magnetic resonance imaging of the posterior columns in vitamin B12 deficiency
    Michael S Okun
    Department of Neurology, University of Florida Movement Disorders Center, McKnight Brain Institute, Gainesville 32610, USA
    Arch Neurol 61:1321. 2004
  4. doi request reprint Inappropriate crying and laughing in Parkinson disease and movement disorders
    Mustafa S Siddiqui
    Department of Neurology, Wake Forest University School of Medicine, Winston Salem, NC, USA
    World J Biol Psychiatry 10:234-40. 2009
  5. doi request reprint Deep brain stimulation of the ventral intermediate nucleus of the thalamus in medically refractory orthostatic tremor: preliminary observations
    Alberto J Espay
    Department of Neurology, The Neuroscience Institute, Movement Disorders Center, University of Cincinnati, Cincinnati, Ohio 45267 0525, USA
    Mov Disord 23:2357-62. 2008
  6. ncbi request reprint The "brittle response" to Parkinson's disease medications: characterization and response to deep brain stimulation
    Daniel Martínez-Ramírez
    Department of Neurology, Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, Florida, United States of America
    PLoS ONE 9:e94856. 2014
  7. pmc Management of deep brain stimulator battery failure: battery estimators, charge density, and importance of clinical symptoms
    Kaihan Fakhar
    Departments of Neurology and Neurosurgery, University of Florida Center for Movement Disorders and Neurorestoration, Gainesville, Florida, United States of America
    PLoS ONE 8:e58665. 2013
  8. pmc Effects of STN and GPi deep brain stimulation on impulse control disorders and dopamine dysregulation syndrome
    Sarah J Moum
    Department of Neurology, Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, Florida, United States of America
    PLoS ONE 7:e29768. 2012
  9. ncbi request reprint Coordinate-based lead location does not predict Parkinson's disease deep brain stimulation outcome
    Kelsey A Nestor
    Department of Neurology, University of Florida, Center for Movement Disorders and Neurorestoration, McKnight Brain Institute, Gainesville, Florida, United States of America Department of Neurosurgery, University of Florida, Center for Movement Disorders and Neurorestoration, McKnight Brain Institute, Gainesville, Florida, United States of America
    PLoS ONE 9:e93524. 2014
  10. pmc Effect of Deep Brain Stimulation on Parkinson's Nonmotor Symptoms following Unilateral DBS: A Pilot Study
    Nelson Hwynn
    Center for Movement Disorders and Neurorestoration, College of Medicine, University of Florida, Gainesville, FL 32610, USA
    Parkinsons Dis 2011:507416. 2011

Research Grants

Detail Information

Publications138 found, 100 shown here

  1. ncbi request reprint Visual-spatial ability in Parkinson's disease
    Gregory P Crucian
    University of Florida Department of Neurology, P O Box 100236, Gainesville, FL 32610 0236, USA
    Front Biosci 8:s992-7. 2003
    ..These findings also indicate that the relationship between visual-spatial ability and frontal-executive function in PD is likely complex, and that the visual-spatial deficits in PD may be sensitive to the sex of the individual with PD...
  2. ncbi request reprint Americo Negrette (1924 to 2003): diagnosing Huntington disease in Venezuela
    Michael S Okun
    Department of Neurology, University of Florida, McKnight Brain Institute, Movement Disorders Center, P O Box 100236, Gainesville, FL 32610, USA
    Neurology 63:340-3. 2004
    ..To elucidate the role of Dr. Americo Negrette in diagnosing and reclassifying the dancing mania in Maracaibo, Venezuela as Huntington disease (HD)...
  3. ncbi request reprint Magnetic resonance imaging of the posterior columns in vitamin B12 deficiency
    Michael S Okun
    Department of Neurology, University of Florida Movement Disorders Center, McKnight Brain Institute, Gainesville 32610, USA
    Arch Neurol 61:1321. 2004
  4. doi request reprint Inappropriate crying and laughing in Parkinson disease and movement disorders
    Mustafa S Siddiqui
    Department of Neurology, Wake Forest University School of Medicine, Winston Salem, NC, USA
    World J Biol Psychiatry 10:234-40. 2009
    ..To examine in a pilot study inappropriate crying and laughing (also termed pseudobulbar affect (PBA)) and underlying mood disturbances in a large clinic based population of Parkinson's disease and movement disorder patients...
  5. doi request reprint Deep brain stimulation of the ventral intermediate nucleus of the thalamus in medically refractory orthostatic tremor: preliminary observations
    Alberto J Espay
    Department of Neurology, The Neuroscience Institute, Movement Disorders Center, University of Cincinnati, Cincinnati, Ohio 45267 0525, USA
    Mov Disord 23:2357-62. 2008
    ..Further efficacy studies on chronic stimulation to disrupt the abnormal oscillatory activity in this disorder are warranted...
  6. ncbi request reprint The "brittle response" to Parkinson's disease medications: characterization and response to deep brain stimulation
    Daniel Martínez-Ramírez
    Department of Neurology, Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, Florida, United States of America
    PLoS ONE 9:e94856. 2014
    ..Formulate a definition and describe the clinical characteristics of PD patients with a "brittle response" (BR) to medications versus a "non-brittle response" (NBR), and characterize the use of DBS for this population...
  7. pmc Management of deep brain stimulator battery failure: battery estimators, charge density, and importance of clinical symptoms
    Kaihan Fakhar
    Departments of Neurology and Neurosurgery, University of Florida Center for Movement Disorders and Neurorestoration, Gainesville, Florida, United States of America
    PLoS ONE 8:e58665. 2013
    ..We aimed in this investigation to study deep brain stimulation (DBS) battery drain with special attention directed toward patient symptoms prior to and following battery replacement...
  8. pmc Effects of STN and GPi deep brain stimulation on impulse control disorders and dopamine dysregulation syndrome
    Sarah J Moum
    Department of Neurology, Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, Florida, United States of America
    PLoS ONE 7:e29768. 2012
    ..We aimed to investigate the effects of subthalamic nucleus (STN) and internal globus pallidus (GPi) deep brain stimulation (DBS) on ICD/DDS frequency and dopaminergic medication usage...
  9. ncbi request reprint Coordinate-based lead location does not predict Parkinson's disease deep brain stimulation outcome
    Kelsey A Nestor
    Department of Neurology, University of Florida, Center for Movement Disorders and Neurorestoration, McKnight Brain Institute, Gainesville, Florida, United States of America Department of Neurosurgery, University of Florida, Center for Movement Disorders and Neurorestoration, McKnight Brain Institute, Gainesville, Florida, United States of America
    PLoS ONE 9:e93524. 2014
    ....
  10. pmc Effect of Deep Brain Stimulation on Parkinson's Nonmotor Symptoms following Unilateral DBS: A Pilot Study
    Nelson Hwynn
    Center for Movement Disorders and Neurorestoration, College of Medicine, University of Florida, Gainesville, FL 32610, USA
    Parkinsons Dis 2011:507416. 2011
    ..Future studies are needed to confirm these findings and determine their clinical significance as well as to examine the strengths/weaknesses of each questionnaire/scale...
  11. ncbi request reprint A trial of scheduled deep brain stimulation for Tourette syndrome: moving away from continuous deep brain stimulation paradigms
    Michael S Okun
    Department of Neurology, University of Florida Center for Movement Disorders and Neurorestoration, Gainesville, FL, USA
    JAMA Neurol 70:85-94. 2013
    ..To collect the information necessary to design the methods and outcome variables for a larger trial of scheduled deep brain stimulation (DBS) for Tourette syndrome...
  12. pmc Emerging opportunities for serotypes of botulinum neurotoxins
    Zhongxing Peng Chen
    University of Florida Center for Movement Disorders and Neurorestoration, Department of Neurology, 3450 Hull Road Gainesville, FL 32607, USA
    Toxins (Basel) 4:1196-222. 2012
    ..However, other BoNT serotypes are under study for possible clinical use and new clinical indications;..
  13. doi request reprint Worsening essential tremor following deep brain stimulation: disease progression versus tolerance
    Christopher G Favilla
    Department of Neurology, Centre for Movement Disorders and Neurorestoration, University of Florida College of Medicine, 100 S Newell Drive, Gainesville, FL 32610, USA
    Brain 135:1455-62. 2012
    ....
  14. pmc Deep brain stimulation in the internal capsule and nucleus accumbens region: responses observed during active and sham programming
    Michael S Okun
    Department of Neurology, Movement Disorders Center, University of Florida, PO Box 100236, Gainesville, FL 32610, USA
    J Neurol Neurosurg Psychiatry 78:310-4. 2007
    ..The stimulation-induced benefits and side effects can be reversibly and blindly applied to a variety of locations in this region...
  15. ncbi request reprint The "chair test" to aid in the diagnosis of psychogenic gait disorders
    Michael S Okun
    Department of Neurology, University of Florida, McKnight Brain Institute, Gainesville, Florida 32610, USA
    Neurologist 13:87-91. 2007
    ..To evaluate the chair test for diagnosis of psychogenic gait disorders...
  16. ncbi request reprint Deep brain stimulation of the GPi treats restless legs syndrome associated with dystonia
    Michael S Okun
    Departments of Neurology, University of Florida, McKnight Brain Institute, Gainesville, Florida 32610, USA
    Mov Disord 20:500-1. 2005
    ....
  17. doi request reprint A case-based review of troubleshooting deep brain stimulator issues in movement and neuropsychiatric disorders
    Michael S Okun
    Department of Neurology and Neurosurgery, Movement Disorders Center, McKnight Brain Institute, Gainesville, FL 32610, USA
    Parkinsonism Relat Disord 14:532-8. 2008
    ..To review the spectrum of problems that can occur in the DBS patient and to suggest potential troubleshooting tips for identification and management of DBS related issues...
  18. pmc Do stable patients with a premorbid depression history have a worse outcome after deep brain stimulation for Parkinson disease?
    Michael S Okun
    UF Center for Movement Disorders and Neurorestoration, Gainesville, Florida 32607, USA
    Neurosurgery 69:357-60; discussion 360-1. 2011
    ..Deep brain stimulation (DBS) has been associated with mood sequelae in a subset of patients operated on in either the subthalamic nucleus or the globus pallidus internus for the treatment of Parkinson disease...
  19. ncbi request reprint What's in a "smile?" Intra-operative observations of contralateral smiles induced by deep brain stimulation
    Michael S Okun
    Movement Disorders Center, University of Florida, Department of Neurology, McKnight Brain Institute, Gaineville, FL 32610, USA
    Neurocase 10:271-9. 2004
    ..To describe smiling and euphoria induced by deep brain stimulation (DBS)...
  20. pmc Parkinson’s disease DBS: what, when, who and why? The time has come to tailor DBS targets
    Michael S Okun
    University of Florida Movement Disorders Center, McKnight Brain Institute, Gainesville, FL USA
    Expert Rev Neurother 10:1847-57. 2010
    ..Our approach is aimed to maximize benefit(s) and minimize risk(s) in order to best tailor therapy for an individual patient...
  21. doi request reprint Piloting the NPF data-driven quality improvement initiative
    Michael S Okun
    National Parkinson Foundation Center of Excellence, University of Florida, Movement Disorders Center, McKnight Brain Institute, Department of Neurology, Gainesville, FL 32611, USA
    Parkinsonism Relat Disord 16:517-21. 2010
    ..To pilot a data-driven quality care program in National Parkinson Foundation (NPF) Centers of Excellence...
  22. ncbi request reprint Management of referred deep brain stimulation failures: a retrospective analysis from 2 movement disorders centers
    Michael S Okun
    Department of Neurology, University of Florida, Movement Disorders Center, McKnight Brain Institute, Gainesville, FL 32610, USA
    Arch Neurol 62:1250-5. 2005
    ..An attempt is made herein to evaluate the reasons for DBS failure in a series of such patients and to make recommendations to improve overall DBS outcomes...
  23. ncbi request reprint Limbic, associative, and motor territories within the targets for deep brain stimulation: potential clinical implications
    Atchar Sudhyadhom
    Department of Neurology, McKnight Brain Institute, 100 South Newell Drive, Gainesville, FL 32610, USA
    Curr Neurol Neurosci Rep 7:278-89. 2007
    ..Alternatively, newer procedures may choose and specifically target non-motor territories for chronic electrical stimulation...
  24. ncbi request reprint Deep brain stimulation and the role of the neuropsychologist
    Michael S Okun
    Department of Neurology, Movement Disorders Center, University of Florida, Gainesville, FL 32610, USA
    Clin Neuropsychol 21:162-89. 2007
    ..Additionally, this article will review all aspects of the DBS procedure that can result in mood, cognitive, and behavioral effects and what role(s) the neuropsychologist should play in screening and follow-up...
  25. ncbi request reprint Testosterone therapy in men with Parkinson disease: results of the TEST-PD Study
    Michael S Okun
    Department of Neurology, University of Florida Movement Disorders Center, McKnight Brain Institute, Gainesville, FL 32610, USA
    Arch Neurol 63:729-35. 2006
    ..Previously, we reported that testosterone deficiency is more common in patients with PD compared with age-matched control subjects, and we also reported in 2 small open-label studies that some nonmotor symptoms responded favorably to TT...
  26. ncbi request reprint A mnemonic for Parkinson disease patients considering DBS: a tool to improve perceived outcome of surgery
    Michael S Okun
    Department of Neurology, Movement Disorders Center, University of Florida McKnight Brain Institute, Gainesville, Florida 32610, USA
    Neurologist 10:290. 2004
    ..This education can help to ensure that outcome meets or exceeds expectation, and as a result they become a more satisfied and easy-to-manage DBS patient...
  27. ncbi request reprint Plasma testosterone levels in Alzheimer and Parkinson diseases
    M S Okun
    Department of Neurology, University of Florida, McKnight Brain Institute, Gainesville 32610, USA
    Neurology 62:411-3. 2004
    ..In normal subjects, low testosterone levels are associated with cognitive and neuropsychiatric symptoms, yet the relationship between testosterone levels and cognitive function in PD and AD remains unclear...
  28. pmc Pseudobulbar crying induced by stimulation in the region of the subthalamic nucleus
    M S Okun
    Department of Neurology, University of Florida McKnight Brain Institute, Gainesville, FL 32610, USA
    J Neurol Neurosurg Psychiatry 75:921-3. 2004
    ..Clinicians should be aware of this potential complication, the importance of differentiating it from stimulation induced depression, and its response to a serotonin reuptake inhibitor, such as sertraline...
  29. ncbi request reprint Babinski's clinical differentiation of organic paralysis from hysterical paralysis: effect on US neurology
    Michael S Okun
    Department of Neurology, University of Florida McKnight Brain Institute, Gainesville, USA
    Arch Neurol 61:778-83. 2004
    ..Joseph F. F. Babinski worked in the shadow of his mentor, Jean M. Charcot, until 1893, but then developed independent studies to examine patients with both types of weakness...
  30. ncbi request reprint Huntington's disease: what we learned from the original essay
    Michael S Okun
    University of Florida McKnight Brain Institute, Gainesville, Florida 32610, USA
    Neurologist 9:175-9. 2003
    ..Many innocent victims were persecuted and even tried as witches as the medical community struggled to arrive at a better understanding of Huntington's disease...
  31. ncbi request reprint Development and initial validation of a screening tool for Parkinson disease surgical candidates
    M S Okun
    Department of Neurology, University of Florida McKnight Brain Institute, 100 S Newell Dr, 3rd Fl, rm L3 100, PO Box 100236, Gainesville, FL 32610, USA
    Neurology 63:161-3. 2004
    ..Part II was a multicenter study to assess the correlation of FLASQ-PD scores. The results of this study suggest that the FLASQ-PD may be a useful triage tool for screening PD patients for DBS surgery...
  32. pmc Cognition and mood in Parkinson's disease in subthalamic nucleus versus globus pallidus interna deep brain stimulation: the COMPARE trial
    Michael S Okun
    Movement Disorders Center, University of Florida, McKnight Brain Institute, College of Medicine, Department of Neurology, Gainesville, FL 32611, USA
    Ann Neurol 65:586-95. 2009
    ..Our aim was to compare in a prospective blinded study the cognitive and mood effects of subthalamic nucleus (STN) vs. globus pallidus interna (GPi) deep brain stimulation (DBS) in Parkinson disease...
  33. ncbi request reprint Beneficial effects of testosterone replacement for the nonmotor symptoms of Parkinson disease
    Michael S Okun
    Department of Neurology, Emory University, Atlanta, GA, USA
    Arch Neurol 59:1750-3. 2002
    ..To investigate whether a single daily dose of testosterone replacement gel has beneficial effects on testosterone deficiency symptoms, cognitive function, nonmotor symptoms of Parkinson disease (PD), and motor symptoms of PD...
  34. ncbi request reprint Lesion therapy for Parkinson's disease and other movement disorders: update and controversies
    Michael S Okun
    Department of Neurology, University of Florida, Gainesville, Florida, USA
    Mov Disord 19:375-89. 2004
    ..We should, however, be careful not to abandon an effective therapy before fully exploring through randomized trials the relative effect of different surgical approaches for the treatment of patients with movement disorders...
  35. pmc Mood changes with deep brain stimulation of STN and GPi: results of a pilot study
    M S Okun
    University of Florida McKnight Brain Institute, Gainesville, Florida 32610, USA
    J Neurol Neurosurg Psychiatry 74:1584-6. 2003
    ..Preliminary data from this study, however, suggest that slight movement dorsal or ventral to the site of optimal motor performance may be associated with more adverse changes in mood with STN stimulation than with GPi stimulation...
  36. ncbi request reprint Mood and motor effects of thalamic deep brain stimulation surgery for essential tremor
    J Graff-Radford
    Department of Neurology, University of Florida Movement Disorders Center, McKnight Brain Institute, Gainesville, FL 32610, USA
    Eur J Neurol 17:1040-6. 2010
    ..The aim of this study was to evaluate the effects of unilateral and bilateral ventralis intermedius (Vim) deep brain stimulation (DBS) on mood and motor function...
  37. pmc Brain penetration effects of microelectrodes and DBS leads in STN or GPi
    J M Mann
    Department of Neurology, University of Florida College of Medicine Shands Hospital, Movement Disorders Center, McKnight Brain Institute, Gainesville, Florida 32610, USA
    J Neurol Neurosurg Psychiatry 80:794-7. 2009
    ..Secondarily, to evaluate whether the longevity of the MER and lead placement effects were influenced by target location (subthalamic nucleus (STN) or globus pallidus interna (GPi))...
  38. pmc The trajectory of apathy after deep brain stimulation: from pre-surgery to 6 months post-surgery in Parkinson's disease
    L Kirsch-Darrow
    Department of Clinical and Health Psychology, College of Public Health and Health, Professions, University of Florida, Box 100165, Gainesville, FL 32610, USA
    Parkinsonism Relat Disord 17:182-8. 2011
    ..Middle-aged adults (<65) had a steeper trajectory of apathy than older adults (≥ 65). Apathy trajectory was not related to motor severity, laterality of DBS, levodopa medication reduction, or motor changes after surgery...
  39. doi request reprint Artistic creativity and DBS: a case report
    V Drago
    Department of Neurology, University of Florida, College of Medicine, Gainesville, FL 32610 0236, USA
    J Neurol Sci 276:138-42. 2009
    ..An artist reported changes in her artistic creativity and art appreciation when treated with left DBS. We sought to study her artistic productions and her appreciation of art while both "on" and "off" left DBS...
  40. ncbi request reprint Usefulness of screening tools for predicting driving performance in people with Parkinson's disease
    Sherrilene Classen
    Institute for Mobility, Activity and Participation, University of Florida, PO Box 100164, Gainesville, FL 32611 0164, USA
    Am J Occup Ther 65:579-88. 2011
    ..We used screening tests administered by a certified driving rehabilitation specialist and by Parkinson's disease (PD) specialty neurologists to develop a model to predict on-road outcomes for patients with PD...
  41. doi request reprint Health comorbidities and cognition in 1948 patients with idiopathic Parkinson's disease
    J D Jones
    Department of Clinical and Health Psychology, McKnight Brain Institute, University of Florida, Gainesville, FL, USA
    Parkinsonism Relat Disord 18:1073-8. 2012
    ..This study examined the prevalence and contribution of comorbidities on cognitive performance in a large cohort of Parkinson patients...
  42. doi request reprint Does laterality of motor impairment tell us something about cognition in Parkinson disease?
    C A Cooper
    Department of Neurology, University of Florida, PO Box 100236, Gainesville, FL 32610, USA
    Parkinsonism Relat Disord 15:315-7. 2009
    ..This suggests that the degree of right-sided symptoms is more correlated to specific cognitive domains than is group classification of laterality...
  43. doi request reprint Useful field of view as a reliable screening measure of driving performance in people with Parkinson's disease: results of a pilot study
    S Classen
    National Older Driver Research and Training Center, Department of Occupational Therapy, University of Florida, Gainesville, Florida, USA
    Traffic Inj Prev 10:593-8. 2009
    ....
  44. pmc Panic and fear induced by deep brain stimulation
    N A Shapira
    Department of Psychiatry, University of Florida, Gainesville, FL, USA
    J Neurol Neurosurg Psychiatry 77:410-2. 2006
    ..Mood, cognitive, and behavioural changes have been reported with deep brain stimulation (DBS) in the thalamus, globus pallidus interna, and anterior limb of the internal capsule/nucleus accumbens region...
  45. doi request reprint Reoperation for suboptimal outcomes after deep brain stimulation surgery
    Tina Marie Ellis
    Department of Neurology, Movement Disorders Center, University of Florida, McKnight Brain Institute, Gainesville, Florida, USA
    Neurosurgery 63:754-60; discussion 760-1. 2008
    ..The goal of the current study was to perform an unblinded retrospective chart review of DBS patients with unsatisfactory outcomes who presented for reoperation...
  46. doi request reprint Mood and energy determinants of quality of life in dystonia
    Anne Soeder
    Department of Neurology, University of Florida, Gainesville, FL, USA
    J Neurol 256:996-1001. 2009
    ..Further studies will be needed to determine the effect of treatment on these associations and whether disturbances in energy are related to sleep disturbances or to primary fatigue issues...
  47. ncbi request reprint Stimulation of the subthalamic nucleus changes the firing pattern of pallidal neurons
    Takao Hashimoto
    Department of Neurology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Neurosci 23:1916-23. 2003
    ....
  48. pmc The late positive potential, emotion and apathy in Parkinson's disease
    J Dietz
    Department of Clinical and Health Psychology, University of Florida, PO Box 100165, Gainesville, FL 32610, USA
    Neuropsychologia 51:960-6. 2013
    ..The data suggest that apathy in PD may be related to a deficit in defensive activation, and may be indexed cortically using event-related potentials...
  49. pmc Dissociating apathy and depression in Parkinson disease
    L Kirsch-Darrow
    Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville 32608, USA
    Neurology 67:33-8. 2006
    ..To examine the hypothesis that apathy is a core feature of Parkinson disease (PD) and that apathy can be dissociated from depression...
  50. ncbi request reprint Lessons learned in deep brain stimulation for movement and neuropsychiatric disorders
    Frank M Skidmore
    Department of Neurology, McKnight Brain Institute, University of Florida College of Medicine in Gainesville, 32610, USA
    CNS Spectr 11:521-36. 2006
    ..Also discussed are the emerging targets, what is known about the cognitive sequelae of DBS, and what has been learned about the complications and therapeutic failures...
  51. doi request reprint Relationship between higher rates of adverse events in deep brain stimulation using standardized prospective recording and patient outcomes
    Adam P Burdick
    Department of Neurosurgery, University of Florida, Gainesville, Florida 32610, USA
    Neurosurg Focus 29:E4. 2010
    ..In this paper the authors disclose the standardized and prospectively recorded AE data from their institution, correlated with clinical outcome and quality of life (QOL) measures...
  52. pmc Emotion and ocular responses in Parkinson's disease
    J Dietz
    Department of Clinical and Health Psychology, University of Florida, Gainesville, FL 32610, United States
    Neuropsychologia 49:3247-53. 2011
    ..These results suggest that PD patients show normal sympathetic arousal to affective stimuli (indexed by pupil diameter), but differences in motor correlates of emotion (eye movements)...
  53. pmc Is the n-back task a valid neuropsychological measure for assessing working memory?
    K M Miller
    Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, FL, USA
    Arch Clin Neuropsychol 24:711-7. 2009
    ..Results suggest the n-back is not a pure measure of working memory, but may be able to detect subtle differences in cognitive functioning between PD patients and controls...
  54. pmc Aspiration and swallowing in Parkinson disease and rehabilitation with EMST: a randomized trial
    M S Troche
    PO Box 117420, University of Florida, Gainesville, FL 32611, USA
    Neurology 75:1912-9. 2010
    ..The current study's objective was to test the treatment outcome of a 4-week device-driven EMST program on swallow safety and define the physiologic mechanisms through measures of swallow timing and hyoid displacement...
  55. doi request reprint Perceptual characteristics of Parkinsonian speech: a comparison of the pharmacological effects of levodopa across speech and non-speech motor systems
    E K Plowman-Prine
    Department of Neurology, University of Florida, Gainesville, FL 32610, USA
    NeuroRehabilitation 24:131-44. 2009
    ..No significant differences were obtained between medicated states ('on'/'off') for any of the 35 individual speech dimensions and speech-sign clusters. Global motor function significantly improved following dopaminergic medications...
  56. ncbi request reprint Stimulation of the subthalamic nucleus in a patient with Parkinson disease and essential tremor
    Natividad P Stover
    Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA
    Arch Neurol 62:141-3. 2005
    ..Some patients with PD have coexistent ET, and the identification of a single surgical target to treat both parkinsonian motor symptoms and ET would be of practical importance...
  57. ncbi request reprint Factors related to extended hospital stays following deep brain stimulation for Parkinson's disease
    Ania Mikos
    Department of Clinical and Health Psychology, University of Florida, Movement Disorders Center, McKnight Brain Institute, Gainesville FL, USA
    Parkinsonism Relat Disord 16:324-8. 2010
    ..This study examined potential factors that might have corresponded to increased post-operative stays following unilateral DBS surgery...
  58. doi request reprint The national DBS brain tissue network pilot study: need for more tissue and more standardization
    V Vedam-Mai
    Department of Neurosurgery, University of Florida, 100 S Newell Drive, Room L3 100, P O Box 100236, Gainesville, FL 32610, USA
    Cell Tissue Bank 12:219-31. 2011
    ..We plan to improve our techniques to remedy omitted clinical/research data, and expand the Network to include a larger donor pool. We will enhance sample preparation to facilitate advanced molecular studies and progenitor cell retrieval...
  59. doi request reprint Turning off artistic ability: the influence of left DBS in art production
    V Drago
    Department of Neurology, University of Florida, College of Medicine, PO Box 100236, Gainesville, FL 32610 0236, USA
    J Neurol Sci 281:116-21. 2009
    ..The patient was an artist before her disease started, permitting us to analyze changes in her artistic-creative production over the course of the illness and during her treatment with DBS...
  60. ncbi request reprint Limb-kinetic apraxia in Parkinson disease
    K Quencer
    Department of Neurology, University of Florida College of Medicine, Center for Neuropsychological Studies, Gainesville, FL 32610, USA
    Neurology 68:150-1. 2007
    ..There were no group differences in FT, a measure of bradykinesia-rigidity, but CR rotation was impaired in PD. Thus, LKA, not related to bradykinesia-rigidity, is associated with PD...
  61. pmc Patient-specific analysis of the relationship between the volume of tissue activated during DBS and verbal fluency
    A Mikos
    Department of Clinical and Health Psychology, McKnight Brain Institute, Gainesville, FL, USA
    Neuroimage 54:S238-46. 2011
    ..These findings suggest subtle effects of stimulation on verbal fluency performance, consistent with the functional nonmotor subregions/somatotopy of the STN...
  62. ncbi request reprint Bilateral sixth nerve paresis in the Bing-Neel syndrome
    M T Bhatti
    Department of Ophthalmology, University of Florida College of Medicine, Box 100284 JHMHSC, Gainesville, FL 32610 0284, USA
    Neurology 64:576-7. 2005
  63. pmc Knee extensor strength, dynamic stability, and functional ambulation: are they related in Parkinson's disease?
    Joe R Nocera
    Brain Rehabilitation Research Center, Malcom Randall Veterans Affairs Medical Center, Gainesville, FL, USA
    Arch Phys Med Rehabil 91:589-95. 2010
    ..To evaluate the relationship between knee extensor strength, postural stability, functional ambulation, and disease severity in Parkinson's disease (PD)...
  64. pmc The relationship between quality of life and swallowing in Parkinson's disease
    Emily K Plowman-Prine
    Department of Neurology, University of Florida, USA
    Mov Disord 24:1352-8. 2009
    ..48, P = 0.003). These exploratory data highlight the psychosocial sequelae that swallowing impairment can have in those with IPD and suggest a possible association between swallowing, social function, and depression...
  65. pmc Greater improvement in quality of life following unilateral deep brain stimulation surgery in the globus pallidus as compared to the subthalamic nucleus
    Laura B Zahodne
    Department of Clinical and Health Psychology, University of Florida, PO Box 100165, Gainesville, FL 32610 0165, USA
    J Neurol 256:1321-9. 2009
    ..Patients receiving GPi DBS reported greater improvements that cannot be explained by differential mood or motor effects; however, verbal fluency changes may have partially contributed to lesser QoL improvements amongst STN patients...
  66. ncbi request reprint A high resolution and high contrast MRI for differentiation of subcortical structures for DBS targeting: the Fast Gray Matter Acquisition T1 Inversion Recovery (FGATIR)
    Atchar Sudhyadhom
    Department of Neurosurgery, University of Florida, Gainesville, FL, USA
    Neuroimage 47:T44-52. 2009
    ..We hope that use of the FGATIR to aid initial targeting will translate in future studies to faster and more accurate procedures with consequent improvements in clinical outcomes...
  67. doi request reprint Depressive symptoms in Parkinson disease correlate with impaired global and specific cognitive performance
    Hubert H Fernandez
    Department of Neurology McKnight Brain Institute, University of Florida, Gainesville, USA
    J Geriatr Psychiatry Neurol 22:223-7. 2009
    ..Our study shows that while depressive symptoms correlated with global cognitive performance, naming, verbal memory, and language are the most susceptible cognitive domains affected with depressive symptoms...
  68. doi request reprint An evaluation of rating scales utilized for deep brain stimulation for dystonia
    Frandy Susatia
    Movement Disorders Center, Department of Neurology, University of Florida, Gainesville, FL 32610, USA
    J Neurol 257:44-58. 2010
    ....
  69. doi request reprint Is rhinorrhea an under-recognized intrinsic symptom of Parkinson disease? A prospective pilot study
    Laura Sedig
    College of Medicine, University of Florida, Gainesville, Florida 32610, USA
    Int J Neurosci 120:258-60. 2010
    ..The purpose of this study is to compare the prevalence of idiopathic rhinorrhea in PD patients versus controls, to determine the correlation between rhinorrhea and anosmia, and the factors associated with rhinorrhea...
  70. doi request reprint Disrupting abnormal electrical activity with deep brain stimulation: is epilepsy the next frontier?
    Maryam Rahman
    Department of Neurosurgery, University of Florida, Gainesville, Florida, USA
    Neurosurg Focus 29:E7. 2010
    ..The future will undoubtedly be filled with optimization of targets and stimulation parameters and the development of best practices. With tailored therapeutic approaches, epilepsy patients have the potential to improve with DBS...
  71. doi request reprint Lack of benefit of accumbens/capsular deep brain stimulation in a patient with both tics and obsessive-compulsive disorder
    Adam Burdick
    University of Florida Department of Neurosurgery, Gainesville, FL, USA
    Neurocase 16:321-30. 2010
    ..The brain target for stimulation was the anterior limb internal capsule (ALIC)...
  72. doi request reprint The relationship between anosmia, constipation, and orthostasis and Parkinson's disease duration: results of a pilot study
    Amit L Ramjit
    College of Medicine, University of Florida Gainesville, FL32608, USA
    Int J Neurosci 120:67-70. 2010
    ..038 and .04 respectively). Our study suggests that increasing levels of dopaminergic therapy inhibits reflexive tachycardia. Furthermore, our study suggests that anosmia and constipation progress with the primary disease process...
  73. pmc Tests of dorsolateral frontal function correlate with objective tests of postural stability in early to moderate stage Parkinson's disease
    Joe R Nocera
    Brain Rehabilitation Research Center, Malcom Randall VAMC, Gainesville, FL, USA
    Parkinsonism Relat Disord 16:590-4. 2010
    ..Greater understanding of the relationship between motor and cognitive processes in Parkinson's disease will be critical for understanding the disease process and its potential therapeutic possibilities...
  74. pmc Cognitive declines after unilateral deep brain stimulation surgery in Parkinson's disease: a controlled study using Reliable Change, part II
    Ania Mikos
    Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA
    Clin Neuropsychol 24:235-45. 2010
    ..These findings must be interpreted in light of group-level differences between the PD control and DBS patients on demographic and disease-related factors...
  75. doi request reprint Quetiapine improves visual hallucinations in Parkinson disease but not through normalization of sleep architecture: results from a double-blind clinical-polysomnography study
    Hubert H Fernandez
    Department of Neurology, College of Medicine, University of Florida, FL, USA
    Int J Neurosci 119:2196-205. 2009
    ..Despite the small sample, this is the first double-blind trial to show quetiapine's efficacy over placebo in controlling VH in the PD population. However, normalization of sleep architecture was not supported as the mechanism...
  76. doi request reprint Can exercise improve language and cognition in Parkinson's disease? A case report
    Joe R Nocera
    Department of Neurology, University of Florida, Gainesville, FL 32611, USA
    Neurocase 16:301-6. 2010
    ..We therefore suggest that future large scale randomized trials are warranted to evaluate the efficacy of aerobic exercise for ameliorating declines in cognitive performance in persons with PD...
  77. doi request reprint The number and nature of emergency department encounters in patients with deep brain stimulators
    Andrew S Resnick
    Department of Neurology, University of Florida, Gainesville, USA
    J Neurol 257:122-31. 2010
    ..The objective of the present study was to review the number and nature of ED encounters in patients with deep brain stimulation (DBS) devices implanted for movement and neuropsychiatric disorders...
  78. doi request reprint Brain penetration effects of microelectrodes and deep brain stimulation leads in ventral intermediate nucleus stimulation for essential tremor
    Takashi Morishita
    Department of Neurology, Movement Disorders Center, University of Florida, McKnight Brain Institute, Gainesville, Florida 32610, USA
    J Neurosurg 112:491-6. 2010
    ..The aim of this study was to determine the impact of intraoperative MER and lead placement on tremor severity in a cohort of patients with essential tremor...
  79. doi request reprint Update on deep brain stimulation for neuropsychiatric disorders
    Herbert E Ward
    University of Florida Department of Psychiatry, McKnight Brain Institute, Movement Disorders Center, PO Box 100283, Gainesville, FL 32610 0383, USA
    Neurobiol Dis 38:346-53. 2010
    ..This review will summarize each disorder (depression, OCD and TS), review pathophysiology (both known and speculated), and update the current observations on DBS in each neuropsychiatric condition...
  80. pmc How cautious should we be when assessing apathy with the Unified Parkinson's Disease Rating Scale?
    Lindsey Kirsch-Darrow
    Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, Florida 32610 0165, USA
    Mov Disord 24:684-8. 2009
    ..g., 3, 4) continues to increase specificity at the expense of dramatically reducing sensitivity. These findings suggest the use of caution when screening for apathy with item 4 due to its poor sensitivity in relation to the AS...
  81. ncbi request reprint Long-term habituation of the smile response with deep brain stimulation
    Utaka S Springer
    Clinical and Health Psychology, McKnight Brain Institute, University of Florida, Gainsville, Florida 32610 0165, USA
    Neurocase 12:191-6. 2006
    ..The smiles could not be elicited even with long washout periods. These findings imply potential long-term habituation and changes in the neural chemistry (possibly neuroplasticity) induced by chronic DBS...
  82. ncbi request reprint Abnormal affective startle modulation in individuals with psychogenic [corrected] movement disorder
    Paul J Seignourel
    Department of Clinical and Health Psychology, University of Florida, Gainesville, Florida, USA
    Mov Disord 22:1265-71. 2007
    ..Abnormal affective startle modulation may be used to help distinguish between malingering and PMD. Future studies using larger samples are needed to better understand the role of emotions in conversion disorder...
  83. ncbi request reprint Transient manic behavior after pallidotomy
    Michael S Okun
    Department of Neurology, University of Florida, Gainesville, FL, USA
    Brain Cogn 52:281-3. 2003
    ..Cases involving transient manic behavior after pallidotomy have not been previously reported. Centers performing pallidotomy or DBS should be aware that lesions or stimulation too anterior in the GPi might lead to manic behavior...
  84. ncbi request reprint Tutorial on maximum inspiratory and expiratory mouth pressures in individuals with idiopathic Parkinson disease (IPD) and the preliminary results of an expiratory muscle strength training program
    Erin P Silverman
    University of Florida, Gainesville, FL 32611, USA
    NeuroRehabilitation 21:71-9. 2006
    ..This improvement has the potential to positively impact high forced respiratory activities, such as forced breathing maneuvers, swallow, cough and speech functions that require greater magnitude and duration of expiration...
  85. ncbi request reprint Pearls in patient selection for deep brain stimulation
    Ramon L Rodriguez
    Department of Neurology, University of Florida Movement Disorders Center, McKnight Brain Institute, Gainesville, Florida, USA
    Neurologist 13:253-60. 2007
    ..General neurologists and even general practitioners may be called upon to screen potential candidates for DBS. The patient selection process plays an important role in this procedure...
  86. ncbi request reprint Rebound psychosis: effect of discontinuation of antipsychotics in Parkinson's disease
    Hubert H Fernandez
    Department of Neurology, University of Florida McKnight Brain Institute, Movement Disorders Program, Gainesville, Florida 32610, USA
    Mov Disord 20:104-5. 2005
    ..After the antipsychotic agent was discontinued, psychosis recurred in 5 of 6 patients. In 3 patients the "rebound psychosis" was worse than the original psychotic episode and required subsequent higher antipsychotic medication doses...
  87. doi request reprint Clinical cases where lesion therapy was chosen over deep brain stimulation
    Amanda K Hooper
    University of Florida, Movement Disorders Center, Gainesville, FL 32601, USA
    Stereotact Funct Neurosurg 86:147-52. 2008
    ..Lesion therapy represents a viable alternative and has several important advantages, including a decreased need for access to specialists and clinical follow-up, improved affordability, and a lower infection risk...
  88. ncbi request reprint Refractory nonmotor symptoms in male patients with Parkinson disease due to testosterone deficiency: a common unrecognized comorbidity
    Michael S Okun
    Department of Neurology, Emory University, 1639 Pierce Dr, Suite 6000, Atlanta, GA 30322, USA
    Arch Neurol 59:807-11. 2002
    ..We observed numerous patients with PD whose nonmotor symptoms were refractory to treatment...
  89. doi request reprint Distribution of motor impairment influences quality of life in Parkinson's disease
    Kim C Stewart
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida 32611, USA
    Mov Disord 23:1466-8. 2008
    ..Patients with greater UE and LE motor impairments had lower QoL scores. However, LE impairments had a greater influence than UE impairments across all QoL measures...
  90. doi request reprint Awareness of expressivity deficits in non-demented Parkinson disease
    Ania E Mikos
    Department of Clinical and Health Psychology, University of Florida, Gainesville, FL 32601, USA
    Clin Neuropsychol 23:805-17. 2009
    ..These findings highlight the view that diminished emotional expressivity in PD should not be mistaken for decreased subjective emotional experience...
  91. pmc Examination of the Lille Apathy Rating Scale in Parkinson disease
    Laura B Zahodne
    Department of Clinical and Health Psychology, University of Florida, Gainesville, Florida 32610 0165, USA
    Mov Disord 24:677-83. 2009
    ..Although the present study does not compare the LARS to a diagnostic gold standard or promote its utility for diagnosing apathy, it provides further support for the LARS as a promising instrument to examine apathy in PD...
  92. doi request reprint Venous air embolism in deep brain stimulation
    Amanda K Hooper
    University of Florida Movement Disorders Center, Gainesville, Fla 32601, USA
    Stereotact Funct Neurosurg 87:25-30. 2009
    ..Although VAEs have been described in many types of neurosurgical procedures, their incidence during DBS surgery is unknown...
  93. doi request reprint Impact of expiratory muscle strength training on voluntary cough and swallow function in Parkinson disease
    Teresa Pitts
    Departments of Communication Sciences and Disorders, University of Florida, Gainesville, FL 32611, USA
    Chest 135:1301-8. 2009
    ..Expiratory muscle strength training (EMST) was tested to improve cough and swallow function...
  94. pmc Cognitive declines one year after unilateral deep brain stimulation surgery in Parkinson's disease: a controlled study using reliable change
    Laura B Zahodne
    Clinical and Health Psychology, University of Florida, Gainesville, FL 32610 0165, USA
    Clin Neuropsychol 23:385-405. 2009
    ..Finally, use of Reliable Change highlights the impact of individual variability and indicates that fluency declines likely reflect significant changes in a subset of patients who demonstrate a poorer surgical outcome overall...
  95. ncbi request reprint Depression symptoms in movement disorders: comparing Parkinson's disease, dystonia, and essential tremor
    Kimberly M Miller
    Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, FL 32608, USA
    Mov Disord 22:666-72. 2007
    ..Clinicians should be aware that depression is a frequent problem in dystonia and ET, in addition to PD, and inquire about depression symptoms in these patients so that they can be appropriately treated...
  96. pmc Measurement of patient-centered outcomes in Parkinson's disease: what do patients really want from their treatment?
    Anne N Nisenzon
    Department of Clinical and Health Psychology, University of Florida, Health Science Center, P O Box 100165, Gainesville, FL 32610 0165, USA
    Parkinsonism Relat Disord 17:89-94. 2011
    ..We therefore argue that taking the patients' perspectives of their condition may allow for a more in-depth assessment of patient goals and subsequent tailoring of care...

Research Grants2

  1. DBS Effects on Mood and Cognition in Parkinsons Disease
    Michael Okun; Fiscal Year: 2007
    ..This proposal includes active and experienced mentoring, access to diverse resources, and a scientific environment suited specifically for the development of the PI as an independent physician scientist. ..