Jorge Oksenberg

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc A knowledge-driven interaction analysis reveals potential neurodegenerative mechanism of multiple sclerosis susceptibility
    W S Bush
    Department of Molecular Physiology and Biophysics, Center for Human Genetics Research, Vanderbilt University, Nashville, TN 37232 0700, USA
    Genes Immun 12:335-40. 2011
  2. pmc In depth comparison of an individual's DNA and its lymphoblastoid cell line using whole genome sequencing
    Dorothee Nickles
    Department of Neurology, University of California San Francisco, San Francisco, CA 94143 0435, USA
    BMC Genomics 13:477. 2012
  3. pmc Detection of identity by descent using next-generation whole genome sequencing data
    Shu Yi Su
    Ernest Gallo Clinic and Research Center, University of California San Francisco, 5858 Horton St, Suite 200, Emeryville, CA 94608, USA
    BMC Bioinformatics 13:121. 2012
  4. pmc Evidence of novel fine-scale structural variation at autism spectrum disorder candidate loci
    Dale J Hedges
    Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, 1501 NW 10 Ave, M 860, Miami, FL 33136, USA
    Mol Autism 3:2. 2012
  5. pmc Genetic variation in the odorant receptors family 13 and the mhc loci influence mate selection in a multiple sclerosis dataset
    Pouya Khankhanian
    Department of Neurology, University of California, San Francisco, CA 94143 0435, USA
    BMC Genomics 11:626. 2010
  6. pmc The molecular signature of therapeutic mesenchymal stem cells exposes the architecture of the hematopoietic stem cell niche synapse
    Enrico Pedemonte
    Department of Neurology, School of Medicine, University of California, San Francisco, CA, USA
    BMC Genomics 8:65. 2007
  7. pmc SNPs in Multi-species Conserved Sequences (MCS) as useful markers in association studies: a practical approach
    Jacob L McCauley
    Center for Human Genetics Research and Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN, USA
    BMC Genomics 8:266. 2007
  8. pmc Copy number variation in African Americans
    Joseph P McElroy
    Department of Neurology, University of California, San Francisco, CA, USA
    BMC Genet 10:15. 2009
  9. doi request reprint Multiple sclerosis genetics--is the glass half full, or half empty?
    Jorge R Oksenberg
    Department of Neurology, School of Medicine, University of California at San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0435, USA
    Nat Rev Neurol 6:429-37. 2010
  10. doi request reprint The genetics of multiple sclerosis: SNPs to pathways to pathogenesis
    Jorge R Oksenberg
    Department of Neurology, School of Medicine, University of California at San Francisco, 513 Parnassus Avenue, San Francisco, California 94143 0435, USA
    Nat Rev Genet 9:516-26. 2008

Research Grants

  1. Immunogenetic Studies in Multiple Sclerosis
    Jorge Oksenberg; Fiscal Year: 2006
  2. Immunomodulation in Multiple Sclerosis by Interferon B
    Jorge Oksenberg; Fiscal Year: 2005
  3. Immunogenetic Studies in Multiple Sclerosis
    Jorge R Oksenberg; Fiscal Year: 2010

Detail Information

Publications66

  1. pmc A knowledge-driven interaction analysis reveals potential neurodegenerative mechanism of multiple sclerosis susceptibility
    W S Bush
    Department of Molecular Physiology and Biophysics, Center for Human Genetics Research, Vanderbilt University, Nashville, TN 37232 0700, USA
    Genes Immun 12:335-40. 2011
    ..Further, the implicated genes cluster within inter-related biological mechanisms that suggest a neurodegenerative component to MS...
  2. pmc In depth comparison of an individual's DNA and its lymphoblastoid cell line using whole genome sequencing
    Dorothee Nickles
    Department of Neurology, University of California San Francisco, San Francisco, CA 94143 0435, USA
    BMC Genomics 13:477. 2012
    ..A detailed analysis of the genetic alterations introduced by EBV transformation is highly relevant, as it will inform on the usefulness and limitations of this approach...
  3. pmc Detection of identity by descent using next-generation whole genome sequencing data
    Shu Yi Su
    Ernest Gallo Clinic and Research Center, University of California San Francisco, 5858 Horton St, Suite 200, Emeryville, CA 94608, USA
    BMC Bioinformatics 13:121. 2012
    ..These sequencing data may provide an opportunity to detect IBD with higher resolution than previously possible, potentially enabling the detection of disease causing loci that were previously undetectable with sparser genetic data...
  4. pmc Evidence of novel fine-scale structural variation at autism spectrum disorder candidate loci
    Dale J Hedges
    Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, 1501 NW 10 Ave, M 860, Miami, FL 33136, USA
    Mol Autism 3:2. 2012
    ..abstract:..
  5. pmc Genetic variation in the odorant receptors family 13 and the mhc loci influence mate selection in a multiple sclerosis dataset
    Pouya Khankhanian
    Department of Neurology, University of California, San Francisco, CA 94143 0435, USA
    BMC Genomics 11:626. 2010
    ..Attempts at replication of these genetic results in human studies, however, have reached conflicting conclusions...
  6. pmc The molecular signature of therapeutic mesenchymal stem cells exposes the architecture of the hematopoietic stem cell niche synapse
    Enrico Pedemonte
    Department of Neurology, School of Medicine, University of California, San Francisco, CA, USA
    BMC Genomics 8:65. 2007
    ....
  7. pmc SNPs in Multi-species Conserved Sequences (MCS) as useful markers in association studies: a practical approach
    Jacob L McCauley
    Center for Human Genetics Research and Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN, USA
    BMC Genomics 8:266. 2007
    ..We chose annotated SNPs in the region based on location within MCSs (termed MCS-SNPs). We then obtained genotypes for 478 MCS-SNPs in 989 individuals from MS families...
  8. pmc Copy number variation in African Americans
    Joseph P McElroy
    Department of Neurology, University of California, San Francisco, CA, USA
    BMC Genet 10:15. 2009
    ..It is important, therefore, to understand the distribution of CNVs within and among populations. This study is the first report of a CNV map in African Americans...
  9. doi request reprint Multiple sclerosis genetics--is the glass half full, or half empty?
    Jorge R Oksenberg
    Department of Neurology, School of Medicine, University of California at San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0435, USA
    Nat Rev Neurol 6:429-37. 2010
    ..This Review briefly summarizes well-established concepts of MS epidemiology and susceptibility, and discusses new knowledge emerging from genome-wide association studies...
  10. doi request reprint The genetics of multiple sclerosis: SNPs to pathways to pathogenesis
    Jorge R Oksenberg
    Department of Neurology, School of Medicine, University of California at San Francisco, 513 Parnassus Avenue, San Francisco, California 94143 0435, USA
    Nat Rev Genet 9:516-26. 2008
    ....
  11. pmc Modeling the cumulative genetic risk for multiple sclerosis from genome-wide association data
    Joanne H Wang
    Department of Neurology, University of California San Francisco, San Francisco, CA 94143 0435, USA
    Genome Med 3:3. 2011
    ..Nevertheless, the knowledge of MS genetics remains incomplete, with many risk alleles still to be revealed...
  12. ncbi request reprint Risk alleles for multiple sclerosis identified by a genomewide study
    David A Hafler
    Division of Molecular Immunology, Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital, and Harvard Medical School, Boston, USA
    N Engl J Med 357:851-62. 2007
    ..Multiple sclerosis has a clinically significant heritable component. We conducted a genomewide association study to identify alleles associated with the risk of multiple sclerosis...
  13. ncbi request reprint Linkage and association with the NOS2A locus on chromosome 17q11 in multiple sclerosis
    Lisa F Barcellos
    Department of Neurology, School of Medicine, University of California at San Francisco, San Francisco, CA 94143 0435, USA
    Ann Neurol 55:793-800. 2004
    ..Our results provide strong evidence for linkage and association to a new candidate disease gene on chromosome 17q11 in MS and suggest that variation within NOS2A or a nearby locus contributes to disease susceptibility...
  14. ncbi request reprint Increased transcriptional activity of milk-related genes following the active phase of experimental autoimmune encephalomyelitis and multiple sclerosis
    David Otaegui
    University of California San Francisco, San Francisco, CA 94143, USA
    J Immunol 179:4074-82. 2007
    ..The potential role of lactogenic hormones in MS is discussed...
  15. ncbi request reprint Heterogeneity at the HLA-DRB1 locus and risk for multiple sclerosis
    Lisa F Barcellos
    Division of Epidemiology, School of Public Health, University of California, Berkeley 94720, USA, and Department of Clinical Neurosciences, University of Cambridge, Addenbrooke s Hospital, UK
    Hum Mol Genet 15:2813-24. 2006
    ....
  16. ncbi request reprint Uncoupling the roles of HLA-DRB1 and HLA-DRB5 genes in multiple sclerosis
    Stacy J Caillier
    Department of Neurology, University of California, San Francisco, CA 94143, USA
    J Immunol 181:5473-80. 2008
    ..The data underscore the power of the African American MS dataset to identify disease genes by association in a region of high linkage disequilibrium...
  17. pmc Conferral of enhanced natural killer cell function by KIR3DS1 in early human immunodeficiency virus type 1 infection
    Brian R Long
    Division of Experimental Medicine, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, USA
    J Virol 82:4785-92. 2008
    ....
  18. doi request reprint Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis
    Sergio E Baranzini
    Department of Neurology, University of California, San Francisco, CA 94143 0435, USA
    Hum Mol Genet 18:767-78. 2009
    ..Gene ontology-based analysis shows a functional dichotomy between genes involved in the susceptibility pathway and those affecting the clinical phenotype...
  19. pmc A major histocompatibility Class I locus contributes to multiple sclerosis susceptibility independently from HLA-DRB1*15:01
    Bruce A C Cree
    Department of Neurology, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 5:e11296. 2010
    ..Whether other major histocompatibility complex (MHC) genes contribute to MS susceptibility is controversial...
  20. doi request reprint Genome-wide pharmacogenomic analysis of the response to interferon beta therapy in multiple sclerosis
    Esther Byun
    Department of Neurology, University of California, San Francisco, San Francisco, CA 94143 0435, USA
    Arch Neurol 65:337-44. 2008
    ..Recombinant interferon beta therapy is widely used to reduce disease activity in multiple sclerosis (MS). However, up to 50% of patients continue to have relapses and worsening disability despite therapy...
  21. pmc Synergy or independence? Deciphering the interaction of HLA Class I and NK cell KIR alleles in early HIV-1 disease progression
    Jason D Barbour
    HIV AIDS Division, Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California, United States of America
    PLoS Pathog 3:e43. 2007
  22. pmc Refining the association of MHC with multiple sclerosis in African Americans
    Joseph P McElroy
    Department of Neurology, University of California, San Francisco, CA 94143, USA
    Hum Mol Genet 19:3080-8. 2010
    ....
  23. doi request reprint Modification of Multiple Sclerosis Phenotypes by African Ancestry at HLA
    Bruce A C Cree
    Department of Neurology, University of California San Francisco, USA
    Arch Neurol 66:226-33. 2009
    ....
  24. pmc Genetic variation influences glutamate concentrations in brains of patients with multiple sclerosis
    Sergio E Baranzini
    Department of Neurology, School of Medicine, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0435, USA
    Brain 133:2603-11. 2010
    ..Spectroscopy-based imaging provides a novel quantitative endophenotype for genetic association studies directed towards identifying new factors that contribute to the heterogeneity of clinical expression of multiple sclerosis...
  25. pmc Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci
    Philip L De Jager
    Division of Molecular Immunology, Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Nat Genet 41:776-82. 2009
    ....
  26. pmc CIITA variation in the presence of HLA-DRB1*1501 increases risk for multiple sclerosis
    Paola G Bronson
    Genetic Epidemiology and Genomics Laboratory, Division of Epidemiology, School of Public Health, University of California, Berkeley, CA 94720 7356, USA
    Hum Mol Genet 19:2331-40. 2010
    ..15-1.95, P = 2.3 x 10(-3)) of CLEC16A rs6498169*G, a putative MS risk allele adjacent to CIITA. Our results provide strong evidence supporting a role for CIITA variation in MS risk, which appears to depend on the presence of DRB1*1501...
  27. pmc Genome, epigenome and RNA sequences of monozygotic twins discordant for multiple sclerosis
    Sergio E Baranzini
    Department of Neurology, University of California at San Francisco, San Francisco, California 94143, USA
    Nature 464:1351-6. 2010
    ..These are the first, to our knowledge, female, twin and autoimmune disease individual genome sequences reported...
  28. doi request reprint Vitamin D status is associated with relapse rate in pediatric-onset multiple sclerosis
    Ellen M Mowry
    MS Center, Department of Neurology, University of California, San Francisco, San Francisco, CA 94117, USA
    Ann Neurol 67:618-24. 2010
    ..We sought to determine if vitamin D status, a risk factor for multiple sclerosis, is associated with the rate of subsequent clinical relapses in pediatric-onset multiple sclerosis...
  29. pmc Pathway and network-based analysis of genome-wide association studies in multiple sclerosis
    Sergio E Baranzini
    Department of Neurology, School of Medicine, University of California San Francisco, 513 Parnassus Ave Room S 256, San Francisco, CA 94143 0435, USA
    Hum Mol Genet 18:2078-90. 2009
    ..In addition to the immunological pathways previously identified, we report here for the first time the potential involvement of neural pathways in MS susceptibility...
  30. ncbi request reprint Genetics of multiple sclerosis
    Jorge R Oksenberg
    Department of Neurology, University of California at San Francisco, School of Medicine, 513 Parnassus Avenue S 256, San Francisco, CA 94143 0435, USA
    Neurol Clin 23:61-75, vi. 2005
  31. ncbi request reprint Gene expression analysis reveals altered brain transcription of glutamate receptors and inflammatory genes in a patient with chronic focal (Rasmussen's) encephalitis
    Sergio E Baranzini
    Department of Neurology, University of California at San Francisco, 513 Parnassus Avenue, S 256, San Francisco, CA 94143 0435, USA
    J Neuroimmunol 128:9-15. 2002
    ..e. IL1 beta, IgVH, and IL2R gamma among others) and a striking down-regulation of several GluRs, in particular mGluR4. This type of analysis may prove useful in describing the molecular events underlying intractable epilepsy...
  32. pmc Mapping multiple sclerosis susceptibility to the HLA-DR locus in African Americans
    Jorge R Oksenberg
    Department of Neurology, University of California at San Francisco, San Francisco, CA 94143 0435, USA
    Am J Hum Genet 74:160-7. 2004
    ..This finding is unlikely to be solely explained by admixture, since a substantial proportion of the susceptibility chromosomes from African American patients with MS displayed haplotypes consistent with an African origin...
  33. pmc Transcription-based prediction of response to IFNbeta using supervised computational methods
    Sergio E Baranzini
    Department of Neurology, School of Medicine University of California, San Francisco, USA
    PLoS Biol 3:e2. 2005
    ..Large-scale kinetic reverse-transcription PCR, coupled with advanced data-mining efforts, can effectively reveal preexisting and drug-induced gene expression signatures associated with therapeutic effects...
  34. ncbi request reprint Modular transcriptional activity characterizes the initiation and progression of autoimmune encephalomyelitis
    Sergio E Baranzini
    Department of Neurology, School of Medicine, University of California, San Francisco, 94143, USA
    J Immunol 174:7412-22. 2005
    ..Our study demonstrates the utility of large-scale transcriptional studies and advanced data mining to decipher complex biological processes such as those involved in MS and other neurodegenerative disorders...
  35. pmc Variation within DNA repair pathway genes and risk of multiple sclerosis
    Farren B S Briggs
    University of California, Berkeley, 94720, USA
    Am J Epidemiol 172:217-24. 2010
    ..Although other candidate genes examined here warrant further follow-up studies, collectively, these results derived from a well-powered study do not support a strong role for common variation within DNA repair pathway genes in MS...
  36. pmc Abrogation of T cell quiescence characterizes patients at high risk for multiple sclerosis after the initial neurological event
    Jean Christophe Corvol
    Departments of Neurology and Radiology, University of California, San Francisco, CA 94143 0435, USA
    Proc Natl Acad Sci U S A 105:11839-44. 2008
    ..These results indicate that CIS patients at high risk of conversion have impaired regulation of T cell quiescence, possibly resulting in earlier activation of pathogenic CD4(+) cells...
  37. ncbi request reprint Genomics and new targets for multiple sclerosis
    Sergio E Baranzini
    University of California, Department of Neurology, School of Medicine, San Francisco, CA 94143 0435, USA
    Pharmacogenomics 6:151-61. 2005
    ..Equally significant, it is likely that locus heterogeneity exists, whereby specific genes influence susceptibility and pathogenesis in some individuals but not in others...
  38. ncbi request reprint Genome-wide network analysis reveals the global properties of IFN-beta immediate transcriptional effects in humans
    Guy Haskin Fernald
    School of Medicine, University of California, San Francisco, CA 94143, USA
    J Immunol 178:5076-85. 2007
    ..Implications of this method in the creation of personalized models of response to therapy are discussed...
  39. ncbi request reprint Mapping gene activity in complex disorders: Integration of expression and genomic scans for multiple sclerosis
    Guy Haskin Fernald
    Department of Neurology, School of Medicine, University of California, 513 Parnassus Avenue, S 256, San Francisco, CA 94143 0435, USA
    J Neuroimmunol 167:157-69. 2005
    ..Integration of genomic and transcriptional information is a powerful tool to dissect genetic susceptibility in complex multifactorial disorders like MS...
  40. ncbi request reprint Clustering of autoimmune diseases in families with a high-risk for multiple sclerosis: a descriptive study
    Lisa F Barcellos
    School of Public Health, Division of Epidemiology, University of California, Berkeley, CA, USA
    Lancet Neurol 5:924-31. 2006
    ..We aimed to identify coexisting autoimmune phenotypes in patients with multiple sclerosis from families with several members with the disease and in their first-degree relatives...
  41. ncbi request reprint New insights into the genetics of multiple sclerosis
    Sergio E Baranzini
    Department of Neurology, San Francisco School of Medicine, University of California, 94143, USA
    J Rehabil Res Dev 39:201-9. 2002
    ..The identification and characterization of the genes are likely to define the basic etiology of the disease, improve risk assessment, and influence therapeutics...
  42. pmc Differential impact of the CD45 juxtamembrane wedge on central and peripheral T cell receptor responses
    Michelle L Hermiston
    Department of Pediatrics, Medicine, Howard Hughes Medical Institute, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 106:546-51. 2009
    ..Together, the data support a role for the CD45 wedge in regulation of T cell responses in vivo and suggest that its effects depend on cellular context...
  43. ncbi request reprint The neurobiology of multiple sclerosis: genes, inflammation, and neurodegeneration
    Stephen L Hauser
    Department of Neurology, School of Medicine, University of California at San Francisco, San Francisco, California 94143, USA
    Neuron 52:61-76. 2006
    ..Together, these advances have set the stage for the development of therapeutic approaches designed to target the demyelinating and neurodegenerative components of the disease and promote repair...
  44. pmc Methods for high-density admixture mapping of disease genes
    Nick Patterson
    Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA
    Am J Hum Genet 74:979-1000. 2004
    ..A particularly important result is that the power of an admixture mapping study to detect a locus will be nearly the same for a wide range of mixture scenarios: the mixture proportion should be 10%-90% from both ancestral populations...
  45. ncbi request reprint Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis
    Simon G Gregory
    Center for Human Genetics, Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nat Genet 39:1083-91. 2007
    ..The SNP influences the amount of soluble and membrane-bound isoforms of the protein by putatively disrupting an exonic splicing silencer...
  46. ncbi request reprint Investigation of seven proposed regions of linkage in multiple sclerosis: an American and French collaborative study
    Margaret A Pericak-Vance
    Center for Human Genetics, Duke University Medical Center, Durham, North Carolina, USA
    Neurogenetics 5:45-8. 2004
    ..Regions on 1p34, 3p14, and 19q13 produced lod scores >0.90 in at least one subset of the data, suggesting that these regions should be examined in more detail...
  47. ncbi request reprint The HLA locus and multiple sclerosis in Spain. Role in disease susceptibility, clinical course and response to interferon-beta
    Pablo Villoslada
    Neuroimmunology Unit, Hospital Vall d Hebron, Barcelona, Spain
    J Neuroimmunol 130:194-201. 2002
    ..Similarly, no difference in the distribution of responders and nonresponders to interferon-beta (IFNB) therapy, as defined by primary and secondary end points, was observed when individuals were stratified according to HLA-DR2 status...
  48. pmc A second major histocompatibility complex susceptibility locus for multiple sclerosis
    Tai Wai Yeo
    Department of Clinical Neurosciences, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    Ann Neurol 61:228-36. 2007
    ..The possibility that other genes in the MHC independently influence susceptibility to multiple sclerosis has been suggested but remains unconfirmed...
  49. ncbi request reprint Multiple sclerosis: deeper understanding of its pathogenesis reveals new targets for therapy
    Lawrence Steinman
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, California 94305, USA
    Annu Rev Neurosci 25:491-505. 2002
    ..Some of these participants may be useful targets for therapy...
  50. ncbi request reprint Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis
    Christopher Lock
    Department of Neurology and Neurological Sciences, Beckman Center, Stanford University, Stanford, California, USA
    Nat Med 8:500-8. 2002
    ..These results in EAE corroborate the microarray studies on MS lesions. Large-scale analysis of transcripts in MS lesions elucidates new aspects of pathology and opens possibilities for therapy...
  51. ncbi request reprint Enhancing linkage analysis of complex disorders: an evaluation of high-density genotyping
    Stephen J Sawcer
    University of Cambridge Neurology Unit, Addenbrooke s Hospital, UK
    Hum Mol Genet 13:1943-9. 2004
    ..The extent of additional information extracted is considerable, indicating that reanalysis of existing multiplex families using these newer systems would substantially increase power...
  52. doi request reprint Evidence for association of chromosome 10 open reading frame (C10orf27) gene polymorphisms and multiple sclerosis
    Robert Goertsches
    Unitat de Neuroimmunologia Clinica, Hospital Universitari Vall d Hebron HUVH, 08035 Barcelona, Spain
    Mult Scler 14:412-4. 2008
    ..Transcript expression in brain lesions from MS patients was increased. These findings suggest C10orf27 as a candidate gene for MS susceptibility and pathogenesis...
  53. doi request reprint Neurogenetics in the Annals: dealing with complexity
    Jorge R Oksenberg
    Ann Neurol 63:A11-4. 2008
  54. pmc A high-density screen for linkage in multiple sclerosis
    Stephen Sawcer
    University of Cambridge, Department of Clinical Neuroscience, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 2QQ, United Kingdom
    Am J Hum Genet 77:454-67. 2005
    ....
  55. ncbi request reprint A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility
    David Reich
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA
    Nat Genet 37:1113-8. 2005
    ..We describe here the first high-powered admixture scan, focusing on 605 African American cases and 1,043 African American controls, and report a locus on chromosome 1 that is significantly associated with multiple sclerosis...
  56. ncbi request reprint The autoimmune disease-associated IL12B and IL23R polymorphisms in multiple sclerosis
    Ann B Begovich
    Celera, Alameda, CA, USA
    Hum Immunol 68:934-7. 2007
    ..Family-based association analysis was performed. There was no evidence of transmission distortion of any of the tested alleles in this data set...
  57. ncbi request reprint Association of the truncating splice site mutation in BTNL2 with multiple sclerosis is secondary to HLA-DRB1*15
    James A Traherne
    Cambridge Institute for Medical Research, Wellcome Trust MRC Building, Cambridge, UK
    Hum Mol Genet 15:155-61. 2006
    ..The association of BTNL2 with MS observed in the African-American data set was also secondary to the primary DRB1*15 association...
  58. pmc Association of polymorphisms in the apolipoprotein E region with susceptibility to and progression of multiple sclerosis
    Silke Schmidt
    Center for Human Genetics, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Am J Hum Genet 70:708-17. 2002
    ..03), whereas a higher proportion of APOE-2 carriers exhibit a mild disease course (P=.02)...
  59. pmc Fine-mapping the genetic basis of CRP regulation in African Americans: a Bayesian approach
    Benjamin Rhodes
    Section of Molecular Genetics and Rheumatology, Faculty of Medicine, Imperial College, Du Cane Road, London W12 0NN, UK
    Hum Genet 123:633-42. 2008
    ....
  60. ncbi request reprint Quantitative longitudinal analysis of T cell receptor repertoire expression in HIV-infected patients on antiretroviral and interleukin-2 therapy
    Uma Sriram
    Department of Neurology University of California at San Francisco, California 94143, USA
    AIDS Res Hum Retroviruses 23:741-7. 2007
    ..These results suggest that homeostasis in the T cell receptor repertoire is more robust in those patients who stay on HAART for a long time and confirm the polyclonal stimulating capacity of IL-2...
  61. pmc The Population Reference Sample, POPRES: a resource for population, disease, and pharmacological genetics research
    Matthew R Nelson
    GlaxoSmithKline, Research Triangle Park, NC 27709, USA
    Am J Hum Genet 83:347-58. 2008
    ..The genotype and demographic data from this reference sample are freely available through the NCBI database of Genotypes and Phenotypes (dbGaP)...
  62. ncbi request reprint Multiple susceptibility loci for multiple sclerosis
    Jonathan L Haines
    Program in Human Genetics, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Hum Mol Genet 11:2251-6. 2002
    ..These regions can now be targeted for detailed study to identify the underlying MS susceptibility genes...
  63. ncbi request reprint Chromosome 7q21-22 and multiple sclerosis
    Pablo Villoslada
    J Neuroimmunol 150:1-2. 2004
  64. ncbi request reprint Complex gene-gene interactions in multiple sclerosis: a multifactorial approach reveals associations with inflammatory genes
    Alison A Motsinger
    Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, 519 Light Hall, Vanderbilt University Medical School, Nashville, TN 37232 0700, USA
    Neurogenetics 8:11-20. 2007
    ..These results suggest that significant epistasis, or gene-gene interactions, may exist even in the absence of statistically significant individual main effects...
  65. pmc The R620W polymorphism of the protein tyrosine phosphatase PTPN22 is not associated with multiple sclerosis
    Ann B Begovich
    Am J Hum Genet 76:184-7. 2005
  66. ncbi request reprint Re: GAMES issue
    Jorge R Oksenberg
    J Neuroimmunol 153:1-2. 2004

Research Grants10

  1. Immunogenetic Studies in Multiple Sclerosis
    Jorge Oksenberg; Fiscal Year: 2006
    ..abstract_text> ..
  2. Immunomodulation in Multiple Sclerosis by Interferon B
    Jorge Oksenberg; Fiscal Year: 2005
    ..In addition to new insights into the fundamental biology of interferons, our results will potentially identify surrogate markers of activity, and define the molecular basis of interferon response heterogeneity. ..
  3. Immunogenetic Studies in Multiple Sclerosis
    Jorge R Oksenberg; Fiscal Year: 2010
    ..Their identification will help to define the basic etiology of MS, improve risk assessment, and influence therapeutics. ..