Stephen J D O'Keefe

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. doi request reprint Products of the colonic microbiota mediate the effects of diet on colon cancer risk
    Stephen J D O'Keefe
    University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Nutr 139:2044-8. 2009
  2. ncbi request reprint Small bowel transplantation
    Stephen J D O'Keefe
    Division of Gastroenterology, University of Pittsburgh Medical School, Pittsburgh, PA 15213, USA
    Curr Gastroenterol Rep 8:360-6. 2006
  3. ncbi request reprint Why do African Americans get more colon cancer than Native Africans?
    Stephen J D O'Keefe
    Division of Gastroenterology and Pathology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Nutr 137:175S-182S. 2007
  4. doi request reprint Safety and efficacy of teduglutide after 52 weeks of treatment in patients with short bowel intestinal failure
    Stephen J D O'Keefe
    Division of Gastroenterology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Clin Gastroenterol Hepatol 11:815-23.e1-3. 2013
  5. doi request reprint Endoscopic evaluation of small intestine transplant grafts
    STEPHEN J O'KEEFE
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Pittsburgh Medical School, Pittsburgh, PA, USA
    Transplantation 94:757-62. 2012
  6. doi request reprint The microbiota and its metabolites in colonic mucosal health and cancer risk
    Kishore Vipperla
    Division of General Internal Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Nutr Clin Pract 27:624-35. 2012
  7. doi request reprint Enteral feeding patients with gastric outlet obstruction
    Stephen O'Keefe
    Department of Medicine, University of Pittsburgh, Pennsylvania, USA
    Nutr Clin Pract 27:76-81. 2012
  8. doi request reprint A guide to enteral access procedures and enteral nutrition
    Stephen J D O'Keefe
    Division of Gastroenterology, University of Pittsburgh School of Medicine, PA 15213, USA
    Nat Rev Gastroenterol Hepatol 6:207-15. 2009
  9. ncbi request reprint Physiological response of the human pancreas to enteral and parenteral feeding
    Steven J D O'Keefe
    Division of Gastroenterology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Curr Opin Clin Nutr Metab Care 9:622-8. 2006
  10. ncbi request reprint Nutrition and colonic health: the critical role of the microbiota
    Stephen J D O'Keefe
    Division of Gastroenterology, University of Pittsburgh Medical School, Pittsburgh, Pennsylvania, USA
    Curr Opin Gastroenterol 24:51-8. 2008

Collaborators

Detail Information

Publications37

  1. doi request reprint Products of the colonic microbiota mediate the effects of diet on colon cancer risk
    Stephen J D O'Keefe
    University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Nutr 139:2044-8. 2009
    ....
  2. ncbi request reprint Small bowel transplantation
    Stephen J D O'Keefe
    Division of Gastroenterology, University of Pittsburgh Medical School, Pittsburgh, PA 15213, USA
    Curr Gastroenterol Rep 8:360-6. 2006
    ..Current results support expansion of the indications for SBTx from use as salvage therapy for patients with TPN failure to preemptive therapy for patients at risk of developing TPN failure...
  3. ncbi request reprint Why do African Americans get more colon cancer than Native Africans?
    Stephen J D O'Keefe
    Division of Gastroenterology and Pathology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Nutr 137:175S-182S. 2007
    ..This supports our hypothesis that CRC risk is determined by interactions between the external (dietary) and internal (bacterial) environments...
  4. doi request reprint Safety and efficacy of teduglutide after 52 weeks of treatment in patients with short bowel intestinal failure
    Stephen J D O'Keefe
    Division of Gastroenterology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Clin Gastroenterol Hepatol 11:815-23.e1-3. 2013
    ..We examined the 12-month tolerability and efficacy of teduglutide to reduce PN dependency...
  5. doi request reprint Endoscopic evaluation of small intestine transplant grafts
    STEPHEN J O'KEEFE
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Pittsburgh Medical School, Pittsburgh, PA, USA
    Transplantation 94:757-62. 2012
    ..The aim of this study was to evaluate the accuracy of endoscopic appearance in assessing histologic evidence of acute cellular rejection (ACR)...
  6. doi request reprint The microbiota and its metabolites in colonic mucosal health and cancer risk
    Kishore Vipperla
    Division of General Internal Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Nutr Clin Pract 27:624-35. 2012
    ..Recognition of the strong potential for food to manipulate microbiota composition has opened up new therapeutic strategies against these diseases based on dietary intervention...
  7. doi request reprint Enteral feeding patients with gastric outlet obstruction
    Stephen O'Keefe
    Department of Medicine, University of Pittsburgh, Pennsylvania, USA
    Nutr Clin Pract 27:76-81. 2012
    ..In conclusion, NGJ feeding provides a relatively safe conservative management for critically ill patients with upper gastrointestinal obstructions, reducing the need for surgery and parenteral feeding...
  8. doi request reprint A guide to enteral access procedures and enteral nutrition
    Stephen J D O'Keefe
    Division of Gastroenterology, University of Pittsburgh School of Medicine, PA 15213, USA
    Nat Rev Gastroenterol Hepatol 6:207-15. 2009
    ..Together, the advances in enteral access have improved patients' outcomes and led to a 70-90% reduction in the demand for total parenteral nutrition...
  9. ncbi request reprint Physiological response of the human pancreas to enteral and parenteral feeding
    Steven J D O'Keefe
    Division of Gastroenterology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Curr Opin Clin Nutr Metab Care 9:622-8. 2006
    ..This review examines recent publications that have investigated this question in clinical practice...
  10. ncbi request reprint Nutrition and colonic health: the critical role of the microbiota
    Stephen J D O'Keefe
    Division of Gastroenterology, University of Pittsburgh Medical School, Pittsburgh, Pennsylvania, USA
    Curr Opin Gastroenterol 24:51-8. 2008
    ..To highlight mechanisms whereby diet affects colonic function and disease patterns...
  11. ncbi request reprint Physiological evaluation of the severity of pancreatic exocrine dysfunction during endoscopy
    Stephen J D O'Keefe
    Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Pancreas 35:30-6. 2007
    ..To evaluate the potential use of a rapid endoscopic test that can be conducted by nonacademic centers, we investigated whether concentration of trypsin in food-stimulated secretion is related to trypsin synthesis and secretion...
  12. ncbi request reprint Short bowel syndrome and intestinal failure: consensus definitions and overview
    Stephen J D O'Keefe
    Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Clin Gastroenterol Hepatol 4:6-10. 2006
    ....
  13. pmc Tube feeding, the microbiota, and Clostridium difficile infection
    Stephen J D O'Keefe
    World J Gastroenterol 16:139-42. 2010
    ..In this review, we highlight the rising worldwide incidence of C. difficile associated diarrhea and the role played by non-residue diets in destabilizing the colonic microbiota...
  14. ncbi request reprint Trypsin and splanchnic protein turnover during feeding and fasting in human subjects
    Stephen J D O'Keefe
    Division of Gastroenterology, University of Pittsburgh Medical School, Pittsburgh, PA, USA
    Am J Physiol Gastrointest Liver Physiol 290:G213-21. 2006
    ..05) compared with no change after intravenous feeding. In conclusion, all common forms of enteral feeding stimulate the synthesis and secretion of pancreatic trypsin, and only parenteral nutrition avoids it...
  15. ncbi request reprint Trypsin secretion and turnover in patients with acute pancreatitis
    Stephen J D O'Keefe
    Division of Gastroenterology, University of Pittsburgh Medical School, Pittsburgh, PA 15213, USA
    Am J Physiol Gastrointest Liver Physiol 289:G181-7. 2005
    ..Our findings could be explained by post-Golgi leakage of enzymes from acinar cells or by loss of synthetic function in some cells with preservation in others...
  16. ncbi request reprint Nutritional support in acute pancreatitis
    Neeraj Kaushik
    Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh School of Medicine, 200 Lothrop Street, PUH, Mezzanine Level, C Wing, Pittsburgh, PA 15213, USA
    Curr Gastroenterol Rep 6:320-6. 2004
    ..This review discusses the advances in our understanding of the pathophysiology of the disease, the results of recent clinical trials of nutritional support, and the challenges that remain in optimizing nutritional management...
  17. ncbi request reprint Nutrition in the management of necrotizing pancreatitis
    Stephen J D O'Keefe
    Pancreatitis Center, Department of Internal Medicine, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, USA
    Clin Gastroenterol Hepatol 1:315-21. 2003
    ..Although enteral feeding is generally better than TPN in the nutritional management of acute pancreatitis, there may be a subgroup of patients with ductular damage due to necrotizing disease in whom TPN and pancreatic rest may be safer...
  18. ncbi request reprint Transnasal endoscopic placement of feeding tubes in the intensive care unit
    Stephen J D O'Keefe
    Division of Gastroenterology, Section of Nutrition, Medical College of Virginia and Virginia Commonwealth University, Richmond, Virginia, USA
    JPEN J Parenter Enteral Nutr 27:349-54. 2003
    ..In an attempt to minimize delays, we describe our technique and results with transnasal endoscopic placement of double-lumen gastric aspiration, jejunal feeding tubes (DLFT)...
  19. ncbi request reprint Nutrition support in severe acute pancreatitis
    Stephen J D O'Keefe
    Division of Gastroenterology, University of Pittsburgh School of Medicine, 200 Lothrop Street, M2 C Wing PUH, Pittsburgh, PA 15213, USA
    Gastroenterol Clin North Am 36:297-312, viii. 2007
    ..This review discusses the evidence on which these statements are based...
  20. pmc Diet, microbiota, and microbial metabolites in colon cancer risk in rural Africans and African Americans
    Junhai Ou
    Department of Gastroenterology, Hepatology and Nutrition, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Am J Clin Nutr 98:111-20. 2013
    ..The recognition that colonic microbiota have a major influence on colonic health suggests that they might mediate colonic carcinogenesis...
  21. ncbi request reprint Therapeutic efficacy of intestinal and multivisceral transplantation: survival and nutrition outcome
    Laura E Matarese
    Thomas E Starzl Transplantation Institute, Intestinal Rehabilitation and Transplantation Center, UPMC Montefiore, 7 South, 3459 Fifth Avenue, Pittsburgh, PA 15213, USA
    Nutr Clin Pract 22:474-81. 2007
    ..Such a therapeutic benefit is commonly maintained among long-term survivors, with full rehabilitation and restoration of quality of life...
  22. ncbi request reprint Nutrition and quality of life following small intestinal transplantation
    Stephen J D O'Keefe
    Intestinal Rehabilitation and Transplant Center, Pittsburgh, Pennsylvania, USA
    Am J Gastroenterol 102:1093-100. 2007
    ..quot;..
  23. ncbi request reprint Enteral feeding without pancreatic stimulation
    Neeraj Kaushik
    Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical School, Pittsburgh, PA, USA
    Pancreas 31:353-9. 2005
    ....
  24. ncbi request reprint Hypocaloric jejunal feeding is better than total parenteral nutrition in acute pancreatitis: results of a randomized comparative study
    Souheil Abou-Assi
    Division of Gastroenterology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23219, USA
    Am J Gastroenterol 97:2255-62. 2002
    ..The aims of this study were to define the indications for, and to evaluate the cost-effectiveness of, nutritional support in patients with acute pancreatitis...
  25. doi request reprint Association between low colonic short-chain fatty acids and high bile acids in high colon cancer risk populations
    Junhai Ou
    Department of Gastroenterology, Hepatology and Nutrition, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Nutr Cancer 64:34-40. 2012
    ..The role of BCFA in colonic carcinogenesis deserves further study...
  26. ncbi request reprint Nutrition support during acute pancreatitis
    Souheil Abou-Assi
    Virginia Commonwealth University Health System, Richmond, Virginia, USA
    Nutrition 18:938-43. 2002
    ..These observations and the fact that enteral feeding is one-tenth the cost of TPN has resulted in the general acceptance of jejunal feeding as the preferred mode for maintaining nutrition in patients with acute pancreatitis...
  27. ncbi request reprint Isolated pancreatic tuberculosis diagnosed by endoscopic ultrasound-guided fine needle aspiration: a case report
    Neeraj Kaushik
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    JOP 7:205-10. 2006
    ..Immediate cytopathologic examination of tissue sampled by EUS increases the diagnostic yield and is standard in many institutions...
  28. ncbi request reprint Pharmacokinetics of tacrolimus and mycophenolic acid are altered, but recover at different times during hepatic regeneration in rats
    Hui Tian
    718 Salk Hall, Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Drug Metab Dispos 33:329-35. 2005
    ..Caution must be exercised in extrapolating in vitro data to in vivo conditions during hepatic regeneration...
  29. pmc Functional evolution of the vitamin D and pregnane X receptors
    Erica J Reschly
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA
    BMC Evol Biol 7:222. 2007
    ..In addition, several assays were used to search for evidence of PXR-mediated hepatic effects in three model non-mammalian species: sea lamprey (Petromyzon marinus), zebrafish (Danio rerio), and African clawed frog (Xenopus laevis)...
  30. ncbi request reprint Treatment of intestinal failure: home parenteral nutrition
    Daniel K Mullady
    Center for Intestinal Health and Nutrition Support, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Nat Clin Pract Gastroenterol Hepatol 3:492-504. 2006
    ....
  31. ncbi request reprint Activity and expression of various isoforms of uridine diphosphate glucuronosyltransferase are differentially regulated during hepatic regeneration in rats
    Hui Tian
    Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Pharm Res 22:2007-15. 2005
    ....
  32. ncbi request reprint Differential effect of saturated and polyunsaturated fatty acids on hepatic glucose metabolism in humans
    John N Clore
    Division of Endocrinology and Metabolism, Virginia Commonwealth University, Richmond, Virginia 2329, USA
    Am J Physiol Endocrinol Metab 287:E358-65. 2004
    ..Thus these studies demonstrate, for the first time in humans, a differential effect of saturated fatty acids and PUFA on hepatic glucose metabolism...
  33. ncbi request reprint Morphology and function of canine small intestinal autografts: with particular interest in the influence of ex vivo graft irradiation
    Takashi Ishikawa
    Thomas, E, Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    J Gastrointest Surg 7:662-71. 2003
    ..Graft irradiation did not induce further defects in intestinal function or cause histopathologic abnormalities...
  34. ncbi request reprint EUS-guided paracentesis for the diagnosis of malignant ascites
    Neeraj Kaushik
    Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Gastrointest Endosc 64:908-13. 2006
    ..Malignant ascites usually represents peritoneal carcinomatosis, increases disease stage, and portends a poor prognosis. There are limited data regarding the yield of EUS-guided paracentesis (EUS-P) for the diagnosis of malignant ascites...
  35. doi request reprint Pancreatic cyst fluid DNA analysis in evaluating pancreatic cysts: a report of the PANDA study
    Asif Khalid
    Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, USA
    Gastrointest Endosc 69:1095-102. 2009
    ..The role of pancreatic cyst fluid DNA analysis in evaluating pancreatic cysts remains unclear...
  36. ncbi request reprint EUS-guided FNA diagnosis of pancreatic endocrine tumors: new trends identified
    Niraj Jani
    Pittsburgh, Pennsylvania, USA
    Gastrointest Endosc 67:44-50. 2008
    ..EUS-guided FNA (EUS-FNA) has been shown to accurately diagnose PETs and to localize tumors for surgical resection...
  37. doi request reprint Identification of enzymes involved in the metabolism of 17alpha-hydroxyprogesterone caproate: an effective agent for prevention of preterm birth
    Shringi Sharma
    Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, Pennsylvania 15261, USA
    Drug Metab Dispos 36:1896-902. 2008
    ..Because CYP3A is involved in the oxidative metabolism of numerous commonly used drugs, 17-OHPC may be involved in clinically relevant metabolic drug interactions with coadministered CYP3A inhibitors or inducers...