Koji Okamoto

Summary

Affiliation: University of Utah
Country: USA

Publications

  1. ncbi request reprint Mitochondrial morphology and dynamics in yeast and multicellular eukaryotes
    Koji Okamoto
    Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah 84132 3201, USA
    Annu Rev Genet 39:503-36. 2005
  2. pmc Tetratricopeptide repeat proteins Tom70 and Tom71 mediate yeast mitochondrial morphogenesis
    Noriko Kondo-Okamoto
    Department of Biochemistry, University of Utah School of Medicine, 15 North Medical Drive East, Salt Lake City, UT 84112 5650, USA
    EMBO Rep 9:63-9. 2008
  3. pmc The novel F-box protein Mfb1p regulates mitochondrial connectivity and exhibits asymmetric localization in yeast
    Noriko Kondo-Okamoto
    Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Mol Biol Cell 17:3756-67. 2006
  4. pmc Multiple pathways influence mitochondrial inheritance in budding yeast
    Rebecca L Frederick
    Department of Biochemistry, University of Utah, Salt Lake City, Utah 84112, USA
    Genetics 178:825-37. 2008
  5. pmc Yeast Miro GTPase, Gem1p, regulates mitochondrial morphology via a novel pathway
    Rebecca L Frederick
    Department of Biology, University of Utah, Salt Lake City, UT 84112, USA
    J Cell Biol 167:87-98. 2004
  6. ncbi request reprint Mmm1p spans both the outer and inner mitochondrial membranes and contains distinct domains for targeting and foci formation
    Noriko Kondo-Okamoto
    Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA
    J Biol Chem 278:48997-9005. 2003
  7. ncbi request reprint Mitochondrial protein import: molecular basis of the ATP-dependent interaction of MtHsp70 with Tim44
    Fernando Moro
    Institut für Physiologische Chemie der Universität München, Butenandtstrasse 5, 81377 Munich, Germany
    J Biol Chem 277:6874-80. 2002
  8. ncbi request reprint Levels of human Fis1 at the mitochondrial outer membrane regulate mitochondrial morphology
    Diana Stojanovski
    Department of Biochemistry, La Trobe University, 3086 Melbourne, Australia
    J Cell Sci 117:1201-10. 2004
  9. pmc The protein import motor of mitochondria: a targeted molecular ratchet driving unfolding and translocation
    Koji Okamoto
    Institut für Physiologische Chemie der Universität München, Butenandtstrasse 5, D 81377 Munchen, Germany
    EMBO J 21:3659-71. 2002

Collaborators

Detail Information

Publications9

  1. ncbi request reprint Mitochondrial morphology and dynamics in yeast and multicellular eukaryotes
    Koji Okamoto
    Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah 84132 3201, USA
    Annu Rev Genet 39:503-36. 2005
    ..Here we review recent advances in the field of mitochondrial dynamics and highlight the importance of these pathways to human health...
  2. pmc Tetratricopeptide repeat proteins Tom70 and Tom71 mediate yeast mitochondrial morphogenesis
    Noriko Kondo-Okamoto
    Department of Biochemistry, University of Utah School of Medicine, 15 North Medical Drive East, Salt Lake City, UT 84112 5650, USA
    EMBO Rep 9:63-9. 2008
    ..Our data indicate an unexpected role for Tom70 in recruitment of soluble proteins to the mitochondrial surface, and indicate that Tom71 has a specialized role in Mfb1-mediated mitochondrial morphogenesis...
  3. pmc The novel F-box protein Mfb1p regulates mitochondrial connectivity and exhibits asymmetric localization in yeast
    Noriko Kondo-Okamoto
    Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Mol Biol Cell 17:3756-67. 2006
    ..We propose that Mfb1p operates in a novel pathway regulating mitochondrial tubular connectivity...
  4. pmc Multiple pathways influence mitochondrial inheritance in budding yeast
    Rebecca L Frederick
    Department of Biochemistry, University of Utah, Salt Lake City, Utah 84112, USA
    Genetics 178:825-37. 2008
    ..This study demonstrates that multiple pathways influence mitochondrial inheritance in yeast and that Miro GTPases have conserved roles in mitochondrial distribution...
  5. pmc Yeast Miro GTPase, Gem1p, regulates mitochondrial morphology via a novel pathway
    Rebecca L Frederick
    Department of Biology, University of Utah, Salt Lake City, UT 84112, USA
    J Cell Biol 167:87-98. 2004
    ..2003. J. Biol. Chem. 278:6495-6502), Gem1p is not required for pheromone-induced yeast cell death. Thus, Gem1p defines a novel mitochondrial morphology pathway which may integrate cell signaling events with mitochondrial dynamics...
  6. ncbi request reprint Mmm1p spans both the outer and inner mitochondrial membranes and contains distinct domains for targeting and foci formation
    Noriko Kondo-Okamoto
    Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA
    J Biol Chem 278:48997-9005. 2003
    ..Our data suggest that the double membrane-spanning topology of Mmm1p at the membrane contact site is critical for formation of tubular mitochondria...
  7. ncbi request reprint Mitochondrial protein import: molecular basis of the ATP-dependent interaction of MtHsp70 with Tim44
    Fernando Moro
    Institut für Physiologische Chemie der Universität München, Butenandtstrasse 5, 81377 Munich, Germany
    J Biol Chem 277:6874-80. 2002
    ....
  8. ncbi request reprint Levels of human Fis1 at the mitochondrial outer membrane regulate mitochondrial morphology
    Diana Stojanovski
    Department of Biochemistry, La Trobe University, 3086 Melbourne, Australia
    J Cell Sci 117:1201-10. 2004
    ..These results indicate that the levels of hFis1 at the mitochondrial surface influences mitochondrial fission events and hence overall mitochondrial morphology within the cell...
  9. pmc The protein import motor of mitochondria: a targeted molecular ratchet driving unfolding and translocation
    Koji Okamoto
    Institut für Physiologische Chemie der Universität München, Butenandtstrasse 5, D 81377 Munchen, Germany
    EMBO J 21:3659-71. 2002
    ..Our observations suggest that Hsp70 acts as an element of a Brownian ratchet, which mediates unfolding and translocation of preproteins across the mitochondrial membranes...