Yuko Ohta

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. pmc Construction of a nurse shark (Ginglymostoma cirratum) bacterial artificial chromosome (BAC) library and a preliminary genome survey
    Meizhong Luo
    Arizona Genomics Institute, Department of Plant Sciences, University of Arizona, Tucson, AZ 85721, USA
    BMC Genomics 7:106. 2006
  2. pmc IgD, like IgM, is a primordial immunoglobulin class perpetuated in most jawed vertebrates
    Yuko Ohta
    Department of Microbiology and Immunology, University of Maryland, 655 West Baltimore Street, Baltimore, MD 21201, USA
    Proc Natl Acad Sci U S A 103:10723-8. 2006
  3. pmc Primordial linkage of β2-microglobulin to the MHC
    Yuko Ohta
    Department of Microbiology and Immunology, University of Maryland, Baltimore, MD 21201, USA
    J Immunol 186:3563-71. 2011
  4. ncbi request reprint Ancestral organization of the MHC revealed in the amphibian Xenopus
    Yuko Ohta
    Department of Microbiology and Immunology, University of Maryland, 655 West Baltimore Street, BRB13 009, Baltimore, MD 21201, USA
    J Immunol 176:3674-85. 2006
  5. pmc Evolutionarily conserved TCR binding sites, identification of T cells in primary lymphoid tissues, and surprising trans-rearrangements in nurse shark
    Michael F Criscitiello
    Department of Microbiology and Immunology, University of Maryland at Baltimore, Baltimore, MD 21201, USA
    J Immunol 184:6950-60. 2010
  6. doi request reprint Evolutionarily conserved and divergent regions of the autoimmune regulator (Aire) gene: a comparative analysis
    Mark Saltis
    Department of Microbiology and Immunology, University of Maryland, Baltimore, MD 21201, USA
    Immunogenetics 60:105-14. 2008
  7. ncbi request reprint Two highly divergent ancient allelic lineages of the transporter associated with antigen processing (TAP) gene in Xenopus: further evidence for co-evolution among MHC class I region genes
    Yuko Ohta
    Department of Microbiology and Immunology, University of Maryland, School of Medicine, Baltimore, USA
    Eur J Immunol 33:3017-27. 2003
  8. pmc Evolution of the B7 family: co-evolution of B7H6 and NKp30, identification of a new B7 family member, B7H7, and of B7's historical relationship with the MHC
    Martin F Flajnik
    Department of Microbiology and Immunology, University of Maryland, Baltimore, MD 21201, USA
    Immunogenetics 64:571-90. 2012
  9. pmc Remarkable conservation of distinct nonclassical MHC class I lineages in divergent amphibian species
    Ana Goyos
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Immunol 186:372-81. 2011
  10. doi request reprint Noncoordinate expression of J-chain and Blimp-1 define nurse shark plasma cell populations during ontogeny
    Caitlin D Castro
    Department of Microbiology and Immunology, University of Maryland, Baltimore, MD, USA
    Eur J Immunol 43:3061-75. 2013

Collaborators

Detail Information

Publications20

  1. pmc Construction of a nurse shark (Ginglymostoma cirratum) bacterial artificial chromosome (BAC) library and a preliminary genome survey
    Meizhong Luo
    Arizona Genomics Institute, Department of Plant Sciences, University of Arizona, Tucson, AZ 85721, USA
    BMC Genomics 7:106. 2006
    ....
  2. pmc IgD, like IgM, is a primordial immunoglobulin class perpetuated in most jawed vertebrates
    Yuko Ohta
    Department of Microbiology and Immunology, University of Maryland, 655 West Baltimore Street, Baltimore, MD 21201, USA
    Proc Natl Acad Sci U S A 103:10723-8. 2006
    ..Our study suggests that IgD/W has played varied roles in different vertebrate taxa since the inception of the adaptive immune system, and it may have been preserved as a flexible locus over evolutionary time to complement steadfast IgM...
  3. pmc Primordial linkage of β2-microglobulin to the MHC
    Yuko Ohta
    Department of Microbiology and Immunology, University of Maryland, Baltimore, MD 21201, USA
    J Immunol 186:3563-71. 2011
    ....
  4. ncbi request reprint Ancestral organization of the MHC revealed in the amphibian Xenopus
    Yuko Ohta
    Department of Microbiology and Immunology, University of Maryland, 655 West Baltimore Street, BRB13 009, Baltimore, MD 21201, USA
    J Immunol 176:3674-85. 2006
    ..Thus, the amphibian MHC is the most evolutionary conserved MHC so far analyzed...
  5. pmc Evolutionarily conserved TCR binding sites, identification of T cells in primary lymphoid tissues, and surprising trans-rearrangements in nurse shark
    Michael F Criscitiello
    Department of Microbiology and Immunology, University of Maryland at Baltimore, Baltimore, MD 21201, USA
    J Immunol 184:6950-60. 2010
    ..Collectively, these data make the first cellular identification of TCR-expressing lymphocytes in a cartilaginous fish...
  6. doi request reprint Evolutionarily conserved and divergent regions of the autoimmune regulator (Aire) gene: a comparative analysis
    Mark Saltis
    Department of Microbiology and Immunology, University of Maryland, Baltimore, MD 21201, USA
    Immunogenetics 60:105-14. 2008
    ..These findings reveal a very rapid evolution of certain regions of aire during vertebrate evolution and support the existence of an aire-dependent mechanism of T cell tolerance dating back at least to the emergence of bony fish...
  7. ncbi request reprint Two highly divergent ancient allelic lineages of the transporter associated with antigen processing (TAP) gene in Xenopus: further evidence for co-evolution among MHC class I region genes
    Yuko Ohta
    Department of Microbiology and Immunology, University of Maryland, School of Medicine, Baltimore, USA
    Eur J Immunol 33:3017-27. 2003
    ..Furthermore, like the LMP7 lineages, the TAP lineages were detected in most Xenopus species that diverged from a common ancestor 80-100 MYA, suggesting that the 'class I region' biallelic lineages are under balancing selection...
  8. pmc Evolution of the B7 family: co-evolution of B7H6 and NKp30, identification of a new B7 family member, B7H7, and of B7's historical relationship with the MHC
    Martin F Flajnik
    Department of Microbiology and Immunology, University of Maryland, Baltimore, MD 21201, USA
    Immunogenetics 64:571-90. 2012
    ..Additionally, the comparative analysis revealed a new B7 family member, B7H7, which was previously designated in the literature as an unknown gene, HHLA2...
  9. pmc Remarkable conservation of distinct nonclassical MHC class I lineages in divergent amphibian species
    Ana Goyos
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Immunol 186:372-81. 2011
    ....
  10. doi request reprint Noncoordinate expression of J-chain and Blimp-1 define nurse shark plasma cell populations during ontogeny
    Caitlin D Castro
    Department of Microbiology and Immunology, University of Maryland, Baltimore, MD, USA
    Eur J Immunol 43:3061-75. 2013
    ....
  11. pmc Novel nonclassical MHC class Ib genes associated with CD8 T cell development and thymic tumors
    Ana Goyos
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Mol Immunol 46:1775-86. 2009
    ..These data provide the first evidence of the expression of any class Ib genes in Xenopus larvae, and suggests evolutionary relationships between certain class Ib genes, malignancy and CD8 T cell ontogeny...
  12. ncbi request reprint Homologs of CD83 from elasmobranch and teleost fish
    Yuko Ohta
    Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Immunol 173:4553-60. 2004
    ..These results suggest that the role of CD83, an adhesion molecule for cell-mediated immunity, has been conserved over 450 million years of vertebrate evolution...
  13. ncbi request reprint Proteasome, transporter associated with antigen processing, and class I genes in the nurse shark Ginglymostoma cirratum: evidence for a stable class I region and MHC haplotype lineages
    Yuko Ohta
    Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Immunol 168:771-81. 2002
    ..These data further support the principle of a primordial class I region with few class I genes. Finally, multiple paternities in one family were demonstrated, with potential segregation distortions...
  14. pmc Comparative and developmental study of the immune system in Xenopus
    Jacques Robert
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA
    Dev Dyn 238:1249-70. 2009
    ..laevis and S. tropicalis, as well as the whole Xenopus genus. Developmental Dynamics 238:1249-1270, 2009. (c) 2009 Wiley-Liss, Inc...
  15. pmc The evolution of multiple isotypic IgM heavy chain genes in the shark
    Victor Lee
    Department of Physiology and Pharmacology, State University of New York Health Science Center, Brooklyn, NY 11203, USA
    J Immunol 180:7461-70. 2008
    ..We found that all domains changed at comparable rates, but V(H) appears to be under strong positive selection for increased amino acid sequence diversity, and surprisingly, so does Cmicro2...
  16. ncbi request reprint The leukocyte common antigen (CD45) of the Pacific hagfish, Eptatretus stoutii: implications for the primordial function of CD45
    Taeko Nagata
    Department of Biosystems Science, School of Advanced Sciences, The Graduate University for Advanced Studies, SOKENDAI, Shonan Village, Hayama 240 0193, Japan
    Immunogenetics 54:286-91. 2002
    ..It is likely that CD45 was recruited to activate lymphocytes through antigen receptors encoded by rearranging genes in jawed vertebrates...
  17. ncbi request reprint Molecular cloning of C4 gene and identification of the class III complement region in the shark MHC
    Tokio Terado
    Department of Experimental Radiology, Shiga University of Medical Science, Ohtsu shi, Shiga, Japan
    J Immunol 171:2461-6. 2003
    ....
  18. ncbi request reprint Cloning and characterization of Xenopus beta2-microglobulin
    Rebecca Stewart
    School of Biological and Biomedical Sciences, University of Durham, Durham DH1 3LE, UK
    Dev Comp Immunol 29:723-32. 2005
    ....
  19. pmc Immunoglobulin heavy chain exclusion in the shark
    Karolina Malecek
    Department of Physiology and Pharmacology, State University of New York Health Science Center at Brooklyn, Brooklyn, New York, United States of America
    PLoS Biol 6:e157. 2008
    ..This regulation may be shared by higher vertebrates in which additional mechanistic and regulatory elements have evolved with their structurally complex IgH locus...
  20. ncbi request reprint Somatic hypermutation and junctional diversification at Ig heavy chain loci in the nurse shark
    Karolina Malecek
    Department of Physiology and Pharmacology, State University of New York Health Science Center, Brooklyn, NY 11203, USA
    J Immunol 175:8105-15. 2005
    ..The cis-regulatory elements targeting somatic hypermutation must have already existed in the ancestral Ig gene, before H and L chain divergence...