Suk Paul Oh

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. pmc Activin type IIA and IIB receptors mediate Gdf11 signaling in axial vertebral patterning
    S Paul Oh
    Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, Florida 32610, USA
    Genes Dev 16:2749-54. 2002
  2. pmc Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis
    S P Oh
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 97:2626-31. 2000
  3. ncbi request reprint Gene-dosage-sensitive genetic interactions between inversus viscerum (iv), nodal, and activin type IIB receptor (ActRIIB) genes in asymmetrical patterning of the visceral organs along the left-right axis
    S Paul Oh
    Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, Florida 32610, USA
    Dev Dyn 224:279-90. 2002
  4. ncbi request reprint The type II activin receptors are essential for egg cylinder growth, gastrulation, and rostral head development in mice
    J Song
    Cardiovascular Research Center, Massachusetts General Hospital, Department of Medicine, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Dev Biol 213:157-69. 1999
  5. ncbi request reprint De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells
    H Lei
    Cardiovascular Research Center, Massachusetts General Hospital East, Charlestown 02129, USA
    Development 122:3195-205. 1996
  6. ncbi request reprint The signaling pathway mediated by the type IIB activin receptor controls axial patterning and lateral asymmetry in the mouse
    S P Oh
    Cardiovascular Research Center, Massachusetts General Hospital East and Department of Medicine, Harvard Medical School, Charlestown 02129, USA
    Genes Dev 11:1812-26. 1997
  7. pmc ALK5- and TGFBR2-independent role of ALK1 in the pathogenesis of hereditary hemorrhagic telangiectasia type 2
    Sung O Park
    Department of Physiology and Functional Genomics, University of Florida College of Medicine, Shands Cancer Center, Gainesville 32610, USA
    Blood 111:633-42. 2008
  8. ncbi request reprint Activin receptor-like kinase 1 is essential for placental vascular development in mice
    Kwon Ho Hong
    Department of Physiology and Functional Genomics, University of Florida College of Medicine, Shands Cancer Center, Gainesville, FL 32610, USA
    Lab Invest 87:670-9. 2007
  9. ncbi request reprint Generation of activin receptor type IIB isoform-specific hypomorphic alleles
    Young Jae Lee
    Department of Physiology and Functional Genomics, University of Florida, Gainesville, Florida 32610, USA
    Genesis 44:487-94. 2006
  10. ncbi request reprint Nonoverlapping expression patterns of ALK1 and ALK5 reveal distinct roles of each receptor in vascular development
    Tsugio Seki
    Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, FL 32610, USA
    Lab Invest 86:116-29. 2006

Collaborators

  • S Kim
  • Mitsuhiro Okano
  • P ten Dijke
  • T Seki
  • Peter ten Dijke
  • L Li
  • Kohei Miyazono
  • LAURA HALE
  • DOUGLAS A contact MARCHUK
  • MALCOLM R WHITMAN
  • KENNETH BLOCH
  • VESA M KAARTINEN
  • Young Jae Lee
  • Kwon Ho Hong
  • Sean Park
  • Frank A Simmen
  • Rosalia C M Simmen
  • Sung O Park
  • Jeong Hoon Joo
  • En Li
  • Seungkyoung Yang
  • Hideyuki Beppu
  • Yoshiaki Fujii-Kuriyama
  • Rahul N Kanadia
  • Sudha Srinivasan
  • H Lei
  • Eunji Lee
  • Sung Ok Park
  • Xiaofang Wu
  • Chul Han
  • J Song
  • Naime Fliess
  • Mohan K Raizada
  • Alice Park
  • Beth L Roman
  • Zhigang Jiang
  • Stephen P Sugrue
  • Moira R Jackson
  • Gustavo C Munguba
  • Mohamed Y Elsagga
  • Rijin Xiao
  • Margaret T Bowman
  • Rachel D Nicholson
  • Timothy J Taxter
  • Michael C Velarde
  • Young Shik Park
  • Philip Laipis
  • Joanna Peris
  • Jin Man Kim
  • Jihye Yun
  • Jae Hoon Chung
  • E Li
  • In Kyung Lim
  • Ho Jae Lee
  • Amanda L Linz
  • Renea R Eason
  • Joonil Park
  • Ji Won Yoon
  • Leon Chatman
  • Tae Jung Kang
  • Jennelle R McQuown
  • S Renee Till
  • Mary E M Porteous
  • Martha A Hanes
  • Valerie J Crusselle
  • Maurice S Swanson
  • Defang Luo
  • Jeffrey K Harrison
  • Carl R Urbinati
  • Tayeashai Dickens
  • M Nomura
  • T Gridley
  • H Schrewe
  • R Jaenisch
  • R Juttermann
  • K A Goss

Detail Information

Publications20

  1. pmc Activin type IIA and IIB receptors mediate Gdf11 signaling in axial vertebral patterning
    S Paul Oh
    Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, Florida 32610, USA
    Genes Dev 16:2749-54. 2002
    ..In addition, we also show that these two receptors can functionally compensate for one another to mediate signaling of another TGF-beta ligand, nodal, during left-right patterning and the development of anterior head structure...
  2. pmc Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis
    S P Oh
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 97:2626-31. 2000
    ..Taken together, our results suggest that the balance between the ALK1 and ALK5 signaling pathways in endothelial cells plays a crucial role in determining vascular endothelial properties during angiogenesis...
  3. ncbi request reprint Gene-dosage-sensitive genetic interactions between inversus viscerum (iv), nodal, and activin type IIB receptor (ActRIIB) genes in asymmetrical patterning of the visceral organs along the left-right axis
    S Paul Oh
    Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, Florida 32610, USA
    Dev Dyn 224:279-90. 2002
    ..We propose that iv functions to establish asymmetric expression of nodal in a gene-dosage-sensitive manner and that nodal signals through the activin type II receptors to specify the left-sidedness by means of a threshold mechanism...
  4. ncbi request reprint The type II activin receptors are essential for egg cylinder growth, gastrulation, and rostral head development in mice
    J Song
    Cardiovascular Research Center, Massachusetts General Hospital, Department of Medicine, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Dev Biol 213:157-69. 1999
    ..These results provide genetic evidence that type II activin receptors are required for egg cylinder growth, primitive streak formation, and rostral head development in mice...
  5. ncbi request reprint De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells
    H Lei
    Cardiovascular Research Center, Massachusetts General Hospital East, Charlestown 02129, USA
    Development 122:3195-205. 1996
    ..These results provide the first evidence that an independently encoded DNA methyltransferase is present in mammalian cells which is capable of de novo methylating cellular and viral DNA in vivo...
  6. ncbi request reprint The signaling pathway mediated by the type IIB activin receptor controls axial patterning and lateral asymmetry in the mouse
    S P Oh
    Cardiovascular Research Center, Massachusetts General Hospital East and Department of Medicine, Harvard Medical School, Charlestown 02129, USA
    Genes Dev 11:1812-26. 1997
    ..These findings provide genetic evidence that the ActRIIB-mediated signaling pathway plays a critical role in patterning both anteroposterior and left-right axes in vertebrate animals...
  7. pmc ALK5- and TGFBR2-independent role of ALK1 in the pathogenesis of hereditary hemorrhagic telangiectasia type 2
    Sung O Park
    Department of Physiology and Functional Genomics, University of Florida College of Medicine, Shands Cancer Center, Gainesville 32610, USA
    Blood 111:633-42. 2008
    ..These data indicate that neither ALK5 nor TGFBR2 is required for ALK1 signaling pertinent to the pathogenesis of HHT and suggest that HHT might not be a TGF-beta subfamily disease...
  8. ncbi request reprint Activin receptor-like kinase 1 is essential for placental vascular development in mice
    Kwon Ho Hong
    Department of Physiology and Functional Genomics, University of Florida College of Medicine, Shands Cancer Center, Gainesville, FL 32610, USA
    Lab Invest 87:670-9. 2007
    ..Results from this study provide valuable information regarding the role of ALK1 in the development of placental vasculature as well as insights into the pathogenesis of HHT...
  9. ncbi request reprint Generation of activin receptor type IIB isoform-specific hypomorphic alleles
    Young Jae Lee
    Department of Physiology and Functional Genomics, University of Florida, Gainesville, Florida 32610, USA
    Genesis 44:487-94. 2006
    ..In this study, we demonstrate that this phenomenon is most likely due to the reduction in the expressed Acvr2b(4) levels rather than to the functional deficiency of the Acvr2b(4) isoform itself...
  10. ncbi request reprint Nonoverlapping expression patterns of ALK1 and ALK5 reveal distinct roles of each receptor in vascular development
    Tsugio Seki
    Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, FL 32610, USA
    Lab Invest 86:116-29. 2006
    ..The Alk5(lacZ) mice will be a valuable resource in identifying the in vivo cellular targets of TGF-beta family signals mediated by Alk5, both during embryonic development as well as in diverse pathological conditions...
  11. pmc B-cell translocation gene 2 (Btg2) regulates vertebral patterning by modulating bone morphogenetic protein/smad signaling
    Sean Park
    Department of Physiology and Functional Genomics, University of Florida, 1600 SW Archer Rd, Room D533d, Gainesville, FL 32610, USA
    Mol Cell Biol 24:10256-62. 2004
    ..In view of the genetic evidence that reduced BMP signaling causes posteriorization of the vertebral pattern, we propose that the observed vertebral phenotype in Btg2-null mice is due to attenuated BMP signaling...
  12. ncbi request reprint Subfertility, uterine hypoplasia, and partial progesterone resistance in mice lacking the Kruppel-like factor 9/basic transcription element-binding protein-1 (Bteb1) gene
    Rosalia C M Simmen
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72202, USA
    J Biol Chem 279:29286-94. 2004
    ..These results identify Bteb1 as a functionally relevant PR-interacting protein and suggest its selective modulation of cellular processes that are regulated by PR-A in the uterine stroma...
  13. ncbi request reprint Isolation of a regulatory region of activin receptor-like kinase 1 gene sufficient for arterial endothelium-specific expression
    Tsugio Seki
    Department of Physiology and Functional Genomics, University of Florida, Gainesville, Fla 32610, USA
    Circ Res 94:e72-7. 2004
    ..The full text of this article is available online at http://circres.ahajournals.org...
  14. ncbi request reprint Arterial endothelium-specific activin receptor-like kinase 1 expression suggests its role in arterialization and vascular remodeling
    Tsugio Seki
    Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, Fla 32610, USA
    Circ Res 93:682-9. 2003
    ....
  15. ncbi request reprint Developmental expression of mouse muscleblind genes Mbnl1, Mbnl2 and Mbnl3
    Rahul N Kanadia
    Department of Molecular Genetics and Microbiology, Powell Gene Therapy Center, University of Florida, College of Medicine, 1600 SW Archer Road, Gainesville, FL 32610 0267, USA
    Gene Expr Patterns 3:459-62. 2003
    ..Our studies reveal a striking overlap between the expression of Dmpk and the muscleblind genes during development of the limbs, nervous system and various muscles, including the diaphragm and tongue...
  16. pmc A murine model for human sepiapterin-reductase deficiency
    Seungkyoung Yang
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, South Korea
    Am J Hum Genet 78:575-87. 2006
    ..This Spr mutant strain of mice will be an invaluable resource to elucidate many important issues regarding SPR and BH(4) deficiencies...
  17. ncbi request reprint Dysregulation of intestinal crypt cell proliferation and villus cell migration in mice lacking Kruppel-like factor 9
    Frank A Simmen
    Arkansas Children s Nutrition Center, 1120 Marshall St, Little Rock, AR 72202, USA
    Am J Physiol Gastrointest Liver Physiol 292:G1757-69. 2007
    ..Results suggest that Klf9 controls the elaboration, from intestine smooth muscle, of molecular mediator(s) of crypt cell proliferation and lineage determination and of villus cell migration...
  18. ncbi request reprint Role of Pinin in neural crest, dorsal dermis, and axial skeleton development and its involvement in the regulation of Tcf/Lef activity in mice
    Jeong Hoon Joo
    Department of Anatomy and Cell Biology, University of Florida College of Medicine, Gainesville, Florida 32610, USA
    Dev Dyn 236:2147-58. 2007
    ..Taken together, the data suggest that Pnn plays important roles during mouse development through its involvement in regulation of Tcf/Lef activity...
  19. ncbi request reprint A mouse model for hereditary hemorrhagic telangiectasia (HHT) type 2
    Sudha Srinivasan
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA
    Hum Mol Genet 12:473-82. 2003
    ..In addition, studies utilizing this animal model can yield valuable information on the role of ALK1 in maintenance of adult vascular architecture including arteriovenous identity...
  20. doi request reprint Genetic ablation of the BMPR2 gene in pulmonary endothelium is sufficient to predispose to pulmonary arterial hypertension
    Kwon Ho Hong
    Department of Physiology and Functional Genomics, Shands Cancer Center, University of Florida College of Medicine, Gainesville, USA
    Circulation 118:722-30. 2008
    ..The present study was designed to investigate whether endothelial Bmpr2 deletion can predispose to PAH...

Research Grants8

  1. ROLE OF ALK1 TGF-BETA SIGNALNG ON ANGIOGENESIS
    S Oh; Fiscal Year: 2003
    ..This knowledge can be readily applicable to various vascular pathogenesis including atherosclerosis, retinopathy and hereditary hemorrhagic telangiectasia. ..
  2. Role of TGF-beta family signaling in HHT and PPH
    S Oh; Fiscal Year: 2007
    ....
  3. Mechanism and therapy for arteriovenous malformation
    Suk Paul Oh; Fiscal Year: 2010
    ..Results from this study map provide important novel insights for developing therapeutic reagents for controlling development of AVMs. ..