S Offenbacher

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. doi request reprint What are the local and systemic implications of third molar retention?
    Steven Offenbacher
    Department of Periodontology, University of North Carolina School of Dentistry, Chapel Hill, NC 27599 7450, USA
    J Oral Maxillofac Surg 70:S58-65. 2012
  2. ncbi request reprint Effects of maternal Campylobacter rectus infection on murine placenta, fetal and neonatal survival, and brain development
    S Offenbacher
    Center for Oral and Systemic Diseases, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599 7455, USA
    J Periodontol 76:2133-43. 2005
  3. pmc Changes in gingival crevicular fluid inflammatory mediator levels during the induction and resolution of experimental gingivitis in humans
    Steven Offenbacher
    UNC Center for Oral and Systemic Diseases, North Carolina Oral Health Institute, UNC School of Dentistry, Durham, NC 27709, USA
    J Clin Periodontol 37:324-33. 2010
  4. doi request reprint Gingival transcriptome patterns during induction and resolution of experimental gingivitis in humans
    Steven Offenbacher
    Department of Periodontology, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27709, USA
    J Periodontol 80:1963-82. 2009
  5. pmc Effects of periodontal therapy on rate of preterm delivery: a randomized controlled trial
    Steven Offenbacher
    Department of Dental Ecology and the Data and Statistical Coordinating Center, University of North Carolina, Chapel Hill, NC, USA
    Obstet Gynecol 114:551-9. 2009
  6. ncbi request reprint Progressive periodontal disease and risk of very preterm delivery
    Steven Offenbacher
    Department of Periodontology, Center for Oral and Systemic Diseases, University of North Carolina School of Dentistry, Chapel Hill, North Carolina 27599 7455, USA
    Obstet Gynecol 107:29-36. 2006
  7. ncbi request reprint Maternal periodontal infections, prematurity, and growth restriction
    Steven Offenbacher
    Center for Oral and Systemic Diseases, UNC School of Dentistry, University of North Carolina, Chapel Hill, North Carolina 27599 7455, USA
    Clin Obstet Gynecol 47:808-21; discussion 881-2. 2004
  8. doi request reprint Rethinking periodontal inflammation
    Steven Offenbacher
    Center for Oral and Systemic Disease, Department of Periodontology, University of North Carolina at Chapel Hill, Manning Drive and Columbia Street, Chapel Hill, NC 27599, USA
    J Periodontol 79:1577-84. 2008
  9. ncbi request reprint Effects of periodontal therapy during pregnancy on periodontal status, biologic parameters, and pregnancy outcomes: a pilot study
    Steven Offenbacher
    Department of Periodontology, Center for Oral and Systemic Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7455, USA
    J Periodontol 77:2011-24. 2006
  10. ncbi request reprint Periodontal disease at the biofilm-gingival interface
    S Offenbacher
    Center for Oral and Systemic Diseases and Department of Periodontology, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7455, USA
    J Periodontol 78:1911-25. 2007

Detail Information

Publications110 found, 100 shown here

  1. doi request reprint What are the local and systemic implications of third molar retention?
    Steven Offenbacher
    Department of Periodontology, University of North Carolina School of Dentistry, Chapel Hill, NC 27599 7450, USA
    J Oral Maxillofac Surg 70:S58-65. 2012
    ....
  2. ncbi request reprint Effects of maternal Campylobacter rectus infection on murine placenta, fetal and neonatal survival, and brain development
    S Offenbacher
    Center for Oral and Systemic Diseases, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599 7455, USA
    J Periodontol 76:2133-43. 2005
    ..The objective of this study was to determine whether maternal Campylobacter rectus infection that induces fetal growth restriction in a mouse model also compromises neonatal pup survival, growth, and neurodevelopment...
  3. pmc Changes in gingival crevicular fluid inflammatory mediator levels during the induction and resolution of experimental gingivitis in humans
    Steven Offenbacher
    UNC Center for Oral and Systemic Diseases, North Carolina Oral Health Institute, UNC School of Dentistry, Durham, NC 27709, USA
    J Clin Periodontol 37:324-33. 2010
    ..The goal of this study is to characterize the changes in 33 biomarkers within the gingival crevicular fluid during the 3-week induction and 4-week resolution of stent-induced, biofilm overgrowth mediated, experimental gingivitis in humans...
  4. doi request reprint Gingival transcriptome patterns during induction and resolution of experimental gingivitis in humans
    Steven Offenbacher
    Department of Periodontology, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27709, USA
    J Periodontol 80:1963-82. 2009
    ..To our knowledge, changes in the patterns of whole-transcriptome gene expression that occur during the induction and resolution of experimental gingivitis in humans were not previously explored using bioinformatic tools...
  5. pmc Effects of periodontal therapy on rate of preterm delivery: a randomized controlled trial
    Steven Offenbacher
    Department of Dental Ecology and the Data and Statistical Coordinating Center, University of North Carolina, Chapel Hill, NC, USA
    Obstet Gynecol 114:551-9. 2009
    ..To test the effects of maternal periodontal disease treatment on the incidence of preterm birth (delivery before 37 weeks of gestation)...
  6. ncbi request reprint Progressive periodontal disease and risk of very preterm delivery
    Steven Offenbacher
    Department of Periodontology, Center for Oral and Systemic Diseases, University of North Carolina School of Dentistry, Chapel Hill, North Carolina 27599 7455, USA
    Obstet Gynecol 107:29-36. 2006
    ..The goal was to estimate whether maternal periodontal disease was predictive of preterm (less than 37 weeks) or very preterm (less than 32 weeks) births...
  7. ncbi request reprint Maternal periodontal infections, prematurity, and growth restriction
    Steven Offenbacher
    Center for Oral and Systemic Diseases, UNC School of Dentistry, University of North Carolina, Chapel Hill, North Carolina 27599 7455, USA
    Clin Obstet Gynecol 47:808-21; discussion 881-2. 2004
  8. doi request reprint Rethinking periodontal inflammation
    Steven Offenbacher
    Center for Oral and Systemic Disease, Department of Periodontology, University of North Carolina at Chapel Hill, Manning Drive and Columbia Street, Chapel Hill, NC 27599, USA
    J Periodontol 79:1577-84. 2008
    ..We propose that we are now able to rethink periodontal disease in terms of a biologic systems model that may help to establish more homogeneous diagnostic categories and can provide insight into the expected response to treatment...
  9. ncbi request reprint Effects of periodontal therapy during pregnancy on periodontal status, biologic parameters, and pregnancy outcomes: a pilot study
    Steven Offenbacher
    Department of Periodontology, Center for Oral and Systemic Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7455, USA
    J Periodontol 77:2011-24. 2006
    ..Few studies have examined the potential effects of periodontal treatment during pregnancy on pregnancy outcomes, periodontal status, and inflammatory biomarkers...
  10. ncbi request reprint Periodontal disease at the biofilm-gingival interface
    S Offenbacher
    Center for Oral and Systemic Diseases and Department of Periodontology, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7455, USA
    J Periodontol 78:1911-25. 2007
    ..A molecular epidemiologic study provided the opportunity to characterize the biology of the biofilm-gingival interface (BGI) in 6,768 community-dwelling subjects...
  11. ncbi request reprint Evidence for periodontitis as a tertiary vascular infection
    Steven Offenbacher
    Center for Oral and Systemic Diseases UNC School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7455, USA
    J Int Acad Periodontol 7:39-48. 2005
    ..This review discusses the evidence for systemic inflammatory responses to oral organisms and the potential role of chronic vessel pathology as a manifestation of tertiary periodontal infections...
  12. ncbi request reprint Commentary: clinical implications of periodontal disease assessments using probing depth and bleeding on probing to measure the status of the periodontal-biofilm interface
    Steven Offenbacher
    Center for Oral Systemic Diseases, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Int Acad Periodontol 7:157-61. 2005
    ..Periodontal disease is a heterogeneous condition, and classifications based upon BOP and PD may be useful considerations in predicting patient clinical response to therapy...
  13. ncbi request reprint Induction of prostaglandin release from macrophages by bacterial endotoxin
    S Offenbacher
    University of North Carolina at Chapel Hill, School of Dentistry, Department of Periodontology, Dental Research Center, 27599 7455, USA
    Clin Infect Dis 28:505-13. 1999
    ....
  14. ncbi request reprint Periodontitis-atherosclerosis syndrome: an expanded model of pathogenesis
    S Offenbacher
    Department of Periodontology, School of Dentistry, University of North Carolina at Chapel Hill 27599 7455, USA
    J Periodontal Res 34:346-52. 1999
    ..The concept of diagnosing and treating a periodontal patient to minimize the deleterious effects of this chronic infectious and inflammatory condition on the cardiovascular system represents an unprecedented challenge to our profession...
  15. ncbi request reprint Potential pathogenic mechanisms of periodontitis associated pregnancy complications
    S Offenbacher
    University of North Carolina at Chapel Hill, School of Dentistry, Department of Periodontology, USA
    Ann Periodontol 3:233-50. 1998
    ..These data suggest that biochemical measures of maternal periodontal status and oral microbial burden are associated with current PLBW...
  16. ncbi request reprint Maternal periodontitis and prematurity. Part II: Maternal infection and fetal exposure
    P N Madianos
    Center for Oral and Systemic Diseases, Departments of Periodontology and Dental Ecology, University of North Carolina at Chapel Hill, School of Dentistry, Chapel Hill, NC, USA
    Ann Periodontol 6:175-82. 2001
    ..The high prevalence of elevated fetal IgM to C. rectus among premature infants raises the possibility that this specific maternal oral pathogen may serve as a primary fetal infectious agent eliciting prematurity...
  17. doi request reprint Third molars and the efficacy of mechanical debridement in reducing pathogen levels in pregnant subjects: a pilot study
    Kevin L Moss
    Department of Dental Ecology, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599, USA
    J Oral Maxillofac Surg 66:1565-9. 2008
    ..To assess the impact of mechanical debridement (scaling and root planing), without adjunctive therapy, on reducing the numbers of periodontal pathogens detected in pregnant subjects with and without visible third molars...
  18. pmc Increased TLR4 expression in murine placentas after oral infection with periodontal pathogens
    R M Arce
    University of North Carolina at Chapel Hill, Center for Oral and Systemic Diseases, NC 27709, USA
    Placenta 30:156-62. 2009
    ....
  19. pmc Toll-like receptor 4 mediates intrauterine growth restriction after systemic Campylobacter rectus infection in mice
    R M Arce
    Department of Periodontology, School of Dentistry, University of North Carolina at Chapel Hill, NC 27599 7455, USA
    Mol Oral Microbiol 27:373-81. 2012
    ..rectus infection, suggesting that placental cytokine activation is likely to be mediated by TLR4 during low birthweight/preterm birth pathogenesis...
  20. ncbi request reprint Maternal periodontitis and prematurity. Part I: Obstetric outcome of prematurity and growth restriction
    S Offenbacher
    Center for Oral and Systemic Diseases, Departments of Periodontology and Dental Ecology, University of North Carolina at Chapel Hill, School of Dentistry, Chapel Hill, NC, USA
    Ann Periodontol 6:164-74. 2001
    ..These studies underscore the need for further consideration of periodontal disease as a potentially new and modifiable risk for preterm birth and growth restriction...
  21. ncbi request reprint The association between periodontal diseases and cardiovascular diseases: a state-of-the-science review
    J D Beck
    Comprehensive Center for Inflammatory Disorders, Center for Oral and Systemic Diseases, University of North Carolina, Chapel Hill, North Carolina, USA
    Ann Periodontol 6:9-15. 2001
    ....
  22. ncbi request reprint Levels of serum interleukin (IL)-6 and gingival crevicular fluid of IL-1beta and prostaglandin E(2) among non-smoking subjects with gingivitis and type 2 diabetes
    O M Andriankaja
    School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7450, USA
    J Periodontol 80:307-16. 2009
    ....
  23. ncbi request reprint Third molar periodontal pathology and caries in senior adults
    Kevin L Moss
    Department of Dental Ecology, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599, USA
    J Oral Maxillofac Surg 65:103-8. 2007
    ..This study was designed to assess the prevalence at enrollment and incidence over 36 months of periodontal pathology and caries affecting third molars in a community-based study of people over the age of 65 years in North Carolina...
  24. doi request reprint Fetal exposure to oral pathogens and subsequent risk for neonatal intensive care admission
    Heather Jared
    Department of Dental Ecology, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    J Periodontol 80:878-83. 2009
    ..The objective of this study was to determine the relationship between fetal exposure to oral pathogens and neonatal intensive care unit (NICU) admission...
  25. ncbi request reprint Maternal serum C-reactive protein concentration early in pregnancy and subsequent pregnancy loss
    Kim A Boggess
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Am J Perinatol 22:299-304. 2005
    ..Future study should be directed at determining the role of maternal inflammation during early pregnancy development and placentation...
  26. ncbi request reprint Treatment of periodontitis by local administration of minocycline microspheres: a controlled trial
    R C Williams
    Department of Periodontology, University of North Carolina, School of Dentistry, Chapel Hill 27599 7450, USA
    J Periodontol 72:1535-44. 2001
    ..Adjunctive therapy with locally delivered antimicrobials has resulted in improved clinical outcomes such as probing depth reduction. This article reports on the efficacy and safety of locally administered microencapsulated minocycline...
  27. ncbi request reprint B-mode ultrasound-detected carotid artery lesions with and without acoustic shadowing and their association with markers of inflammation and endothelial activation: the atherosclerosis risk in communities study
    Kelly J Hunt
    CVD Program, Department of Epidemiology, School of Public Health, University of North Carolina, 137 E Franklin St, Bank of America, Suite 306, Chapel Hill, NC, USA
    Atherosclerosis 162:145-55. 2002
    ..38 (95% CI: 1.10, 1.74)], a marker of endothelial activation. Associations with endothelial adhesion molecules were inconsistent. Further studies aimed at elucidating the mechanisms of arterial mineralization are warranted...
  28. ncbi request reprint Persistently high levels of periodontal pathogens associated with preterm pregnancy outcome
    Dongming Lin
    Center for Oral and Systemic Diseases, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7455, USA
    J Periodontol 78:833-41. 2007
    ..Few studies examining the association between periodontal diseases and preterm birth have explored the underlying microbial and antibody responses associated with oral infection...
  29. pmc Genome-wide association study of periodontal pathogen colonization
    K Divaris
    Department of Pediatric Dentistry, School of Dentistry, University of North Carolina Chapel Hill, 228 Brauer Hall, CB 7450, NC 27599, USA
    J Dent Res 91:21S-28S. 2012
    ..Investigations replicating these findings may lead to an improved understanding of the complex nature of host-microbiome interactions that characterizes states of health and disease...
  30. ncbi request reprint Gingival crevicular fluid interleukin-1beta, prostaglandin E2 and periodontal status in a community population
    Y Zhong
    Department of Dental Ecology, School of Dentistry, University of North Carolina at Chapel Hill, NC 27599, USA
    J Clin Periodontol 34:285-93. 2007
    ....
  31. ncbi request reprint Bacterial infection promotes DNA hypermethylation
    Y A Bobetsis
    University of North Carolina at Chapel Hill, Center for Oral and Systemic Diseases, Department of Periodontology, UNC School of Dentistry, CB 7455, DRC Rm 222, Chapel Hill, NC 27599 7455, USA
    J Dent Res 86:169-74. 2007
    ..This novel finding, correlating infection with epigenetic alterations, provides a mechanism linking environmental signals to placental phenotype, with consequences for development...
  32. pmc Characterization of the invasive and inflammatory traits of oral Campylobacter rectus in a murine model of fetoplacental growth restriction and in trophoblast cultures
    R M Arce
    Center for Oral and Systemic Diseases, NC Oral Health Institute, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    J Reprod Immunol 84:145-53. 2010
    ..In conclusion, the trophoblast-invasive trait of C. rectus that appears limited to human trophoblasts may play a role in facilitating bacterial translocation and placental inflammation during early gestation...
  33. ncbi request reprint Third molars associated with periodontal pathology in older Americans
    John R Elter
    School of Dentistry, University of North Carolina, Chapel Hill, NC 27599, USA
    J Oral Maxillofac Surg 63:179-84. 2005
    ..The study goal was to assess the association between the presence of visible third molars and periodontal pathology in a community-dwelling sample of middle-aged and older adults...
  34. ncbi request reprint Acute-phase inflammatory response to periodontal disease in the US population
    G D Slade
    Department of Dental Ecology, University of North Carolina at Chapel Hill, 27599 7450, USA
    J Dent Res 79:49-57. 2000
    ..Periodontal disease and edentulism were associated with systemic inflammatory response in the US population, most notably among people who had no established risk factors for elevated CRP...
  35. doi request reprint Gender differences in systemic inflammation and atheroma formation following Porphyromonas gingivalis infection in heterozygous apolipoprotein E-deficient mice
    C Champagne
    Center for Oral and Systemic Diseases, School of Dentistry, University of North Carolina Chapel Hill, Chapel Hill, NC 27599 7450, USA
    J Periodontal Res 44:569-77. 2009
    ..In this study, we investigated whether infection with a major periodontal pathogen, Porphyromonas gingivalis, affected the inflammatory and atherosclerotic response of male and female mice differently...
  36. doi request reprint Therapeutic effect of a topical CCR2 antagonist on induced alveolar bone loss in mice
    S P Barros
    Department of Periodontology, School of Dentistry, University of North Carolina, Chapel Hill, NC, USA
    J Periodontal Res 46:246-51. 2011
    ..The study objective was to determine the effect of an experimental oral/topical chemokine (C-C motif) receptor 2 (CCR2)-antagonist treatment on alveolar bone loss in a mouse model of Porphyromonas gingivalis-induced periodontitis...
  37. pmc Association of systemic oxidative stress with suppressed serum IgG to commensal oral biofilm and modulation by periodontal infection
    R E Singer
    Center for Oral and Systemic Diseases and Department of Periodontology, University of North Carolina at Chapel Hill School of Dentistry, Chapel Hill, NC, USA
    Antioxid Redox Signal 11:2973-83. 2009
    ..Levels of oral microbial burden, periodontitis severity, and smoking are, by comparison, minor modifiers of serum IgG responses to the commensal oral biofilm...
  38. ncbi request reprint Third molars and progression of periodontal pathology during pregnancy
    Kevin L Moss
    School of Dentistry, University of North Carolina, Chapel Hill, North Carolina 27599 7450, USA
    J Oral Maxillofac Surg 65:1065-9. 2007
    ..This study was conducted to evaluate the association between third molar periodontal pathology at enrollment and periodontal disease progression during pregnancy...
  39. doi request reprint Periodontal disease, oxidative stress, and risk for preeclampsia
    Amanda L Horton
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of North Carolina, Chapel Hill, NC 27599 7516, USA
    J Periodontol 81:199-204. 2010
    ..Periodontal infection is also associated with increased oxidative stress. Our objective was to determine the relationship among maternal periodontal disease, maternal oxidative stress, and the development of preeclampsia...
  40. ncbi request reprint The Periodontitis and Vascular Events (PAVE) pilot study: recruitment, retention, and community care controls
    David J Couper
    Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA
    J Periodontol 79:80-9. 2008
    ....
  41. ncbi request reprint The concept of "risk" and the emerging discipline of periodontal medicine
    D W Paquette
    Department of Periodontology, School of Dentistry, University of North Carolina, Chapel Hill 27599 7450, USA
    J Contemp Dent Pract 1:1-8. 1999
    ....
  42. ncbi request reprint Pharmacodynamic effects of ketoprofen on crevicular fluid prostanoids in adult periodontitis
    D W Paquette
    Dental Research Center, School of Dentistry, University of North Carolina at Chapel Hill, 27599 7450, USA
    J Clin Periodontol 27:558-66. 2000
    ..These data indicate that both topical and systemic KTP therapies pharmacodynamically reduce GCF PGE2 levels in adult periodontitis subjects, allowing for potential inhibition of disease progression...
  43. ncbi request reprint Relationship of periodontal disease to carotid artery intima-media wall thickness: the atherosclerosis risk in communities (ARIC) study
    J D Beck
    University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Arterioscler Thromb Vasc Biol 21:1816-22. 2001
    ..These results provide the first indication that periodontitis may play a role in the pathogenesis of atheroma formation, as well as in cardiovascular events...
  44. ncbi request reprint Relationship of periodontal disease and edentulism to stroke/TIA
    J R Elter
    School of Dentistry, CB7450, University of North Carolina, Chapel Hill, NC 27599 7450, USA
    J Dent Res 82:998-1001. 2003
    ..5% of periodontal examinees, 15.6% of dentate non-examinees, and 22.5% of edentulous persons. The highest quartile of AL (OR 1.3, CI 1.02-1.7) and edentulism (OR 1.4, CI 1.5-2.0) were associated with Stroke/TIA...
  45. ncbi request reprint Titanium surface topography alters cell shape and modulates bone morphogenetic protein 2 expression in the J774A.1 macrophage cell line
    J Takebe
    Dental Research Center, University of North Carolina School of Dentistry, Chapel Hill, North Carolina 27599, USA
    J Biomed Mater Res A 64:207-16. 2003
    ..This first demonstration of BMP-2 expression by cpTi adherent macrophages suggests that the macrophage may contribute surface-specific osteoinductive signals during bone formation at implanted alloplastic surfaces...
  46. pmc Porphyromonas gingivalis infection during pregnancy increases maternal tumor necrosis factor alpha, suppresses maternal interleukin-10, and enhances fetal growth restriction and resorption in mice
    Dongming Lin
    Center for Oral and Systemic Diseases, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Infect Immun 71:5156-62. 2003
    ..These data demonstrate that P. gingivalis-induced murine FGR is associated with systemic dissemination of the organism and activated maternal immune and inflammatory responses...
  47. ncbi request reprint Porphyromonas gingivalis bacteremia induces coronary and aortic atherosclerosis in normocholesterolemic and hypercholesterolemic pigs
    Nadine Brodala
    School of Dentistry and Department of Periodontology, University of North Carolina at Chapel Hill and the Center of Oral and Systemic Diseases, Chapel Hill, NC 27516 3114, USA
    Arterioscler Thromb Vasc Biol 25:1446-51. 2005
    ..The aim of this study was to determine whether recurrent intravenous injections with Porphyromonas gingivalis (P gingivalis), mimicking periodontitis-associated bacteremia, promotes coronary artery and aortic atherosclerosis in pigs...
  48. pmc Results from the Periodontitis and Vascular Events (PAVE) Study: a pilot multicentered, randomized, controlled trial to study effects of periodontal therapy in a secondary prevention model of cardiovascular disease
    Steven Offenbacher
    Department of Periodontology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    J Periodontol 80:190-201. 2009
    ..In the Periodontitis and Vascular Events (PAVE) pilot study, periodontal therapy was provided as an intervention in a secondary cardiac event prevention model through five coordinated cardiac-dental centers...
  49. ncbi request reprint Impact of tooth loss on oral and systemic health
    S Offenbacher
    Department of Periodontology, University of North Carolina, School of Dentistry, Chapel Hill, NC, USA
    Gen Dent 60:494-500; quiz p. 501-2. 2012
    ..albicans to the oral mucosa, or both. Ongoing investigations are attempting to incorporate interventions into matrices, to provide a local and sustained presence to therapeutic interventions...
  50. pmc MicroRNA modulation in obesity and periodontitis
    R Perri
    Department of Periodontology and School of Dentistry, University of North Carolina at Chapel Hill, NC, USA
    J Dent Res 91:33-8. 2012
    ....
  51. ncbi request reprint Relationship between periodontal disease and C-reactive protein among adults in the Atherosclerosis Risk in Communities study
    Gary D Slade
    Center for Oral and Systemic Disease, Department of Dental Ecology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7450, USA
    Arch Intern Med 163:1172-9. 2003
    ..We evaluated the association between periodontal disease and CRP levels in adults in the Atherosclerosis Risk in Communities study...
  52. ncbi request reprint Clinical risk factors associated with incidence and progression of periodontal conditions in pregnant women
    Kevin L Moss
    Department of Dental Ecology, School of Dentistry, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA
    J Clin Periodontol 32:492-8. 2005
    ..This study aimed to identify clinical factors that were predictive of incidence/progression of periodontal measures in pregnant women adjusting for relevant predictors...
  53. ncbi request reprint Third molars associated with periodontal pathology in the Third National Health and Nutrition Examination Survey
    John R Elter
    School of Dentistry, University of North Carolina, Chapel Hill, NC, USA
    J Oral Maxillofac Surg 62:440-5. 2004
    ..Assess the association between visible third molars (VTM) and periodontal pathology in Third National Health and Nutrition Examination Survey (NHANES III)...
  54. pmc Porphyromonas gingivalis infection in pregnant mice is associated with placental dissemination, an increase in the placental Th1/Th2 cytokine ratio, and fetal growth restriction
    Dongming Lin
    Center for Oral and Systemic Diseases, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Infect Immun 71:5163-8. 2003
    ..gingivalis that results in growth restriction of the targeted fetus, which is associated with a shift in the placental Th1/Th2 cytokine balance...
  55. ncbi request reprint The oral conditions and pregnancy study: periodontal status of a cohort of pregnant women
    Susan Lieff
    University of North Carolina, Department of Dental Ecology and Center for Oral and Systemic Diseases, Chapel Hill, NC, USA
    J Periodontol 75:116-26. 2004
    ..Our objective was to describe the oral health of pregnant women, to determine oral health changes during pregnancy, and to determine factors associated with maternal periodontal health or disease...
  56. ncbi request reprint Changes in third molar and nonthird molar periodontal pathology over time
    George H Blakey
    Department of Oral and Maxillofacial Surgery, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599, USA
    J Oral Maxillofac Surg 65:1577-83. 2007
    ..The purpose of this study was to assess changes in periodontal probing depth (PD) over time for third molar and nonthird molar regions in young adults...
  57. ncbi request reprint Antepartum vaginal bleeding, fetal exposure to oral pathogens, and risk for preterm birth at <35 weeks of gestation
    Kim A Boggess
    Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, NC, USA
    Am J Obstet Gynecol 194:954-60. 2006
    ..The purpose of this study was to determine the risks for fetal exposure to oral pathogens and the relationship between vaginal bleeding and fetal exposure in preterm birth risk...
  58. ncbi request reprint Mechanical loading and delta12prostaglandin J2 induce bone morphogenetic protein-2, peroxisome proliferator-activated receptor gamma-1, and bone nodule formation in an osteoblastic cell line
    C Siddhivarn
    Center for Oral and Systemic Diseases and Department of Periodontology, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599 7455, USA
    J Periodontal Res 42:383-92. 2007
    ....
  59. pmc Epigenetics: connecting environment and genotype to phenotype and disease
    S P Barros
    Center for Oral and Systemic Diseases, Department of Periodontology, School of Dentistry, University of North Carolina at Chapel Hill, Room 222, CB 7455, Chapel Hill, NC 27599, USA
    J Dent Res 88:400-8. 2009
    ..The challenge in oral biology will be to understand the mechanisms that modify MVPs in oral tissues and to identify those epigenetic patterns that modify disease pathogenesis or responses to therapy...
  60. ncbi request reprint The oral and systemic impact of third molar periodontal pathology
    Kevin L Moss
    Department of Dental Ecology, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599 7450, USA
    J Oral Maxillofac Surg 65:1739-45. 2007
    ..Assess also, the associations between postpartum periodontal status by jaw and a systemic impact, preterm birth, or elevated serum C-reactive protein (CRP)...
  61. doi request reprint Changes over time in the periodontal status of young adults with no third molar periodontal pathology at enrollment
    George H Blakey
    Department of Oral and Maxillofacial Surgery, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599 7450, USA
    J Oral Maxillofac Surg 67:2425-30. 2009
    ..To assess changes in periodontal status over time in subjects with all third molar region periodontal probing depths (PDs) of less than 4 mm at enrollment...
  62. doi request reprint Third molar caries experience in middle-aged and older Americans: a prevalence study
    Elda L Fisher
    Department of Oral and Maxillofacial Surgery, School of Dentistry, University of North Carolina, Chapel Hill, NC, USA
    J Oral Maxillofac Surg 68:634-40. 2010
    ..To assess the prevalence of third molar caries experience in a middle-aged and older population and the relationship of these findings to caries experience in teeth more anterior in the mouth...
  63. ncbi request reprint Risk indicators for third molar caries and periodontal disease in senior adults
    Kevin L Moss
    Department of Dental Ecology, School of Dentistry, University of North Carolina, Chapel Hill, NC, USA
    J Oral Maxillofac Surg 65:958-63. 2007
    ....
  64. ncbi request reprint Reliability of third molar probing measures and the systemic impact of third molar periodontal pathology
    Kevin L Moss
    Department of Dental Ecology, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599 7450, USA
    J Oral Maxillofac Surg 64:652-8. 2006
    ....
  65. ncbi request reprint Commonality in chronic inflammatory diseases: periodontitis, diabetes, and coronary artery disease
    Janet H Southerland
    Department of Dental Ecology, University of North Carolina, Chapel Hill, NC, USA
    Periodontol 2000 40:130-43. 2006
  66. ncbi request reprint Antibodies to periodontal organisms are associated with decreased kidney function. The Dental Atherosclerosis Risk In Communities study
    Abhijit V Kshirsagar
    Division of Nephrology and Hypertension, UNC Kidney Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Blood Purif 25:125-32. 2007
    ..Increasing evidence suggests that clinical signs of periodontal disease are independently associated with renal impairment. However, no studies have examined the possible linkage of kidney disease with serum antibody to oral pathogens...
  67. ncbi request reprint Progression of periodontal disease in the second/third molar region in subjects with asymptomatic third molars
    George H Blakey
    Department of Oral and Maxillofacial Surgery, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599 7450, USA
    J Oral Maxillofac Surg 64:189-93. 2006
    ..To assess the change in periodontal status over time by periodontal probing depth (PD) in the third molar region...
  68. pmc ASC-dependent RIP2 kinase regulates reduced PGE2 production in chronic periodontitis
    D J Taxman
    Department of Microbiology and Immunology, School of Medicine University of North Carolina, Chapel Hill, NC, USA
    J Dent Res 91:877-82. 2012
    ..These findings identify a novel ASC-RIPK2 axis in the generation of PGE(2) that is repressed in patients diagnosed with chronic adult periodontitis...
  69. ncbi request reprint Drug release from cast films of ethylene vinyl acetate (EVA) copolymer: Stability of drugs by 1H NMR and solid state 13C CP/MAS NMR
    S Kalachandra
    Center for Oral and Systemic Diseases, Department of Periodontology, School of Dentistry, Dental Research Center, University of North Carolina, Chapel Hill, NC 27599 7450, USA
    J Mater Sci Mater Med 16:597-605. 2005
    ..Spectral analyses for CDA and NST revealed that the chemical and physical structures of the drugs remained unaffected during the film casting process...
  70. ncbi request reprint A polymeric device for delivery of anti-microbial and anti-fungal drugs in the oral environment: effect of temperature and medium on the rate of drug release
    D M Lin
    Department of Periodontology, Center for Oral and Systemic Diseases, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7455, USA
    Dent Mater 19:589-96. 2003
    ....
  71. ncbi request reprint Relationships among clinical measures of periodontal disease and their associations with systemic markers
    James D Beck
    Department of Dental Ecology University of North Carolina, Chapel Hill, North Carolina, USA
    Ann Periodontol 7:79-89. 2002
    ..Another important consideration is the temporal relationship between the exposure and the outcome of interest...
  72. ncbi request reprint Systemic effects of periodontitis: epidemiology of periodontal disease and cardiovascular disease
    James D Beck
    Department of Dental Ecology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Periodontol 76:2089-100. 2005
    ..Principal component analyses illustrate the complexity of the interactions among risk factors, exposures, and outcomes. These analyses provide an initial clustering that describes and suggests the presence of specific syndromes...
  73. doi request reprint Triclosan inhibition of acute and chronic inflammatory gene pathways
    Silvana P Barros
    School of Dentistry, Center for Oral and Systemic Diseases, North Carolina Oral Health Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27709, USA
    J Clin Periodontol 37:412-8. 2010
    ....
  74. doi request reprint Periodontal disease adversely affects the survival of patients with end-stage renal disease
    Abhijit V Kshirsagar
    Division of Nephrology and Hypertension, Department of Medicine, UNC Kidney Center, School of Medicine, University of North Carolina at Chapel Hill, NC 27599 7155, USA
    Kidney Int 75:746-51. 2009
    ..Our findings suggest a need for larger studies to confirm this connection, along with intervention trials to determine if treating periodontitis reduces cardiovascular disease mortality in dialysis patients...
  75. ncbi request reprint Campylobacter rectus mediates growth restriction in pregnant mice
    Alvin Yeo
    Center for Oral and Systemic Diseases, Department of Periodontology, University of North Carolina, School of Dentistry, Chapel Hill, 27599, USA
    J Periodontol 76:551-7. 2005
    ..Our objective was to determine the effects of Campylobacter rectus (C. rectus) infection on pregnancy outcomes in a mouse model...
  76. ncbi request reprint Fetal immune response to oral pathogens and risk of preterm birth
    Kim A Boggess
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of North Carolina School of Medicine, Chapel Hill 27599 7516, USA
    Am J Obstet Gynecol 193:1121-6. 2005
    ..The purpose of this study was to determine the relationship between fetal inflammatory and immune responses to oral pathogens and risk for preterm birth...
  77. ncbi request reprint Insulin-like growth factor and interleukin-1beta levels and subsequent fetal size in response to chronic Porphyromonas gingivalis exposure in the pregnant rabbit
    Kim A Boggess
    Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill School of Medicine, 27599, USA
    Am J Obstet Gynecol 193:1219-23. 2005
    ..The purpose of this study was to describe maternal insulin-like growth factor, interleukin-1beta, and fetal size in a rabbit model of Porphyromonas gingivalis exposure...
  78. ncbi request reprint Maternal periodontal disease is associated with an increased risk for preeclampsia
    Kim A Boggess
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Obstet Gynecol 101:227-31. 2003
    ..To determine if maternal periodontal disease is associated with the development of preeclampsia...
  79. doi request reprint Maternal periodontal disease and soluble fms-like tyrosine kinase-1 expression
    Amanda L Horton
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of North Carolina, Chapel Hill, NC, USA
    J Periodontol 80:1506-10. 2009
    ..This study was conducted to examine the relationship between maternal periodontal disease and plasma angiogenic factor expression of soluble fms-like tyrosine kinase (sFlt)-1...
  80. ncbi request reprint Periodontal pathology associated with asymptomatic third molars
    George H Blakey
    Department of Oral and Maxillofacial Surgery, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599 7450, USA
    J Oral Maxillofac Surg 60:1227-33. 2002
    ....
  81. ncbi request reprint Inflammatory mediators and periodontitis in patients with asymptomatic third molars
    Raymond P White
    Department of Oral and Maxillofacial Surgery, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599 7450, USA
    J Oral Maxillofac Surg 60:1241-5. 2002
    ..Our goal was to report the detection and levels of gingival crevicular fluid (GCF) inflammatory mediators, sampled at the mesial of 4 first molars and distal of 4 second molars, in 316 patients with asymptomatic third molars...
  82. ncbi request reprint Aortic arch atheroma progression and recurrent vascular events in patients with stroke or transient ischemic attack
    Souvik Sen
    Department of Neurology, University of North Carolina, Chapel Hill, USA
    Circulation 116:928-35. 2007
    ..It is not known whether progression of aortic arch (AA) atheroma is associated with vascular events in patients with stroke or transient ischemic attack (TIA)...
  83. ncbi request reprint Associations between IgG antibody to oral organisms and carotid intima-medial thickness in community-dwelling adults
    James D Beck
    Department of Dental Ecology, CB 7450, University of North Carolina, Chapel Hill, NC 27599, USA
    Atherosclerosis 183:342-8. 2005
    ..The aims of this study are to describe the relationships between IgG antibodies to 17 oral organisms and atherosclerosis as indexed by carotid intima-medial wall thickness (IMT) and to evaluate the role of smoking...
  84. ncbi request reprint Locally delivered minocycline microspheres for the treatment of periodontitis in smokers
    David Paquette
    Department of Periodontology, University of North Carolina, School of Dentistry, Chapel Hill, NC 27599 7450, USA
    J Clin Periodontol 30:787-94. 2003
    ....
  85. ncbi request reprint Periodontal disease early in pregnancy is associated with maternal systemic inflammation among African American women
    Amanda L Horton
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of North Carolina, Chapel Hill, NC 27599 7516, USA
    J Periodontol 79:1127-32. 2008
    ....
  86. ncbi request reprint Changes over time in position and periodontal probing status of retained third molars
    Ceib Phillips
    Department of Orthodontics, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599 7450, USA
    J Oral Maxillofac Surg 65:2011-7. 2007
    ....
  87. ncbi request reprint Severe periodontitis is associated with low serum albumin among patients on maintenance hemodialysis therapy
    Abhijit V Kshirsagar
    Division of Nephrology and Hypertension, UNC Kidney Center, School of Medicine, Chapel Hill, NC 27599 7155, USA
    Clin J Am Soc Nephrol 2:239-44. 2007
    ..Investigation of the potential contribution of periodontitis to serum albumin and possibly to morbidity and mortality among patients with end-stage kidney disease seems warranted...
  88. ncbi request reprint Periodontal disease and coronary heart disease: a reappraisal of the exposure
    James D Beck
    Department of Dental Ecology, University of North Carolina, Chapel Hill, NC 27599, USA
    Circulation 112:19-24. 2005
    ....
  89. ncbi request reprint Chronic maternal and fetal Porphyromonas gingivalis exposure during pregnancy in rabbits
    Kim A Boggess
    Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, NC, USA
    Am J Obstet Gynecol 192:554-7. 2005
    ..This study was undertaken to develop a rabbit model of maternal exposure to Porphyromonas gingivalis and determine whether fetal or placental exposure occurs...
  90. ncbi request reprint Chronic oral inflammation and the progression of periodontal pathology in the third molar region
    Raymond P White
    Department of Oral and Maxillofacial Surgery, School of Dentistry, University of North Carolina, Chapel Hill, NC 37599 7450, USA
    J Oral Maxillofac Surg 64:880-5. 2006
    ..To assess the association between risk markers of chronic oral inflammation and changes over time in periodontal probing depth (PD) in the third molar region, the distal of a second molar, or around a third molar...
  91. ncbi request reprint The Periodontitis and Vascular Events (PAVE) pilot study: adverse events
    James D Beck
    Department of Dental Ecology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Periodontol 79:90-6. 2008
    ..This article describes the occurrence of adverse events during the pilot study...
  92. ncbi request reprint Relationship of periodontal disease and tooth loss to prevalence of coronary heart disease
    John R Elter
    Center for Oral and Systemic Diseases, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599 7450, USA
    J Periodontol 75:782-90. 2004
    ..Studies relating periodontal disease to coronary heart disease (CHD) have provided equivocal results using tooth loss and/or clinical signs of periodontal disease as measures of periodontal exposure...
  93. ncbi request reprint Association of leukocyte count with progression of aortic atheroma in stroke/transient ischemic attack patients
    Souvik Sen
    Department of Neurology, University of North Carolina, Chapel Hill, NC, USA
    Stroke 38:2900-5. 2007
    ..Leukocyte count is an independent predictor of stroke. We investigated the association between leukocyte count and progression of aortic atheroma over 12 months in stroke/transient ischemic attack (TIA) patients...
  94. doi request reprint Maternal periodontal disease, systemic inflammation, and risk for preeclampsia
    Michael Ruma
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, NC 27599 7516, USA
    Am J Obstet Gynecol 198:389.e1-5. 2008
    ..Our objective was to determine the relationship between maternal periodontal disease, maternal systemic inflammation, and the development of preeclampsia...
  95. doi request reprint Risk markers for periodontal pathology over time in the third molar and non-third molar regions in young adults
    Raymond P White
    Department of Oral and Maxillofacial Surgery, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599, USA
    J Oral Maxillofac Surg 66:749-54. 2008
    ..This study was conducted to analyze the clinical impact of risk markers for third molar and non-third molar periodontal pathology over time...
  96. doi request reprint Vitamin D status and periodontal disease among pregnant women
    Kim A Boggess
    Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Periodontol 82:195-200. 2011
    ..The objective of this study is to examine the relationship between maternal vitamin D status and periodontal disease...
  97. doi request reprint Visible third molars as risk indicator for increased periodontal probing depth
    Raymond P White
    Department of Oral and Maxillofacial Surgery, University of North Carolina School of Dentistry, Chapel Hill, NC, USA
    J Oral Maxillofac Surg 69:92-103. 2011
    ..To assess the relationship between visible third molars and the periodontal status of teeth more anterior in the mouth from reports that included periodontal probing data for all teeth...
  98. pmc Alteration of PTGS2 promoter methylation in chronic periodontitis
    S Zhang
    Center for Oral and Systemic Diseases, University of North Carolina at Chapel Hill, Durham, 27709, USA
    J Dent Res 89:133-7. 2010
    ..These findings suggest that the chronic persistence of the biofilm and inflammation may be associated with epigenetic changes in local tissues at the biofilm-gingival interface...
  99. pmc Lesions of endodontic origin and risk of coronary heart disease
    D J Caplan
    Department of Dental Ecology, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599, USA
    J Dent Res 85:996-1000. 2006
    ..These findings are consistent with research that suggests relationships between chronic periodontal inflammation and the development of CHD, especially among younger men...
  100. ncbi request reprint Periodontitis: a potential risk factor for spontaneous preterm birth
    S Offenbacher
    Department of Periodontology, School of Dentistry, University of North Carolina at Chapel Hill, USA
    Compend Contin Educ Dent 22:17-20. 2001
    ....
  101. ncbi request reprint Macrophage cell lines produce osteoinductive signals that include bone morphogenetic protein-2
    C M Champagne
    Dental Research Center, University of North Carolina School of Dentistry, Chapel Hill, NC 27599 7450, USA
    Bone 30:26-31. 2002
    ..This first study of macrophage BMP-2 expression indicates that the macrophage is capable of physiological regulation consistent with a key role in osteoinduction for osseous wound healing...