PATRICK H O'FARRELL

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc DNA replication times the cell cycle and contributes to the mid-blastula transition in Drosophila embryos
    Mark L McCleland
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 187:7-14. 2009
  2. pmc Influence of cyclin type and dose on mitotic entry and progression in the early Drosophila embryo
    Mark L McCleland
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA
    J Cell Biol 184:639-46. 2009
  3. pmc Different cyclin types collaborate to reverse the S-phase checkpoint and permit prompt mitosis
    Kai Yuan
    Department of Biochemistry, University of California, San Francisco, San Francisco, CA 94158, USA
    J Cell Biol 198:973-80. 2012
  4. pmc Quiescence: early evolutionary origins and universality do not imply uniformity
    PATRICK H O'FARRELL
    Department of Biochemistry, University of California, San Francisco, CA 94158 2200, USA
    Philos Trans R Soc Lond B Biol Sci 366:3498-507. 2011
  5. pmc Mitotic regulators govern progress through steps in the centrosome duplication cycle
    S J Vidwans
    Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California 94143 0448, USA
    J Cell Biol 147:1371-8. 1999
  6. pmc Triggering the all-or-nothing switch into mitosis
    P H O'Farrell
    Dept of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143 0448, USA
    Trends Cell Biol 11:512-9. 2001
  7. pmc The pre-omics era: the early days of two-dimensional gels
    PATRICK H O'FARRELL
    Department of Biochemistry and Biophysics, UCSF, San Francisco, CA 94158 2517, USA
    Proteomics 8:4842-52. 2008
  8. pmc RNAi of mitotic cyclins in Drosophila uncouples the nuclear and centrosome cycle
    Mark L McCleland
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94143 2200, USA
    Curr Biol 18:245-54. 2008
  9. pmc Embryonic onset of late replication requires Cdc25 down-regulation
    Jeffrey A Farrell
    Department of Biochemistry, University of California at San Francisco, San Francisco, California 94143, USA
    Genes Dev 26:714-25. 2012
  10. pmc Functional dissection of an innate immune response by a genome-wide RNAi screen
    Edan Foley
    Department of Biochemistry and Biophysics, University of California, San Francisco, USA
    PLoS Biol 2:E203. 2004

Research Grants

  1. Nitric Oxide Signaling in Hypoxia and Immunity in Drosophila
    PATRICK H O apos FARRELL; Fiscal Year: 2010
  2. DEVELOPMENTAL PROGRAMS OF CELL CYCLE CONTROL
    PATRICK O FARRELL; Fiscal Year: 2001
  3. NITRIC OXIDE AND RESPONSES TO HYPOXIA IN DROSOPHILA
    PATRICK O FARRELL; Fiscal Year: 2001
  4. Nitric Oxide Signaling in Hypoxia and Immunity in Drosophila
    PATRICK O FARRELL; Fiscal Year: 2009
  5. DEVELOPMENTAL PROGRAMS OF CELL CYCLE CONTROL
    PATRICK O FARRELL; Fiscal Year: 2009
  6. DEVELOPMENTAL PROGRAMS OF CELL CYCLE CONTROL
    PATRICK O FARRELL; Fiscal Year: 2007
  7. NITRIC OXIDE AND RESPONSES TO HYPOXIA IN DROSOPHILA
    PATRICK O FARRELL; Fiscal Year: 2002
  8. DEVELOPMENTAL PROGRAMS OF CELL CYCLE CONTROL
    PATRICK O FARRELL; Fiscal Year: 2002
  9. DEVELOPMENTAL PROGRAMS OF CELL CYCLE CONTROL
    PATRICK O FARRELL; Fiscal Year: 2003
  10. DEVELOPMENTAL PROGRAMS OF CELL CYCLE CONTROL
    PATRICK O FARRELL; Fiscal Year: 2004

Collaborators

  • Gilles R X Hickson
  • Arnaud Echard
  • Raul Andino
  • Jason Stumpff
  • Ethan Bier
  • PATRICK O FARRELL
  • Mark L McCleland
  • Jeffrey A Farrell
  • Antony W Shermoen
  • Kai Yuan
  • Edan Foley
  • PATRICK H O apos FARRELL
  • Pascale F Dijkers
  • Shannon L Stroschein-Stevenson
  • Steven Z DeLuca
  • Hong Xu
  • Smruti J Vidwans
  • Hansong Ma
  • Soo Jung Lee
  • Alexander D Johnson
  • Maria Carla Saleh
  • Devin H Parry
  • Jean Karim Hériché
  • Rita O Teodoro
  • S J Vidwans
  • Renny Feldman
  • Armin Hekele
  • Ronald P Van Rij
  • Amethyst Gillis
  • Dan Ang
  • Mei Lie Wong
  • Janet Iwasa
  • Barrett Foat
  • Nikita Yakubovich
  • Paul J DiGregorio
  • M L Wong

Detail Information

Publications34

  1. pmc DNA replication times the cell cycle and contributes to the mid-blastula transition in Drosophila embryos
    Mark L McCleland
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 187:7-14. 2009
    ..We conclude that normal S phase and replication checkpoint activities are important timers of the undisturbed cell cycle before, but not after, the MBT...
  2. pmc Influence of cyclin type and dose on mitotic entry and progression in the early Drosophila embryo
    Mark L McCleland
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA
    J Cell Biol 184:639-46. 2009
    ....
  3. pmc Different cyclin types collaborate to reverse the S-phase checkpoint and permit prompt mitosis
    Kai Yuan
    Department of Biochemistry, University of California, San Francisco, San Francisco, CA 94158, USA
    J Cell Biol 198:973-80. 2012
    ..We conclude that different cyclin types have distinct abilities to reverse the checkpoint but that they collaborate to do so rapidly...
  4. pmc Quiescence: early evolutionary origins and universality do not imply uniformity
    PATRICK H O'FARRELL
    Department of Biochemistry, University of California, San Francisco, CA 94158 2200, USA
    Philos Trans R Soc Lond B Biol Sci 366:3498-507. 2011
    ..Consideration of quiescence in different models gives us an overview of this diversity...
  5. pmc Mitotic regulators govern progress through steps in the centrosome duplication cycle
    S J Vidwans
    Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California 94143 0448, USA
    J Cell Biol 147:1371-8. 1999
    ..Common regulation of the nuclear and centrosome cycles by mitotic regulators may ensure precise duplication of the centrosome...
  6. pmc Triggering the all-or-nothing switch into mitosis
    P H O'Farrell
    Dept of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143 0448, USA
    Trends Cell Biol 11:512-9. 2001
    ..The pathways that flip this switch alter the balance of modifying reactions to favor dephosphorylation, thereby generating a flood of mitotic kinase...
  7. pmc The pre-omics era: the early days of two-dimensional gels
    PATRICK H O'FARRELL
    Department of Biochemistry and Biophysics, UCSF, San Francisco, CA 94158 2517, USA
    Proteomics 8:4842-52. 2008
    ..The challenge then and now is to use a capability for global analysis to produce new insights into fundamental aspects of biology and to drive substantive technical advances...
  8. pmc RNAi of mitotic cyclins in Drosophila uncouples the nuclear and centrosome cycle
    Mark L McCleland
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94143 2200, USA
    Curr Biol 18:245-54. 2008
    ..However, we still know very little of how individual cell-cycle events are coupled to this oscillator and how the timing of each event is controlled...
  9. pmc Embryonic onset of late replication requires Cdc25 down-regulation
    Jeffrey A Farrell
    Department of Biochemistry, University of California at San Francisco, San Francisco, California 94143, USA
    Genes Dev 26:714-25. 2012
    ..These findings suggest that high Cdc25 and Cdk1 contribute to the speed of the rapid, pre-MBT S phases and that down-regulation of these activities plays a broader role in MBT-associated changes than was previously suspected...
  10. pmc Functional dissection of an innate immune response by a genome-wide RNAi screen
    Edan Foley
    Department of Biochemistry and Biophysics, University of California, San Francisco, USA
    PLoS Biol 2:E203. 2004
    ..Molecular analysis revealed that Defense repressor 1 is upregulated by Dredd in a feedback loop. We propose that interruption of this feedback loop contributes to signal transduction...
  11. pmc Involvement of an SCFSlmb complex in timely elimination of E2F upon initiation of DNA replication in Drosophila
    Jean Karim Hériché
    Department of Biochemistry and Biophysics, University of California, San Francisco, 513 Parnassus Street, San Francisco, CA 94143 0448, USA
    BMC Genet 4:9. 2003
    ..SCF action contributes to cell cycle progression but few of the key targets of its action have been identified...
  12. pmc Terminal cytokinesis events uncovered after an RNAi screen
    Arnaud Echard
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143 2200, USA
    Curr Biol 14:1685-93. 2004
    ..We have shown that the stability of the intercellular bridge is essential for successful cytokinesis and have defined genes contributing to this stability...
  13. pmc Rho-dependent control of anillin behavior during cytokinesis
    Gilles R X Hickson
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA
    J Cell Biol 180:285-94. 2008
    ..We propose that such interactions occur dynamically and transiently to promote furrow stability...
  14. pmc The degradation of two mitotic cyclins contributes to the timing of cytokinesis
    Arnaud Echard
    Department of Biochemistry and Biophysics, University of California, San Francisco, Genentech Hall, 600 16th Street, San Francisco, CA 94143, USA
    Curr Biol 13:373-83. 2003
    ..We examined the interface between mitotic cyclin destruction and the timing of cytokinesis...
  15. pmc Sister chromatids fail to separate during an induced endoreplication cycle in Drosophila embryos
    Smruti J Vidwans
    Department of Biochemistry and Biophysics, University of California, San Francisco, Box 0448, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Curr Biol 12:829-33. 2002
    ....
  16. pmc Cyclin B destruction triggers changes in kinetochore behavior essential for successful anaphase
    Devin H Parry
    Department of Biochemistry and Biophysics, University of California San Francisco, Genentech Hall, 600 16th Street, San Francisco, CA 94143, USA
    Curr Biol 13:647-53. 2003
    ..These findings show that, in addition to loss of sister chromosome cohesion, successful anaphase requires a kinetochore behavioral transition triggered by CYC-B destruction...
  17. pmc Drosophila calcineurin promotes induction of innate immune responses
    Pascale F Dijkers
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94143 2200, USA
    Curr Biol 17:2087-93. 2007
    ..Thus, CanA1 provides an additional input into Relish-promoted immune responses and functions in hemocytes to promote a tissue-to-tissue signaling cascade required for robust immune response...
  18. pmc Rho-kinase controls cell shape changes during cytokinesis
    Gilles R X Hickson
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94143 2200, USA
    Curr Biol 16:359-70. 2006
    ..To explore the initiation of cytokinesis, we focused on the earliest cell shape change, cell elongation, which occurs during anaphase B and prior to cytokinetic furrowing...
  19. pmc Mechanism and regulation of Cdc25/Twine protein destruction in embryonic cell-cycle remodeling
    Jeffrey A Farrell
    Department of Biochemistry, University of California, San Francisco, San Francisco, CA 94158, USA
    Curr Biol 23:118-26. 2013
    ..Both changes set the stage for gastrulation and require downregulation of Cdc25 phosphatase, which was previously attributed to the elimination of its transcripts at the MBT...
  20. doi request reprint Phagocytosis of Candida albicans by RNAi-treated Drosophila S2 cells
    Shannon L Stroschein-Stevenson
    Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, California, USA
    Methods Mol Biol 470:347-58. 2009
    ..We have screened an RNAi library representing 7216 fly genes conserved among metazoans to identify proteins required for the phagocytosis of the human fungal pathogen Candida albicans...
  21. pmc Anomalous centriole configurations are detected in Drosophila wing disc cells upon Cdk1 inactivation
    Smruti J Vidwans
    Department of Biochemistry and Biophysics, University of California San Francisco, 513 Parnassus Avenue, Box 0448, San Francisco, CA 94143, USA
    J Cell Sci 116:137-43. 2003
    ..These findings suggest that regulatory events rather than rigid structural constraints dictate features of the stereotyped duplication program of centrioles...
  22. pmc Nitric oxide-induced suspended animation promotes survival during hypoxia
    Rita O Teodoro
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143 0448, USA
    EMBO J 22:580-7. 2003
    ..We suggest that hypoxia-induced stasis preserves the status quo of embryonic processes and promotes survival. Our data implicate nitric oxide as a mediator of this response and provide a system in which to investigate its action...
  23. pmc Developmental control of late replication and S phase length
    Antony W Shermoen
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143 2200, USA
    Curr Biol 20:2067-77. 2010
    ..It is not known how S phase duration is regulated. Here we examined prolongation of embryonic S phases, its coupling to development, and its relationship to the appearance of heterochromatin...
  24. pmc The endocytic pathway mediates cell entry of dsRNA to induce RNAi silencing
    Maria Carla Saleh
    Department of Microbiology and Immunology, University of California San Francisco, CA 94143 2280, USA
    Nat Cell Biol 8:793-802. 2006
    ..The possible role of these receptors in dsRNA entry may link RNA interference (RNAi) silencing to other innate immune responses...
  25. pmc Barriers to male transmission of mitochondrial DNA in sperm development
    Steven Z DeLuca
    Department of Biochemistry, UCSF, San Francisco, CA 94110, USA
    Dev Cell 22:660-8. 2012
    ..Our results show that mitochondrial DNA is eliminated during spermatogenesis, thereby removing the capacity of sperm to transmit the mitochondrial genome to the next generation...
  26. pmc Dissection of a hypoxia-induced, nitric oxide-mediated signaling cascade
    Pascale F Dijkers
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143 2200, USA
    Mol Biol Cell 20:4083-90. 2009
    ..These findings reveal the use of unconventional steps in an NO pathway involved in sensing hypoxia and initiating signaling...
  27. pmc Anillin: a pivotal organizer of the cytokinetic machinery
    Gilles R X Hickson
    Department of Biochemistry and Biophysics, University of California, San Francisco, Genentech Hall, 600 16th Street, San Francisco, CA 94158, USA
    Biochem Soc Trans 36:439-41. 2008
    ....
  28. pmc An RNA interference screen identifies a novel regulator of target of rapamycin that mediates hypoxia suppression of translation in Drosophila S2 cells
    Soo Jung Lee
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158 2517, USA
    Mol Biol Cell 19:4051-61. 2008
    ..Our results identify Ptp61F as a novel modulator of TOR activity and suggest that its function during hypoxia contributes to the down-regulation of protein synthesis...
  29. pmc Identification of Drosophila gene products required for phagocytosis of Candida albicans
    Shannon L Stroschein-Stevenson
    Department of Microbiology and Immunology, University of California, San Francisco, California, USA
    PLoS Biol 4:e4. 2006
    ..albicans or Staphylococcus aureus) and that TepIII is required for the efficient phagocytosis of S. aureus (but not C. albicans or E. coli). Thus, this family of fly proteins distinguishes different pathogens for subsequent phagocytosis...
  30. pmc Nitric oxide contributes to induction of innate immune responses to gram-negative bacteria in Drosophila
    Edan Foley
    Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California 94143, USA
    Genes Dev 17:115-25. 2003
    ..We propose that NO mediates an early step of the signal transduction pathway, inducing the innate immune response upon natural infection with gram-negative bacteria...
  31. pmc Manipulating the metazoan mitochondrial genome with targeted restriction enzymes
    Hong Xu
    Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, CA 94158 2200, USA
    Science 321:575-7. 2008
    ..Thus, germline expression of mitochondrial restriction enzymes creates a powerful selection and has allowed direct isolation of mitochondrial mutants in a metazoan...
  32. pmc Transmission of mitochondrial mutations and action of purifying selection in Drosophila melanogaster
    Hansong Ma
    Department of Biochemistry, University of California, San Francisco, San Francisco, California, USA
    Nat Genet 46:393-7. 2014
    ..While they are so balanced, these stably transmitted mutations have no detrimental phenotype, but their segregation could contribute to disease phenotypes and somatic aging. ..
  33. pmc Illuminating DNA replication during Drosophila development using TALE-lights
    Kai Yuan
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA
    Curr Biol 24:R144-5. 2014
    ..This replication behavior suggests that developmental signals can separately influence the timing of different satellite sequences. ..
  34. pmc Embryonic cleavage cycles: how is a mouse like a fly?
    PATRICK H O'FARRELL
    Department Biochemistry and Biophysics, GH S372C Genentech Hall, UCSF, San Francisco, CA 94143 2200, USA
    Curr Biol 14:R35-45. 2004
    ..The deferral of events in mammalian embryogenesis might be due to an evolutionary shift in the timing of fertilization...

Research Grants34

  1. Nitric Oxide Signaling in Hypoxia and Immunity in Drosophila
    PATRICK H O apos FARRELL; Fiscal Year: 2010
    ..Our findings have the potential to influence treatment of cardiac infarct and stroke, and could have an impact on areas as diverse as sustaining organs for transplantation, and cancer therapies. ..
  2. DEVELOPMENTAL PROGRAMS OF CELL CYCLE CONTROL
    PATRICK O FARRELL; Fiscal Year: 2001
    ....
  3. NITRIC OXIDE AND RESPONSES TO HYPOXIA IN DROSOPHILA
    PATRICK O FARRELL; Fiscal Year: 2001
    ..Similar tools will be developed to dissect the signal transduction pathway that provokes adaptive changes in behavior and cell cycle progression in response to reduced oxygen. ..
  4. Nitric Oxide Signaling in Hypoxia and Immunity in Drosophila
    PATRICK O FARRELL; Fiscal Year: 2009
    ..Our findings have the potential to influence treatment of cardiac infarct and stroke, and could have an impact on areas as diverse as sustaining organs for transplantation, and cancer therapies. ..
  5. DEVELOPMENTAL PROGRAMS OF CELL CYCLE CONTROL
    PATRICK O FARRELL; Fiscal Year: 2009
    ..Using real-time visualization of tagged proteins and RNAi we are detailing the interactions between cyclin:Cdk and the cytokinetic machinery. ..
  6. DEVELOPMENTAL PROGRAMS OF CELL CYCLE CONTROL
    PATRICK O FARRELL; Fiscal Year: 2007
    ..Using real-time visualization of tagged proteins and RNAi we are detailing the interactions between cyclin:Cdk and the cytokinetic machinery. ..
  7. NITRIC OXIDE AND RESPONSES TO HYPOXIA IN DROSOPHILA
    PATRICK O FARRELL; Fiscal Year: 2002
    ..Similar tools will be developed to dissect the signal transduction pathway that provokes adaptive changes in behavior and cell cycle progression in response to reduced oxygen. ..
  8. DEVELOPMENTAL PROGRAMS OF CELL CYCLE CONTROL
    PATRICK O FARRELL; Fiscal Year: 2002
    ..We will use genetic and cell biological tools to define the new regulatory pathways and will then pursue their biochemical dissection. ..
  9. DEVELOPMENTAL PROGRAMS OF CELL CYCLE CONTROL
    PATRICK O FARRELL; Fiscal Year: 2003
    ..We will use genetic and cell biological tools to define the new regulatory pathways and will then pursue their biochemical dissection. ..
  10. DEVELOPMENTAL PROGRAMS OF CELL CYCLE CONTROL
    PATRICK O FARRELL; Fiscal Year: 2004
    ..We will use genetic and cell biological tools to define the new regulatory pathways and will then pursue their biochemical dissection. ..
  11. DEVELOPMENTAL PROGRAMS OF CELL CYCLE CONTROL
    PATRICK O FARRELL; Fiscal Year: 2005
    ..We will use genetic and cell biological tools to define the new regulatory pathways and will then pursue their biochemical dissection. ..
  12. DEVELOPMENTAL PROGRAMS OF CELL CYCLE CONTROL
    PATRICK O FARRELL; Fiscal Year: 2006
    ..Using real-time visualization of tagged proteins and RNAi we are detailing the interactions between cyclin:Cdk and the cytokinetic machinery. ..
  13. NITRIC OXIDE AND RESPONSES TO HYPOXIA IN DROSOPHILA
    PATRICK O FARRELL; Fiscal Year: 2007
    ..These studies will provide new models for the action of signals central to human physiology and health. ..
  14. NITRIC OXIDE AND RESPONSES TO HYPOXIA IN DROSOPHILA
    PATRICK O FARRELL; Fiscal Year: 2006
    ..These studies will provide new models for the action of signals central to human physiology and health. ..
  15. MOLECULAR DETERMINANTS OF DEVELOPMENTAL FATE
    PATRICK O FARRELL; Fiscal Year: 1990
    ..Because of the rapid progress of our knowledge of the genetic control of early pattern formation in Drosophila our biochemical dissections can be integrated in a biological perspective of growing detail...
  16. MOLECULAR DETERMINANTS OF DEVELOPMENTAL FATE
    PATRICK O FARRELL; Fiscal Year: 1993
    ..Because of the rapid progress of our knowledge of the genetic control of early pattern formation in Drosophila our biochemical dissections can be integrated in a biological perspective of growing detail...
  17. NITRIC OXIDE AND RESPONSES TO HYPOXIA IN DROSOPHILA
    PATRICK O FARRELL; Fiscal Year: 2000
    ..Similar tools will be developed to dissect the signal transduction pathway that provokes adaptive changes in behavior and cell cycle progression in response to reduced oxygen. ..
  18. MOLECULAR DETERMINANTS OF DEVELOPMENTAL FATE
    PATRICK O FARRELL; Fiscal Year: 1992
    ..Because of the rapid progress of our knowledge of the genetic control of early pattern formation in Drosophila our biochemical dissections can be integrated in a biological perspective of growing detail...
  19. NITRIC OXIDE AND RESPONSES TO HYPOXIA IN DROSOPHILA
    PATRICK O FARRELL; Fiscal Year: 2003
    ..Similar tools will be developed to dissect the signal transduction pathway that provokes adaptive changes in behavior and cell cycle progression in response to reduced oxygen. ..
  20. NITRIC OXIDE AND RESPONSES TO HYPOXIA IN DROSOPHILA
    PATRICK O FARRELL; Fiscal Year: 2005
    ..These studies will provide new models for the action of signals central to human physiology and health. ..
  21. NITRIC OXIDE AND RESPONSES TO HYPOXIA IN DROSOPHILA
    PATRICK O FARRELL; Fiscal Year: 2004
    ..These studies will provide new models for the action of signals central to human physiology and health. ..
  22. MOLECULAR DETERMINANTS OF DEVELOPMENTAL FATE
    PATRICK O FARRELL; Fiscal Year: 1991
    ..Because of the rapid progress of our knowledge of the genetic control of early pattern formation in Drosophila our biochemical dissections can be integrated in a biological perspective of growing detail...
  23. DEVELOPMENTAL PROGRAMS OF CELL CYCLE CONTROL
    PATRICK O FARRELL; Fiscal Year: 1999
    ....
  24. DEVELOPMENTAL PROGRAMS OF CELL CYCLE CONTROL
    PATRICK O FARRELL; Fiscal Year: 2000
    ....