William Oetting

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. doi request reprint Getting ready for the Human Phenome Project: the 2012 forum of the Human Variome Project
    William S Oetting
    Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN, USA
    Hum Mutat 34:661-6. 2013
  2. pmc Donor polymorphisms of toll-like receptor 4 associated with graft failure in liver transplant recipients
    William S Oetting
    College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA
    Liver Transpl 18:1399-405. 2012
  3. pmc Validation of genetic variants associated with early acute rejection in kidney allograft transplantation
    William S Oetting
    Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA
    Clin Transplant 26:418-23. 2012
  4. pmc Validation of single nucleotide polymorphisms associated with acute rejection in kidney transplant recipients using a large multi-center cohort
    William S Oetting
    College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA
    Transpl Int 24:1231-8. 2011
  5. doi request reprint Exome and genome analysis as a tool for disease identification and treatment: the 2011 Human Genome Variation Society scientific meeting
    William S Oetting
    Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota, USA
    Hum Mutat 33:586-90. 2012
  6. doi request reprint Clinical genetics & human genome variation: the 2008 Human Genome Variation Society scientific meeting
    William S Oetting
    School of Pharmacy, University of Minnesota, Minneapolis, Minnesota, USA
    Hum Mutat 30:852-6. 2009
  7. doi request reprint Impact of next generation sequencing: the 2009 Human Genome Variation Society Scientific Meeting
    William S Oetting
    College of Pharmacy and Institute of Human Genetics, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Hum Mutat 31:500-3. 2010
  8. doi request reprint Large scale DNA sequencing: new challenges emerge--the 2007 Human Genome Variation Society scientific meeting
    William S Oetting
    School of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Hum Mutat 29:765-8. 2008
  9. doi request reprint The R402Q tyrosinase variant does not cause autosomal recessive ocular albinism
    William S Oetting
    Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Am J Med Genet A 149:466-9. 2009
  10. doi request reprint Exploring the functional consequences of genomic variation: the 2010 Human Genome Variation Society Scientific Meeting
    William S Oetting
    College of Pharmacy, Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, Minneapolis 55455, USA
    Hum Mutat 32:486-90. 2011

Research Grants

  1. Gene Polymorphisms and Kidney Transplant Outcome
    William Oetting; Fiscal Year: 2005

Collaborators

Detail Information

Publications35

  1. doi request reprint Getting ready for the Human Phenome Project: the 2012 forum of the Human Variome Project
    William S Oetting
    Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN, USA
    Hum Mutat 34:661-6. 2013
    ..Improved systems and tools that enhance the collection of phenotype data from clinicians are urgently needed. This meeting begins the HVP's effort toward this important goal...
  2. pmc Donor polymorphisms of toll-like receptor 4 associated with graft failure in liver transplant recipients
    William S Oetting
    College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA
    Liver Transpl 18:1399-405. 2012
    ..Donor polymorphisms in TLR4 could be important factors in modulating TLR4 activity and, therefore, affect the risk of graft loss. Additionally, there is a suggestion of an interaction between polymorphisms within TLR4 and the HCV status...
  3. pmc Validation of genetic variants associated with early acute rejection in kidney allograft transplantation
    William S Oetting
    Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA
    Clin Transplant 26:418-23. 2012
    ..The lack of validation for the other 19 variants may be due to the small effect size, or that, they are not associated with AR. These results stress the need for larger cohorts for both future studies as well as for validation studies...
  4. pmc Validation of single nucleotide polymorphisms associated with acute rejection in kidney transplant recipients using a large multi-center cohort
    William S Oetting
    College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA
    Transpl Int 24:1231-8. 2011
    ..Our results suggest that careful validation of previously reported associations with AR is necessary, and different strategies other than candidate gene studies can help to identify causative genetic variants associated with AR...
  5. doi request reprint Exome and genome analysis as a tool for disease identification and treatment: the 2011 Human Genome Variation Society scientific meeting
    William S Oetting
    Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota, USA
    Hum Mutat 33:586-90. 2012
    ..This year's annual meeting focused on these issues...
  6. doi request reprint Clinical genetics & human genome variation: the 2008 Human Genome Variation Society scientific meeting
    William S Oetting
    School of Pharmacy, University of Minnesota, Minneapolis, Minnesota, USA
    Hum Mutat 30:852-6. 2009
    ..These topics and others were discussed in this year's meeting...
  7. doi request reprint Impact of next generation sequencing: the 2009 Human Genome Variation Society Scientific Meeting
    William S Oetting
    College of Pharmacy and Institute of Human Genetics, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Hum Mutat 31:500-3. 2010
    ..With the combined efforts of investigators using next-generation sequencing to help understand the impact of genetic variants on disease, the use of the personal genome in medicine will soon become a reality...
  8. doi request reprint Large scale DNA sequencing: new challenges emerge--the 2007 Human Genome Variation Society scientific meeting
    William S Oetting
    School of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Hum Mutat 29:765-8. 2008
    ..For the technology to be useful in a medical setting it will be crucial to answer to these questions...
  9. doi request reprint The R402Q tyrosinase variant does not cause autosomal recessive ocular albinism
    William S Oetting
    Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Am J Med Genet A 149:466-9. 2009
    ..We conclude that the codon 402 variant of the tyrosinase gene is not associated with albinism...
  10. doi request reprint Exploring the functional consequences of genomic variation: the 2010 Human Genome Variation Society Scientific Meeting
    William S Oetting
    College of Pharmacy, Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, Minneapolis 55455, USA
    Hum Mutat 32:486-90. 2011
    ..The 2010 annual meeting of the HGVS focused on methods being designed for this purpose...
  11. ncbi request reprint CD14 promoter polymorphisms in atopic families: implications for modulated allergen-specific immunoglobulin E and G1 responses
    Duaine R Jackola
    The Asthma and Allergy Program, Division of Pulmonary, Allergy and Critical Care Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Int Arch Allergy Immunol 139:217-24. 2006
    ..We sought to determine if a single nucleotide polymorphism in the CD14 promoter region is associated with atopy in atopic families, and to assess its influence on serum levels of CD14 and allergen-specific IgE and IgG1 responses...
  12. ncbi request reprint Mendelian randomization: a novel test of the gateway hypothesis and models of gene-environment interplay
    Daniel E Irons
    Department of Psychology, University of Minnesota, 75 East River Road, Minneapolis, MN 55455, USA
    Dev Psychopathol 19:1181-95. 2007
    ....
  13. pmc Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation
    Ajay Israni
    Department of Nephrology, Hennepin County Medical Center, University of Minnesota, Minneapolis, MN, USA
    Transplantation 90:1401-8. 2010
    ..Therefore, this study investigated single-nucleotide polymorphisms (SNPs) to identify genetic variants associated with AR, accounting for center variation, in a multicenter, prospective, observation study...
  14. pmc Genetic determinants of mycophenolate-related anemia and leukopenia after transplantation
    Pamala A Jacobson
    Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA
    Transplantation 91:309-16. 2011
    ..Toxicity leads to dose reduction, addition of colony-stimulating factors or erythropoietin, or discontinuation of immunosuppressive therapy. The causes of and risk factors associated with toxicity are unclear...
  15. pmc Novel polymorphisms associated with tacrolimus trough concentrations: results from a multicenter kidney transplant consortium
    Pamala A Jacobson
    Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA
    Transplantation 91:300-8. 2011
    ..Although its effect is important, it incompletely explains the variability in tacrolimus concentrations and has a relatively low minor allele frequency in whites relative to African Americans (AA)...
  16. pmc Linkage analysis of a cluster-based quantitative phenotype constructed from pulmonary function test data in 27 multigenerational families with multiple asthmatic members
    Cavan Reilly
    Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, Minn, USA
    Hum Hered 64:136-45. 2007
    ....
  17. ncbi request reprint New insights into ocular albinism type 1 (OA1): Mutations and polymorphisms of the OA1 gene
    William S Oetting
    Department of Medicine and Institute of Human Genetics, University of Minnesota, Minneapolis, Minnesota, USA
    Hum Mutat 19:85-92. 2002
    ..Mutation and polymorphism data on this gene is available from the International Albinism Center - Albinism Database web site (http://www.cbc.umn.edu/tad)...
  18. pmc MC1R mutations modify the classic phenotype of oculocutaneous albinism type 2 (OCA2)
    Richard A King
    Department of Genetics, University of Minnesota, Minneapolis, MN, 55455, USA
    Am J Hum Genet 73:638-45. 2003
    ..This is the first demonstration of a gene modifying the OCA phenotype in humans...
  19. ncbi request reprint P gene mutations associated with oculocutaneous albinism type II (OCA2)
    William S Oetting
    Department of Medicine, Institute of Human Genetics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Hum Mutat 25:323. 2005
    ..This information will also help define the critical functional domains of the P protein. Mutations associated with OCA2 can be found in the Albinism Database (http://albinismdb.med.umn.edu)...
  20. ncbi request reprint Oculocutaneous albinism type 1: the last 100 years
    William S Oetting
    Department of Medicine, University of Minnesota, Minneapolis, MN, USA
    Pigment Cell Res 16:307-11. 2003
    ..Though much of the research in albinism has involved OCA1, there are many unanswered questions about OCA1 and albinism, in general. The next 100 yr should still provide many surprises as did the first 100 yr...
  21. ncbi request reprint Tyrosinase gene mutations in oculocutaneous albinism 1 (OCA1): definition of the phenotype
    Richard A King
    Department of Medicine, University of Minnesota, Minneapolis, Minn 55455, USA
    Hum Genet 113:502-13. 2003
    ....
  22. ncbi request reprint The 2004 Human Genome Variation Society scientific meeting
    William S Oetting
    Department ofMedicine, Genetics and Institute of Human Genetics, University of Minnesota, Minneapolis, MN 55455, USA
    Hum Mutat 26:160-3. 2005
    ..New mutation detection methods and methods to identify the effect of a mutation on phenotype were also presented. This meeting report summarizes these presentations...
  23. ncbi request reprint 2005 Human Genome Variation Society Scientific Meeting
    William S Oetting
    Department of Medicine, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Hum Mutat 27:286-9. 2006
    ..The human genome era is moving into a new phase, and these talks are representative of the new directions in which the study of human DNA variation is going in this exciting area of research...
  24. ncbi request reprint Variations in the catechol O-methyltransferase polymorphism and prefrontally guided behaviors in adolescents
    Dustin Wahlstrom
    Department of Psychology, Center for Neurobehavorial Development, University of Minnesota Twin Cities, Minneapolis, Minnesota 55455, USA
    Biol Psychiatry 61:626-32. 2007
    ..These genotypic variations and their associations with executive functions have been described in adults and prepubescent children, but there is a paucity of research assessing these relations in adolescent samples...
  25. ncbi request reprint The 2006 Human Genome Variation Society scientific meeting
    William S Oetting
    School of Pharmacy, University of Minnesota, Minneapolis, Minnesota, USA
    Hum Mutat 28:517-21. 2007
    ..These talks are representative of the questions, problems, and solutions that are being considered by researchers involved in the study of variation in the human genome...
  26. ncbi request reprint A genome-wide search for allergic response (atopy) genes in three ethnic groups: Collaborative Study on the Genetics of Asthma
    Malcolm N Blumenthal
    Department of Medicine, University of Minnesota, MMC 434 Mayo, 420 Delaware SE, Minneapolis, MN 55455, USA
    Hum Genet 114:157-64. 2004
    ..65), 8p (D8S1113, lod=1.60), 12p (D12S372, lod=1.54) and 14q (D14S749, lod=1.70). These results suggest that several regions may harbor genes contributing to the risk for atopy and these may interact with one another in a complex manner...
  27. ncbi request reprint X-linked high myopia associated with cone dysfunction
    Terri L Young
    Department of Ophthalmology, University of Minnesota Medical School, Minneapolis, USA
    Arch Ophthalmol 122:897-908. 2004
    ..We studied a second family from Minnesota with a similar X-linked phenotype, also of Danish descent. All affected males had protanopia instead of deuteranopia...
  28. doi request reprint Pharmacogenetic effect of the UGT polymorphisms on mycophenolate is modified by calcineurin inhibitors
    L aurelle A Johnson
    Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA
    Eur J Clin Pharmacol 64:1047-56. 2008
    ..These enzymes are highly polymorphic resulting in low activity and high expression phenotypes. We hypothesized that polymorphisms of UGT1A9 and 1A8 may alter MPA pharmacokinetics in kidney transplantation...
  29. ncbi request reprint Paradoxical urinary phenytoin metabolite (S)/(R) ratios in CYP2C19*1/*2 patients
    Upendra A Argikar
    Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis, MN 55414, USA
    Epilepsy Res 71:54-63. 2006
    ..Furthermore, our study suggests that measurement of urine ratios cannot be used as a marker for genotype determination...
  30. ncbi request reprint Identification and characterization of a DNase hypersensitive region of the human tyrosinase gene
    James P Fryer
    Department of Medicine and Institute of Human Genetics, University of Minnesota, Minneapolis, MN 55455, USA
    Pigment Cell Res 16:679-84. 2003
    ..We believe that this region of homology contains sequences critical in the regulation of the human tyrosinase gene and is a candidate for the location of OCA1 mutations...
  31. pmc Differential genotype dependent inhibition of CYP2C9 in humans
    Vikas Kumar
    Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA
    Drug Metab Dispos 36:1242-8. 2008
    ..In summary, the presence of CYP2C9(*)3 alleles (either one or two alleles) can alter the degree of drug interaction observed upon coadministration of inhibitors...
  32. pmc Power of multifactor dimensionality reduction and penalized logistic regression for detecting gene-gene interaction in a case-control study
    Hua He
    Division of Biostatistics, School of Public Health, University of Minnesota, Minnesota, USA
    BMC Med Genet 10:127. 2009
    ..On the other hand, the Multifactor Dimensionality Reduction (MDR) is a nonparametric and genetic model-free approach to detect genotype combinations associated with disease risk...
  33. ncbi request reprint Reduced recombination in maternal meiosis coupled with non-disjunction at meiosis II leading to recurrent 47,XXX
    Orit Reish
    Genetic Institute, Assaf Harofeh Medical Center, Zerifin, Israel
    Chromosome Res 12:125-32. 2004
    ..This information may contribute to further understanding of mechanisms leading to X chromosome non-disjunction and may assist in counseling of families with this chromosomal rearrangement...
  34. ncbi request reprint A call for mutations
    Richard G H Cotton
    Genet Med 7:370. 2005
  35. ncbi request reprint Interpreting missense variants: comparing computational methods in human disease genes CDKN2A, MLH1, MSH2, MECP2, and tyrosinase (TYR)
    Philip A Chan
    Vermont Cancer Center, University of Vermont, Burlington, Vermont, USA
    Hum Mutat 28:683-93. 2007
    ..The results support the clinical use of computational methods as one tool to help interpret missense variants in genes associated with human genetic disease...

Research Grants4

  1. Gene Polymorphisms and Kidney Transplant Outcome
    William Oetting; Fiscal Year: 2005
    ..abstract_text> ..