Research Topics
| Greg OdorizziSummaryAffiliation: University of Colorado Country: USA Publications
Research Grants
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Detail Information
Publications
The multiple personalities of AlixGreg Odorizzi
Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309 0347, USA
J Cell Sci 119:3025-32. 2006..With this blueprint in hand, we can now ask whether Alix acts simply as an adaptor that links different proteins into networks or, instead, contributes a specific function to distinct molecular machineries...- Bro1 is an endosome-associated protein that functions in the MVB pathway in Saccharomyces cerevisiaeGreg Odorizzi
Department of Molecular, Cellular and Developmental Biology, University of Colorado, Campus Box 347, Boulder, CO 80309, USA
J Cell Sci 116:1893-903. 2003..Our data suggest that the function of Bro1 in the MVB pathway takes place on endosomal membranes and occurs in concert with or downstream of the function of the ESCRT-III complex... 
Dual mechanisms specify Doa4-mediated deubiquitination at multivesicular bodiesCaleb Richter
Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA
EMBO J 26:2454-64. 2007..Thus, by recruiting Doa4 to late endosomes and stimulating its catalytic activity, Bro1 fulfills a novel dual role in coordinating deubiquitination in the MVB pathway...- Bro1 binding to Snf7 regulates ESCRT-III membrane scission activity in yeastMegan Wemmer
Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA
J Cell Biol 192:295-306. 2011..This stabilization effect correlates with a reduced frequency in the detachment of intralumenal vesicles as observed by electron tomography, implicating Bro1 as a regulator of ESCRT-III disassembly and membrane scission activity... - Regulators of Vps4 ATPase activity at endosomes differentially influence the size and rate of formation of intralumenal vesiclesDaniel P Nickerson
Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309 0347, USA
Mol Biol Cell 21:1023-32. 2010..These morphological effects probably result from Vps4-mediated manipulations of ESCRT-III, because we show dissociation of ESCRT-0, -I, and -II from endosomes is not directly dependent on Vps4 activity... - Bro1 coordinates deubiquitination in the multivesicular body pathway by recruiting Doa4 to endosomesNatalie Luhtala
Molecular, Cellular, and Developmental Biology, 347 UCB, University of Colorado, Boulder, CO 80309 0347, USA
J Cell Biol 166:717-29. 2004..Thus, our results point to a key role for Bro1 in coordinating the timing and location of deubiquitination by Doa4 in the MVB pathway... - A concentric circle model of multivesicular body cargo sortingDaniel P Nickerson
Department of Molecular, Cellular, and Developmental Biology, University of Colorado, 347 UCB, Boulder, Colorado 80309 0347, USA
EMBO Rep 8:644-50. 2007..Recent structural and functional studies of ESCRT complexes suggest an alternative model that might direct the next series of breakthroughs in understanding protein sorting through the MVB pathway... - Direct binding to Rsp5 mediates ubiquitin-independent sorting of Sna3 via the multivesicular body pathwayMatthew W McNatt
Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309 0347, USA
Mol Biol Cell 18:697-706. 2007.... - Did2 coordinates Vps4-mediated dissociation of ESCRT-III from endosomesDaniel P Nickerson
Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA
J Cell Biol 175:715-20. 2006.... 
Class E compartments form in response to ESCRT dysfunction in yeast due to hyperactivity of the Vps21 Rab GTPaseMatthew R G Russell
Department of Molecular, Cellular and Developmental Biology, University of Colorado at Boulder, Campus Box 347, Boulder, CO 80309, USA
J Cell Sci 125:5208-20. 2012..Indeed, genetic disruption of Rab conversion without ESCRT dysfunction autonomously drives the class E compartment morphology without blocking ILV budding...- Molecular mechanisms of late endosome morphology, identity and sortingMatthew Robert Geoffrey Russell
Molecular, Cellular, and Developmental Biology, 347 UCB, University of Colorado, Boulder, CO 80309-0347, USA
Curr Opin Cell Biol 18:422-8. 2006....
Research Grants
- Molecular Analysis of Multivesicular Body FormationCHARLES ODORIZZI; Fiscal Year: 2007..Biochemical and genetic studies will be used to characterize other factors that participate in the recruitment of Brolp to late endosomes or functionally cooperate with Bro1p in the MVB pathway. ..
- Molecular Analysis of Multivesicular Body FormationCHARLES ODORIZZI; Fiscal Year: 2009..The ESCRT machinery also is usurped by the human immunodeficiency virus-1 for the production of infectious virions, making components of the ESCRT machinery candidate targets for anti-viral therapies. ..
- Molecular Analysis of Multivesicular Body FormationCHARLES G ODORIZZI; Fiscal Year: 2010..The ESCRT machinery also is usurped by the human immunodeficiency virus-1 for the production of infectious virions, making components of the ESCRT machinery candidate targets for anti-viral therapies. ..
- Molecular Analysis of Multivesicular Body FormationCHARLES ODORIZZI; Fiscal Year: 2009..The ESCRT machinery also is usurped by the human immunodeficiency virus-1 for the production of infectious virions, making components of the ESCRT machinery candidate targets for anti-viral therapies. ..