Greg Odorizzi

Summary

Affiliation: University of Colorado
Country: USA

Publications

  1. ncbi The multiple personalities of Alix
    Greg Odorizzi
    Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309 0347, USA
    J Cell Sci 119:3025-32. 2006
  2. pmc Bro1 coordinates deubiquitination in the multivesicular body pathway by recruiting Doa4 to endosomes
    Natalie Luhtala
    Molecular, Cellular, and Developmental Biology, 347 UCB, University of Colorado, Boulder, CO 80309 0347, USA
    J Cell Biol 166:717-29. 2004
  3. pmc Bro1 binding to Snf7 regulates ESCRT-III membrane scission activity in yeast
    Megan Wemmer
    Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA
    J Cell Biol 192:295-306. 2011
  4. pmc Did2 coordinates Vps4-mediated dissociation of ESCRT-III from endosomes
    Daniel P Nickerson
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA
    J Cell Biol 175:715-20. 2006
  5. ncbi Bro1 is an endosome-associated protein that functions in the MVB pathway in Saccharomyces cerevisiae
    Greg Odorizzi
    Department of Molecular, Cellular and Developmental Biology, University of Colorado, Campus Box 347, Boulder, CO 80309, USA
    J Cell Sci 116:1893-903. 2003
  6. pmc Dual mechanisms specify Doa4-mediated deubiquitination at multivesicular bodies
    Caleb Richter
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA
    EMBO J 26:2454-64. 2007
  7. pmc Doa4 function in ILV budding is restricted through its interaction with the Vps20 subunit of ESCRT-III
    Caleb M Richter
    Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA
    J Cell Sci 126:1881-90. 2013
  8. pmc Regulators of Vps4 ATPase activity at endosomes differentially influence the size and rate of formation of intralumenal vesicles
    Daniel P Nickerson
    Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309 0347, USA
    Mol Biol Cell 21:1023-32. 2010
  9. pmc Direct binding to Rsp5 mediates ubiquitin-independent sorting of Sna3 via the multivesicular body pathway
    Matthew W McNatt
    Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309 0347, USA
    Mol Biol Cell 18:697-706. 2007
  10. pmc Class E compartments form in response to ESCRT dysfunction in yeast due to hyperactivity of the Vps21 Rab GTPase
    Matthew R G Russell
    Department of Molecular, Cellular and Developmental Biology, University of Colorado at Boulder, Campus Box 347, Boulder, CO 80309, USA
    J Cell Sci 125:5208-20. 2012

Research Grants

  1. Molecular Analysis of Multivesicular Body Formation
    CHARLES ODORIZZI; Fiscal Year: 2004
  2. Molecular Analysis of Multivesicular Body Formation
    CHARLES ODORIZZI; Fiscal Year: 2005
  3. Molecular Analysis of Multivesicular Body Formation
    CHARLES ODORIZZI; Fiscal Year: 2007
  4. Molecular Analysis of Multivesicular Body Formation
    CHARLES G ODORIZZI; Fiscal Year: 2010
  5. Molecular Analysis of Multivesicular Body Formation
    CHARLES ODORIZZI; Fiscal Year: 2009
  6. Molecular Analysis of Multivesicular Body Formation
    CHARLES ODORIZZI; Fiscal Year: 2003
  7. Molecular Analysis of Multivesicular Body Formation
    CHARLES ODORIZZI; Fiscal Year: 2006
  8. Molecular Analysis of Multivesicular Body Formation
    CHARLES ODORIZZI; Fiscal Year: 2009

Collaborators

  • Scott D Emr
  • Markus Babst
  • David Katzmann
  • Anjon Audhya
  • CHARLES ODORIZZI
  • Daniel P Nickerson
  • Matthew West
  • CHARLES G ODORIZZI
  • Matthew R G Russell
  • Caleb M Richter
  • Megan Wemmer
  • Matthew W McNatt
  • Caleb Richter
  • Matthew Robert Geoffrey Russell
  • Natalie Luhtala
  • Tess Shideler
  • Matt West
  • Ishara Azmi
  • Brian Davies
  • Ryan Henry
  • Ian McKittrick
  • Daniel Patrick Nickerson

Detail Information

Publications12

  1. ncbi The multiple personalities of Alix
    Greg Odorizzi
    Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309 0347, USA
    J Cell Sci 119:3025-32. 2006
    ..With this blueprint in hand, we can now ask whether Alix acts simply as an adaptor that links different proteins into networks or, instead, contributes a specific function to distinct molecular machineries...
  2. pmc Bro1 coordinates deubiquitination in the multivesicular body pathway by recruiting Doa4 to endosomes
    Natalie Luhtala
    Molecular, Cellular, and Developmental Biology, 347 UCB, University of Colorado, Boulder, CO 80309 0347, USA
    J Cell Biol 166:717-29. 2004
    ..Thus, our results point to a key role for Bro1 in coordinating the timing and location of deubiquitination by Doa4 in the MVB pathway...
  3. pmc Bro1 binding to Snf7 regulates ESCRT-III membrane scission activity in yeast
    Megan Wemmer
    Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA
    J Cell Biol 192:295-306. 2011
    ..This stabilization effect correlates with a reduced frequency in the detachment of intralumenal vesicles as observed by electron tomography, implicating Bro1 as a regulator of ESCRT-III disassembly and membrane scission activity...
  4. pmc Did2 coordinates Vps4-mediated dissociation of ESCRT-III from endosomes
    Daniel P Nickerson
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA
    J Cell Biol 175:715-20. 2006
    ....
  5. ncbi Bro1 is an endosome-associated protein that functions in the MVB pathway in Saccharomyces cerevisiae
    Greg Odorizzi
    Department of Molecular, Cellular and Developmental Biology, University of Colorado, Campus Box 347, Boulder, CO 80309, USA
    J Cell Sci 116:1893-903. 2003
    ..Our data suggest that the function of Bro1 in the MVB pathway takes place on endosomal membranes and occurs in concert with or downstream of the function of the ESCRT-III complex...
  6. pmc Dual mechanisms specify Doa4-mediated deubiquitination at multivesicular bodies
    Caleb Richter
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA
    EMBO J 26:2454-64. 2007
    ..Thus, by recruiting Doa4 to late endosomes and stimulating its catalytic activity, Bro1 fulfills a novel dual role in coordinating deubiquitination in the MVB pathway...
  7. pmc Doa4 function in ILV budding is restricted through its interaction with the Vps20 subunit of ESCRT-III
    Caleb M Richter
    Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA
    J Cell Sci 126:1881-90. 2013
    ..This rescue in ILV biogenesis requires Doa4 expression but is independent of its Ub hydrolase activity. Thus, binding of Vps20 to the Doa4 N-terminus inhibits a non-catalytic function of Doa4 that promotes ILV formation...
  8. pmc Regulators of Vps4 ATPase activity at endosomes differentially influence the size and rate of formation of intralumenal vesicles
    Daniel P Nickerson
    Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309 0347, USA
    Mol Biol Cell 21:1023-32. 2010
    ..These morphological effects probably result from Vps4-mediated manipulations of ESCRT-III, because we show dissociation of ESCRT-0, -I, and -II from endosomes is not directly dependent on Vps4 activity...
  9. pmc Direct binding to Rsp5 mediates ubiquitin-independent sorting of Sna3 via the multivesicular body pathway
    Matthew W McNatt
    Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309 0347, USA
    Mol Biol Cell 18:697-706. 2007
    ....
  10. pmc Class E compartments form in response to ESCRT dysfunction in yeast due to hyperactivity of the Vps21 Rab GTPase
    Matthew R G Russell
    Department of Molecular, Cellular and Developmental Biology, University of Colorado at Boulder, Campus Box 347, Boulder, CO 80309, USA
    J Cell Sci 125:5208-20. 2012
    ..Indeed, genetic disruption of Rab conversion without ESCRT dysfunction autonomously drives the class E compartment morphology without blocking ILV budding...
  11. pmc A concentric circle model of multivesicular body cargo sorting
    Daniel P Nickerson
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, 347 UCB, Boulder, Colorado 80309 0347, USA
    EMBO Rep 8:644-50. 2007
    ..Recent structural and functional studies of ESCRT complexes suggest an alternative model that might direct the next series of breakthroughs in understanding protein sorting through the MVB pathway...
  12. ncbi Molecular mechanisms of late endosome morphology, identity and sorting
    Matthew Robert Geoffrey Russell
    Molecular, Cellular, and Developmental Biology, 347 UCB, University of Colorado, Boulder, CO 80309 0347, USA
    Curr Opin Cell Biol 18:422-8. 2006
    ....

Research Grants9

  1. Molecular Analysis of Multivesicular Body Formation
    CHARLES ODORIZZI; Fiscal Year: 2004
    ..Biochemical and genetic studies will be used to characterize other factors that participate in the recruitment of Brolp to late endosomes or functionally cooperate with Bro1p in the MVB pathway. ..
  2. Molecular Analysis of Multivesicular Body Formation
    CHARLES ODORIZZI; Fiscal Year: 2005
    ..Biochemical and genetic studies will be used to characterize other factors that participate in the recruitment of Brolp to late endosomes or functionally cooperate with Bro1p in the MVB pathway. ..
  3. Molecular Analysis of Multivesicular Body Formation
    CHARLES ODORIZZI; Fiscal Year: 2007
    ..Biochemical and genetic studies will be used to characterize other factors that participate in the recruitment of Brolp to late endosomes or functionally cooperate with Bro1p in the MVB pathway. ..
  4. Molecular Analysis of Multivesicular Body Formation
    CHARLES G ODORIZZI; Fiscal Year: 2010
    ..The ESCRT machinery also is usurped by the human immunodeficiency virus-1 for the production of infectious virions, making components of the ESCRT machinery candidate targets for anti-viral therapies. ..
  5. Molecular Analysis of Multivesicular Body Formation
    CHARLES ODORIZZI; Fiscal Year: 2009
    ..The ESCRT machinery also is usurped by the human immunodeficiency virus-1 for the production of infectious virions, making components of the ESCRT machinery candidate targets for anti-viral therapies. ..
  6. Molecular Analysis of Multivesicular Body Formation
    CHARLES ODORIZZI; Fiscal Year: 2003
    ..Biochemical and genetic studies will be used to characterize other factors that participate in the recruitment of Brolp to late endosomes or functionally cooperate with Bro1p in the MVB pathway. ..
  7. Molecular Analysis of Multivesicular Body Formation
    CHARLES ODORIZZI; Fiscal Year: 2006
    ..Biochemical and genetic studies will be used to characterize other factors that participate in the recruitment of Brolp to late endosomes or functionally cooperate with Bro1p in the MVB pathway. ..
  8. Molecular Analysis of Multivesicular Body Formation
    CHARLES ODORIZZI; Fiscal Year: 2009
    ..The ESCRT machinery also is usurped by the human immunodeficiency virus-1 for the production of infectious virions, making components of the ESCRT machinery candidate targets for anti-viral therapies. ..