M Sue O'Dorisio

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. pmc G-protein coupled receptor expression patterns delineate medulloblastoma subgroups
    Kelsey L Whittier
    Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IA 2524 JCP, USA
    Acta Neuropathol Commun 1:66. 2013
  2. ncbi request reprint Age-dependent levels of plasma neuropeptides in normal children
    M Sue O'Dorisio
    Department of Pediatrics, University of Iowa, Iowa City, IA, USA
    Regul Pept 109:189-92. 2002
  3. doi request reprint Combining anatomic and molecularly targeted imaging in the diagnosis and surveillance of embryonal tumors of the nervous and endocrine systems in children
    M Sue O'Dorisio
    Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Cancer Metastasis Rev 27:665-77. 2008
  4. pmc Phase I trial of 90Y-DOTATOC therapy in children and young adults with refractory solid tumors that express somatostatin receptors
    Yusuf Menda
    Department of Radiology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA
    J Nucl Med 51:1524-31. 2010
  5. pmc Repeatability of gallium-68 DOTATOC positron emission tomographic imaging in neuroendocrine tumors
    Yusuf Menda
    Department of Radiology, University of Iowa Carver College of Medicine, Iowa City, IA 52241, USA
    Pancreas 42:937-43. 2013
  6. pmc Gastric inhibitory polypeptide receptor (GIPR) is a promising target for imaging and therapy in neuroendocrine tumors
    Scott K Sherman
    Department of Surgery, University of Iowa Carver College of Medicine, Iowa City, IA
    Surgery 154:1206-13; discussion 1214. 2013
  7. ncbi request reprint MIBG and somatostatin receptor analogs in children: current concepts on diagnostic and therapeutic use
    Farzana D Pashankar
    Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    J Nucl Med 46:55S-61S. 2005
  8. pmc Overexpression of membrane proteins in primary and metastatic gastrointestinal neuroendocrine tumors
    Jennifer C Carr
    Department of Surgery, University of Iowa Carver College of Medicine, Iowa City, IA, USA
    Ann Surg Oncol 20:S739-46. 2013
  9. pmc Improved synthesis and biological evaluation of chelator-modified α-MSH analogs prepared by copper-free click chemistry
    Nicholas J Baumhover
    Department of Radiology, Carver College of Medicine, The University of Iowa, 500 Newton Road, ML B180, Iowa City, IA 52242, USA
    Bioorg Med Chem Lett 21:5757-61. 2011
  10. ncbi request reprint Utility of radiolabeled somatostatin receptor analogues for staging/restaging and treatment of somatostatin receptor-positive pediatric tumors
    Geetika Khanna
    Department of Radiology, University of Iowa Carver College of Medicine, 200 Hawkins Drive, Iowa City, Iowa 52242, USA
    Oncologist 13:382-9. 2008

Collaborators

Detail Information

Publications26

  1. pmc G-protein coupled receptor expression patterns delineate medulloblastoma subgroups
    Kelsey L Whittier
    Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IA 2524 JCP, USA
    Acta Neuropathol Commun 1:66. 2013
    ..We hypothesized that analysis of GPCR expression would identify clear subsets of medulloblastoma and suggest distinct GPCRs that might serve as molecular targets for both imaging and therapy...
  2. ncbi request reprint Age-dependent levels of plasma neuropeptides in normal children
    M Sue O'Dorisio
    Department of Pediatrics, University of Iowa, Iowa City, IA, USA
    Regul Pept 109:189-92. 2002
    ..Octreotide doses of 2-3 microg/kg daily resulted in a 40-60% decrease in plasma levels of IGF-1, pancreastatin and GRP. These results are the first publication of plasma neuropeptide levels in normal children...
  3. doi request reprint Combining anatomic and molecularly targeted imaging in the diagnosis and surveillance of embryonal tumors of the nervous and endocrine systems in children
    M Sue O'Dorisio
    Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Cancer Metastasis Rev 27:665-77. 2008
    ....
  4. pmc Phase I trial of 90Y-DOTATOC therapy in children and young adults with refractory solid tumors that express somatostatin receptors
    Yusuf Menda
    Department of Radiology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA
    J Nucl Med 51:1524-31. 2010
    ..The purpose of this study was to conduct a phase I trial of (90)Y-DOTATOC to determine the dose-toxicity profile in children and young adults with somatostatin receptor-positive tumors...
  5. pmc Repeatability of gallium-68 DOTATOC positron emission tomographic imaging in neuroendocrine tumors
    Yusuf Menda
    Department of Radiology, University of Iowa Carver College of Medicine, Iowa City, IA 52241, USA
    Pancreas 42:937-43. 2013
    ..To evaluate the repeatability of gallium-68 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic (DOTA)-D-Phe1-Try3-octreotide (68Ga-DOTATOC) positron emission tomography (PET) in neuroendocrine tumors...
  6. pmc Gastric inhibitory polypeptide receptor (GIPR) is a promising target for imaging and therapy in neuroendocrine tumors
    Scott K Sherman
    Department of Surgery, University of Iowa Carver College of Medicine, Iowa City, IA
    Surgery 154:1206-13; discussion 1214. 2013
    ..The aim of this study was to evaluate gene expression of new therapeutic targets in NETs relative to SSTR2...
  7. ncbi request reprint MIBG and somatostatin receptor analogs in children: current concepts on diagnostic and therapeutic use
    Farzana D Pashankar
    Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    J Nucl Med 46:55S-61S. 2005
    ..This review focuses on the use of MIBG (which is a false transmitter) and octreotide (which is a ligand for G protein receptor) in the diagnosis and treatment of solid tumors that affect children and young adults...
  8. pmc Overexpression of membrane proteins in primary and metastatic gastrointestinal neuroendocrine tumors
    Jennifer C Carr
    Department of Surgery, University of Iowa Carver College of Medicine, Iowa City, IA, USA
    Ann Surg Oncol 20:S739-46. 2013
    ..We set out to validate these expression differences in a large group of primary neuroendocrine tumors and to determine whether they are present in corresponding liver and lymph node metastases...
  9. pmc Improved synthesis and biological evaluation of chelator-modified α-MSH analogs prepared by copper-free click chemistry
    Nicholas J Baumhover
    Department of Radiology, Carver College of Medicine, The University of Iowa, 500 Newton Road, ML B180, Iowa City, IA 52242, USA
    Bioorg Med Chem Lett 21:5757-61. 2011
    ..The resulting bioconjugates bind with high affinity and specificity to their cell-surface receptor targets in vitro and appear stable to degradation in mouse serum over 3h of incubation at 37°C...
  10. ncbi request reprint Utility of radiolabeled somatostatin receptor analogues for staging/restaging and treatment of somatostatin receptor-positive pediatric tumors
    Geetika Khanna
    Department of Radiology, University of Iowa Carver College of Medicine, 200 Hawkins Drive, Iowa City, Iowa 52242, USA
    Oncologist 13:382-9. 2008
    ..Finally, we discuss the potential role of somatostatin receptor-targeted radiotherapy for improving the duration and quality of life of children with these tumors...
  11. ncbi request reprint Somatostatin inhibits IGF-1 mediated induction of VEGF in human retinal pigment epithelial cells
    Jeffrey W Sall
    Interdisciplinary Program in Neuroscience, University of Iowa Hospitals and Clinics, 200 Hawkins Drive 2520 JCP, Iowa City, IA 52242, USA
    Exp Eye Res 79:465-76. 2004
    ..Furthermore, these data suggest a rationale for the use of octreotide as a prophylactic and therapeutic option in disease states that cause ocular neovascularization...
  12. ncbi request reprint 90Y-edotreotide for metastatic carcinoid refractory to octreotide
    David L Bushnell
    Department of Radiology, University of Iowa Roy J and Lucille A Carver College of Medicine, 200 Hawkins Dr, Iowa City, IA 52242, USA
    J Clin Oncol 28:1652-9. 2010
    ..The goal of this study was to evaluate the clinical effect of using (90)Y-edotreotide to treat symptomatic patients with carcinoid tumors...
  13. pmc Differentiation of small bowel and pancreatic neuroendocrine tumors by gene-expression profiling
    Jennifer C Carr
    Department of Surgery, University of Iowa Carver College of Medicine, Iowa City, IA 52242 1086, USA
    Surgery 152:998-1007. 2012
    ..Because knowledge of the primary site has important implications for treatment, we set out to define gene-expression profiles to differentiate between small-bowel NETs (SBNETs) and pancreatic NETs (PNETs)...
  14. pmc A DOTA-peptide conjugate by copper-free click chemistry
    Molly E Martin
    Department of Pediatrics, Carver College of Medicine, University of Iowa, 4235 MERF 375 Newton Road, Iowa City, IA 52242, USA
    Bioorg Med Chem Lett 20:4805-7. 2010
    ..The resulting conjugate was radiolabeled with (111)In to afford a potential targeted molecular imaging agent with high specific activity and an excellent radiochemical purity...
  15. ncbi request reprint A lymphocyte-generated fragment of vasoactive intestinal peptide with VPAC1 agonist activity and VPAC2 antagonist effects
    Monica A Summers
    Depaertment of Pediatrics, University of Iowa City, Iowa City, Iowa 52242, USA
    J Pharmacol Exp Ther 306:638-45. 2003
    ..Lymphoblasts did not hydrolyze VIP4-28 to a form with VPAC1 antagonist activity. VIP4-28 thus is a lymphocyte-generated VIP fragment with potent agonist activity for VPAC1 and potent antagonist activity for VPAC2...
  16. ncbi request reprint Prognostic value of quantifying apoptosis factor expression in favorable histology wilms tumors
    Michal A Miller
    Department of Surgery, University of Iowa, Iowa City, Iowa 52242, USA
    J Pediatr Hematol Oncol 27:11-4. 2005
    ..Although survivin mRNA was present at markedly greater levels than in normal kidney, none of the factors assayed independently or as a ratio was associated with stage of disease or risk for tumor recurrence in this group of tumors...
  17. ncbi request reprint Development of a highly sensitive and specific carboxy-terminal human pancreastatin assay to monitor neuroendocrine tumor behavior
    Thomas M O'Dorisio
    Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, USA
    Pancreas 39:611-6. 2010
    ..Existing pancreastatin assays, which depend on antibodies that cross-react in varying percents with the larger prohormone, may lack sensitivity and specificity to detect small changes in neuroendocrine tumor volume...
  18. doi request reprint Incidence, survival, and prevalence of neuroendocrine tumors versus neuroblastoma in children and young adults: nine standard SEER registries, 1975-2006
    Pournima Navalkele
    Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, Iowa, USA
    Pediatr Blood Cancer 56:50-7. 2011
    ..Outcomes were compared with neuroblastoma, a pediatric malignancy that shares several biomarkers...
  19. ncbi request reprint Atypical teratoid/rhabdoid tumor case report: treatment with surgical excision, radiation therapy, and alternative medicines
    Terese L Howes
    Department of Radiation Oncology, University of Iowa Hospitals and Clinics, W 189 Z GH, Iowa City, IA 52242, USA
    J Neurooncol 72:85-8. 2005
    ..The patient has been maintained on an extensive regimen of alternative therapies since completion of radiation therapy...
  20. ncbi request reprint Potential increased tumor-dose delivery with combined 131I-MIBG and 90Y-DOTATOC treatment in neuroendocrine tumors: a theoretic model
    Mark T Madsen
    Department of Radiology, University of Iowa, 200 Hawkins Dr, Iowa City, 52242, USA
    J Nucl Med 47:660-7. 2006
    ..In this paper, we investigate the conditions in which combined-agent therapy is advantageous and we quantify the expected tumor-dose gain...
  21. doi request reprint Neuroendocrine tumors in children and young adults: rare or not so rare
    Marie Ellen Sarvida
    Department of Pediatrics, Ronald McDonald Children s Hospital, Loyola University Medical Center, 2160 South First Avenue, Maywood, IL 60153, USA
    Endocrinol Metab Clin North Am 40:65-80, vii. 2011
    ..This article summarizes the epidemiology and reviews the diagnostic and therapeutic challenges of NETs in children and youth, noting especially those NETs that are more prevalent in young people than in older adults...
  22. ncbi request reprint Somatostatin receptor scintigraphy in surveillance of pediatric brain malignancies
    Geetika Khanna
    Department of Radiology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA
    Pediatr Blood Cancer 50:561-6. 2008
    ..This retrospective study evaluates the role of SRS in post-treatment surveillance of PBTs...
  23. ncbi request reprint ECM1 expression in thyroid tumors--a comparison of real-time RT-PCR and IHC
    Geeta Lal
    Department of Surgery, Section of Surgical Oncology and Endocrine Surgery University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA
    J Surg Res 149:62-8. 2008
    ..The purpose of the current study is to evaluate and compare ECM1 expression by real-time RT-PCR with immunohistochemistry (IHC) as diagnostic aids in thyroid neoplasms...
  24. doi request reprint The role of vasoactive intestinal peptide (VIP) in megakaryocyte proliferation
    Chaneun Nam
    Department of Pediatrics, Division of Hematology Oncology, Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA
    J Mol Neurosci 37:160-7. 2009
    ..001), thus increasing potential for proplatelet formation. These results suggest that VIP acts in an autocrine fashion via VPAC1 to inhibit megakaryocyte proliferation and induce proplatelet formation...
  25. ncbi request reprint Human plasmacytoid dendritic cell function: inhibition of IFN-alpha secretion and modulation of immune phenotype by vasoactive intestinal peptide
    Dorit Fabricius
    Department of Pediatrics, Holden Comprehensive Cancer Center, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 177:5920-7. 2006
    ..VIP may thus be involved in the modulation of immune responses to viral infections as well as in the maintenance of immune tolerance...
  26. pmc 2-deoxy-D-glucose induces oxidative stress and cell killing in human neuroblastoma cells
    Damon C Shutt
    Free Radical and Radiation Biology Program, Department of Radiation Oncology and Division of Hematology and Oncology, Department of Pediatrics, Holden Comprehensive Cancer Center, University of Iowa Carver College of Medicine, Iowa City, IA, USA
    Cancer Biol Ther 9:853-61. 2010
    ..These results support the hypothesis that inhibitors of glucose metabolism could represent useful adjuvants in the treatment of neuroblastoma by selectively enhancing metabolic oxidative stress...

Research Grants12

  1. RADIORECEPTOR GUIDED SURGERY OF NEURAL CREST TUMORS
    M O DORISIO; Fiscal Year: 2001
    ..Patients will be recruited from our nationally recognized, multidisciplinary neuroendocrine tumor clinic to participate in this trial of image guided surgical therapy. ..
  2. PHASE I TRIAL OF 90Y-DOTA-TYR3-OCTREOTIDE IN CHILDREN W*
    M SUE O DORISIO; Fiscal Year: 2007
    ..Abstract Not Provided. ..
  3. Hemotologic and Oncologic Diseases of Childhood
    M SUE O DORISIO; Fiscal Year: 2007
    ..We propose didactic sessions, group discussions and additional individual mentoring opportunities to support women seeking academic careers. (END OF ABSTRACT) ..
  4. 90Y-DOTA-TYR3-OCTREOTIDE IN CHILDREN W/SOMATOSTATIN REC*
    M O DORISIO; Fiscal Year: 2005
    ..Abstract Not Provided. ..
  5. PHASE I TRIAL OF 90Y-DOTA-TYR3-OCTREOTIDE IN CHILDREN W*
    M O DORISIO; Fiscal Year: 2006
    ..Abstract Not Provided. ..
  6. PHASE I TRIAL OF 90Y-DOTA-TYR3-OCTREOTIDE IN CHILDREN W*
    M O DORISIO; Fiscal Year: 2005
    ..Abstract Not Provided. ..
  7. Academic Public Private Partnership Program
    M O DORISIO; Fiscal Year: 2004
    ..abstract_text> ..
  8. RADIORECEPTOR GUIDED SURGERY OF NEURAL CREST TUMORS
    M O DORISIO; Fiscal Year: 2003
    ..Patients will be recruited from our nationally recognized, multidisciplinary neuroendocrine tumor clinic to participate in this trial of image guided surgical therapy. ..
  9. RADIORECEPTOR GUIDED SURGERY OF NEURAL CREST TUMORS
    M O DORISIO; Fiscal Year: 2002
    ..Patients will be recruited from our nationally recognized, multidisciplinary neuroendocrine tumor clinic to participate in this trial of image guided surgical therapy. ..
  10. Phase I Trial of 90Y Octreotide in Childhood Solid Tumor
    M O DORISIO; Fiscal Year: 2002
    ..The sst2 expression will be compared with tumor dosimetry and tumor response in order to determine if Real-time RT-PCR analysis of tumor receptor expression can predict response. ..