M Sue O'Dorisio

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. ncbi Age-dependent levels of plasma neuropeptides in normal children
    M Sue O'Dorisio
    Department of Pediatrics, University of Iowa, Iowa City, IA, USA
    Regul Pept 109:189-92. 2002
  2. ncbi Combining anatomic and molecularly targeted imaging in the diagnosis and surveillance of embryonal tumors of the nervous and endocrine systems in children
    M Sue O'Dorisio
    Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Cancer Metastasis Rev 27:665-77. 2008
  3. ncbi Phase I trial of 90Y-DOTATOC therapy in children and young adults with refractory solid tumors that express somatostatin receptors
    Yusuf Menda
    Department of Radiology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA
    J Nucl Med 51:1524-31. 2010
  4. ncbi Improved synthesis and biological evaluation of chelator-modified α-MSH analogs prepared by copper-free click chemistry
    Nicholas J Baumhover
    Department of Radiology, Carver College of Medicine, The University of Iowa, 500 Newton Road, ML B180, Iowa City, IA 52242, USA
    Bioorg Med Chem Lett 21:5757-61. 2011
  5. ncbi Utility of radiolabeled somatostatin receptor analogues for staging/restaging and treatment of somatostatin receptor-positive pediatric tumors
    Geetika Khanna
    Department of Radiology, University of Iowa Carver College of Medicine, 200 Hawkins Drive, Iowa City, Iowa 52242, USA
    Oncologist 13:382-9. 2008
  6. ncbi 90Y-edotreotide for metastatic carcinoid refractory to octreotide
    David L Bushnell
    Department of Radiology, University of Iowa Roy J and Lucille A Carver College of Medicine, 200 Hawkins Dr, Iowa City, IA 52242, USA
    J Clin Oncol 28:1652-9. 2010
  7. ncbi A DOTA-peptide conjugate by copper-free click chemistry
    Molly E Martin
    Department of Pediatrics, Carver College of Medicine, University of Iowa, 4235 MERF 375 Newton Road, Iowa City, IA 52242, USA
    Bioorg Med Chem Lett 20:4805-7. 2010
  8. ncbi Differentiation of small bowel and pancreatic neuroendocrine tumors by gene-expression profiling
    Jennifer C Carr
    Department of Surgery, University of Iowa Carver College of Medicine, Iowa City, IA 52242 1086, USA
    Surgery 152:998-1007. 2012
  9. ncbi Development of a highly sensitive and specific carboxy-terminal human pancreastatin assay to monitor neuroendocrine tumor behavior
    Thomas M O'Dorisio
    Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, USA
    Pancreas 39:611-6. 2010
  10. ncbi Incidence, survival, and prevalence of neuroendocrine tumors versus neuroblastoma in children and young adults: nine standard SEER registries, 1975-2006
    Pournima Navalkele
    Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, Iowa, USA
    Pediatr Blood Cancer 56:50-7. 2011

Research Grants

  1. PHASE I TRIAL OF 90Y-DOTA-TYR3-OCTREOTIDE IN CHILDREN W*
    M SUE O DORISIO; Fiscal Year: 2007
  2. Hemotologic and Oncologic Diseases of Childhood
    M SUE O DORISIO; Fiscal Year: 2007
  3. Academic Public Private Partnership Program
    M O DORISIO; Fiscal Year: 2004
  4. RADIORECEPTOR GUIDED SURGERY OF NEURAL CREST TUMORS
    M O DORISIO; Fiscal Year: 2003
  5. Phase I Trial of 90Y Octreotide in Childhood Solid Tumor
    M O DORISIO; Fiscal Year: 2002

Collaborators

Detail Information

Publications16

  1. ncbi Age-dependent levels of plasma neuropeptides in normal children
    M Sue O'Dorisio
    Department of Pediatrics, University of Iowa, Iowa City, IA, USA
    Regul Pept 109:189-92. 2002
    ..Octreotide doses of 2-3 microg/kg daily resulted in a 40-60% decrease in plasma levels of IGF-1, pancreastatin and GRP. These results are the first publication of plasma neuropeptide levels in normal children...
  2. ncbi Combining anatomic and molecularly targeted imaging in the diagnosis and surveillance of embryonal tumors of the nervous and endocrine systems in children
    M Sue O'Dorisio
    Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Cancer Metastasis Rev 27:665-77. 2008
    ....
  3. ncbi Phase I trial of 90Y-DOTATOC therapy in children and young adults with refractory solid tumors that express somatostatin receptors
    Yusuf Menda
    Department of Radiology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA
    J Nucl Med 51:1524-31. 2010
    ..The purpose of this study was to conduct a phase I trial of (90)Y-DOTATOC to determine the dose-toxicity profile in children and young adults with somatostatin receptor-positive tumors...
  4. ncbi Improved synthesis and biological evaluation of chelator-modified α-MSH analogs prepared by copper-free click chemistry
    Nicholas J Baumhover
    Department of Radiology, Carver College of Medicine, The University of Iowa, 500 Newton Road, ML B180, Iowa City, IA 52242, USA
    Bioorg Med Chem Lett 21:5757-61. 2011
    ..The resulting bioconjugates bind with high affinity and specificity to their cell-surface receptor targets in vitro and appear stable to degradation in mouse serum over 3h of incubation at 37°C...
  5. ncbi Utility of radiolabeled somatostatin receptor analogues for staging/restaging and treatment of somatostatin receptor-positive pediatric tumors
    Geetika Khanna
    Department of Radiology, University of Iowa Carver College of Medicine, 200 Hawkins Drive, Iowa City, Iowa 52242, USA
    Oncologist 13:382-9. 2008
    ..Finally, we discuss the potential role of somatostatin receptor-targeted radiotherapy for improving the duration and quality of life of children with these tumors...
  6. ncbi 90Y-edotreotide for metastatic carcinoid refractory to octreotide
    David L Bushnell
    Department of Radiology, University of Iowa Roy J and Lucille A Carver College of Medicine, 200 Hawkins Dr, Iowa City, IA 52242, USA
    J Clin Oncol 28:1652-9. 2010
    ..The goal of this study was to evaluate the clinical effect of using (90)Y-edotreotide to treat symptomatic patients with carcinoid tumors...
  7. ncbi A DOTA-peptide conjugate by copper-free click chemistry
    Molly E Martin
    Department of Pediatrics, Carver College of Medicine, University of Iowa, 4235 MERF 375 Newton Road, Iowa City, IA 52242, USA
    Bioorg Med Chem Lett 20:4805-7. 2010
    ..The resulting conjugate was radiolabeled with (111)In to afford a potential targeted molecular imaging agent with high specific activity and an excellent radiochemical purity...
  8. ncbi Differentiation of small bowel and pancreatic neuroendocrine tumors by gene-expression profiling
    Jennifer C Carr
    Department of Surgery, University of Iowa Carver College of Medicine, Iowa City, IA 52242 1086, USA
    Surgery 152:998-1007. 2012
    ..Because knowledge of the primary site has important implications for treatment, we set out to define gene-expression profiles to differentiate between small-bowel NETs (SBNETs) and pancreatic NETs (PNETs)...
  9. ncbi Development of a highly sensitive and specific carboxy-terminal human pancreastatin assay to monitor neuroendocrine tumor behavior
    Thomas M O'Dorisio
    Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, USA
    Pancreas 39:611-6. 2010
    ..Existing pancreastatin assays, which depend on antibodies that cross-react in varying percents with the larger prohormone, may lack sensitivity and specificity to detect small changes in neuroendocrine tumor volume...
  10. ncbi Incidence, survival, and prevalence of neuroendocrine tumors versus neuroblastoma in children and young adults: nine standard SEER registries, 1975-2006
    Pournima Navalkele
    Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, Iowa, USA
    Pediatr Blood Cancer 56:50-7. 2011
    ..Outcomes were compared with neuroblastoma, a pediatric malignancy that shares several biomarkers...
  11. ncbi Potential increased tumor-dose delivery with combined 131I-MIBG and 90Y-DOTATOC treatment in neuroendocrine tumors: a theoretic model
    Mark T Madsen
    Department of Radiology, University of Iowa, 200 Hawkins Dr, Iowa City, 52242, USA
    J Nucl Med 47:660-7. 2006
    ..In this paper, we investigate the conditions in which combined-agent therapy is advantageous and we quantify the expected tumor-dose gain...
  12. ncbi Neuroendocrine tumors in children and young adults: rare or not so rare
    Marie Ellen Sarvida
    Department of Pediatrics, Ronald McDonald Children s Hospital, Loyola University Medical Center, 2160 South First Avenue, Maywood, IL 60153, USA
    Endocrinol Metab Clin North Am 40:65-80, vii. 2011
    ..This article summarizes the epidemiology and reviews the diagnostic and therapeutic challenges of NETs in children and youth, noting especially those NETs that are more prevalent in young people than in older adults...
  13. ncbi Somatostatin receptor scintigraphy in surveillance of pediatric brain malignancies
    Geetika Khanna
    Department of Radiology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA
    Pediatr Blood Cancer 50:561-6. 2008
    ..This retrospective study evaluates the role of SRS in post-treatment surveillance of PBTs...
  14. ncbi ECM1 expression in thyroid tumors--a comparison of real-time RT-PCR and IHC
    Geeta Lal
    Department of Surgery, Section of Surgical Oncology and Endocrine Surgery University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA
    J Surg Res 149:62-8. 2008
    ..The purpose of the current study is to evaluate and compare ECM1 expression by real-time RT-PCR with immunohistochemistry (IHC) as diagnostic aids in thyroid neoplasms...
  15. ncbi The role of vasoactive intestinal peptide (VIP) in megakaryocyte proliferation
    Chaneun Nam
    Department of Pediatrics, Division of Hematology Oncology, Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA
    J Mol Neurosci 37:160-7. 2009
    ..001), thus increasing potential for proplatelet formation. These results suggest that VIP acts in an autocrine fashion via VPAC1 to inhibit megakaryocyte proliferation and induce proplatelet formation...
  16. ncbi 2-deoxy-D-glucose induces oxidative stress and cell killing in human neuroblastoma cells
    Damon C Shutt
    Free Radical and Radiation Biology Program, Department of Radiation Oncology and Division of Hematology and Oncology, Department of Pediatrics, Holden Comprehensive Cancer Center, University of Iowa Carver College of Medicine, Iowa City, IA, USA
    Cancer Biol Ther 9:853-61. 2010
    ..These results support the hypothesis that inhibitors of glucose metabolism could represent useful adjuvants in the treatment of neuroblastoma by selectively enhancing metabolic oxidative stress...

Research Grants12

  1. PHASE I TRIAL OF 90Y-DOTA-TYR3-OCTREOTIDE IN CHILDREN W*
    M SUE O DORISIO; Fiscal Year: 2007
    ..Abstract Not Provided. ..
  2. Hemotologic and Oncologic Diseases of Childhood
    M SUE O DORISIO; Fiscal Year: 2007
    ..We propose didactic sessions, group discussions and additional individual mentoring opportunities to support women seeking academic careers. (END OF ABSTRACT) ..
  3. Academic Public Private Partnership Program
    M O DORISIO; Fiscal Year: 2004
    ..abstract_text> ..
  4. RADIORECEPTOR GUIDED SURGERY OF NEURAL CREST TUMORS
    M O DORISIO; Fiscal Year: 2003
    ..Patients will be recruited from our nationally recognized, multidisciplinary neuroendocrine tumor clinic to participate in this trial of image guided surgical therapy. ..
  5. Phase I Trial of 90Y Octreotide in Childhood Solid Tumor
    M O DORISIO; Fiscal Year: 2002
    ..The sst2 expression will be compared with tumor dosimetry and tumor response in order to determine if Real-time RT-PCR analysis of tumor receptor expression can predict response. ..