Aoife O'Donovan

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi Altered inflammatory activity associated with reduced hippocampal volume and more severe posttraumatic stress symptoms in Gulf War veterans
    Aoife O'Donovan
    University of California, San Francisco, CA, USA San Francisco Veteran s Affairs Medical Center and Northern California Institute for Research and Education, San Francisco, CA, USA Electronic address
    Psychoneuroendocrinology 51:557-66. 2015
  2. pmc Elevated risk for autoimmune disorders in iraq and afghanistan veterans with posttraumatic stress disorder
    Aoife O'Donovan
    Department of Psychiatry, University of California, San Francisco, California San Francisco Veterans Affairs Medical Center and Northern California Institute for Research and Education, San Francisco, California Electronic address
    Biol Psychiatry 77:365-74. 2015
  3. doi Suicidal ideation is associated with elevated inflammation in patients with major depressive disorder
    Aoife O'Donovan
    School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland
    Depress Anxiety 30:307-14. 2013
  4. doi Exaggerated neurobiological sensitivity to threat as a mechanism linking anxiety with increased risk for diseases of aging
    Aoife O'Donovan
    Department of Psychiatry, University of California, San Francisco, CA, USA
    Neurosci Biobehav Rev 37:96-108. 2013
  5. pmc Lifetime exposure to traumatic psychological stress is associated with elevated inflammation in the Heart and Soul Study
    Aoife O'Donovan
    Department of Psychiatry, University of California, San Francisco, CA 94143 0848, USA
    Brain Behav Immun 26:642-9. 2012
  6. pmc Stress appraisals and cellular aging: a key role for anticipatory threat in the relationship between psychological stress and telomere length
    Aoife O'Donovan
    Department of Psychiatry, University of California, San Francisco, CA, USA
    Brain Behav Immun 26:573-9. 2012
  7. doi Clinical anxiety, cortisol and interleukin-6: evidence for specificity in emotion-biology relationships
    Aoife O'Donovan
    Department of Psychiatry and Mental Health Research, St Vincent s University Hospital, University College Dublin, Ireland
    Brain Behav Immun 24:1074-7. 2010
  8. pmc Transcriptional control of monocyte gene expression in post-traumatic stress disorder
    Aoife O'Donovan
    Veteran s Affairs Medical Center, San Francisco, CA 94121, USA
    Dis Markers 30:123-32. 2011
  9. pmc Cumulative inflammatory load is associated with short leukocyte telomere length in the Health, Aging and Body Composition Study
    Aoife O'Donovan
    Department of Psychiatry, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 6:e19687. 2011
  10. pmc Childhood trauma associated with short leukocyte telomere length in posttraumatic stress disorder
    Aoife O'Donovan
    Department of Psychiatry, University of California, San Francisco, California Northern California Institute for Research and Education, San Francisco, California, USA
    Biol Psychiatry 70:465-71. 2011

Collaborators

Detail Information

Publications23

  1. doi Altered inflammatory activity associated with reduced hippocampal volume and more severe posttraumatic stress symptoms in Gulf War veterans
    Aoife O'Donovan
    University of California, San Francisco, CA, USA San Francisco Veteran s Affairs Medical Center and Northern California Institute for Research and Education, San Francisco, CA, USA Electronic address
    Psychoneuroendocrinology 51:557-66. 2015
    ..However, few studies have examined associations between inflammatory markers and hippocampal volume, and none have examined these associations in the context of PTSD...
  2. pmc Elevated risk for autoimmune disorders in iraq and afghanistan veterans with posttraumatic stress disorder
    Aoife O'Donovan
    Department of Psychiatry, University of California, San Francisco, California San Francisco Veterans Affairs Medical Center and Northern California Institute for Research and Education, San Francisco, California Electronic address
    Biol Psychiatry 77:365-74. 2015
    ..Posttraumatic stress disorder (PTSD) is associated with endocrine and immune abnormalities that could increase risk for autoimmune disorders. However, little is known about the risk for autoimmune disorders among individuals with PTSD...
  3. doi Suicidal ideation is associated with elevated inflammation in patients with major depressive disorder
    Aoife O'Donovan
    School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland
    Depress Anxiety 30:307-14. 2013
    ..However, greater severity of depression and the medical lethality of suicide attempts could account for such elevated inflammation in suicide attempters and suicide completers...
  4. doi Exaggerated neurobiological sensitivity to threat as a mechanism linking anxiety with increased risk for diseases of aging
    Aoife O'Donovan
    Department of Psychiatry, University of California, San Francisco, CA, USA
    Neurosci Biobehav Rev 37:96-108. 2013
    ..Chronic inflammation, in turn, increases risk for diseases of aging. Exaggerated neurobiological sensitivity to threat may thus be a treatment target for reducing disease risk in anxious individuals...
  5. pmc Lifetime exposure to traumatic psychological stress is associated with elevated inflammation in the Heart and Soul Study
    Aoife O'Donovan
    Department of Psychiatry, University of California, San Francisco, CA 94143 0848, USA
    Brain Behav Immun 26:642-9. 2012
    ..High lifetime exposure to traumatic stress may contribute to an accelerated rate of CVD progression through elevated inflammation...
  6. pmc Stress appraisals and cellular aging: a key role for anticipatory threat in the relationship between psychological stress and telomere length
    Aoife O'Donovan
    Department of Psychiatry, University of California, San Francisco, CA, USA
    Brain Behav Immun 26:573-9. 2012
    ..Exaggerated anticipatory threat appraisals may be a common and modifiable psychological mechanism of psychological stress effects on cellular aging...
  7. doi Clinical anxiety, cortisol and interleukin-6: evidence for specificity in emotion-biology relationships
    Aoife O'Donovan
    Department of Psychiatry and Mental Health Research, St Vincent s University Hospital, University College Dublin, Ireland
    Brain Behav Immun 24:1074-7. 2010
    ..Conversely, the groups had equivalent levels of CRP in all analyses. Results are indicative of anxiety-specific effects on inflammatory activity, and highlight a pathway by which anxiety may increase risk for inflammatory diseases...
  8. pmc Transcriptional control of monocyte gene expression in post-traumatic stress disorder
    Aoife O'Donovan
    Veteran s Affairs Medical Center, San Francisco, CA 94121, USA
    Dis Markers 30:123-32. 2011
    ..Altered transcriptional control of monocyte gene expression could contribute to exaggerated inflammatory activity in PTSD...
  9. pmc Cumulative inflammatory load is associated with short leukocyte telomere length in the Health, Aging and Body Composition Study
    Aoife O'Donovan
    Department of Psychiatry, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 6:e19687. 2011
    ..However, in spite of the proposed causal links between inflammatory activity and LTL, there is little clinical evidence in support of their covariation and interaction...
  10. pmc Childhood trauma associated with short leukocyte telomere length in posttraumatic stress disorder
    Aoife O'Donovan
    Department of Psychiatry, University of California, San Francisco, California Northern California Institute for Research and Education, San Francisco, California, USA
    Biol Psychiatry 70:465-71. 2011
    ..We also examined childhood trauma, a risk factor for both PTSD and short LTL, as a potential contributor to short LTL in PTSD...
  11. pmc Physical activity moderates effects of stressor-induced rumination on cortisol reactivity
    Eli Puterman
    Department of Psychiatry, University of California, 3333 California Street, Suite 465, San Francisco, CA 94118, USA
    Psychosom Med 73:604-11. 2011
    ....
  12. pmc Good stress, bad stress and oxidative stress: insights from anticipatory cortisol reactivity
    Kirstin Aschbacher
    Department of Psychiatry, University of California San Francisco, San Francisco, CA, USA The Institute for Integrative Health, Baltimore, MD, USA Electronic address
    Psychoneuroendocrinology 38:1698-708. 2013
    ..It also supports the less studied model of 'eustress' - that manageable levels of life stress may enhance psychobiological resilience to oxidative damage...
  13. pmc Suppressed monocyte gene expression profile in men versus women with PTSD
    Thomas C Neylan
    Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Brain Behav Immun 25:524-31. 2011
    ..Changes in immune cell gene expression may contribute to medical morbidity in PTSD...
  14. pmc Hyperinsulinemic response to oral glucose challenge in individuals with posttraumatic stress disorder
    Madhu N Rao
    San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Francisco, CA, USA Electronic address
    Psychoneuroendocrinology 49:171-81. 2014
    ..Secondarily, we assessed potential mediators such as sleep, cortisol and adiponectin...
  15. doi Anger is associated with increased IL-6 stress reactivity in women, but only among those low in social support
    Eli Puterman
    Department of Psychiatry, School of Medicine, University of California, San Francisco, CA, USA
    Int J Behav Med 21:936-45. 2014
    ..Affective states (anger, fear, and anxiety) predict interleukin-6 (IL-6) reactivity to acute stress; in turn, this reactivity predicts risk of cardiovascular disease progression...
  16. pmc Shorter leukocyte telomere length in midlife women with poor sleep quality
    Aric A Prather
    Robert Wood Johnson Foundation Health and Society Scholars Program, Center for Health and Community, University of California San Francisco, 3333 California Street, Suite 465, San Francisco, CA 94118, USA
    J Aging Res 2011:721390. 2011
    ..Conclusions. This study provides the first evidence that poor sleep quality explains significant variation in LTL, a marker of cellular aging...
  17. pmc Educational attainment and late life telomere length in the Health, Aging and Body Composition Study
    Nancy Adler
    University of California, San Francisco, USA
    Brain Behav Immun 27:15-21. 2013
    ..10). This study provides the first demonstration of an association between educational attainment and LTL in a US population where higher education appears to have a protective effect against telomere shortening, particularly in blacks...
  18. pmc Black sheep get the blues: a psychobiological model of social rejection and depression
    George M Slavich
    Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94143 0848, USA
    Neurosci Biobehav Rev 35:39-45. 2010
    ..This response also may be moderated by several factors, including prior life stress, prior depression, and genes implicated in stress reactivity...
  19. pmc The power of exercise: buffering the effect of chronic stress on telomere length
    Eli Puterman
    Department of Psychiatry, University of California San Francisco, San Francisco, California, USA
    PLoS ONE 5:e10837. 2010
    ..We predicted that chronic stress would be related to short telomere length (TL) in sedentary individuals, whereas in those who exercise, stress would not have measurable effects on telomere shortening...
  20. doi Access to social support in life and in the laboratory: combined impact on cardiovascular reactivity to stress and state anxiety
    Aoife O'Donovan
    Department of Psychiatry, University College Dublin, Ireland
    J Health Psychol 13:1147-56. 2008
    ..05). Self-reported anxiety post-stressor was significantly higher when functional support was not mentioned (p = .03)...
  21. doi Anxiety is associated with higher levels of global DNA methylation and altered expression of epigenetic and interleukin-6 genes
    Therese M Murphy
    aMedical School, University of Exeter, Royal Devon and Exeter Hospital, Exeter, UK bDepartment of Psychiatry, San Francisco and San Francisco VA Medical Center, University of California, USA cDepartment of Psychiatry and Mental Health Research, Education and Research Centre, St Vincent s University Hospital dThe UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, UCD School of Medicine and Medical Science, Dublin eSchool of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
    Psychiatr Genet 25:71-8. 2015
    ..However, the relationship between IL-6 and DNA methyltransferases (DNMTs) and EZH2 expression has not previously been examined in anxious individuals...
  22. doi Sex differences in neurosteroid and hormonal responses to metyrapone in posttraumatic stress disorder
    Sabra S Inslicht
    Stress and Health Research Program, San Francisco VA Medical Center, 4150 Clement St 116P, San Francisco, CA, 94121, USA
    Psychopharmacology (Berl) 231:3581-95. 2014
    ..The potential that progesterone and allopregnanolone reactivity modulate HPA axis responses and account for sex differences in PTSD has not been previously examined...
  23. doi Quality of life predicts outcome in a heart failure disease management program
    Christina O'Loughlin
    Department of Cardiology, St Vincent s University Hospital, Dublin, Ireland
    Int J Cardiol 139:60-7. 2010
    ....