MARTHA E O'DONNELL

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Intravenous HOE-642 reduces brain edema and Na uptake in the rat permanent middle cerebral artery occlusion model of stroke: evidence for participation of the blood-brain barrier Na/H exchanger
    MARTHA E O'DONNELL
    Department of Physiology and Membrane Biology, School of Medicine, University of California, Davis, California 95616, USA
    J Cereb Blood Flow Metab 33:225-34. 2013
  2. ncbi request reprint Bumetanide inhibition of the blood-brain barrier Na-K-Cl cotransporter reduces edema formation in the rat middle cerebral artery occlusion model of stroke
    MARTHA E O'DONNELL
    Department of Physiology and Membrane Biology, School of Medicine, University of California, Davis 95616, USA
    J Cereb Blood Flow Metab 24:1046-56. 2004
  3. ncbi request reprint The role of the blood-brain barrier Na-K-2Cl cotransporter in stroke
    MARTHA E O'DONNELL
    Department of Physiology and Membrane Biology, University of California, One Shields Ave, Davis, CA 95616, USA
    Adv Exp Med Biol 559:67-75. 2004
  4. ncbi request reprint Estradiol reduces activity of the blood-brain barrier Na-K-Cl cotransporter and decreases edema formation in permanent middle cerebral artery occlusion
    MARTHA E O'DONNELL
    Department of Physiology and Membrane Biology, School of Medicine, University of California, Davis, California 95616, USA
    J Cereb Blood Flow Metab 26:1234-49. 2006
  5. ncbi request reprint Arginine vasopressin stimulation of cerebral microvascular endothelial cell Na-K-Cl cotransporter activity is V1 receptor and [Ca] dependent
    MARTHA E O'DONNELL
    Department of Physiology and Membrane Biology, University of California, One Shields Ave, Davis, CA 95616, USA
    Am J Physiol Cell Physiol 289:C283-92. 2005
  6. ncbi request reprint Hypoxia effects on cell volume and ion uptake of cerebral microvascular endothelial cells
    Julien Brillault
    Department of Physiology and Membrane Biology, University of California, Davis, CA 95616, USA
    Am J Physiol Cell Physiol 294:C88-96. 2008
  7. pmc Effects of estradiol on ischemic factor-induced astrocyte swelling and AQP4 protein abundance
    Jennifer M Rutkowsky
    Department of Physiology and Membrane Biology, University of California, Davis, California 95616, USA
    Am J Physiol Cell Physiol 301:C204-12. 2011
  8. ncbi request reprint Moderate-to-severe ischemic conditions increase activity and phosphorylation of the cerebral microvascular endothelial cell Na+-K+-Cl- cotransporter
    Shahin Foroutan
    Dept of Physiology and Membrane Biology, School of Medicine, Univ of California, One Shields Ave, Davis, CA 95616, USA
    Am J Physiol Cell Physiol 289:C1492-501. 2005
  9. pmc Cerebral metabolic alterations in rats with diabetic ketoacidosis: effects of treatment with insulin and intravenous fluids and effects of bumetanide
    Nicole Glaser
    Department of Pediatrics, University of California, Davis, California, USA
    Diabetes 59:702-9. 2010
  10. pmc Cerebral microvascular endothelial cell Na/H exchange: evidence for the presence of NHE1 and NHE2 isoforms and regulation by arginine vasopressin
    Tina I Lam
    Department of Physiology and Membrane Biology, University of California, Davis, CA 95616, USA
    Am J Physiol Cell Physiol 297:C278-89. 2009

Research Grants

  1. Blood-Brain Barrier in Cerebral Ischemia
    MARTHA O DONNELL; Fiscal Year: 2002
  2. BLOOD-BRAIN BARRIER ION TRANSPORT IN CEREBRAL ISCHEMIA
    MARTHA O DONNELL; Fiscal Year: 2009
  3. BLOOD-BRAIN BARRIER ION TRANSPORT IN CEREBRAL ISCHEMIA
    MARTHA O DONNELL; Fiscal Year: 2007
  4. Blood-Brain Barrier in Cerebral Ischemia
    MARTHA O DONNELL; Fiscal Year: 2005
  5. 2004 Barriers of CNS
    MARTHA O DONNELL; Fiscal Year: 2004
  6. Blood-Brain Barrier in Cerebral Ischemia
    MARTHA O DONNELL; Fiscal Year: 2004
  7. Blood-Brain Barrier in Cerebral Ischemia
    MARTHA O DONNELL; Fiscal Year: 2003
  8. Blood-Brain-CSF Barriers, CNS Homeostasis, Drug Delivery
    MARTHA O DONNELL; Fiscal Year: 2002
  9. BLOOD-BRAIN BARRIER ION TRANSPORT IN CEREBRAL ISCHEMIA
    MARTHA E O apos DONNELL; Fiscal Year: 2010

Collaborators

  • Phyllis M Wise
  • Heike Wulff
  • Steven Anderson
  • MARTHA O DONNELL
  • Breanna K Wallace
  • Tina I Lam
  • Natalie Yuen
  • MARTHA E O apos DONNELL
  • Nicole Glaser
  • Shahin Foroutan
  • Jennifer M Rutkowsky
  • Julien Brillault
  • Yi Je Chen
  • Daniel J Tancredi
  • Elaine Chang
  • Nicholas R Klug
  • Karen A Jelks
  • Silke Bodendiek
  • Girija Raman
  • Abdul I Barakat
  • Biff Forbush

Detail Information

Publications17

  1. pmc Intravenous HOE-642 reduces brain edema and Na uptake in the rat permanent middle cerebral artery occlusion model of stroke: evidence for participation of the blood-brain barrier Na/H exchanger
    MARTHA E O'DONNELL
    Department of Physiology and Membrane Biology, School of Medicine, University of California, Davis, California 95616, USA
    J Cereb Blood Flow Metab 33:225-34. 2013
    ..These findings support the hypothesis that edema formation and brain Na uptake during the early hours of cerebral ischemia involve BBB Na/H exchanger activity as well as Na-K-Cl cotransporter activity...
  2. ncbi request reprint Bumetanide inhibition of the blood-brain barrier Na-K-Cl cotransporter reduces edema formation in the rat middle cerebral artery occlusion model of stroke
    MARTHA E O'DONNELL
    Department of Physiology and Membrane Biology, School of Medicine, University of California, Davis 95616, USA
    J Cereb Blood Flow Metab 24:1046-56. 2004
    ..Bumetanide also reduced infarct size, determined by TTC staining. These findings suggest that a luminal BBB Na-K-Cl cotransporter contributes to edema formation during cerebral ischemia...
  3. ncbi request reprint The role of the blood-brain barrier Na-K-2Cl cotransporter in stroke
    MARTHA E O'DONNELL
    Department of Physiology and Membrane Biology, University of California, One Shields Ave, Davis, CA 95616, USA
    Adv Exp Med Biol 559:67-75. 2004
    ..Collectively, these findings suggest that the BBB Na-K-2Cl cotransporter does indeed substantially contribute to cerebral edema formation in stroke...
  4. ncbi request reprint Estradiol reduces activity of the blood-brain barrier Na-K-Cl cotransporter and decreases edema formation in permanent middle cerebral artery occlusion
    MARTHA E O'DONNELL
    Department of Physiology and Membrane Biology, School of Medicine, University of California, Davis, California 95616, USA
    J Cereb Blood Flow Metab 26:1234-49. 2006
    ..These findings support the hypothesis that estrogen attenuates stimulation of BBB Na-K-Cl cotransporter activity, reducing edema formation during stroke...
  5. ncbi request reprint Arginine vasopressin stimulation of cerebral microvascular endothelial cell Na-K-Cl cotransporter activity is V1 receptor and [Ca] dependent
    MARTHA E O'DONNELL
    Department of Physiology and Membrane Biology, University of California, One Shields Ave, Davis, CA 95616, USA
    Am J Physiol Cell Physiol 289:C283-92. 2005
    ..These findings support the hypothesis that AVP, through a V(1) receptor- and [Ca]-dependent mechanism, stimulates the BBB Na-K-Cl cotransporter to participate in ischemia-induced edema formation...
  6. ncbi request reprint Hypoxia effects on cell volume and ion uptake of cerebral microvascular endothelial cells
    Julien Brillault
    Department of Physiology and Membrane Biology, University of California, Davis, CA 95616, USA
    Am J Physiol Cell Physiol 294:C88-96. 2008
    ....
  7. pmc Effects of estradiol on ischemic factor-induced astrocyte swelling and AQP4 protein abundance
    Jennifer M Rutkowsky
    Department of Physiology and Membrane Biology, University of California, Davis, California 95616, USA
    Am J Physiol Cell Physiol 301:C204-12. 2011
    ....
  8. ncbi request reprint Moderate-to-severe ischemic conditions increase activity and phosphorylation of the cerebral microvascular endothelial cell Na+-K+-Cl- cotransporter
    Shahin Foroutan
    Dept of Physiology and Membrane Biology, School of Medicine, Univ of California, One Shields Ave, Davis, CA 95616, USA
    Am J Physiol Cell Physiol 289:C1492-501. 2005
    ..These findings support the hypothesis that hypoxia stimulation of the BBB Na+-K+-Cl- cotransporter contributes to ischemia-induced brain edema formation...
  9. pmc Cerebral metabolic alterations in rats with diabetic ketoacidosis: effects of treatment with insulin and intravenous fluids and effects of bumetanide
    Nicole Glaser
    Department of Pediatrics, University of California, Davis, California, USA
    Diabetes 59:702-9. 2010
    ..Recent data suggest that cerebral hypoperfusion and activation of cerebral ion transporters may be involved, but data describing cerebral metabolic alterations during DKA are lacking...
  10. pmc Cerebral microvascular endothelial cell Na/H exchange: evidence for the presence of NHE1 and NHE2 isoforms and regulation by arginine vasopressin
    Tina I Lam
    Department of Physiology and Membrane Biology, University of California, Davis, CA 95616, USA
    Am J Physiol Cell Physiol 297:C278-89. 2009
    ..Our findings support the hypothesis that a BBB Na/H exchanger, possibly NHE1 and/or NHE2, is stimulated during ischemia to participate in cerebral edema formation...
  11. pmc Ischemic factor-induced increases in cerebral microvascular endothelial cell Na/H exchange activity and abundance: evidence for involvement of ERK1/2 MAP kinase
    Natalie Yuen
    Department of Physiology and Membrane Biology, University of California, Davis, California
    Am J Physiol Cell Physiol 306:C931-42. 2014
    ..Furthermore, we found that these factors rapidly increase BBB ERK1/2 activity and that ERK1/2 inhibition reduces or abolishes ischemic factor stimulation of NKCC and NHE activities...
  12. pmc Ischemia-induced stimulation of cerebral microvascular endothelial cell Na-K-Cl cotransport involves p38 and JNK MAP kinases
    Breanna K Wallace
    Dept of Physiology and Membrane Biology, School of Medicine, Univ of California, Davis, CA 95616, USA
    Am J Physiol Cell Physiol 302:C505-17. 2012
    ..These findings support the hypothesis that ischemic factor stimulation of the BBB NKCC involves activation of p38 and JNK MAPKs...
  13. ncbi request reprint Shear stress and 17beta-estradiol modulate cerebral microvascular endothelial Na-K-Cl cotransporter and Na/H exchanger protein levels
    Elaine Chang
    Department of Mechanical and Aeronautical Engineering, University of California, Davis, California 95616, USA
    Am J Physiol Cell Physiol 294:C363-71. 2008
    ..They also support the hypothesis that estradiol attenuates edema formation in ischemic stroke in part by reducing the abundance of BBB NKCC protein...
  14. ncbi request reprint Bumetanide reduces cerebral edema formation in rats with diabetic ketoacidosis
    Tina I Lam
    Department of Physiology and Membrane Biology, University of California, One Shields Avenue, Davis, CA 95616, USA
    Diabetes 54:510-6. 2005
    ..Evidence is also presented here that acetoacetate and beta-hydroxybutyrate stimulate brain microvascular Na-K-Cl cotransporter activity. These findings suggest that the Na-K-Cl cotransporter contributes to brain edema in DKA...
  15. pmc Ischemia-induced stimulation of Na-K-Cl cotransport in cerebral microvascular endothelial cells involves AMP kinase
    Breanna K Wallace
    Department of Physiology and Membrane Biology, University of California, Davis, CA 95616, USA
    Am J Physiol Cell Physiol 301:C316-26. 2011
    ..These findings suggest that ischemic factor stimulation of the BBB Na-K-Cl cotransporter involves activation of AMPK...
  16. pmc Cerebral blood flow and cerebral edema in rats with diabetic ketoacidosis
    Natalie Yuen
    Department of Physiology and Membrane Biology, University of California, Davis, California, USA
    Diabetes 57:2588-94. 2008
    ..Diminished cerebral blood flow (CBF) during DKA, however, has not been previously demonstrated. We investigated CBF and edema formation in a rat model of DKA and determined the effects of bumetanide, an inhibitor of Na-K-Cl cotransport...
  17. pmc The KCa3.1 blocker TRAM-34 reduces infarction and neurological deficit in a rat model of ischemia/reperfusion stroke
    Yi Je Chen
    Department of Pharmacology, Genome and Biomedical Sciences Facility, University of California, Davis, California 95616, USA
    J Cereb Blood Flow Metab 31:2363-74. 2011
    ..Our findings suggest that KCa3.1 blockade constitutes an attractive approach for the treatment of ischemic stroke because it is still effective when initiated 12 hours after the insult...

Research Grants10

  1. Blood-Brain Barrier in Cerebral Ischemia
    MARTHA O DONNELL; Fiscal Year: 2002
    ..The proposed studies should reveal whether therapeutic approaches aimed at blocking BBB Na-K-Cl cotransporter activity may be of value for attenuating ischemia-induced brain edema. ..
  2. BLOOD-BRAIN BARRIER ION TRANSPORT IN CEREBRAL ISCHEMIA
    MARTHA O DONNELL; Fiscal Year: 2009
    ..The fact that luminal-facing BBB Na transporters appear to contribute to edema formation and are readily accessible to intravenously administered drugs makes them a therapeutic target that we must investigate. ..
  3. BLOOD-BRAIN BARRIER ION TRANSPORT IN CEREBRAL ISCHEMIA
    MARTHA O DONNELL; Fiscal Year: 2007
    ..The proposed studies will reveal whether therapeutic approaches aimed at preventing ischemia stimulation of Na-K-CI cotransporter and/or Na/H exchange activity may be of value for attenuating stroke-induced brain edema. ..
  4. Blood-Brain Barrier in Cerebral Ischemia
    MARTHA O DONNELL; Fiscal Year: 2005
    ..The proposed studies should reveal whether therapeutic approaches aimed at blocking BBB Na-K-Cl cotransporter activity may be of value for attenuating ischemia-induced brain edema. ..
  5. 2004 Barriers of CNS
    MARTHA O DONNELL; Fiscal Year: 2004
    ..Two open workshops/debates to occur during the meeting are also planned. The maximum permitted attendance at this meeting is 150 scientists. ..
  6. Blood-Brain Barrier in Cerebral Ischemia
    MARTHA O DONNELL; Fiscal Year: 2004
    ..The proposed studies should reveal whether therapeutic approaches aimed at blocking BBB Na-K-Cl cotransporter activity may be of value for attenuating ischemia-induced brain edema. ..
  7. Blood-Brain Barrier in Cerebral Ischemia
    MARTHA O DONNELL; Fiscal Year: 2003
    ..The proposed studies should reveal whether therapeutic approaches aimed at blocking BBB Na-K-Cl cotransporter activity may be of value for attenuating ischemia-induced brain edema. ..
  8. Blood-Brain-CSF Barriers, CNS Homeostasis, Drug Delivery
    MARTHA O DONNELL; Fiscal Year: 2002
    ..It is also intended to have three open workshops/debates during the meeting. One is already in place on "Microdialysis". The maximum permitted attendance at this meeting is 150 scientists. ..
  9. BLOOD-BRAIN BARRIER ION TRANSPORT IN CEREBRAL ISCHEMIA
    MARTHA E O apos DONNELL; Fiscal Year: 2010
    ..The fact that luminal-facing BBB Na transporters appear to contribute to edema formation and are readily accessible to intravenously administered drugs makes them a therapeutic target that we must investigate. ..