Kathryn A O'Donnell

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc A Sleeping Beauty mutagenesis screen reveals a tumor suppressor role for Ncoa2/Src-2 in liver cancer
    Kathryn A O'Donnell
    Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 109:E1377-86. 2012
  2. pmc Controlled insertional mutagenesis using a LINE-1 (ORFeus) gene-trap mouse model
    Kathryn A O'Donnell
    Department of Molecular Biology and Genetics, and High Throughput Biology Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 110:E2706-13. 2013
  3. pmc Poly(A) binding protein C1 is essential for efficient L1 retrotransposition and affects L1 RNP formation
    Lixin Dai
    High Throughput Biology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Mol Cell Biol 32:4323-36. 2012
  4. pmc Domesticated DNA transposon proteins mediate retrotransposon control
    Kathryn A O'Donnell
    Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, 733 N Broadway, Baltimore, MD 21205, USA
    Cell Res 18:331-3. 2008
  5. pmc A role for retrotransposon LINE-1 in fetal oocyte attrition in mice
    Safia Malki
    Department of Embryology, Carnegie Institution for Science, Baltimore, MD 21218, USA
    Dev Cell 29:521-33. 2014
  6. pmc Characterization of a synthetic human LINE-1 retrotransposon ORFeus-Hs
    Wenfeng An
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mob DNA 2:2. 2011

Collaborators

Detail Information

Publications7

  1. pmc A Sleeping Beauty mutagenesis screen reveals a tumor suppressor role for Ncoa2/Src-2 in liver cancer
    Kathryn A O'Donnell
    Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 109:E1377-86. 2012
    ..These findings reveal genes and pathways that functionally restrain MYC-mediated liver tumorigenesis and therefore may provide targets for cancer therapy...
  2. pmc Controlled insertional mutagenesis using a LINE-1 (ORFeus) gene-trap mouse model
    Kathryn A O'Donnell
    Department of Molecular Biology and Genetics, and High Throughput Biology Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 110:E2706-13. 2013
    ....
  3. pmc Poly(A) binding protein C1 is essential for efficient L1 retrotransposition and affects L1 RNP formation
    Lixin Dai
    High Throughput Biology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Mol Cell Biol 32:4323-36. 2012
    ..Our data suggest that PABPC1 is essential for the formation of L1 RNA-protein complexes and may play a role in L1 RNP translocation in the host cell...
  4. pmc Domesticated DNA transposon proteins mediate retrotransposon control
    Kathryn A O'Donnell
    Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, 733 N Broadway, Baltimore, MD 21205, USA
    Cell Res 18:331-3. 2008
  5. pmc A role for retrotransposon LINE-1 in fetal oocyte attrition in mice
    Safia Malki
    Department of Embryology, Carnegie Institution for Science, Baltimore, MD 21218, USA
    Dev Cell 29:521-33. 2014
    ..We propose that FOA serves to select oocytes with limited L1 activity that are therefore best suited for the next generation...
  6. pmc Characterization of a synthetic human LINE-1 retrotransposon ORFeus-Hs
    Wenfeng An
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mob DNA 2:2. 2011
    ..Owing to the elevated expression of the L1 RNA/protein and its high retrotransposition ability, ORFeus-Hs and its chimeric derivatives will be useful tools for mechanistic L1 studies and mammalian genome manipulation...