Research Topics
Species | JAMES M O'DONNELLSummaryAffiliation: University of Tennessee Country: USA Publications
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Publications
Antidepressant effects of inhibitors of cAMP phosphodiesterase (PDE4)Han-Ting Zhang
Department of Pharmacology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
Trends Pharmacol Sci 25:158-63. 2004- Antidepressant effects assessed using behavior maintained under a differential-reinforcement-of-low-rate (DRL) operant scheduleJAMES M O'DONNELL
Department of Pharmacology, University of Tennessee Health Science Center, 874 Union Avenue, Memphis, TN 38163, USA
Neurosci Biobehav Rev 29:785-98. 2005..Finally, the results of studies using DRL behavior highlight important roles for central beta-1 adrenergic receptors, as well as 5-HT1A, 5-HT1B, 5-HT2A, and 5-HT2C receptors, in the mediation of antidepressant-like behavioral effects... - Interaction between the antidepressant-like behavioral effects of beta adrenergic agonists and the cyclic AMP PDE inhibitor rolipram in ratsHan Ting Zhang
Department of Pharmacology, The University of Tennessee Health Science Center, 874 Union Avenue, Memphis, TN 38163, USA
Psychopharmacology (Berl) 182:104-15. 2005..However, it is not known if PDE4 is associated with beta adrenergic receptors in the mediation of antidepressant-like effects... - Effects of the novel PDE4 inhibitors MEM1018 and MEM1091 on memory in the radial-arm maze and inhibitory avoidance tests in ratsHan Ting Zhang
Department of Pharmacology, University of Tennessee Health Science Center, 874 Union Avenue, Memphis, TN 38163, USA
Psychopharmacology (Berl) 179:613-9. 2005..Inhibition of cyclic AMP (cAMP)-specific phosphodiesterase (PDE4) enhances memory in rodents. MEM1018 and MEM1091 are newly developed PDE4 inhibitors that had not been evaluated as yet for their effects on working and reference memory... - Antagonism of the antidepressant-like effects of clenbuterol by central administration of beta-adrenergic antagonists in ratsHan Ting Zhang
Department of Pharmacology, University of Tennessee Health Science Center, 874 Union Avenue, Memphis, TN 38163, USA
Psychopharmacology (Berl) 170:102-7. 2003..At present, it is not known what brain sites are involved in mediating such effects, although some recent evidence suggests the importance of the dorsal hippocampus... - Inhibition of the phosphodiesterase 4 (PDE4) enzyme reverses memory deficits produced by infusion of the MEK inhibitor U0126 into the CA1 subregion of the rat hippocampusHan Ting Zhang
Department of Pharmacology, The University of Tennessee Health Science Center, Memphis, TN 38163, USA
Neuropsychopharmacology 29:1432-9. 2004..PDE4 is likely to be an important link between the cAMP/PKA and MEK/ERK signaling pathways in the mediation of memory... - Antidepressant-induced increase in high-affinity rolipram binding sites in rat brain: dependence on noradrenergic and serotonergic functionYu Zhao
Department of Pharmacology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
J Pharmacol Exp Ther 307:246-53. 2003..Collectively, these results suggest that antidepressants, although acting through different pathways, may eventually lead to the regulation of components of the cAMP signal transduction system... - Antidepressant-like profile and reduced sensitivity to rolipram in mice deficient in the PDE4D phosphodiesterase enzymeHan Ting Zhang
Department of Pharmacology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
Neuropsychopharmacology 27:587-95. 2002.... - Inhibitor binding to type 4 phosphodiesterase (PDE4) assessed using [3H]piclamilast and [3H]rolipramYu Zhao
Department of Pharmacology, University of Tennessee Health Science Center, 874 Union Avenue, Memphis, TN 38163, USA
J Pharmacol Exp Ther 305:565-72. 2003..The results indicated that [(3)H]piclamilast is a useful tool to directly study inhibitor interaction with the HARBS and the LARBS in rat brain... - Antidepressant-like effects of PDE4 inhibitors mediated by the high-affinity rolipram binding state (HARBS) of the phosphodiesterase-4 enzyme (PDE4) in ratsHan Ting Zhang
Departments of Behavioral Medicine and Psychiatry and Neurobiology and Anatomy, West Virginia University Health Sciences Center, Morgantown, WV 26506, USA
Psychopharmacology (Berl) 186:209-17. 2006..Phosphodiesterase-4 (PDE4) has two conformation states based on rolipram binding, the high-affinity rolipram binding state (HARBS) and the low-affinity rolipram binding state (LARBS); their functions remain to be fully explained... 
Anxiogenic-like behavioral phenotype of mice deficient in phosphodiesterase 4B (PDE4B)Han Ting Zhang
Department of Behavioral Medicine and Psychiatry, West Virginia University Health Sciences Center, Morgantown, WV 26506, USA
Neuropsychopharmacology 33:1611-23. 2008..Taken together, these results suggest that the PDE4B subfamily is involved in signaling pathways that contribute to anxiogenic-like effects on behavior...
Cognitive dysfunction induced by chronic administration of common cancer chemotherapeutics in ratsGregory W Konat
Department of Neurobiology and Anatomy, West Virginia University School of Medicine, 4052 HSCN, P O Box 9128, Morgantown, WV 26506 9128, USA
Metab Brain Dis 23:325-33. 2008..Moreover, the results strongly indicate that the damaging effect is mediated by oxidative stress, as memory dysfunction is preventable by the co-administration of NAC...