Ira Ockene

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. pmc Outcomes of a Latino community-based intervention for the prevention of diabetes: the Lawrence Latino Diabetes Prevention Project
    Ira S Ockene
    Division of Cardiovascular Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Am J Public Health 102:336-42. 2012
  2. pmc Design and methods for a randomized clinical trial treating comorbid obesity and major depressive disorder
    Kristin L Schneider
    Department of Medicine, Division of Preventive and Behavioral Medicine, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA, USA
    BMC Psychiatry 8:77. 2008
  3. pmc Methodology of a diabetes prevention translational research project utilizing a community-academic partnership for implementation in an underserved Latino community
    Philip A Merriam
    Division of Preventive and Behavioral Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    BMC Med Res Methodol 9:20. 2009
  4. pmc Design and methods for testing a simple dietary message to improve weight loss and dietary quality
    Philip A Merriam
    Division of Preventive and Behavioral Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    BMC Med Res Methodol 9:87. 2009
  5. pmc Design and methods for a randomized clinical trial of a diabetes self-management intervention for low-income Latinos: Latinos en Control
    Milagros C Rosal
    Department of Medicine, Division of Preventive and Behavioral Medicine, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    BMC Med Res Methodol 9:81. 2009
  6. pmc Methodological limitations of psychosocial interventions in patients with an implantable cardioverter-defibrillator (ICD) A systematic review
    Elena Salmoirago-Blotcher
    University of Massachusetts Medical School, 55 Lake Ave Worcester, MA 01655 0002, USA
    BMC Cardiovasc Disord 9:56. 2009
  7. pmc Adherence with urate-lowering therapies for the treatment of gout
    Leslie R Harrold
    Department of Medicine, The Meyers Primary Care Institute, Worcester, MA 01605, USA
    Arthritis Res Ther 11:R46. 2009
  8. ncbi request reprint Variability and classification accuracy of serial high-sensitivity C-reactive protein measurements in healthy adults
    I S Ockene
    Department of Medicine, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655, USA
    Clin Chem 47:444-50. 2001
  9. ncbi request reprint Seasonal variation in serum cholesterol levels: treatment implications and possible mechanisms
    Ira S Ockene
    Division of Cardiovascular Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Arch Intern Med 164:863-70. 2004
  10. pmc Association between dietary glycemic index, glycemic load, and high-sensitivity C-reactive protein
    Jennifer A Griffith
    Division of Preventive and Behavioral Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Nutrition 24:401-6. 2008

Research Grants

Detail Information

Publications48

  1. pmc Outcomes of a Latino community-based intervention for the prevention of diabetes: the Lawrence Latino Diabetes Prevention Project
    Ira S Ockene
    Division of Cardiovascular Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Am J Public Health 102:336-42. 2012
    ..We tested the effectiveness of a community-based, literacy-sensitive, and culturally tailored lifestyle intervention on weight loss and diabetes risk reduction among low-income, Spanish-speaking Latinos at increased diabetes risk...
  2. pmc Design and methods for a randomized clinical trial treating comorbid obesity and major depressive disorder
    Kristin L Schneider
    Department of Medicine, Division of Preventive and Behavioral Medicine, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA, USA
    BMC Psychiatry 8:77. 2008
    ..Treating depression directly prior to behavioral weight loss treatment might bolster weight loss outcomes in this population, but this has not yet been tested in a randomized clinical trial...
  3. pmc Methodology of a diabetes prevention translational research project utilizing a community-academic partnership for implementation in an underserved Latino community
    Philip A Merriam
    Division of Preventive and Behavioral Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    BMC Med Res Methodol 9:20. 2009
    ..Latinos comprise the largest racial/ethnic group in the United States and have 2-3 times the prevalence of type 2 diabetes mellitus as Caucasians...
  4. pmc Design and methods for testing a simple dietary message to improve weight loss and dietary quality
    Philip A Merriam
    Division of Preventive and Behavioral Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    BMC Med Res Methodol 9:87. 2009
    ..g., fiber intake, may make the message much easier to comprehend and adhere, such that respondents can achieve greater weight loss, better dietary quality and overall metabolic health...
  5. pmc Design and methods for a randomized clinical trial of a diabetes self-management intervention for low-income Latinos: Latinos en Control
    Milagros C Rosal
    Department of Medicine, Division of Preventive and Behavioral Medicine, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    BMC Med Res Methodol 9:81. 2009
    ..They also have lower literacy levels and are more likely to live in poverty. Interventions are needed to improve diabetes control among low-income Latinos...
  6. pmc Methodological limitations of psychosocial interventions in patients with an implantable cardioverter-defibrillator (ICD) A systematic review
    Elena Salmoirago-Blotcher
    University of Massachusetts Medical School, 55 Lake Ave Worcester, MA 01655 0002, USA
    BMC Cardiovasc Disord 9:56. 2009
    ..Different psychosocial interventions have been employed to improve this condition, but previous reviews have suggested that methodological issues may limit the validity of such interventions...
  7. pmc Adherence with urate-lowering therapies for the treatment of gout
    Leslie R Harrold
    Department of Medicine, The Meyers Primary Care Institute, Worcester, MA 01605, USA
    Arthritis Res Ther 11:R46. 2009
    ..Adherence to urate-lowering drugs (ULDs) has not been well evaluated among those with gout. Our aim was to assess the level and determinants of non-adherence with ULDs prescribed for gout...
  8. ncbi request reprint Variability and classification accuracy of serial high-sensitivity C-reactive protein measurements in healthy adults
    I S Ockene
    Department of Medicine, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655, USA
    Clin Chem 47:444-50. 2001
    ..Because of its relationship to inflammation, hs-CRP has considerable biologic variation. This study was carried out to characterize CRP variation and to compare it to another risk factor, total serum cholesterol...
  9. ncbi request reprint Seasonal variation in serum cholesterol levels: treatment implications and possible mechanisms
    Ira S Ockene
    Division of Cardiovascular Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Arch Intern Med 164:863-70. 2004
    ..Although the mechanism for this phenomenon is not clear, such variation could result in larger numbers of people being diagnosed as having hypercholesterolemia during the winter...
  10. pmc Association between dietary glycemic index, glycemic load, and high-sensitivity C-reactive protein
    Jennifer A Griffith
    Division of Preventive and Behavioral Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Nutrition 24:401-6. 2008
    ..This study examined the relation between quality of dietary carbohydrate intake, as measured by glycemic index (GI) and glycemic load (GL), and serum high-sensitivity C-reactive protein (hs-CRP) levels...
  11. doi request reprint Translational research at community health centers: challenges and successes in recruiting and retaining low-income Latino patients with type 2 diabetes into a randomized clinical trial
    Milagros C Rosal
    University of Massachusetts Medical School, Department of Medicine, Division of Preventive and Behavioral Medicine, 55 Lake Avenue North, Worcester, MA 01655, USA
    Diabetes Educ 36:733-49. 2010
    ..To describe methods used to recruit and retain low-income Latinos in a randomized clinical trial (RCT) of a diabetes self-management intervention at 5 community health centers (CHCs) in Massachusetts...
  12. doi request reprint Religion and healthy lifestyle behaviors among postmenopausal women: the women's health initiative
    Elena Salmoirago-Blotcher
    Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Behav Med 34:360-71. 2011
    ..Further research is needed to get a deeper understanding of the relationship between religious involvement and healthy lifestyle behaviors and of the inconsistent patterns in this association...
  13. pmc Association between dietary fiber and markers of systemic inflammation in the Women's Health Initiative Observational Study
    Yunsheng Ma
    Division of Preventive and Behavioral Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Nutrition 24:941-9. 2008
    ....
  14. doi request reprint Gender differences in predictors of body weight and body weight change in healthy adults
    David E Chiriboga
    Division of Preventive and Behavioral Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Obesity (Silver Spring) 16:137-45. 2008
    ..Analysis of naturally occurring changes in body weight can provide valuable insights in improving our understanding of the influence of demographic, lifestyle, and psychosocial factors on weight gain in middle-age adults...
  15. pmc Randomized trial of a literacy-sensitive, culturally tailored diabetes self-management intervention for low-income latinos: latinos en control
    Milagros C Rosal
    Department of Medicine, Division of Preventive and Behavioral Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Diabetes Care 34:838-44. 2011
    ..To test whether a theory-based, literacy, and culturally tailored self-management intervention, Latinos en Control, improves glycemic control among low-income Latinos with type 2 diabetes...
  16. doi request reprint Awareness of diabetes risk factors and prevention strategies among a sample of low-income Latinos with no known diagnosis of diabetes
    Milagros C Rosal
    Division of Preventive and Behavioral Medicine, Department of Medicine, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Diabetes Educ 37:47-55. 2011
    ..This study assessed awareness of type 2 diabetes risk and severity, perceived risk factors, knowledge of diabetes prevention strategies, and challenges of and opportunities for prevention among low-income Latinos in Lawrence, Massachusetts...
  17. doi request reprint A simple dietary message to improve dietary quality: Results from a pilot investigation
    Barbara C Olendzki
    University of Massachusetts Medical School, Worcester, USA
    Nutrition 25:736-44. 2009
    ..The present study compared the feasibility of two simple messages (a high-fiber diet or a low saturated fat diet) to a combination message (high fiber/low saturated fat) on their potential to affect dietary quality and metabolic health...
  18. pmc Association of depressive symptoms and lifestyle behaviors among Latinos at risk of type 2 diabetes
    Sherry L Pagoto
    Division of Preventive and Behavioral Medicine, Universityof Massachusetts Medical School, 55 Lake AveNorth, Worcester, MA 01655, USA
    J Am Diet Assoc 109:1246-50. 2009
    ..Higher CES-D scores were associated with lower diet quality (P<0.05), but were not associated with BMI or physical activity. Depression and lower dietary quality can contribute to risk for type 2 diabetes among Latinos...
  19. pmc Number of 24-hour diet recalls needed to estimate energy intake
    Yunsheng Ma
    Division of Preventive and Behavioral Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Ann Epidemiol 19:553-9. 2009
    ..Twenty-four-hour diet recall interviews (24HRs) are used to assess diet and to validate other diet assessment instruments. Therefore it is important to know how many 24HRs are required to describe an individual's intake...
  20. pmc Patients and providers view gout differently: a qualitative study
    Leslie R Harrold
    Department of Medicine, University of Massachusetts Medical School, Meyers Primary Care Institute and Fallon Clinic, Worcester, USA
    Chronic Illn 6:263-71. 2010
    ..We sought to examine patients' and providers' views on the treatment of gout to better understand why management is suboptimal...
  21. pmc What are patients actually eating: the dietary practices of cardiovascular disease patients
    Yunsheng Ma
    Division of Preventive and Behavioral Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Curr Opin Cardiol 25:518-21. 2010
    ..To examine dietary quality for patients after a coronary heart disease (CHD) event using a selective review...
  22. pmc The dynamics of chronic gout treatment: medication gaps and return to therapy
    Leslie R Harrold
    Meyers Primary Care Institute, Worcester, Mass, USA
    Am J Med 123:54-9. 2010
    ..To identify gaps in therapy with urate-lowering drugs for the treatment of gout as well as factors associated with resuming therapy...
  23. doi request reprint Underreporting of energy intake and associated factors in a Latino population at risk of developing type 2 diabetes
    Barbara C Olendzki
    University of Massachusetts Medical School, Division of Preventive and Behavioral Medicine, 55 Lake Ave N, Shaw Bldg, Worcester, MA 01655, USA
    J Am Diet Assoc 108:1003-8. 2008
    ..Energy intake underreporting is prevalent in this low-income, low-literacy Caribbean Latino population. Future studies are needed to develop dietary assessment measures that minimize underreporting in this population...
  24. pmc Dietary quality 1 year after diagnosis of coronary heart disease
    Yunsheng Ma
    Division of Preventive and Behavioral Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Am Diet Assoc 108:240-6; discussion 246-7. 2008
    ..The purpose of this ancillary study is to determine the quality of diets in patients with documented coronary heart disease (CHD)...
  25. ncbi request reprint Association between eating patterns and obesity in a free-living US adult population
    Yunsheng Ma
    Division of Preventive and Behavioral Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Am J Epidemiol 158:85-92. 2003
    ..5, 95% confidence interval: 1.57, 12.90), as was greater frequency of eating breakfast or dinner away from home. Further investigation of these associations in prospective studies is warranted...
  26. ncbi request reprint Body mass index, but not physical activity, is associated with C-reactive protein
    Eric S Rawson
    Divisions of Preventive and Behavioral Medicine and Cardiovascular Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Med Sci Sports Exerc 35:1160-6. 2003
    ....
  27. pmc Association between dietary carbohydrates and body weight
    Yunsheng Ma
    Division of Preventive and Behavioral Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Am J Epidemiol 161:359-67. 2005
    ..Results suggest that the type of carbohydrate may be related to body weight. However, further research is required to elucidate this association and its implications for weight management...
  28. ncbi request reprint Effect of soy protein containing isoflavones on blood lipids in moderately hypercholesterolemic adults: a randomized controlled trial
    Yunsheng Ma
    Division of Preventive and Behavioral Medicine, Department of Medicine, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    J Am Coll Nutr 24:275-85. 2005
    ..Dietary intake of soy protein with isoflavones may be associated with reductions in serum cholesterol...
  29. pmc Association between carbohydrate intake and serum lipids
    Yunsheng Ma
    Division of Preventive and Behavioral Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Am Coll Nutr 25:155-63. 2006
    ..The effect of dietary carbohydrate on blood lipids has received considerable attention in light of the current trend in lowering carbohydrate intake for weight loss...
  30. pmc Association between dietary fiber and serum C-reactive protein
    Yunsheng Ma
    Division of Preventive and Behavioral Medicine and the Division of Cardiovascular Medicine, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Am J Clin Nutr 83:760-6. 2006
    ..Data on longitudinal associations between dietary fiber intake and CRP are currently lacking...
  31. pmc Methodology for adding glycemic index and glycemic load values to 24-hour dietary recall database
    Barbara C Olendzki
    Division of Preventive and Behavioral Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Nutrition 22:1087-95. 2006
    ..We also calculated daily GI and GL values from the 24HR...
  32. pmc A randomized clinical trial comparing low-glycemic index versus ADA dietary education among individuals with type 2 diabetes
    Yunsheng Ma
    Division of Preventive and Behavioral Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Nutrition 24:45-56. 2008
    ..We compared the effects of a low glycemic index (GI) diet with the American Diabetes Association (ADA) diet on glycosylated hemoglobin (HbA1c) among individuals with type 2 diabetes...
  33. pmc A dietary quality comparison of popular weight-loss plans
    Yunsheng Ma
    Division of Preventive and Behavioral Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Am Diet Assoc 107:1786-91. 2007
    ..Dietary quality varied across popular weight-loss plans. Ornish, Weight Watchers high-carbohydrate, and New Glucose Revolution weight-loss plans have an increased capacity for cardiovascular disease prevention when assessed by the AHEI...
  34. doi request reprint Statin therapy and the risk for diabetes among adult women: do the benefits outweigh the risk?
    Yunsheng Ma
    Associate Professor of Medicine, Division of Preventive and Behavioral Medicine, Department of Medicine, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Ther Adv Cardiovasc Dis 7:41-4. 2013
    ..The purpose of this review was to examine statin therapy and the risk for diabetes among adult women using a selective review...
  35. ncbi request reprint Diabetes self-management among low-income Spanish-speaking patients: a pilot study
    Milagros C Rosal
    University of Massachusetts Medical School, Preventative and Behavioural Medicine, Worcester, MA 01655, USA
    Ann Behav Med 29:225-35. 2005
    ..However, little is known about how to effectively promote self-management in this population...
  36. pmc Seasonal and sex variation of high-sensitivity C-reactive protein in healthy adults: a longitudinal study
    David E Chiriboga
    Division of Preventive and Behavioral Medicine and Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Clin Chem 55:313-21. 2009
    ..Cross-sectional studies have reported seasonal variation in high-sensitivity C-reactive protein (hsCRP). However, longitudinal data are lacking...
  37. pmc Design and methods for a pilot study of a phone-delivered, mindfulness-based intervention in patients with implantable cardioverter defibrillators
    Elena Salmoirago-Blotcher
    Division of Cardiovascular Medicine, University of Massachusetts Medical School, 55 Lake Avenue North, Room S3 855, Worcester, MA 01655, USA
    Evid Based Complement Alternat Med 2012:972106. 2012
    ..Conclusions. If proven feasible and effective, phone-delivered mindfulness-based interventions could improve psychological distress in ICD outpatients with serious cardiovascular conditions...
  38. ncbi request reprint Task force #4--adherence issues and behavior changes: achieving a long-term solution. 33rd Bethesda Conference
    Ira S Ockene
    Preventive Cardiology Program, University of Massachusetts Medical School, Worcester 01655 0002, USA
    J Am Coll Cardiol 40:630-40. 2002
  39. pmc Can attention control conditions have detrimental effects on behavioral medicine randomized trials?
    Sherry L Pagoto
    Division of Preventive and Behavioral Medicine, Department of Medicine, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01760, USA
    Psychosom Med 75:137-43. 2013
    ..The primary aim of the present study is to demonstrate a scenario in which use of AC in a behavioral randomized trial was unnecessary and possibly detrimental...
  40. pmc Spontaneous coronary artery dissection during cabergoline therapy
    Nishaki Kiran Mehta
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Tex Heart Inst J 39:92-4. 2012
    ..The possible association of cabergoline with coronary artery spasm and dissection should be considered in patients who present with chest pain while taking this medication...
  41. pmc The dietary quality of persons with heart failure in NHANES 1999-2006
    Stephenie C Lemon
    Division of Preventive and Behavioral Medicine, S7 745, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    J Gen Intern Med 25:135-40. 2010
    ..Dietary quality may impact heart failure outcomes. However, the current status of the dietary quality of persons with heart failure has not been previously reported...
  42. pmc Constipation and risk of cardiovascular disease among postmenopausal women
    Elena Salmoirago-Blotcher
    Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester, 01655, USA
    Am J Med 124:714-23. 2011
    ..Because many factors predisposing to constipation also are risk factors for cardiovascular disease, we hypothesized that constipation may be associated with increased risk of cardiovascular events...
  43. ncbi request reprint Barriers to preventive interventions for coronary heart disease
    David E Chiriboga
    Preventive Medicine Program, Department of Family Medicine and Community Health, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Cardiol Clin 21:459-70. 2003
    ....
  44. ncbi request reprint Calculated low density lipoprotein cholesterol levels frequently underestimate directly measured low density lipoprotein cholesterol determinations in patients with serum triglyceride levels < or =4.52 mmol/l: an analysis comparing the LipiDirect magne
    Dennis A Tighe
    Department of Medicine, Division of Cardiovascular Medicine, University of Massachusetts Medical School, 55 Lake Avenue, North, Worcester, MA 01655, USA
    Clin Chim Acta 365:236-42. 2006
    ..This calculation is known to be inaccurate with serum triglyceride (TG) concentrations >4.52 mmol/l, however, its accuracy among relatively healthy patient cohorts with TG concentrations < or =4.52 mmol/l is less well studied...
  45. ncbi request reprint AHA Guidelines for Primary Prevention of Cardiovascular Disease and Stroke: 2002 Update: Consensus Panel Guide to Comprehensive Risk Reduction for Adult Patients Without Coronary or Other Atherosclerotic Vascular Diseases. American Heart Association Scien
    Thomas A Pearson
    Circulation 106:388-91. 2002
  46. ncbi request reprint Secondary prevention of coronary heart disease in the elderly (with emphasis on patients > or =75 years of age): an American Heart Association scientific statement from the Council on Clinical Cardiology Subcommittee on Exercise, Cardiac Rehabilitation, a
    Mark A Williams
    Circulation 105:1735-43. 2002
  47. ncbi request reprint Moderate to vigorous physical activity and risk of upper-respiratory tract infection
    Charles E Matthews
    Department of Epidemiology and Biostatistics, Norman J Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USA
    Med Sci Sports Exerc 34:1242-8. 2002
    ..This investigation examined differences in URTI risk between physically inactive and moderately active adults...
  48. doi request reprint Brief supported lifestyle counseling: modest interventions yield modest effects
    David D McManus
    Arch Intern Med 168:129-30. 2008

Research Grants7

  1. SYSTEMS TO ENHANCE PROVIDER COUNSELING IN HYPERLIPIDEMIA
    Ira Ockene; Fiscal Year: 2002
    ....
  2. IMPROVING ADHERENCE TO PHARMACOLOGICAL TREATMENT
    Ira Ockene; Fiscal Year: 2003
    ..Proportion of selected non-lipid-lowering prescribed medication taken by patients as measured by CMA; and 3. Percentage of patients with an LDL level <130 mg per dl ..
  3. Determinants of C-Reactive Protein
    Ira Ockene; Fiscal Year: 2005
    ..PRIMARY HYPOTHESIS: BMI will be the strongest predictor of hs-CRP. SECONDARY HYPOTHESES: Dietary glycemic load, omega 3 fatty acid intake, and depression will be secondary determinants of hs-CRP. ..
  4. Lawrence Latino Diabetes Prevention Project
    Ira Ockene; Fiscal Year: 2007
    ..All assessments will be oral, and delivered in either Spanish or English. The study will be a collaborative effort between the UMass Medical School, the GLFHC, and the research laboratories at UMass-Lowell. ..