I G Obrosova

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi request reprint Update on the pathogenesis of diabetic neuropathy
    Irina G Obrosova
    University of Michigan, Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Michigan Medical Center, 1150 West Medical Center Drive, MSRB II, Room 5570, Ann Arbor, MI 48109 0678, USA
    Curr Diab Rep 3:439-45. 2003
  2. ncbi request reprint Aldose reductase inhibitor fidarestat prevents retinal oxidative stress and vascular endothelial growth factor overexpression in streptozotocin-diabetic rats
    Irina G Obrosova
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Michigan Medical Center, 1150 West Medical Center Drive, MSRB II, Room 5570, Ann Arbor, MI 48109 0678, USA
    Diabetes 52:864-71. 2003
  3. ncbi request reprint Early oxidative stress in the diabetic kidney: effect of DL-alpha-lipoic acid
    Irina G Obrosova
    Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    Free Radic Biol Med 34:186-95. 2003
  4. ncbi request reprint Role of poly(ADP-ribose) polymerase activation in diabetic neuropathy
    Irina G Obrosova
    Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan, USA
    Diabetes 53:711-20. 2004
  5. ncbi request reprint An aldose reductase inhibitor reverses early diabetes-induced changes in peripheral nerve function, metabolism, and antioxidative defense
    Irina G Obrosova
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0354, USA
    FASEB J 16:123-5. 2002
  6. ncbi request reprint Taurine counteracts oxidative stress and nerve growth factor deficit in early experimental diabetic neuropathy
    I G Obrosova
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Michigan Medical Center, 1150 West Medical Center Drive, MSRB 2, Room 5570, Ann Arbor, Michigan 48109 0678, USA
    Exp Neurol 172:211-9. 2001
  7. ncbi request reprint Antioxidants attenuate early up regulation of retinal vascular endothelial growth factor in streptozotocin-diabetic rats
    I G Obrosova
    Department of Internal Medicine, University of Michigan Medical Centre, Ann Arbor 48109 0354, USA
    Diabetologia 44:1102-10. 2001
  8. ncbi request reprint Diabetes-induced changes in retinal NAD-redox status: pharmacological modulation and implications for pathogenesis of diabetic retinopathy
    I G Obrosova
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Michigan Medical Center, 1150 West Medical Center Drive, MSRB 11, Room 5570, Ann Arbor, MI 48109 0678, USA
    Pharmacology 62:172-80. 2001
  9. ncbi request reprint Evaluation of alpha(1)-adrenoceptor antagonist on diabetes-induced changes in peripheral nerve function, metabolism, and antioxidative defense
    I G Obrosova
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0354, USA
    FASEB J 14:1548-58. 2000
  10. ncbi request reprint Early changes in lipid peroxidation and antioxidative defense in diabetic rat retina: effect of DL-alpha-lipoic acid
    I G Obrosova
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Michigan Medical Center, 1150 West Medical Center Drive, MSRB 2, Room 5570, Ann Arbor, MI 48109 0354, USA
    Eur J Pharmacol 398:139-46. 2000

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Update on the pathogenesis of diabetic neuropathy
    Irina G Obrosova
    University of Michigan, Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Michigan Medical Center, 1150 West Medical Center Drive, MSRB II, Room 5570, Ann Arbor, MI 48109 0678, USA
    Curr Diab Rep 3:439-45. 2003
    ..Further studies are needed to understand the role of other signaling pathways as well as interactions among previously discovered mechanisms in the pathogenesis of PDN...
  2. ncbi request reprint Aldose reductase inhibitor fidarestat prevents retinal oxidative stress and vascular endothelial growth factor overexpression in streptozotocin-diabetic rats
    Irina G Obrosova
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Michigan Medical Center, 1150 West Medical Center Drive, MSRB II, Room 5570, Ann Arbor, MI 48109 0678, USA
    Diabetes 52:864-71. 2003
    ..In conclusion, increased AR activity contributes to retinal oxidative stress and VEGF protein overexpression in early diabetes. The findings justify the rationale for evaluation of fidarestat on diabetic retinopathy...
  3. ncbi request reprint Early oxidative stress in the diabetic kidney: effect of DL-alpha-lipoic acid
    Irina G Obrosova
    Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    Free Radic Biol Med 34:186-95. 2003
    ..controls, and these activities, except glutathione peroxidase, were decreased by DL-alpha-lipoic acid. In conclusion, enhanced oxidative stress is present in rat renal cortex in early diabetes, and is prevented by DL-alpha-lipoic acid...
  4. ncbi request reprint Role of poly(ADP-ribose) polymerase activation in diabetic neuropathy
    Irina G Obrosova
    Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan, USA
    Diabetes 53:711-20. 2004
    ..Thus, the current work identifies PARP activation as an important mechanism in diabetic neuropathy and provides the first evidence for the potential therapeutic value of PARP inhibitors in this devastating complication of diabetes...
  5. ncbi request reprint An aldose reductase inhibitor reverses early diabetes-induced changes in peripheral nerve function, metabolism, and antioxidative defense
    Irina G Obrosova
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0354, USA
    FASEB J 16:123-5. 2002
    ..In conclusion, treatment with adequate doses of ARIs (that is, doses that completely inhibit increased sorbitol pathway activity) is an effective approach for reversal of, at least, early diabetic neuropathy...
  6. ncbi request reprint Taurine counteracts oxidative stress and nerve growth factor deficit in early experimental diabetic neuropathy
    I G Obrosova
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Michigan Medical Center, 1150 West Medical Center Drive, MSRB 2, Room 5570, Ann Arbor, Michigan 48109 0678, USA
    Exp Neurol 172:211-9. 2001
    ..The findings are consistent with the important role for oxidative stress in impaired neurotrophic support in EDN...
  7. ncbi request reprint Antioxidants attenuate early up regulation of retinal vascular endothelial growth factor in streptozotocin-diabetic rats
    I G Obrosova
    Department of Internal Medicine, University of Michigan Medical Centre, Ann Arbor 48109 0354, USA
    Diabetologia 44:1102-10. 2001
    ....
  8. ncbi request reprint Diabetes-induced changes in retinal NAD-redox status: pharmacological modulation and implications for pathogenesis of diabetic retinopathy
    I G Obrosova
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Michigan Medical Center, 1150 West Medical Center Drive, MSRB 11, Room 5570, Ann Arbor, MI 48109 0678, USA
    Pharmacology 62:172-80. 2001
    ..Hypoxia-like metabolic changes in the diabetic retina originate from aldose reductase, but not sorbitol dehydrogenase activity...
  9. ncbi request reprint Evaluation of alpha(1)-adrenoceptor antagonist on diabetes-induced changes in peripheral nerve function, metabolism, and antioxidative defense
    I G Obrosova
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0354, USA
    FASEB J 14:1548-58. 2000
    ....
  10. ncbi request reprint Early changes in lipid peroxidation and antioxidative defense in diabetic rat retina: effect of DL-alpha-lipoic acid
    I G Obrosova
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Michigan Medical Center, 1150 West Medical Center Drive, MSRB 2, Room 5570, Ann Arbor, MI 48109 0354, USA
    Eur J Pharmacol 398:139-46. 2000
    ..In conclusion, accumulation of 4-hydroxyalkenals is an early marker of oxidative stress in the diabetic retina. Increased lipid peroxidation occurs in the absence of GSH depletion, and is prevented by DL-alpha-lipoic acid...
  11. ncbi request reprint Interaction between osmotic and oxidative stress in diabetic precataractous lens: studies with a sorbitol dehydrogenase inhibitor
    I G Obrosova
    Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109 0678, USA
    Biochem Pharmacol 58:1945-54. 1999
    ..SDIs provide a valuable tool for exploring mechanisms of oxidative injury in sites of diabetic complications...
  12. ncbi request reprint Evaluation of orally active poly(ADP-ribose) polymerase inhibitor in streptozotocin-diabetic rat model of early peripheral neuropathy
    F Li
    Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109, USA
    Diabetologia 47:710-7. 2004
    ..This study was designed to characterise the effects of the potent, orally active poly(ADP-ribose) polymerase inhibitor PJ34 in the Wistar rat model of early diabetic neuropathy...
  13. pmc PARP inhibition or gene deficiency counteracts intraepidermal nerve fiber loss and neuropathic pain in advanced diabetic neuropathy
    Irina G Obrosova
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Free Radic Biol Med 44:972-81. 2008
    ..The results support a rationale for the development of potent and low-toxicity PARP inhibitors and PARP inhibitor-containing combination therapies...
  14. pmc Aldose reductase inhibition counteracts nitrosative stress and poly(ADP-ribose) polymerase activation in diabetic rat kidney and high-glucose-exposed human mesangial cells
    Viktor R Drel
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, 70808, USA
    Free Radic Biol Med 40:1454-65. 2006
    ..These findings reveal new beneficial properties of the AR inhibitor F and provide the rationale for detailed studies of F on diabetic nephropathy...
  15. pmc Poly(ADP-ribose) polymerase inhibition alleviates experimental diabetic sensory neuropathy
    Olga Ilnytska
    Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Diabetes 55:1686-94. 2006
    ..In conclusion, PARP activation contributes to early diabetic sensory neuropathy by mechanisms that may include oxidative stress but not neuronal apoptosis...
  16. ncbi request reprint Thioredoxin interacting protein is increased in sensory neurons in experimental diabetes
    Sally A Price
    Faculty of Life Sciences, Stopford Building, University of Manchester, 3 613 4 Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Brain Res 1116:206-14. 2006
    ..These results indicate another mechanism by which diabetes may cause oxidative damage in peripheral nerve, and may represent a novel target for therapeutic intervention...
  17. ncbi request reprint The leptin-deficient (ob/ob) mouse: a new animal model of peripheral neuropathy of type 2 diabetes and obesity
    Viktor R Drel
    Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Diabetes 55:3335-43. 2006
    ..The results support the role for increased aldose reductase activity in functional and structural changes of PDN in type 2 diabetes...
  18. ncbi request reprint Nitrosative stress and peripheral diabetic neuropathy in leptin-deficient (ob/ob) mice
    Igor Vareniuk
    Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Exp Neurol 205:425-36. 2007
    ..Peroxynitrite decomposition catalysts alleviate Type 2 diabetes-associated sensory nerve dysfunction, likely by mechanism(s) not involving arrest of degenerative changes or enhanced regeneration of small sensory nerve fibers...
  19. ncbi request reprint High-fat diet induced neuropathy of pre-diabetes and obesity: effects of "healthy" diet and aldose reductase inhibition
    Irina G Obrosova
    Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Diabetes 56:2598-608. 2007
    ..This study evaluated neuropathic changes and their amenability to dietary and pharmacological interventions in mice fed a high-fat diet (HFD), a model of pre-diabetes and alimentary obesity...
  20. pmc A peroxynitrite decomposition catalyst counteracts sensory neuropathy in streptozotocin-diabetic mice
    Viktor R Drel
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Eur J Pharmacol 569:48-58. 2007
    ..In conclusion, nitrosative stress plays an important role in sensory neuropathy associated with Type 1 diabetes. The findings provide rationale for further studies of peroxynitrite decomposition catalysts in a long-term diabetic model...
  21. ncbi request reprint Role of nitrosative stress in early neuropathy and vascular dysfunction in streptozotocin-diabetic rats
    Irina G Obrosova
    Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Am J Physiol Endocrinol Metab 293:E1645-55. 2007
    ..The findings reveal the important role of nitrosative stress in early neuropathy and vasculopathy and provide the rationale for further studies of peroxynitrite decomposition catalysts in long-term diabetic models...
  22. pmc Evaluation of the peroxynitrite decomposition catalyst Fe(III) tetra-mesitylporphyrin octasulfonate on peripheral neuropathy in a mouse model of type 1 diabetes
    Viktor R Drel
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Int J Mol Med 20:783-92. 2007
    ..The findings provide rationale for development of potent peroxynitrite decomposition catalysts for the treatment of diabetic neuropathy...
  23. ncbi request reprint Taurine reverses neurological and neurovascular deficits in Zucker diabetic fatty rats
    Fei Li
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Neurobiol Dis 22:669-76. 2006
    ..An 84% deficit of dorsal root ganglion neuron calcitonin gene-related peptide in D rats was prevented by taurine. In summary, the antioxidant taurine reverses neurological and neurovascular deficits in experimental type 2 diabetes...
  24. ncbi request reprint Increased sorbitol pathway activity generates oxidative stress in tissue sites for diabetic complications
    Irina G Obrosova
    Divison of Nutrition and Chronic Disease, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Antioxid Redox Signal 7:1543-52. 2005
    ..quot;..
  25. pmc Oxidative-nitrosative stress and poly(ADP-ribose) polymerase (PARP) activation in experimental diabetic neuropathy: the relation is revisited
    Irina G Obrosova
    Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Rd, Baton Rouge, Louisiana 70808, USA
    Diabetes 54:3435-41. 2005
    ..The relations between oxidative-nitrosative stress and PARP activation in diabetes are bi- rather than unidirectional, and PARP activation cannot only result from but also lead to free radical and oxidant generation...
  26. ncbi request reprint How does glucose generate oxidative stress in peripheral nerve?
    Irina G Obrosova
    Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    Int Rev Neurobiol 50:3-35. 2002
    ..Growing evidence indicates that AR has a key role in oxidative stress in the peripheral nerve and contributes to superoxide production by the vascular endothelium. The potential mechanisms of this phenonmenon are discussed...
  27. ncbi request reprint Diabetes-induced overexpression of endothelin-1 and endothelin receptors in the rat renal cortex is mediated via poly(ADP-ribose) polymerase activation
    Alexander G Minchenko
    Department of Anesthesiology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    FASEB J 17:1514-6. 2003
    ..PARP inhibitors could provide a novel therapeutic approach for diabetic complications including nephropathy, and other diseases that involve the endothelin system...
  28. ncbi request reprint Poly(ADP-ribose) polymerase inhibitors counteract diabetes- and hypoxia-induced retinal vascular endothelial growth factor overexpression
    Irina G Obrosova
    Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI, USA
    Int J Mol Med 14:55-64. 2004
    ..The results justify studies of PARP inhibitors in models of retinopathy of prematurity and diabetic retinopathy...
  29. ncbi request reprint Taurine replacement attenuates hyperalgesia and abnormal calcium signaling in sensory neurons of STZ-D rats
    Fei Li
    Department of Internal Medicine, Michigan Diabetes Research and Training Center, University of Michigan, Ann Arbor Veterans Administration Hospitals, Ann Arbor, Michigan, USA
    Am J Physiol Endocrinol Metab 288:E29-36. 2005
    ..These data indicate that taurine is important in the regulation of neuronal Ca2+ signaling and that taurine deficiency may predispose one to nerve hyperexcitability and pain, complicating diabetes...
  30. ncbi request reprint Role for nitrosative stress in diabetic neuropathy: evidence from studies with a peroxynitrite decomposition catalyst
    Irina G Obrosova
    Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
    FASEB J 19:401-3. 2005
    ..This provides the rationale for development of agents counteracting peroxynitrite formation and promoting peroxynitrite decomposition, and their evaluation in DN...
  31. pmc Aldose reductase inhibition counteracts oxidative-nitrosative stress and poly(ADP-ribose) polymerase activation in tissue sites for diabetes complications
    Irina G Obrosova
    Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Diabetes 54:234-42. 2005
    ..These findings reveal the new beneficial properties of fidarestat, thus further justifying the ongoing clinical trials of this specific, potent, and low-toxic ARI...
  32. pmc Role of nitrosative stress and peroxynitrite in the pathogenesis of diabetic complications. Emerging new therapeutical strategies
    Pal Pacher
    Laboratory of Physiologic Studies, National Institutes of Health, NIAAA, Bethesda, MD 20892 9413, USA
    Curr Med Chem 12:267-75. 2005
    ....
  33. ncbi request reprint Low-dose poly(ADP-ribose) polymerase inhibitor-containing combination therapies reverse early peripheral diabetic neuropathy
    Fei Li
    Department of Internal Medicine, University of Michigan, Ann Arbor, USA
    Diabetes 54:1514-22. 2005
    ..In conclusion, low-dose PARP inhibitor-containing combination therapies may constitute a new approach for treatment of PDN...
  34. ncbi request reprint Role for poly(ADP-ribose) polymerase activation in diabetic nephropathy, neuropathy and retinopathy
    Irina G Obrosova
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, 70808, USA
    Curr Vasc Pharmacol 3:267-83. 2005
    ..This review describes recent studies addressing the role for poly(ADP-ribose) polymerase activation in diabetic nephropathy, neuropathy and retinopathy...
  35. ncbi request reprint Increased JNK phosphorylation and oxidative stress in response to increased glucose flux through increased GLUT1 expression in rat retinal endothelial cells
    Jie Zhou
    Departments of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Invest Ophthalmol Vis Sci 46:3403-10. 2005
    ..To investigate whether increased glucose flux through increased glucose transporter1 (GLUT1) expression results in increased oxidative stress and increased c-jun N-terminal kinase (JNK) phosphorylation...
  36. pmc Aldose reductase inhibitor fidarestat counteracts diabetes-associated cataract formation, retinal oxidative-nitrosative stress, glial activation, and apoptosis
    Viktor R Drel
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Int J Mol Med 21:667-76. 2008
    ....
  37. pmc Cannabidiol attenuates high glucose-induced endothelial cell inflammatory response and barrier disruption
    Mohanraj Rajesh
    Section on Oxidative Stress Tissue Injury, Laboratory of Physiological Studies, National Institutes of Health NIAAA, 5625 Fishers Lane, MSC 9413, Bethesda, MD 20892 9413, USA
    Am J Physiol Heart Circ Physiol 293:H610-9. 2007
    ....