T J O'Brien
Affiliation: University of Arkansas for Medical Sciences
- The CA 125 gene: an extracellular superstructure dominated by repeat sequencesT J O'Brien
Department of Obstetrics and Gynecology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
Tumour Biol 22:348-66. 2001..Sequencing the gene provides us with the ability to initiate the quest to understand the biological function of CA 125...
- Ovarian tumor cells express a novel multi-domain cell surface serine proteaseL J Underwood
Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205 7199, USA
Biochim Biophys Acta 1502:337-50. 2000..These features imply that TADG-12 will be at the cell surface, and it may be useful as a molecular target for therapy or a diagnostic marker...
- Novel immunotherapeutic strategies in gynecologic oncology. Dendritic cell-based immunotherapy for ovarian cancerA D Santin
Department of Otolaryngology, University of Arkansas for Medical Sciences, USA
Minerva Ginecol 54:133-44. 2002..In this review, we describe these ovarian tumor antigens and assess the potential for therapeutic DC vaccination for the treatment of chemotherapy-resistant ovarian cancer...
- Discrimination between uterine serous papillary carcinomas and ovarian serous papillary tumours by gene expression profilingA D Santin
Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Arkansas for Medical Sciences, UAMS Medical Center, 4301 West Markham, Little Rock, AR 72205 7199, USA
Br J Cancer 90:1814-24. 2004..A therapeutic strategy targeting HER-2/neu may be beneficial in patients harbouring chemotherapy-resistant USPC...
- Cloning of tumor-associated differentially expressed gene-14, a novel serine protease overexpressed by ovarian carcinomaL J Underwood
Department of Obstetrics, University of Arkansas for Medical Sciences, Little Rock 72205 7199, USA
Cancer Res 59:4435-9. 1999..Northern blot data confirm this overexpression, and immunohistochemical staining suggests that this protein is secreted. As such, the TADG14 protease may be useful as a diagnostic tool or as a molecular target for therapy...