Kevin D O'Brien

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint Antioxidant supplements block the response of HDL to simvastatin-niacin therapy in patients with coronary artery disease and low HDL
    M C Cheung
    Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, School of Medicine, University of Washington, Seattle 98103, USA
    Arterioscler Thromb Vasc Biol 21:1320-6. 2001
  2. ncbi request reprint Glycosylphosphatidylinositol-specific phospholipase D is expressed by macrophages in human atherosclerosis and colocalizes with oxidation epitopes
    K D O'Brien
    Division of Cardiology, Department of Medicine, University of Washington, Seattle, USA
    Circulation 99:2876-82. 1999
  3. ncbi request reprint Association of angiotensin-converting enzyme with low-density lipoprotein in aortic valvular lesions and in human plasma
    Kevin D O'Brien
    Division of Cardiology, University of Washington, Seattle 98195 6422, USA
    Circulation 106:2224-30. 2002
  4. ncbi request reprint Hemodynamic effects of the angiotensin-converting enzyme inhibitor, ramipril, in patients with mild to moderate aortic stenosis and preserved left ventricular function
    Kevin D O'Brien
    Division of Cardiology, University of Washington, Seattle, WA 98195 6422, USA
    J Investig Med 52:185-91. 2004
  5. ncbi request reprint Smooth muscle cell biglycan overexpression results in increased lipoprotein retention on extracellular matrix: implications for the retention of lipoproteins in atherosclerosis
    Kevin D O'Brien
    Division of Cardiology, Box 356422, Department of Medicine, University of Washington, 1959N E Pacific St, Seattle, WA 98195 6422, USA
    Atherosclerosis 177:29-35. 2004
  6. ncbi request reprint Diet-induced weight loss is associated with decreases in plasma serum amyloid a and C-reactive protein independent of dietary macronutrient composition in obese subjects
    Kevin D O'Brien
    Department of Medicine, Division of Cardiology, Box 356422, University of Washington, 1959 Northeast Pacific Street, Seattle, Washington 98195 6422, USA
    J Clin Endocrinol Metab 90:2244-9. 2005
  7. ncbi request reprint Serum amyloid A and lipoprotein retention in murine models of atherosclerosis
    Kevin D O'Brien
    Division of Cardiology, University of Washington, Seattle, WA 98195 6422, USA
    Arterioscler Thromb Vasc Biol 25:785-90. 2005
  8. ncbi request reprint Angiotensin-converting enzyme inhibitors and change in aortic valve calcium
    Kevin D O'Brien
    Division of Cardiology, Box 356422, Department of Medicine, University of Washington, 1959 NE Pacific St, Seattle, WA 98195, USA
    Arch Intern Med 165:858-62. 2005
  9. ncbi request reprint Comparison of apolipoprotein and proteoglycan deposits in human coronary atherosclerotic plaques: colocalization of biglycan with apolipoproteins
    K D O'Brien
    Department of Medicine, University of Washington, Seattle 98195, USA
    Circulation 98:519-27. 1998
  10. ncbi request reprint Epidemiology and genetics of calcific aortic valve disease
    Kevin D O'Brien
    Division of Cardiology, University of Washington, Seattle, WA 98195 6422, USA
    J Investig Med 55:284-91. 2007

Research Grants

  1. Plaque Inflammation and Dysfunctional HDL in AIM-HIGH
    KEVIN O BRIEN; Fiscal Year: 2009
  2. Plaque Inflammation and Dysfunctional HDL in AIM-HIGH
    KEVIN DOUGLAS O apos BRIEN; Fiscal Year: 2010

Detail Information

Publications113 found, 100 shown here

  1. ncbi request reprint Antioxidant supplements block the response of HDL to simvastatin-niacin therapy in patients with coronary artery disease and low HDL
    M C Cheung
    Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, School of Medicine, University of Washington, Seattle 98103, USA
    Arterioscler Thromb Vasc Biol 21:1320-6. 2001
    ..This unexpected adverse interaction between antioxidants and lipid therapy may have important implications for the management of CAD...
  2. ncbi request reprint Glycosylphosphatidylinositol-specific phospholipase D is expressed by macrophages in human atherosclerosis and colocalizes with oxidation epitopes
    K D O'Brien
    Division of Cardiology, Department of Medicine, University of Washington, Seattle, USA
    Circulation 99:2876-82. 1999
    ..Because of its potential regulatory role in inflammatory reactions, we hypothesized that GPI-PLD might be expressed in atherosclerosis...
  3. ncbi request reprint Association of angiotensin-converting enzyme with low-density lipoprotein in aortic valvular lesions and in human plasma
    Kevin D O'Brien
    Division of Cardiology, University of Washington, Seattle 98195 6422, USA
    Circulation 106:2224-30. 2002
    ..In atherosclerosis, angiotensin-converting enzyme (ACE) is expressed by a subset of macrophages. This study was undertaken to determine whether ACE might be present in aortic sclerosis or stenosis lesions...
  4. ncbi request reprint Hemodynamic effects of the angiotensin-converting enzyme inhibitor, ramipril, in patients with mild to moderate aortic stenosis and preserved left ventricular function
    Kevin D O'Brien
    Division of Cardiology, University of Washington, Seattle, WA 98195 6422, USA
    J Investig Med 52:185-91. 2004
    ..We determined the hemodynamic effects of ACE inhibitors in patients with mild to moderate aortic stenosis (AS) and preserved left ventricular function...
  5. ncbi request reprint Smooth muscle cell biglycan overexpression results in increased lipoprotein retention on extracellular matrix: implications for the retention of lipoproteins in atherosclerosis
    Kevin D O'Brien
    Division of Cardiology, Box 356422, Department of Medicine, University of Washington, 1959N E Pacific St, Seattle, WA 98195 6422, USA
    Atherosclerosis 177:29-35. 2004
    ..These results are consistent with the hypothesis that biglycan, through its glycosaminoglycan side chains, may mediate lipoprotein retention on atherosclerotic plaque ECM...
  6. ncbi request reprint Diet-induced weight loss is associated with decreases in plasma serum amyloid a and C-reactive protein independent of dietary macronutrient composition in obese subjects
    Kevin D O'Brien
    Department of Medicine, Division of Cardiology, Box 356422, University of Washington, 1959 Northeast Pacific Street, Seattle, Washington 98195 6422, USA
    J Clin Endocrinol Metab 90:2244-9. 2005
    ..03). Thus, in otherwise healthy, obese women, weight loss was associated with significant decreases in both SAA and CRP. These effects were proportional to the amount of weight lost but independent of dietary macronutrient composition...
  7. ncbi request reprint Serum amyloid A and lipoprotein retention in murine models of atherosclerosis
    Kevin D O'Brien
    Division of Cardiology, University of Washington, Seattle, WA 98195 6422, USA
    Arterioscler Thromb Vasc Biol 25:785-90. 2005
    ..Because SAA associates primarily with lipoproteins in plasma and has proteoglycan binding domains, we postulated that SAA might mediate lipoprotein retention on atherosclerotic extracellular matrix...
  8. ncbi request reprint Angiotensin-converting enzyme inhibitors and change in aortic valve calcium
    Kevin D O'Brien
    Division of Cardiology, Box 356422, Department of Medicine, University of Washington, 1959 NE Pacific St, Seattle, WA 98195, USA
    Arch Intern Med 165:858-62. 2005
    ....
  9. ncbi request reprint Comparison of apolipoprotein and proteoglycan deposits in human coronary atherosclerotic plaques: colocalization of biglycan with apolipoproteins
    K D O'Brien
    Department of Medicine, University of Washington, Seattle 98195, USA
    Circulation 98:519-27. 1998
    ....
  10. ncbi request reprint Epidemiology and genetics of calcific aortic valve disease
    Kevin D O'Brien
    Division of Cardiology, University of Washington, Seattle, WA 98195 6422, USA
    J Investig Med 55:284-91. 2007
    ..Together these latter sets of studies emphasize that unique "nonatherosclerotic" factors can influence calcific aortic valve disease development, suggesting the possibility of novel therapeutic strategies for this condition...
  11. ncbi request reprint Serum amyloid A: the "other" inflammatory protein
    Kevin D O'Brien
    Division of Cardiology, University of Washington, Seattle 98195 6422, USA
    Curr Atheroscler Rep 8:62-8. 2006
    ..Lying at the intersection of inflammation, dyslipidemia, obesity, and insulin resistance, SAA may play a key role in regulating the contributions of these processes to atherogenesis...
  12. ncbi request reprint Pathogenesis of calcific aortic valve disease: a disease process comes of age (and a good deal more)
    Kevin D O'Brien
    Division of Cardiology, Box 356422, University of Washington, Seattle, WA 98195 6422, USA
    Arterioscler Thromb Vasc Biol 26:1721-8. 2006
    ..These studies will be reviewed and organized into a proposed global hypothesis for the pathogenesis of calcific aortic valve disease...
  13. ncbi request reprint Neovascular expression of E-selectin, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 in human atherosclerosis and their relation to intimal leukocyte content
    K D O'Brien
    Department of Medicine, University of Washington, Seattle 98195 6422
    Circulation 93:672-82. 1996
    ..However, no previous study has evaluated either the distribution of these three molecules at different sites within the arterial intima or their relation to plaque leukocyte content...
  14. ncbi request reprint Oxidation-specific epitopes in human coronary atherosclerosis are not limited to oxidized low-density lipoprotein
    K D O'Brien
    Division of Cardiology, School of Medicine, University of Washington, Seattle 98195 6422, USA
    Circulation 94:1216-25. 1996
    ....
  15. ncbi request reprint Features of the metabolic syndrome and diabetes mellitus as predictors of aortic valve calcification in the Multi-Ethnic Study of Atherosclerosis
    Ronit Katz
    University of Washington, Seattle, WA, USA
    Circulation 113:2113-9. 2006
    ....
  16. ncbi request reprint Acrolein impairs ATP binding cassette transporter A1-dependent cholesterol export from cells through site-specific modification of apolipoprotein A-I
    Baohai Shao
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 280:36386-96. 2005
    ..Thus, acrolein might contribute to atherogenesis by impairing cholesterol removal from the artery wall...
  17. ncbi request reprint Usefulness of aortic valve calcium scores by electron beam computed tomography as a marker for aortic stenosis
    David M Shavelle
    Division of Cardiology, Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    Am J Cardiol 92:349-53. 2003
    ..Results of this study suggest that AVC scores should be calculated routinely for coronary calcium screening EBT scans, and that patients with Agatston AVC scores above a certain level (e.g., >150) should be referred for echocardiography...
  18. pmc Aortic valve calcium independently predicts coronary and cardiovascular events in a primary prevention population
    David S Owens
    Department of Medicine, University of Washington, Seattle, Washington 98195 6422, USA
    JACC Cardiovasc Imaging 5:619-25. 2012
    ..This study sought to test whether aortic valve calcium (AVC) is independently associated with coronary and cardiovascular events in a primary-prevention population...
  19. pmc Serum amyloid A3 does not contribute to circulating SAA levels
    Tsuyoshi Chiba
    Department of Medicine, University of Washington, Seattle, Washington, USA
    J Lipid Res 50:1353-62. 2009
    ..In contrast, SAA3 could be detected in medium from cultured adipocytes. Our findings indicate that the expression of SAA3 in adipose tissue is upregulated by obesity, but it does not contribute to the circulating pool of SAA in mice...
  20. pmc Relationship between common carotid intima-media thickness and thoracic aortic calcification: the Multi-Ethnic Study of Atherosclerosis
    Junichiro Takasu
    Division of Cardiology, Los Angeles Biomedical Research Institute at Harbor UCLA, Torrance, CA 90502, USA
    Atherosclerosis 209:142-6. 2010
    ..No previous study has examined the relationship between CIMT and TAC in a large patient cohort. We performed a cross-sectional study to determine whether, at baseline, there is a relationship between CIMT and CT-determined TAC score...
  21. pmc Diabetes and arterial extracellular matrix changes in a porcine model of atherosclerosis
    Thomas O McDonald
    Division of Cardiology, Department of Medicine, University of Washington, Seattle, WA 98195 6422, USA
    J Histochem Cytochem 55:1149-57. 2007
    ..62, p=0.001). In this porcine model, diabetes was associated with multiple extracellular matrix changes that have been associated with increased lesion instability, greater atherogenic lipoprotein retention, and accelerated atherogenesis...
  22. pmc Inhibition of intestinal cholesterol absorption decreases atherosclerosis but not adipose tissue inflammation
    Tomio Umemoto
    Division of Metabolism, Endocrinology, and Nutrition, University of Washington, Seattle, WA, USA
    J Lipid Res 53:2380-9. 2012
    ....
  23. pmc Monocyte-to-macrophage differentiation: synthesis and secretion of a complex extracellular matrix
    Mary Y Chang
    Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 287:14122-35. 2012
    ....
  24. doi request reprint Age modification of the association of lipoprotein, lipid, and lipoprotein ratio with carotid intima-media thickness (from the Multi-Ethnic Study of Atherosclerosis [MESA])
    Pathmaja Paramsothy
    Department Medicine, Division of Cardiology, University of Washington, Seattle, USA
    Am J Cardiol 109:658-64. 2012
    ..In conclusion, abnormal lipoproteins and lipoprotein ratios in middle-aged and older patients are powerful risk factors for early atherosclerosis as manifested by an increased CIMT...
  25. ncbi request reprint Increase in serum amyloid a evoked by dietary cholesterol is associated with increased atherosclerosis in mice
    Katherine E Lewis
    Department of Medicine, University of Washington, Seattle, Wash 98195 6426, USA
    Circulation 110:540-5. 2004
    ..Therefore, we hypothesized that diet-induced increases in SAA would increase atherosclerosis independent of their effect on plasma cholesterol levels...
  26. pmc Age-modification of lipoprotein, lipid, and lipoprotein ratio-associated risk for coronary artery calcium (from the Multi-Ethnic Study of Atherosclerosis [MESA])
    Pathmaja Paramsothy
    Department of Medicine, Division of Cardiology, University of Washington, Seattle, Washington, USA
    Am J Cardiol 105:352-8. 2010
    ..However, these associations were markedly attenuated by age. In conclusion, abnormal lipoprotein levels in middle age are a powerful risk factor for early atherosclerosis, as manifested by prevalent CAC...
  27. pmc Dietary cholesterol worsens adipose tissue macrophage accumulation and atherosclerosis in obese LDL receptor-deficient mice
    Savitha Subramanian
    Department of Medicine, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195 6426, USA
    Arterioscler Thromb Vasc Biol 28:685-91. 2008
    ..This study was undertaken to determine whether dietary cholesterol and obesity have additive effects on inflammation and atherosclerosis...
  28. pmc CREB downregulation in vascular disease: a common response to cardiovascular risk
    Irene E Schauer
    Department of Medicine, University of Colorado at Denver Anschutz Medical Campus, Aurora, CO, USA
    Arterioscler Thromb Vasc Biol 30:733-41. 2010
    ....
  29. pmc T cell activation inhibitors reduce CD8+ T cell and pro-inflammatory macrophage accumulation in adipose tissue of obese mice
    Vince N Montes
    Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, Washington, USA
    PLoS ONE 8:e67709. 2013
    ..These data suggest that the presence of pro-inflammatory T cells and macrophages can be altered with co-stimulatory inhibitors, but may not be a significant contributor to the whole body IR phenotype. ..
  30. pmc Relationship between coronary artery and descending thoracic aortic calcification as detected by computed tomography: the Multi-Ethnic Study of Atherosclerosis
    Junichiro Takasu
    Division of Cardiology, Los Angeles Biomedical Research Institute at Harbor UCLA, Torrance, CA 90502, USA
    Atherosclerosis 204:440-6. 2009
    ..Previous studies demonstrate that DTAC is associated with obstructive CAD and coronary risk factors. However, no prior studies have examined the association of CAC and DTAC as detected by cardiac CT in a large population-based cohort...
  31. pmc Relationship of metabolic syndrome with incident aortic valve calcium and aortic valve calcium progression: the Multi-Ethnic Study of Atherosclerosis (MESA)
    Ronit Katz
    University of Washington, Seattle, Washington, USA
    Diabetes 58:813-9. 2009
    ..The purpose of this study was to determine whether MetS is associated with increased risks for the development of new ("incident") AVC or for progression of established AVC as assessed by CT...
  32. ncbi request reprint Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease
    B G Brown
    Department of Medicine, University of Washington School of Medicine, Seattle 98195, USA
    N Engl J Med 345:1583-92. 2001
    ..CONCLUSIONS: Simvastatin plus niacin provides marked clinical and angiographically measurable benefits in patients with coronary disease and low HDL levels. The use of antioxidant vitamins in this setting must be questioned...
  33. pmc Apolipoprotein AI and high-density lipoprotein have anti-inflammatory effects on adipocytes via cholesterol transporters: ATP-binding cassette A-1, ATP-binding cassette G-1, and scavenger receptor B-1
    Tomio Umemoto
    Department of Medicine, Division of Metabolism, Endocrinology, and Nutrition, University of Washington, Seattle, WA 98195, USA
    Circ Res 112:1345-54. 2013
    ..However, little is known concerning anti-inflammatory effects of HDL and apoAI on adipocytes...
  34. ncbi request reprint Cell-associated and extracellular phospholipid transfer protein in human coronary atherosclerosis
    Kevin D O'Brien
    Division of Cardiology, Department of Medicine, University of Washington, Seattle, Wash, USA
    Circulation 108:270-4. 2003
    ..However, whether PLTP might participate directly in human atherosclerotic lesion formation is unknown...
  35. pmc Toll-like receptor 4 deficiency decreases atherosclerosis but does not protect against inflammation in obese low-density lipoprotein receptor-deficient mice
    Yilei Ding
    Division of Metabolism, Endocrinology and Nutrition and Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington, Seattle, 98109, USA
    Arterioscler Thromb Vasc Biol 32:1596-604. 2012
    ..The present study was undertaken to determine whether TLR4 deficiency has a protective role in inflammation, insulin resistance, and atherosclerosis induced by a diabetogenic diet...
  36. pmc Differential effect of saturated and unsaturated free fatty acids on the generation of monocyte adhesion and chemotactic factors by adipocytes: dissociation of adipocyte hypertrophy from inflammation
    Chang Yeop Han
    Department of Medicine, University of Washington, Seattle, Washington, USA
    Diabetes 59:386-96. 2010
    ..The current objective was to determine how the other major nutrient, free fatty acids (FFAs), affects these molecules and monocyte recruitment by adipocytes...
  37. pmc Stages of systemic hypertension and blood pressure as correlates of computed tomography-assessed aortic valve calcium (from the Multi-Ethnic Study of Atherosclerosis)
    Jason Linefsky
    University of Washington, Seattle, Washington, USA
    Am J Cardiol 107:47-51. 2011
    ..In conclusion, stage I/II hypertension and higher systolic BP and pulse pressure were associated with prevalent AVC. These risk associations were strongest in participants < 65 years of age...
  38. pmc Incidence and progression of aortic valve calcium in the Multi-ethnic Study of Atherosclerosis (MESA)
    David S Owens
    University of Washington, Seattle, Washington, USA
    Am J Cardiol 105:701-8. 2010
    ..AVC progression risk was associated with male gender and the baseline Agatston score. Additional research is needed to determine whether age- and stage-specific mechanisms underlie the risk of AVC progression...
  39. ncbi request reprint HMG CoA reductase inhibitor (statin) and aortic valve calcium
    David M Shavelle
    Division of Cardiology, Department of Medicine, University of Washington, Seattle, WA 98195 6422, USA
    Lancet 359:1125-6. 2002
    ..006) and 44-49% fewer statin patients had definite AVC progression (p=0.043). These findings suggest that statins may decrease AVC accumulation...
  40. ncbi request reprint Cholesterol feeding increases C-reactive protein and serum amyloid A levels in lean insulin-sensitive subjects
    Lisa R Tannock
    Department of Medicine, University of Washington, 1959 NE Pacific St, Seattle, WA 98195 6426, USA
    Circulation 111:3058-62. 2005
    ..Inflammatory markers associated with elevated cardiovascular risk are increased by cholesterol feeding in animal models. However, whether dietary cholesterol increases inflammatory marker levels in humans is not known...
  41. ncbi request reprint Monocyte chemoattractant protein deficiency fails to restrain macrophage infiltration into adipose tissue [corrected]
    Elizabeth A Kirk
    Nutritional Sciences Program, Department of Pathobiology, University of Washington, Seattle, Washington 98195, USA
    Diabetes 57:1254-61. 2008
    ..We hypothesized that the absence of MCP-1 would improve the former and diminish the latter...
  42. ncbi request reprint Interaction of age with lipoproteins as predictors of aortic valve calcification in the multi-ethnic study of atherosclerosis
    David S Owens
    Division of Cardiology, Department of Internal Medicine, University of Washington, 1959 NE Pacific St, Seattle, WA 98195 6422, USA
    Arch Intern Med 168:1200-7. 2008
    ....
  43. pmc Dietary cholesterol exacerbates hepatic steatosis and inflammation in obese LDL receptor-deficient mice
    Savitha Subramanian
    Diabetes and Obesity Center of Excellence, University of Washington, Seattle, WA, USA
    J Lipid Res 52:1626-35. 2011
    ..Dietary cholesterol appears to confer a second "hit" that results in a distinct hepatic phenotype characterized by increased inflammation and oxidative stress...
  44. pmc Reduced vascular nitric oxide-cGMP signaling contributes to adipose tissue inflammation during high-fat feeding
    Priya Handa
    Department of Medicine, 815 Mercer St, University of Washington, Seattle, WA 98109, USA
    Arterioscler Thromb Vasc Biol 31:2827-35. 2011
    ....
  45. pmc Tesaglitazar, a dual peroxisome proliferator-activated receptor alpha/gamma agonist, reduces atherosclerosis in female low density lipoprotein receptor deficient mice
    Ebele C Chira
    Department of Medicine, University of Washington, Seattle, WA, USA
    Atherosclerosis 195:100-9. 2007
    ..We tested whether the dual PPAR-alpha/gamma agonist, tesaglitazar (TZ), would reduce atherosclerosis in a non-diabetic, atherosclerosis-prone mouse model, independent of effects on plasma lipids...
  46. pmc Relationship of apolipoproteins A-1 and B, and lipoprotein(a) to cardiovascular outcomes: the AIM-HIGH trial (Atherothrombosis Intervention in Metabolic Syndrome with Low HDL/High Triglyceride and Impact on Global Health Outcomes)
    John J Albers
    Northwest Lipid Metabolism and Diabetes Research Laboratories, Department of Medicine, University of Washington, Seattle, Washington
    J Am Coll Cardiol 62:1575-9. 2013
    ....
  47. ncbi request reprint Hemorrhage in the atherosclerotic carotid plaque: a high-resolution MRI study
    Baocheng Chu
    Department of Radiology, University of Washington, USA
    Stroke 35:1079-84. 2004
    ..The aim of this study was to develop criteria for the identification of the stages of intraplaque hemorrhage using high-resolution MRI...
  48. ncbi request reprint Aortic valve sclerosis as a marker of active atherosclerosis
    Kelley R Branch
    Division of Cardiology, University of Washington Medical Center, 1959 NE Pacific Street, Box 356422, Seattle, WA 98195 6422, USA
    Curr Cardiol Rep 4:111-7. 2002
    ....
  49. pmc Associations of LV hypertrophy with prevalent and incident valve calcification: Multi-Ethnic Study of Atherosclerosis
    Sammy Elmariah
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    JACC Cardiovasc Imaging 5:781-8. 2012
    ..The aim of this study was to evaluate the relationship between percentage of predicted left ventricular mass (%PredLVM) and valve calcification in the MESA (Multi-Ethnic Study of Atherosclerosis) study...
  50. pmc Plasma glycosylphosphatidylinositol-specific phospholipase D predicts the change in insulin sensitivity in response to a low-fat but not a low-carbohydrate diet in obese women
    Dona L Gray
    Department of Medicine, Indiana University, Indianapolis, IN 46202, USA
    Metabolism 57:473-8. 2008
    ..Plasma GPI-PLD may serve as a clinical tool to determine the effect of a low-fat diet on insulin sensitivity...
  51. ncbi request reprint Phospholipid transfer protein activity is associated with inflammatory markers in patients with cardiovascular disease
    Marian C Cheung
    Division of Metabolism, Endocrinology, and Nutrition, University of Washington, Seattle, WA 98109 4517, USA
    Biochim Biophys Acta 1762:131-7. 2006
    ..These findings show for the first time that plasma PLTP activity is associated positively with CRP in CVD, a state of chronic inflammation...
  52. pmc Retrovirally mediated overexpression of glycosaminoglycan-deficient biglycan in arterial smooth muscle cells induces tropoelastin synthesis and elastic fiber formation in vitro and in neointimae after vascular injury
    Jin Yong Hwang
    Hope Heart Program, Benaroya Research Institute, Seattle, WA 98101, USA
    Am J Pathol 173:1919-28. 2008
    ..These findings suggest that the GAG chains of biglycan serve as inhibitors of elastin synthesis and assembly, and that biglycan can act as an important modulator of the composition of the extracellular matrix of blood vessels...
  53. pmc Association of serum phosphate levels with aortic valve sclerosis and annular calcification: the cardiovascular health study
    Jason P Linefsky
    Health Services Research and Development Northwest Center for Excellence, Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98195 6422, USA
    J Am Coll Cardiol 58:291-7. 2011
    ..This study was conducted to evaluate mineral metabolism markers as potential risk factors for calcific aortic valve disease...
  54. ncbi request reprint Acrolein modifies apolipoprotein A-I in the human artery wall
    Baohai Shao
    Division of Metabolism, Endocrinology and Nutrition, Box 356426, University of Washington, Seattle, WA 98195
    Ann N Y Acad Sci 1043:396-403. 2005
    ..Our observations suggest that acrolein may interfere with normal HDL cholesterol transport by modifying apoA-I. This structural damage might play a critical role in atherogenesis by impairing cholesterol removal from artery wall cells...
  55. ncbi request reprint Biglycan, a vascular proteoglycan, binds differently to HDL2 and HDL3: role of apoE
    K L Olin
    Departments of Medicine, University of Washington, Seattle, USA
    Arterioscler Thromb Vasc Biol 21:129-35. 2001
    ..Thus, apoE is an important determinant of HDL binding to extracellular vascular proteoglycans and may play a role in HDL retention in the artery wall...
  56. pmc Validation of the severity index by cardiac catheterization and Doppler echocardiography in patients with aortic sclerosis and stenosis
    David M Shavelle
    Los Angeles BioMedical Research Institute at Harbor UCLA Research, Division of Cardiology, Torrance, CA, USA
    Cardiovasc Ultrasound 4:12. 2006
    ..0001; r = 0.84, p < 0.0001, respectively). These results confirm that the severity index correlates with hemodynamic severity of aortic valve disease and may prove to be a useful measure in patients with aortic sclerosis and AS...
  57. ncbi request reprint Effect of scanner type on the reproducibility of extracoronary measures of calcification: the multi-ethnic study of atherosclerosis
    Matthew J Budoff
    Division of Cardiology, Los Angeles Biomedical Research Institute at Harbor UCLA, 1124 W Carson Street, RB2, Torrance, CA 90502, USA
    Acad Radiol 14:1043-9. 2007
    ..Accurate quantification of calcification of the aortic valve, mitral annulus (MAC), and thoracic aortic (TAC) may be possible by using cardiac CT...
  58. ncbi request reprint The influence of oxidatively modified low density lipoproteins on expression of platelet-derived growth factor by human monocyte-derived macrophages
    L T Malden
    Department of Pathology, University of Washington, Seattle 98195
    J Biol Chem 266:13901-7. 1991
    ..This modulation may influence chemotaxis and mitogenesis of smooth muscle cells locally in the artery wall during atherogenesis...
  59. ncbi request reprint Statin use and risks of death or fatal rejection in the Heart Transplant Lipid Registry
    Audrey H Wu
    Division of Cardiology, Department of Medicine, University of Washington, Seattle, Washington, USA
    Am J Cardiol 95:367-72. 2005
    ..Statin therapy was significantly associated with lower risk of death and fatal rejection, benefits that were independent of lipid values...
  60. ncbi request reprint Interaction of native and modified low-density lipoproteins with extracellular matrix
    A Chait
    Department of Medicine and Pathology, University of Washington, Seattle 98195, USA
    Curr Opin Lipidol 11:457-63. 2000
    ..Thus, the interaction of atherogenic lipoproteins with arterial wall matrix molecules can influence the genesis and progression of atherosclerosis and its complications...
  61. doi request reprint SAA and PLTP activity in plasma of periodontal patients before and after full-mouth tooth extraction
    S Vuletic
    Department of Medicine, University of Washington, Seattle, Washington 98109, United States
    Oral Dis 14:514-9. 2008
    ..To assess whether treatment of advanced periodontal disease affects plasma levels of serum amyloid A (SAA) and phospholipid transfer protein (PLTP) activity...
  62. ncbi request reprint Lipid altering or antioxidant vitamins for patients with coronary disease and very low HDL cholesterol? The HDL-Atherosclerosis Treatment Study Design
    B G Brown
    Department of Medicine, University of Washington School of Medicine, Seattle, USA
    Can J Cardiol 14:6A-13A. 1998
    ..Based on these observations, a three-year angiographic study was proposed and received funding. Enrollment began in January 1995 and was completed in January 1997...
  63. ncbi request reprint Vascular (humoral) cardiac allograft rejection manifesting as inducible myocardial ischemia on nuclear perfusion imaging
    Kelley R Branch
    Division of Cardiology, University of Washington Medical Center, Seattle, USA
    J Nucl Cardiol 12:123-4. 2005
  64. pmc Associations between aspirin and other non-steroidal anti-inflammatory drugs and aortic valve or coronary artery calcification: the Multi-Ethnic Study of Atherosclerosis and the Heinz Nixdorf Recall Study
    Joseph A Delaney
    College of Pharmacy, University of Florida, USA
    Atherosclerosis 229:310-6. 2013
    ..The association between non-steroidal anti-inflammatory drugs (NSAIDs) and the incidence of valvular and arterial calcification is not well established despite known associations between these drugs and cardiovascular events...
  65. ncbi request reprint Progression of cardiovascular damage: the role of renin-angiotensin system blockade
    Jeffrey L Probstfield
    Clinical Trials Service Unit, Division of Cardiology, Department of Medicine, University of Washington School of Medicine, Seattle, Washington, USA
    Am J Cardiol 105:10A-20A. 2010
    ..Both ACE inhibitors and ARBs have been shown to exert multiple antiatherogenic actions, and to reduce clinical events in high-risk participants; their use is recommended in current guidelines for the secondary prevention of CVD...
  66. ncbi request reprint Oxidized LDL bind to nonproteoglycan components of smooth muscle extracellular matrices
    M Y Chang
    Departments of Pathology, Division of Metabolism, Endocrinology, and Nutrition, School of Medicine, 1959 NE Pacific, BB-928 Health Sciences, Box 356426, University of Washington, Seattle, WA 98195-6426, USA
    J Lipid Res 42:824-33. 2001
    ..The markedly enhanced retention of oxidized LDL compared with native LDL may play an important role in the progression of atherosclerosis...
  67. ncbi request reprint Inhibition of low density lipoprotein oxidation in vitro by the 6- and 7-hydroxy-metabolites of doxazosin, an alpha 1-adrenergic antihypertensive agent
    A Chait
    Department of Medicine, University of Washington, Seattle 98195
    Am J Hypertens 7:159-67. 1994
    ..Thus, these metabolites of doxazosin may exert their antioxidant effect in the aqueous milieu of the lipoprotein, similar to vitamin C, and may be useful for the prevention of atherosclerosis in hypertensive individuals...
  68. ncbi request reprint Human monocyte-derived macrophages secrete two forms of proteoglycan-macrophage colony-stimulating factor that differ in their ability to bind low density lipoproteins
    M Y Chang
    Department of Pathology, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 273:15985-92. 1998
    ..The demonstration of two forms of human monocyte-derived macrophage PG-100/PG-MCSF which bind LDL may represent an additional role for macrophages in the extracellular trapping of lipoproteins in atherosclerosis...
  69. pmc The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques
    Janine M van Gils
    Marc and Ruti Bell Vascular Biology and Disease Program, Leon H Charney Division of Cardiology, Department of Medicine, New York University School of Medicine, New York, New York, USA
    Nat Immunol 13:136-43. 2012
    ..Thus, netrin-1 promoted atherosclerosis by retaining macrophages in the artery wall. Our results establish a causative role for negative regulators of leukocyte migration in chronic inflammation...
  70. pmc Murine norovirus increases atherosclerotic lesion size and macrophages in Ldlr(-/-) mice
    Jisun Paik
    Department of Comparative Medicine, University of Washington, Seattle, Washington, USA
    Comp Med 61:330-8. 2011
    ..Increased lesion size was associated with increased macrophages, suggesting that MNV may influence macrophage activation or accumulation in the lesion area...
  71. ncbi request reprint Advanced glycation end product precursors impair ABCA1-dependent cholesterol removal from cells
    Marisa Passarelli
    Department of Medicine, Box 356426, University of Washington, Seattle, WA 98195 6426, USA
    Diabetes 54:2198-205. 2005
    ....
  72. pmc Inflammation in carotid atherosclerotic plaque: a dynamic contrast-enhanced MR imaging study
    William S Kerwin
    Department of Radiology, Division of Cardiology, and Department of Surgery, University of Washington, 815 Mercer St, Seattle, WA 98109, USA
    Radiology 241:459-68. 2006
    ..To prospectively evaluate if there is an association between plaque enhancement at magnetic resonance (MR) imaging and proinflammatory cardiovascular risk factors and plaque content...
  73. ncbi request reprint MMP9 production by human monocyte-derived macrophages is decreased on polymerized type I collagen
    S Lepidi
    Department of Surgery, University of Washington School of Medicine, Seattle, USA
    J Vasc Surg 34:1111-8. 2001
    ..In addition, cells in contact with the collagen matrix are potentially more responsive to soluble mediators such as platelet-derived growth factor, interleukin 1beta, and tumor necrosis factor alpha...
  74. ncbi request reprint Effects of CP-900691, a novel peroxisome proliferator-activated receptor α, agonist on diabetic nephropathy in the BTBR ob/ob mouse
    Bardia Askari
    1 Department of Pathology, University of Washington, Seattle, WA, USA 2 Department of Pharmaceutical and Biomedical Sciences, Touro College of Pharmacy, New York, NY, USA
    Lab Invest 94:851-62. 2014
    ....
  75. pmc How to best manage glycemia and non-glycemia during the time of acute myocardial infarction
    Irl B Hirsch
    Division of Metabolism, University of Washington School of Medicine, Seattle, Washington, USA
    Diabetes Technol Ther 14:S22-32. 2012
    ..The use of continuous glucose monitoring in this population may allow better ability to safely reach glycemic targets, which it is hoped will improve glycemic control...
  76. ncbi request reprint Thiazolidinediones reduce the LDL binding affinity of non-human primate vascular cell proteoglycans
    L R Tannock
    Department of Medicine, University of Washington, Seattle, 98195, USA
    Diabetologia 47:837-43. 2004
    ..Thiazolidinediones have been shown to reduce atherosclerosis in mouse models. The aim of this study was to determine whether thiazolidinediones modify vascular proteoglycan synthesis in a way that decreases LDL binding...
  77. ncbi request reprint Dietary isoflavones reduce plasma cholesterol and atherosclerosis in C57BL/6 mice but not LDL receptor-deficient mice
    E A Kirk
    Department of Medicine and the Nutritional Sciences Program, University of Washington, Seattle, WA 98195, USA
    J Nutr 128:954-9. 1998
    ..These findings suggest that soy isoflavones might lower cholesterol levels by increasing LDL receptor activity, and the reduction in cholesterol may offer some protection against atherosclerosis...
  78. ncbi request reprint Comprehensive nutrition plan improves cardiovascular risk factors in essential hypertension
    D A McCarron
    Department of Medicine, Oregon Health Sciences University, Portland 97201, USA
    Am J Hypertens 11:31-40. 1998
    ..Compared with typical dietary therapy, the comprehensive CCNW meal plan has significantly greater effects on multiple cardiovascular risk factors while yielding greater compliance and improved quality of life...
  79. ncbi request reprint The effect of apolipoprotein E deficiency on islet amyloid deposition in human islet amyloid polypeptide transgenic mice
    J Vidal
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, Washington, USA
    Diabetologia 46:71-9. 2003
    ..As apolipoprotein E (apoE), another component of islet amyloid deposits, plays a critical role in amyloid formation in Alzheimer's disease, we hypothesised that apoE could play an important role in islet amyloid formation...
  80. ncbi request reprint Safety and tolerability of simvastatin plus niacin in patients with coronary artery disease and low high-density lipoprotein cholesterol (The HDL Atherosclerosis Treatment Study)
    Xue Qiao Zhao
    Department of Medicine, Division of Cardiology, University of Washington School of Medicine, Seattle, Washington 98103, USA
    Am J Cardiol 93:307-12. 2004
    ..Thus, the simvastatin plus niacin regimen is effective, safe, and well tolerated in patients with or without diabetes mellitus...
  81. ncbi request reprint Lipoprotein-matrix interactions in macrovascular disease in diabetes
    Lisa R Tannock
    Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, WA 98195 6426, USA
    Front Biosci 9:1728-42. 2004
    ..This article reviews the scientific evidence in support of the response to retention hypothesis, with a specific focus on the effects of diabetes to modify lipoprotein retention...
  82. pmc Diabetes and diabetes-associated lipid abnormalities have distinct effects on initiation and progression of atherosclerotic lesions
    Catherine B Renard
    Department of Pathology, University of Washington, Seattle, Washington, USA
    J Clin Invest 114:659-68. 2004
    ..Thus, diabetes and diabetes-associated lipid abnormalities have distinct effects on initiation and progression of atherosclerotic lesions...
  83. ncbi request reprint Lysophosphatidylcholine regulates synthesis of biglycan and the proteoglycan form of macrophage colony stimulating factor
    Mary Y Chang
    Department of Medicine, University of Washington, Seattle, Wash 98195 6426, USA
    Arterioscler Thromb Vasc Biol 23:809-15. 2003
    ..It is not known which component of Ox-LDL is responsible for these effects. This study investigated the ability of several bioactive components of Ox-LDL to regulate proteoglycan synthesis...
  84. ncbi request reprint Induction of glutathione synthesis in macrophages by oxidized low-density lipoproteins is mediated by consensus antioxidant response elements
    Florian Bea
    Department of Pathobiology, University of Washington, Seattle, Wash 98195, USA
    Circ Res 92:386-93. 2003
    ..These data suggest that AREs play a direct role in mediating the induction of GSH synthesis by oxLDL and in protecting macrophages against oxidized lipid-induced oxidative stress...
  85. ncbi request reprint ApoC-III content of apoB-containing lipoproteins is associated with binding to the vascular proteoglycan biglycan
    Katherine Olin-Lewis
    Department of Medicine, University of Washington, Seattle, WA, USA
    J Lipid Res 43:1969-77. 2002
    ..ApoC-III content may thus be a marker for lipoproteins characterized as having an increased ability to bind proteoglycans...
  86. ncbi request reprint Antioxidant vitamins and lipid therapy: end of a long romance?
    B Greg Brown
    Department of Medicine, Division of Cardiology, University of Washington School of Medicine, Seattle, USA
    Arterioscler Thromb Vasc Biol 22:1535-46. 2002
    ..We conclude that they should rarely, if ever, be recommended for cardiovascular protection...
  87. ncbi request reprint Apolipoprotein E mediates the retention of high-density lipoproteins by mouse carotid arteries and cultured arterial smooth muscle cell extracellular matrices
    Katherine Olin-Lewis
    Departments of Medicine, University of Washington, Seattle, Wash 98195 6426, USA
    Circ Res 90:1333-9. 2002
    ....
  88. ncbi request reprint Prevention Conference VI: Diabetes and Cardiovascular Disease: Writing Group II: pathogenesis of atherosclerosis in diabetes
    Robert H Eckel
    Circulation 105:e138-43. 2002
  89. ncbi request reprint Arterial smooth muscle cell proteoglycans synthesized in the presence of glucosamine demonstrate reduced binding to LDL
    Lisa R Tannock
    Department of Medicine, Box 356426, University of Washington, Seattle, WA 98195 6426, USA
    J Lipid Res 43:149-57. 2002
    ..Thus, glucose and glucosamine have different effects on proteoglycan biosynthesis and different effects on lipoprotein retention...
  90. ncbi request reprint Triglyceride-rich lipoproteins from subjects with type 2 diabetes do not demonstrate increased binding to biglycan, a vascular proteoglycan
    Lisa R Tannock
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Clin Endocrinol Metab 87:35-40. 2002
    ..Therefore, increased affinity of TG-rich lipoproteins for biglycan is unlikely to explain the increased atherosclerosis in type 2 diabetes...
  91. ncbi request reprint The p17 cleaved form of caspase-3 is present within viable macrophages in vitro and in atherosclerotic plaque
    Thomas Q Nhan
    Department of Pathology, School of Medicine, University of Washington, Seattle, WA 98195, USA
    Arterioscler Thromb Vasc Biol 23:1276-82. 2003
    ..In vitro studies of macrophage death in response to oxidized LDL (oxLDL) were undertaken as a model for the formation of the necrotic core of atherosclerotic plaque...
  92. ncbi request reprint Human atherosclerotic intima and blood of patients with established coronary artery disease contain high density lipoprotein damaged by reactive nitrogen species
    Subramaniam Pennathur
    Department of Medicine, School of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 279:42977-83. 2004
    ..Thus, nitrated HDL might represent a previously unsuspected link between nitrosative stress, atherosclerosis, and inflammation...
  93. ncbi request reprint Adipocyte-derived serum amyloid A3 and hyaluronan play a role in monocyte recruitment and adhesion
    Chang Yeop Han
    Department of Medicine, University of Washington, Seattle, Washington 98195 6426, USA
    Diabetes 56:2260-73. 2007
    ..We hypothesize that adipocyte hypertrophy leads to increased production of SAA and hyaluronan, which act in concert to recruit and retain monocytes, thereby leading to local inflammation in adipose tissue...
  94. ncbi request reprint Reciprocal and coordinate regulation of serum amyloid A versus apolipoprotein A-I and paraoxonase-1 by inflammation in murine hepatocytes
    Chang Yeop Han
    Department of Medicine, University of Washington, Seattle, WA 98195 6426, USA
    Arterioscler Thromb Vasc Biol 26:1806-13. 2006
    ..Because cytokines stimulate the hepatic expression of inflammatory markers, we investigated their role in regulating SAA, apoA-I, and PON-1 expression...
  95. ncbi request reprint Diabetes and cardiovascular disease. Introduction
    Alan Chait
    Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, WA 98195 6426, USA
    Atheroscler Suppl 7:1-4. 2006
  96. pmc Type 1 diabetes promotes disruption of advanced atherosclerotic lesions in LDL receptor-deficient mice
    Fredrik Johansson
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 105:2082-7. 2008
    ..These findings indicate an important link between diabetes, plaque disruption, and the innate immune system...
  97. ncbi request reprint Glucosamine supplementation accelerates early but not late atherosclerosis in LDL receptor-deficient mice
    Lisa R Tannock
    Department of Internal Medicine, University of Kentucky, Lexington, KY 40536 0200, USA
    J Nutr 136:2856-61. 2006
    ..Although long-term glucosamine supplementation exacerbated the hyperlipidemia in male mice, no increase in atherosclerosis occurred. Thus, glucosamine supplementation appears to be safe, with no adverse vascular consequences...
  98. ncbi request reprint Diet-induced increases in adiposity, but not plasma lipids, promote macrophage infiltration into white adipose tissue
    Kimberly R Coenen
    Vanderbilt University Medical Center, Room 702 Light Hall, Nashville, TN 37232 0615, USA
    Diabetes 56:564-73. 2007
    ..These data have important implications for the pathogenesis of diet-induced obesity in humans, even when plasma lipid abnormalities are not present...
  99. pmc Shotgun proteomics implicates protease inhibition and complement activation in the antiinflammatory properties of HDL
    Tomas Vaisar
    Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98195, USA
    J Clin Invest 117:746-56. 2007
    ....
  100. ncbi request reprint Leptin deficiency suppresses progression of atherosclerosis in apoE-deficient mice
    Tsuyoshi Chiba
    Vascular Medicine and Geriatrics, Department of Medicine, Tokyo Medical and Dental University, Graduate School, Yushima 1 5 45, Bunkyo ku, Tokyo 113 8519, Japan
    Atherosclerosis 196:68-75. 2008
    ..Exogenous leptin significantly increased atherosclerotic areas in apoE(-/-) mice, even though it decreased food intake and body weight. Our findings support the notion that leptin accelerates atherosclerosis...
  101. ncbi request reprint Fish oil increases cholesterol storage in white adipose tissue with concomitant decreases in inflammation, hepatic steatosis, and atherosclerosis in mice
    Viswanathan Saraswathi
    Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Nutr 137:1776-82. 2007
    ..05) and decreased atherosclerotic lesion area (P < 0.05). Taken together, these data highlight the specific role of WAT in regulating dietary fish oil-mediated improvement in systemic lipid homeostasis and atherosclerosis...

Research Grants3

  1. Plaque Inflammation and Dysfunctional HDL in AIM-HIGH
    KEVIN O BRIEN; Fiscal Year: 2009
    ..We will test the hypothesis that niacin helps to block the inflammation that breaks down atherosclerotic plaques by improving the ability of "good" cholesterol, HDL, to repair inflammatory damage to the plaque. ..
  2. Plaque Inflammation and Dysfunctional HDL in AIM-HIGH
    KEVIN DOUGLAS O apos BRIEN; Fiscal Year: 2010
    ..We will test the hypothesis that niacin helps to block the inflammation that breaks down atherosclerotic plaques by improving the ability of "good" cholesterol, HDL, to repair inflammatory damage to the plaque. ..