CHARLES P O'BRIEN

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Neuroplasticity in addictive disorders
    CHARLES P O'BRIEN
    Department of Psychiatry, University of Pennsylvania, Treatment Research Center, Philadelphia, PA 19104 6178, USA
    Dialogues Clin Neurosci 11:350-3. 2009
  2. pmc Review. Evidence-based treatments of addiction
    CHARLES P O'BRIEN
    Department of Psychiatry, University of Pennsylvania, 3900 Chestnut Street, Philadelphia, PA 19104 6178, USA
    Philos Trans R Soc Lond B Biol Sci 363:3277-86. 2008
  3. pmc Addiction and dependence in DSM-V
    Charles O'Brien
    Center for Studies of Addiction, University of Pennsylvania, Philadelphia, PA 19104 6178, USA
    Addiction 106:866-7. 2011
  4. ncbi request reprint Research advances in the understanding and treatment of addiction
    CHARLES P O'BRIEN
    University of Pennsylvania, VA Medical Center, Philadelphia, PA 19104 6178, USA
    Am J Addict 12:S36-47. 2003
  5. doi request reprint Penn/VA center for studies of addiction
    CHARLES P O'BRIEN
    University of Pennsylvania, Treatment Research Center, 3900 Chestnut Street, Philadelphia, PA 19104 6178, USA
    Neuropharmacology 56:44-7. 2009
  6. pmc A 50-year-old woman addicted to heroin: review of treatment of heroin addiction
    CHARLES P O'BRIEN
    VA Mental Illness Research, Education and Clinical Center, and Department of Psychiatry, University of Pennsylvania, Philadelphia 19104 6178, USA
    JAMA 300:314-21. 2008
  7. ncbi request reprint Can we design and replicate clinical trials with a multiple drug focus
    CHARLES P O'BRIEN
    Department of Psychiatry, University of Pennsylvania School of Medicine, 3900 Chestnut Street, Philadelphia 19104 6178, USA
    Drug Alcohol Depend 70:135-7. 2003
  8. ncbi request reprint Naltrexone for probationers and parolees
    Charles O'Brien
    Treatment Research Center, University of Pennsylvania, 3900 Chestnut Street, Philadelphia, 19104 6178, USA
    J Subst Abuse Treat 31:107-11. 2006
  9. ncbi request reprint Anticraving medications for relapse prevention: a possible new class of psychoactive medications
    CHARLES P O'BRIEN
    University of Pennsylvania Philadelphia VA Medical Center, Philadelphia, PA 19104 6178, USA
    Am J Psychiatry 162:1423-31. 2005
  10. ncbi request reprint Priority actions to improve the care of persons with co-occurring substance abuse and other mental disorders: a call to action
    CHARLES P O'BRIEN
    Department of Psychiatry, University of Pennsylvania School of Medicine, 3900 Chestnut Street, Philadelphia, PA 19104 6178, USA
    Biol Psychiatry 56:703-13. 2004

Research Grants

Detail Information

Publications123 found, 100 shown here

  1. pmc Neuroplasticity in addictive disorders
    CHARLES P O'BRIEN
    Department of Psychiatry, University of Pennsylvania, Treatment Research Center, Philadelphia, PA 19104 6178, USA
    Dialogues Clin Neurosci 11:350-3. 2009
    ..It therefore requires chronic treatment with medications and behavioral therapies based on an understanding of the fundamental nature of these changes in the brain...
  2. pmc Review. Evidence-based treatments of addiction
    CHARLES P O'BRIEN
    Department of Psychiatry, University of Pennsylvania, 3900 Chestnut Street, Philadelphia, PA 19104 6178, USA
    Philos Trans R Soc Lond B Biol Sci 363:3277-86. 2008
    ..Addiction is a chronic disease that tends to recur when treatment is stopped; thus, long-term treatment is recommended...
  3. pmc Addiction and dependence in DSM-V
    Charles O'Brien
    Center for Studies of Addiction, University of Pennsylvania, Philadelphia, PA 19104 6178, USA
    Addiction 106:866-7. 2011
    ..These changes are anticipated to improve clarification and diagnosis and treatment of substance use and related disorders...
  4. ncbi request reprint Research advances in the understanding and treatment of addiction
    CHARLES P O'BRIEN
    University of Pennsylvania, VA Medical Center, Philadelphia, PA 19104 6178, USA
    Am J Addict 12:S36-47. 2003
    ..In this paper, strategies for effective treatment of addiction, including long-term relapse management and new pharmacological therapies such as naltrexone and acamprosate, are discussed...
  5. doi request reprint Penn/VA center for studies of addiction
    CHARLES P O'BRIEN
    University of Pennsylvania, Treatment Research Center, 3900 Chestnut Street, Philadelphia, PA 19104 6178, USA
    Neuropharmacology 56:44-7. 2009
    ..Some of the findings that came out of both the Penn/VA laboratory and clinical studies are now widely accepted and form the basis of standard clinical practice. These concepts and evidence will be briefly reviewed below...
  6. pmc A 50-year-old woman addicted to heroin: review of treatment of heroin addiction
    CHARLES P O'BRIEN
    VA Mental Illness Research, Education and Clinical Center, and Department of Psychiatry, University of Pennsylvania, Philadelphia 19104 6178, USA
    JAMA 300:314-21. 2008
    ..The treatment of heroin addiction as a chronic disease is reviewed, including social, medical, and cultural issues and pharmacologic treatment with methadone and the more experimental medication options of buprenorphine and naltrexone...
  7. ncbi request reprint Can we design and replicate clinical trials with a multiple drug focus
    CHARLES P O'BRIEN
    Department of Psychiatry, University of Pennsylvania School of Medicine, 3900 Chestnut Street, Philadelphia 19104 6178, USA
    Drug Alcohol Depend 70:135-7. 2003
  8. ncbi request reprint Naltrexone for probationers and parolees
    Charles O'Brien
    Treatment Research Center, University of Pennsylvania, 3900 Chestnut Street, Philadelphia, 19104 6178, USA
    J Subst Abuse Treat 31:107-11. 2006
    ..This special issue presents data, discussions, and suggestions regarding the ethical use of naltrexone in incarcerated populations or in those under supervision for parole or probation...
  9. ncbi request reprint Anticraving medications for relapse prevention: a possible new class of psychoactive medications
    CHARLES P O'BRIEN
    University of Pennsylvania Philadelphia VA Medical Center, Philadelphia, PA 19104 6178, USA
    Am J Psychiatry 162:1423-31. 2005
    ..Recent developments in pharmacogenetics may result in improved selection of medications based on genotype...
  10. ncbi request reprint Priority actions to improve the care of persons with co-occurring substance abuse and other mental disorders: a call to action
    CHARLES P O'BRIEN
    Department of Psychiatry, University of Pennsylvania School of Medicine, 3900 Chestnut Street, Philadelphia, PA 19104 6178, USA
    Biol Psychiatry 56:703-13. 2004
  11. ncbi request reprint Benzodiazepine use, abuse, and dependence
    CHARLES P O'BRIEN
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Clin Psychiatry 66:28-33. 2005
    ..Due to the chronic nature of anxiety, long-term low-dose benzodiazepine treatment may be necessary for some patients; this continuation of treatment should not be considered abuse or addiction...
  12. pmc Dopamine transporter genotype modulation of neural responses to smoking cues: confirmation in a new cohort
    Teresa R Franklin
    Research Assistant Professor of Neuroscience, Addiction Treatment Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, 3900 Chestnut Street, Philadelphia, PA 19104, USA
    Addict Biol 16:308-22. 2011
    ..Despite heterogeneity introduced by a host of factors, including variance in other genes involved in smoking behavior, we confirm that DAT genotype predicts the direction and location of neural responses to SCs...
  13. pmc Initiating acamprosate within-detoxification versus post-detoxification in the treatment of alcohol dependence
    Kyle M Kampman
    Department of Psychiatry, University of Pennsylvania School of Medicine, 3900, Chestnut Street, Philadelphia, PA 19104, USA
    Addict Behav 34:581-6. 2009
    ..This trial compared the efficacy of acamprosate, started at the beginning of detoxification, to acamprosate started at the completion of detoxification, in the treatment of alcohol dependence...
  14. pmc Reward-related brain response and craving correlates of marijuana cue exposure: a preliminary study in treatment-seeking marijuana-dependent subjects
    Marina Goldman
    Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA
    J Addict Med 7:8-16. 2013
    ....
  15. pmc Further evidence for association of polymorphisms in the CNR1 gene with cocaine addiction: confirmation in an independent sample and meta-analysis
    Toni Kim Clarke
    Psychiatric Pharmacogenetics Laboratory Center for Neurobiology and Behavior Treatment Research Center Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Addict Biol 18:702-8. 2013
    ..Furthermore, as this population consists of American individuals of African descent, the possibility of population stratification should not be excluded...
  16. pmc Association between the catechol-O-methyltransferase Val158Met polymorphism and cocaine dependence
    Falk W Lohoff
    Department of Psychiatry, Translational Research Laboratories, Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 33:3078-84. 2008
    ..Additional studies are required to elucidate the role of COMT in the pathophysiology of substance use disorders...
  17. pmc Effects of varenicline on smoking cue–triggered neural and craving responses
    Teresa Franklin
    Department of Psychiatry, University of Pennsylvania and Veterans Affairs Medical Center, Philadelphia, PA 19104, USA
    Arch Gen Psychiatry 68:516-26. 2011
    ....
  18. pmc Association analysis between polymorphisms in the conserved dopamine neurotrophic factor (CDNF) gene and cocaine dependence
    Falk W Lohoff
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Neurosci Lett 453:199-203. 2009
    ..However, additional studies using larger sample sizes, comprehensive SNP coverage, and clinically homogenous populations are necessary before confidently excluding CDNF as a significant genetic risk factor for cocaine dependence...
  19. pmc Low frequency genetic variants in the μ-opioid receptor (OPRM1) affect risk for addiction to heroin and cocaine
    Toni Kim Clarke
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA
    Neurosci Lett 542:71-5. 2013
    ..02; 95% C.I. 0.47 [0.24-0.92]). This study suggests a potential role for rare OPRM1 variants in addiction disorders and highlights an area worthy of future study...
  20. pmc DAT genotype modulates brain and behavioral responses elicited by cigarette cues
    Teresa R Franklin
    Department of Psychiatry, Addiction Treatment Research Center, University of Pennsylvania and Philadelphia VA Medical Center, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 34:717-28. 2009
    ..These results provide evidence that genetic variation in the DAT gene contributes to the neural and behavioral responses elicited by smoking cues...
  21. ncbi request reprint A functional prodynorphin promoter polymorphism and opioid dependence
    Riju Ray
    Department of Pharmacology, University of Pennsylvania, Philadelphia, 19104, USA
    Psychiatr Genet 15:295-8. 2005
    ..We examined this polymorphism for association in our sample of 168 opioid-dependent patients and 122 ethnically and geographically matched controls...
  22. ncbi request reprint No association between polymorphisms in the prostate apoptosis factor-4 gene and cocaine dependence
    Andrew E Weller
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Psychiatr Genet 16:193-6. 2006
    ..The aim of this study is to investigate whether polymorphisms in the human Par-4 gene contribute to the etiology of cocaine dependence...
  23. pmc Gender differences with high-dose naltrexone in patients with co-occurring cocaine and alcohol dependence
    Helen M Pettinati
    Department of Psychiatry, Center for the Study of Addictions, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Subst Abuse Treat 34:378-90. 2008
    ..Thus, 150 mg/day naltrexone added to a psychosocial treatment resulted in reductions in cocaine and alcohol use and drug severity in men, compared to higher rates of cocaine and alcohol use and drug severity in women...
  24. pmc A double blind, placebo-controlled trial that combines disulfiram and naltrexone for treating co-occurring cocaine and alcohol dependence
    Helen M Pettinati
    Center for the Study of Addictions, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Addict Behav 33:651-67. 2008
    ..This is a double blind, placebo-controlled trial that evaluated the efficacy of disulfiram, naltrexone and their combination in patients with co-occurring cocaine and alcohol dependence...
  25. pmc A double-blind, placebo-controlled trial of modafinil for cocaine dependence
    Charles A Dackis
    University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Subst Abuse Treat 43:303-12. 2012
    ..06). Our negative findings might be explained by gender differences and/or inadequate psychosocial treatment intensity in patients with severe cocaine dependence...
  26. pmc Modulation of resting brain cerebral blood flow by the GABA B agonist, baclofen: a longitudinal perfusion fMRI study
    Teresa R Franklin
    Department of Psychiatry, University of Pennsylvania, Center for Studies of Addiction and VA Medical Center, Philadelphia, PA, USA franklin
    Drug Alcohol Depend 117:176-83. 2011
    ..Its mechanism in humans is unknown. Here, we used continuous arterial spin labeled (CASL) perfusion fMRI to examine baclofen's effects on blood flow in the human brain...
  27. ncbi request reprint Analysis of variations in the tryptophan hydroxylase-2 (TPH2) gene in cocaine dependence
    John P Dahl
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, USA
    Addict Biol 11:76-83. 2006
    ..This work suggests that variations in the TPH2 gene are not a risk factor for the development of cocaine dependence, but these findings require confirmation in larger, independent samples of cocaine-dependent and control subjects...
  28. pmc Genetic variants in the cocaine- and amphetamine-regulated transcript gene (CARTPT) and cocaine dependence
    Falk W Lohoff
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Neurosci Lett 440:280-3. 2008
    ....
  29. doi request reprint Association analysis between polymorphisms in the dopamine D2 receptor (DRD2) and dopamine transporter (DAT1) genes with cocaine dependence
    Falk W Lohoff
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Neurosci Lett 473:87-91. 2010
    ..However, additional studies using larger sample sizes and clinically homogenous populations are necessary before confidently excluding these variants as contributing genetic risk factors for CD...
  30. pmc A VBM study demonstrating 'apparent' effects of a single dose of medication on T1-weighted MRIs
    Teresa R Franklin
    Department of Psychiatry, Center for Studies of Addiction, University of Pennsylvania School of Medicine, 3900 Chestnut Street, Philadelphia, PA 19104, USA
    Brain Struct Funct 218:97-104. 2013
    ....
  31. pmc Current status of co-occurring mood and substance use disorders: a new therapeutic target
    Helen M Pettinati
    Penn VA Center for Studies of Addiction, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA
    Am J Psychiatry 170:23-30. 2013
    ..With new data becoming available, it appears that we need to revisit current practice in the pharmacological management of co-occurring mood and substance use disorders...
  32. pmc Acute baclofen diminishes resting baseline blood flow to limbic structures: a perfusion fMRI study
    Teresa R Franklin
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA franklin
    Drug Alcohol Depend 125:60-6. 2012
    ..In the present study, we hypothesized that a single dose of baclofen would have effects similar to repeated dosing...
  33. ncbi request reprint A double-blind, placebo-controlled trial of amantadine, propranolol, and their combination for the treatment of cocaine dependence in patients with severe cocaine withdrawal symptoms
    Kyle M Kampman
    Department of Psychiatry, University of Pennsylvania School of Medicine, 3900 Chestnut Street, Philadelphia, PA 19104, USA
    Drug Alcohol Depend 85:129-37. 2006
    ..This trial evaluated the efficacy of amantadine, propranolol and their combination in cocaine dependent patients with severe cocaine withdrawal symptoms...
  34. pmc A double-blind, placebo-controlled pilot trial of quetiapine for the treatment of Type A and Type B alcoholism
    Kyle M Kampman
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Clin Psychopharmacol 27:344-51. 2007
    ..Quetiapine is an atypical antipsychotic with a favorable side effect profile, and may be a promising medication for the treatment of alcohol dependence, particularly Type B alcoholism...
  35. ncbi request reprint The status of naltrexone in the treatment of alcohol dependence: specific effects on heavy drinking
    Helen M Pettinati
    Center for the Study of Addictions, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6178, USA
    J Clin Psychopharmacol 26:610-25. 2006
    ..Clinical trial results in this article are evaluated by the type of outcome measure used to determine naltrexone's treatment advantage, that is, measures related to reducing heavy drinking versus those related to increasing abstinence...
  36. ncbi request reprint Association of a polymorphism in the Homer1 gene with cocaine dependence in an African American population
    John P Dahl
    Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Clinical Research Building, Philadelphia, 19104, USA
    Psychiatr Genet 15:277-83. 2005
    ..The purpose of this study is to determine whether single-nucleotide polymorphisms in the Homer1 and Homer2 genes associate with the cocaine-dependent phenotype in an African American population...
  37. pmc Low prefrontal perfusion linked to depression symptoms in methadone-maintained opiate-dependent patients
    Jesse J Suh
    Center for Studies of Addiction, Department of Psychiatry, University of Pennsylvania School of Medicine, 3900 Chestnut Street, Philadelphia, PA 19104, United States
    Drug Alcohol Depend 99:11-7. 2009
    ..In this study, we examined the link between resting rCBF in the PFC and current depressive symptoms in methadone-maintained opiate-dependent (MM) patients with or without major depression...
  38. ncbi request reprint Decreased gray matter concentration in the insular, orbitofrontal, cingulate, and temporal cortices of cocaine patients
    Teresa R Franklin
    Addiction Treatment Research Center, Department of Psychiatry, University of Pennsylvania and Philadelphia VA Medical Center, Philadelphia, PA 19104 6178, USA
    Biol Psychiatry 51:134-42. 2002
    ..To date, a focal structural analysis of the brains of cocaine patients has not been undertaken...
  39. pmc A placebo-controlled randomized clinical trial of naltrexone in the context of different levels of psychosocial intervention
    David W Oslin
    Center for the Study of Addictions, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Alcohol Clin Exp Res 32:1299-308. 2008
    ....
  40. ncbi request reprint Injectable, sustained-release naltrexone for the treatment of opioid dependence: a randomized, placebo-controlled trial
    Sandra D Comer
    Division on Substance Abuse, New York State Psychiatric Institute, and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York 10032, USA
    Arch Gen Psychiatry 63:210-8. 2006
    ..Oral naltrexone can completely antagonize the effects produced by opioid agonists. However, poor compliance with naltrexone has been a major obstacle to the effective treatment of opioid dependence...
  41. doi request reprint Clinical pharmacokinetics of lofexidine, the alpha 2-adrenergic receptor agonist, in opiate addicts plasma using a highly sensitive liquid chromatography tandem mass spectrometric analysis
    Elmer Yu
    University of Pennsylvania and Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania, USA
    Am J Drug Alcohol Abuse 34:611-6. 2008
    ..Lofexidine is an orally bioavailable alpha 2-adrenergic receptor agonist analogue of clonidine that acts centrally to suppress opiate withdrawal symptoms...
  42. pmc Gender differences in predictors of treatment attrition with high dose naltrexone in cocaine and alcohol dependence
    Jesse J Suh
    Center for Studies of Addiction, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA Suh
    Am J Addict 17:463-8. 2008
    ..Further research on the impact of pre-treatment and in-treatment gender differences with naltrexone is warranted...
  43. pmc Case-control association study of WLS variants in opioid and cocaine addicted populations
    Richard C Crist
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, USA
    Psychiatry Res 208:62-6. 2013
    ..However, this study does not exclude the possibilities that rare variants in WLS may affect susceptibility to drug addiction, or that common variants with small effect size may fall below the detection level of our analysis...
  44. pmc Depot naltrexone decreases rewarding properties of sugar in patients with opioid dependence
    Daniel D Langleben
    Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
    Psychopharmacology (Berl) 220:559-64. 2012
    ..05 to 0.83 m...
  45. pmc A double-blind, placebo-controlled trial combining sertraline and naltrexone for treating co-occurring depression and alcohol dependence
    Helen M Pettinati
    Center for the Studies of Addiction, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, USA
    Am J Psychiatry 167:668-75. 2010
    ....
  46. pmc The GABA B agonist baclofen reduces cigarette consumption in a preliminary double-blind placebo-controlled smoking reduction study
    Teresa R Franklin
    Department of Psychiatry, University of Pennsylvania, Philadelphia School of Medicine, PA 19104, USA
    Drug Alcohol Depend 103:30-6. 2009
    ..These preliminary results demonstrate provisional evidence of the utility of baclofen to aid in smoking cessation and indicate further investigation...
  47. pmc Menstrual cycle phase at quit date predicts smoking status in an NRT treatment trial: a retrospective analysis
    Teresa R Franklin
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6178, USA
    J Womens Health (Larchmt) 17:287-92. 2008
    ..However, no experimental data have been published to support this claim. Our objective was to determine whether MC phase affected smoking status in premenopausal female smokers participating in a smoking cessation treatment trial...
  48. ncbi request reprint Novel exonic mu-opioid receptor gene (OPRM1) polymorphisms not associated with opioid dependence
    Rachel J Smith
    Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Am J Med Genet B Neuropsychiatr Genet 133:105-9. 2005
    ..The results indicate that polymorphisms in the novel splice variant are not associated with opioid dependence, but are in LD with other polymorphisms in OPRM1...
  49. ncbi request reprint A pilot trial of olanzapine for the treatment of cocaine dependence
    Kyle M Kampman
    Department of Psychiatry, School of Medicine, Treatment Research Center, University of Pennsylvania, 3900 Chestnut Street, Philadelphia, PA 19104, USA
    Drug Alcohol Depend 70:265-73. 2003
    ....
  50. ncbi request reprint A double-blind, placebo-controlled trial of modafinil for cocaine dependence
    Charles A Dackis
    University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Neuropsychopharmacology 30:205-11. 2005
    ..This study provides preliminary evidence, which should be confirmed by a larger study, that modafinil improves clinical outcome when combined with psychosocial treatment for cocaine dependence...
  51. ncbi request reprint Alcohol potentiates hepatitis C virus replicon expression
    Ting Zhang
    Division of Allergy and Immunology, Joseph Stokes Jr Research Institute at The Children s Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Hepatology 38:57-65. 2003
    ..Thus, alcohol may play an important role in vivo as a cofactor in HCV disease progression and compromise IFN-alpha-based therapy against HCV infection...
  52. doi request reprint Neuronal calcium sensor-1 and cocaine addiction: a genetic association study in African-Americans and European Americans
    Pushpinder K Multani
    Psychiatric Pharmacogenetics Laboratory, Center for Neurobiology and Behavior, Department of Psychiatry, Philadelphia, PA, USA
    Neurosci Lett 531:46-51. 2012
    ..0001, allelic p = 0.002) with a gender specific effect for males (allelic p = 0.005, genotypic p = 0.0003). Our data suggest that genetic variants in the NCS-1 gene contribute to susceptibility of CA in individuals of African descent...
  53. ncbi request reprint Effect of naltrexone on oral consumption of concurrently available ethanol and cocaine in the rat
    Michael F Stromberg
    Department of Psychiatry, University of Pennsylvania, 3900 Chestnut Street, Philadelphia, PA 19104, USA
    Alcohol 28:169-79. 2002
    ..The implications of these findings for the clinical use of naltrexone in populations with comorbid ethanol and cocaine abuse are discussed...
  54. pmc A double-blind, placebo-controlled pilot trial of acamprosate for the treatment of cocaine dependence
    Kyle M Kampman
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    Addict Behav 36:217-21. 2011
    ..Therefore, we conducted a double-blind placebo-controlled pilot trial of acamprosate for the treatment of cocaine dependence...
  55. ncbi request reprint Modafinil and cocaine: a double-blind, placebo-controlled drug interaction study
    Charles A Dackis
    Department of Psychiatry, University of Pennsylvania, 3900 Chestnut Street, Philadelphia, PA 19104, USA
    Drug Alcohol Depend 70:29-37. 2003
    ..Furthermore, pretreatment with modafinil did not intensify cocaine euphoria or cocaine-induced craving. In fact, cocaine euphoria was significantly blunted (P=0.02) in one of our subjective measures...
  56. ncbi request reprint The status of disulfiram: a half of a century later
    Jesse J Suh
    Treatment Research Center, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Clin Psychopharmacol 26:290-302. 2006
    ..Preliminary evidence also suggests that disulfiram treatment could be a viable treatment for cocaine dependence because it was shown to reduce cocaine use among nonalcoholic, cocaine-dependent patients...
  57. pmc A randomized trial of oral naltrexone for treating opioid-dependent offenders
    Donna M Coviello
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA coviello
    Am J Addict 19:422-32. 2010
    ..The study provides limited support for the use of oral naltrexone for offenders who are not closely monitored by the criminal justice system...
  58. ncbi request reprint A pilot trial of topiramate for the treatment of cocaine dependence
    Kyle M Kampman
    Department of Psychiatry, University of Pennsylvania School of Medicine, 3900 Chestnut Street, Philadelphia, PA 19104, USA
    Drug Alcohol Depend 75:233-40. 2004
    ..Topiramate, an anticonvulsant, raises cerebral GABA levels, facilitates GABAergic neurotransmission and inhibits glutametergic activity at AMPA/kainite receptors. Thus, it may be useful for treating cocaine dependence...
  59. doi request reprint The dopamine receptor D2 (DRD2) SNP rs1076560 is associated with opioid addiction
    Toni Kim Clarke
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104, USA
    Ann Hum Genet 78:33-9. 2014
    ..No association was found with cocaine dependence. These data demonstrate the importance of dopamine gene variants in the risk for opioid dependence and highlight a functional polymorphism that warrants further study. ..
  60. ncbi request reprint Alcohol suppresses IL-2-induced CC chemokine production by natural killer cells
    Ting Zhang
    Department of Pediatrics, Division of Allergy and Immunology, Joseph Stokes Jr Research Institute at The Children s Hospital of Philadelphia, PA 19104, USA
    Alcohol Clin Exp Res 29:1559-67. 2005
    ..We investigated whether alcohol impairs NK cell function, particularly production of CC chemokines induced by interleukin (IL)-2, the natural ligands for CCR5 receptor...
  61. ncbi request reprint Targeting treatments for alcohol dependence: the pharmacogenetics of naltrexone
    David W Oslin
    University of Pennsylvania, Geriartric and Addiction Psychiatry, Philadelphia, PA 19104, USA
    Addict Biol 11:397-403. 2006
    ..This article reviews the biological correlates and outlines a scientific agenda for better understanding the role of opioid neurotransmission in the etiology, maintenance and treatment of alcohol dependence...
  62. doi request reprint Concurrent naltrexone and prolonged exposure therapy for patients with comorbid alcohol dependence and PTSD: a randomized clinical trial
    Edna B Foa
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    JAMA 310:488-95. 2013
    ..Alcohol dependence comorbid with posttraumatic stress disorder (PTSD) has been found to be resistant to treatment. In addition, there is a concern that prolonged exposure therapy for PTSD may exacerbate alcohol use...
  63. pmc A multisite pilot study of extended-release injectable naltrexone treatment for previously opioid-dependent parolees and probationers
    Donna M Coviello
    University of Pennsylvania, Philadelphia, Pennsylvania, USA coviello
    Subst Abus 33:48-59. 2012
    ..The findings indicate that XR-NTX holds promise as a feasible, effective treatment option for opioid-dependent offenders...
  64. pmc Covariates of craving in actively drinking alcoholics
    Subhajit Chakravorty
    Veterans Integrated Service Network, Mental Illness Research, Education and Clinical Center, Philadelphia V A Medical Center, Philadelphia, Pennsylvania 19104, USA
    Am J Addict 19:450-7. 2010
    ..The results from this study suggest that alcohol craving is a complex phenomenon influenced by multiple factors...
  65. ncbi request reprint Concurrent cocaine withdrawal alters alcohol withdrawal symptoms
    Kyle M Kampman
    Department of Psychiatry, University of Pennsylvania School of Medicine and the Department of Veterans Affairs Medical Center, Philadelphia, USA
    J Addict Dis 21:13-26. 2002
    ..Both subject and clinician factors may explain the difference in oxazepam use...
  66. pmc Long-acting injectable versus oral naltrexone maintenance therapy with psychosocial intervention for heroin dependence: a quasi-experiment
    Adam C Brooks
    Treatment Research Institute, 600 Public Ledger Bldg, 150 S Independence Mall West, Philadelphia, PA 19106, USA
    J Clin Psychiatry 71:1371-8. 2010
    ..To conduct a quasi-experimental comparison of early clinical outcomes between injectable, sustained-release, depot naltrexone formulation versus oral naltrexone maintenance therapy in individuals with opiate dependence...
  67. pmc Results of an initial clinical trial of varenicline for the treatment of cocaine dependence
    Jennifer G Plebani
    University of Pennsylvania, Department of Psychiatry, Treatment Research Center, 3900 Chestnut Street, Philadelphia, PA 19104, United States plebani
    Drug Alcohol Depend 121:163-6. 2012
    ..Cocaine use, abuse and dependence remains a pressing public health problem. Based on its mechanism of action, varenicline, an alpha4beta2 partial agonist seemed to be a likely candidate for treating cocaine dependence...
  68. ncbi request reprint Acute effect of methadone maintenance dose on brain FMRI response to heroin-related cues
    Daniel D Langleben
    Department of Psychiatry, University of Pennsylvania, Treatment Research Center, Philadelphia, PA 19104, USA
    Am J Psychiatry 165:390-4. 2008
    ..The authors sought to identify the functional neuroanatomy of the brain response to visual heroin-related stimuli in methadone maintenance patients...
  69. pmc A Phase 3 placebo-controlled, double-blind, multi-site trial of the alpha-2-adrenergic agonist, lofexidine, for opioid withdrawal
    Elmer Yu
    University of Pennsylvania and Philadelphia Veterans Affairs Medical Center, Philadelphia VAMC 116, University and Woodland Avenues, Philadelphia, PA 19104, USA
    Drug Alcohol Depend 97:158-68. 2008
    ..Lofexidine has been reported to have more significant effects on decreasing opioid withdrawal symptoms with less hypotension than clonidine...
  70. ncbi request reprint Limbic activation to cigarette smoking cues independent of nicotine withdrawal: a perfusion fMRI study
    Teresa R Franklin
    Department of Psychiatry, Addiction Treatment Research Center, University of Pennsylvania, 3900 Chestnut Street, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 32:2301-9. 2007
    ....
  71. pmc Prelude to passion: limbic activation by "unseen" drug and sexual cues
    Anna Rose Childress
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    PLoS ONE 3:e1506. 2008
    ..conscious recognition? Can the brain response to "unseen" reward cues predict the future affective response to recognizable versions of such cues, revealing a link between affective/motivational processes inside and outside awareness?..
  72. ncbi request reprint A randomized, double-blind, placebo-controlled safety study of high-dose dextromethorphan in methadone-maintained male inpatients
    James W Cornish
    Veteran s Affairs Medical Center, University and Woodland Aves, Philadelphia, PA 19104, USA
    Drug Alcohol Depend 67:177-83. 2002
    ..Overall, DM was well-tolerated by the methadone-maintained opiate-dependent subjects studied here. These results support the further exploration of DM as an adjunct medication during methadone replacement therapy...
  73. ncbi request reprint Cocaine dependence severity predicts outcome in outpatient detoxification from cocaine and alcohol
    Kyle M Kampman
    Department of Psychiatry, University of Pennsylvania School of Medicine, Treatment Research Center, 3900 Chestnut Street, Philadelphia, PA 19104, USA
    Am J Addict 13:74-82. 2004
    ..Among cocaine- and alcohol-dependent subjects, cocaine dependence severity appears to be a more important predictor of detoxification success than alcohol dependence severity...
  74. ncbi request reprint Confirmation of the association between a polymorphism in the promoter region of the prodynorphin gene and cocaine dependence
    John P Dahl
    Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Clinical Research Building, Philadelphia, PA 19104, USA
    Am J Med Genet B Neuropsychiatr Genet 139:106-8. 2005
    ....
  75. ncbi request reprint A genetic association study of the mu opioid receptor and severe opioid dependence
    James J Crowley
    Department of Pharmacology, University of Pennsylvania, 415 Curie Boulevard, Philadelphia, PA 19104, USA
    Psychiatr Genet 13:169-73. 2003
    ..A recent report (Hoehe et al., 2000) found a significant association between a specific combination of OPRM1 single nucleotide polymorphisms (SNPs) and substance dependence...
  76. pmc Identifying risk factors for marijuana use among veterans affairs patients
    Marina Goldman
    Department of Psychiatry MG, JJS, KL, RS, HX, CPO, DWO, University of Pennsylvania School of Medicine, Philadelphia, PA and Philadelphia Veterans Affairs Medical Center VAMC Philadelphia JJS, Jr, CPO, DWO and VISN 4 Mental Illness Research, Education and Clinical Center MIRECC, Philadelphia, PA
    J Addict Med 4:47-51. 2010
    ..If data commonly collected in the primary care setting (eg, use of alcohol, smoking status, and depression symptoms) could predict cannabis use, then providers can implement targeted marijuana screening in high-risk groups...
  77. doi request reprint Long-term opioid blockade and hedonic response: preliminary data from two open-label extension studies with extended-release naltrexone
    CHARLES P O'BRIEN
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Addict 20:106-12. 2011
    ..The differential hedonic ratings suggest that, in patients who persist with long-term continuous therapy, XR-NTX may selectively inhibit the pleasure associated with drinking alcohol, compared to a variety of other activities. ..
  78. doi request reprint Opioid therapy in patients with chronic noncancer pain: diagnostic and clinical challenges
    Martin D Cheatle
    Center for Studies of Addiction, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Adv Psychosom Med 30:61-91. 2011
    ..Pharmacologic and nonpharmacologic treatment strategies for the patient with pain and opioid addiction are reviewed...
  79. pmc Drug treatment as HIV prevention: a research update
    David S Metzger
    HIV AIDS Prevention Research Division, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Acquir Immune Defic Syndr 55:S32-6. 2010
    ..Although there are challenges to implementing drug treatment programs for maximum impact, the scientific literature leaves no doubt about the effectiveness of drug treatment as an HIV prevention strategy...
  80. ncbi request reprint A functional polymorphism of the mu-opioid receptor gene is associated with naltrexone response in alcohol-dependent patients
    David W Oslin
    Center for the Study of Addictions, Department of Psychiatry, University of Pennsylvania, 3535 Market Street, Room 3002, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 28:1546-52. 2003
    ..If replicated, these results would help to identify alcohol-dependent individuals who may be most likely to respond to treatment with naltrexone...
  81. ncbi request reprint A matched comparison study of medical and psychiatric complications and anesthesia and analgesia requirements in methadone-maintained liver transplant recipients
    Robert M Weinrieb
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA
    Liver Transpl 10:97-106. 2004
    ..Posttransplant, 20% of patients receiving MMT used alcohol or illicit drugs. Data do not support withholding the provision of liver transplantation to patients receiving MMT, but larger, well-controlled studies are warranted...
  82. ncbi request reprint Selective serotonin re-uptake inhibitors and the risk of bleeding
    Robert M Weinrieb
    University of Pennsylvania, Department of Psychiatry, 3440 Market Street, Suite 370, Philadelphia, PA 19104, USA
    Expert Opin Drug Saf 4:337-44. 2005
    ..Clinicians should caution patients about combining SSRIs with aspirin or NSAIDs. Pharmacotherapy to reduce the risk of GI bleeding should be considered in high risk patients...
  83. ncbi request reprint Adding a nicotine blocking agent to cigarette tapering
    Peter Gariti
    Treatment Research Center, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Subst Abuse Treat 27:17-25. 2004
    ..Biochemically confirmed abstinence rates at followups did not differ between treatment groups (AD&C = 10%, 13%, 10% vs. PD&C = 3%, 10%, 13%). There is not enough evidence to suggest a Stage II trial...
  84. pmc Treatment outcomes in type A and B alcohol dependence 6 months after serotonergic pharmacotherapy
    William Dundon
    Center for the Studies of Addiction, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6178, USA
    Alcohol Clin Exp Res 28:1065-73. 2004
    ..The purpose of this study was to assess in this original study group whether treatment gains in the type A alcoholics were maintained or whether treatment outcomes changed for the type B alcoholics after discontinuing pharmacotherapy...
  85. ncbi request reprint An examination of potential sex and race effects in a study of continuing care for alcohol- and cocaine-dependent patients
    James R McKay
    Treatment Research Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6178, USA
    Alcohol Clin Exp Res 27:1321-3. 2003
  86. ncbi request reprint A critical review of selective serotonin reuptake inhibitor-associated bleeding: balancing the risk of treating hepatitis C-infected patients
    Robert M Weinrieb
    Department of Psychiatry, University of Pennsylvania, Philadelphia, USA
    J Clin Psychiatry 64:1502-10. 2003
    ..Because there is an increased risk of bleeding in HCV-infected patients who have developed cirrhosis and either portal hypertension or hepatic failure or both, we critically reviewed the literature on SSRI-associated bleeding...
  87. ncbi request reprint Accumbal neural responses during the initiation and maintenance of intravenous cocaine self-administration
    Laura L Peoples
    Department of Psychology, University of Pennsylvania, Philadelphia 19104, USA
    J Neurophysiol 91:314-23. 2004
    ..Finally, the data have potential implications for understanding mechanisms that transduce accumbal-mediated drug effects that contribute to drug addiction...
  88. ncbi request reprint Affiliation with deviant peers among children of substance dependent fathers from pre-adolescence into adolescence: associations with problem behaviors
    Howard B Moss
    Treatment Research Center, University of Pennsylvania, 3900 Chestnut Street, Philadelphia, PA 19104, USA
    Drug Alcohol Depend 71:117-25. 2003
    ..However, little data are available concerning the developmental trajectories of deviant peer affiliation...
  89. ncbi request reprint Rapid relapse generally follows treatment for substance use disorders among adolescents
    Jack R Cornelius
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Addict Behav 28:381-6. 2003
    ..1993). In J. S. Baer, G. A. Marlatt, & R. J. McMahon (Eds.), Addictive behaviors across the life span (pp. 160-183). London: SAGE.] in showing that most adolescents relapse quickly following treatment for substance use disorders...
  90. ncbi request reprint Physical and sexual abuse, depression and alcohol use disorders in adolescents: onsets and outcomes
    Duncan B Clark
    Department of Psychiatry and Pharmaceutical Sciences, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Drug Alcohol Depend 69:51-60. 2003
    ..These results indicate that MDD among adolescents with AUD may be partly attributable to PS Abuse...
  91. ncbi request reprint Carbohydrate-deficient transferrin levels reflect heavy drinking in alcohol-dependent women seeking treatment
    Margaret R Rukstalis
    Center for the Study of Addictions, Department of Psychiatry, University of Pennsylvania, and Philadelphia Medical Center for Veteran Affairs, Philadelphia Pennsylvania 19104, USA
    Alcohol Clin Exp Res 26:1539-44. 2002
    ..The study also examined the extent that E2 levels mediated the relationship between CDT levels and heavy drinking in the alcohol-dependent women...
  92. ncbi request reprint Psychiatric and substance use disorders as risk factors for attempted suicide among adolescents: a case control study
    Thomas M Kelly
    Western Psychiatric Institute and Clinic, Pittsburgh Adolescent Alcohol Research Center, University of Pittsburgh Medical School, PA 15213, USA
    Suicide Life Threat Behav 32:301-12. 2002
    ..Evaluation of these particular comorbid conditions should be part of the adolescent suicide risk assessment...
  93. ncbi request reprint Attention-deficit/hyperactivity disorder and conduct disorder symptomatology in adolescents with alcohol use disorder
    Brooke S G Molina
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    Psychol Addict Behav 16:161-4. 2002
    ..The findings did not differ between boys and girls, revealing that in a treatment sample of adolescents, ADHD-CD comorbidity may need to be assessed and treated, but it is not broadly indicative of severity...
  94. ncbi request reprint Family functioning and peer affiliation in children of fathers with antisocial personality disorder and substance dependence: associations with problem behaviors
    Howard B Moss
    Center for Education and Drug Abuse Research, University of Pittsburgh and St Francis Medical Center, Pittsburgh, PA, USA
    Am J Psychiatry 159:607-14. 2002
    ..The authors examined associations between the child's psychopathology, paternal substance dependence/antisocial personality disorder status, and measures of family and peer environments...
  95. ncbi request reprint The effectiveness of telephone-based continuing care in the clinical management of alcohol and cocaine use disorders: 12-month outcomes
    James R McKay
    Department of Psychiatry, University of Pennsylvania, Treatment Research Center, 3900 Chestnut Street, Philadelphia, PA 19104, USA
    J Consult Clin Psychol 72:967-79. 2004
    ..However, in participants with alcohol dependence only (n = 91), TEL produced better alcohol use outcomes than STND on all measures examined and better outcomes than RP on some of the measures...
  96. pmc Effects of an intensive street-level police intervention on syringe exchange program use in Philadelphia, PA
    Corey S Davis
    BS, University of Pennsylvania, Center for the Study of Addiction, HIV AIDS Prevention Research Division, 3535 Market Street, Suite 4058, Philadelphia, PA 19104 3309, USA
    Am J Public Health 95:233-6. 2005
    ..Declines in use among Black and male participants were much more pronounced than decreases among White and female participants...
  97. ncbi request reprint Do patient characteristics and initial progress in treatment moderate the effectiveness of telephone-based continuing care for substance use disorders?
    James R McKay
    University of Pennsylvania, Treatment Research Center, Philadelphia, PA 19104, USA
    Addiction 100:216-26. 2005
    ..To determine whether substance use severity, psychiatric severity, social support, self-help attendance or motivation moderated substance use outcomes in a telephone-based continuing care intervention...
  98. ncbi request reprint Initial reliability and validity studies of the revised Treatment Services Review (TSR-6)
    John S Cacciola
    University of Pennsylvania Center for Studies of Addiction, Philadelphia, PA 19104, USA The Treatment Research Institute, Philadelphia, PA 19106, USA
    Drug Alcohol Depend 92:37-47. 2008
    ..Report the results of initial reliability and validity analyses for a revised Treatment Services Review (TSR-6) instrument which measures a broader range of services than the original TSR...
  99. ncbi request reprint Accumbal neurons that are activated during cocaine self-administration are spared from inhibitory effects of repeated cocaine self-administration
    Laura L Peoples
    Department of Psychology, University of Pennsylvania, Philadelphia, PA 19106, USA
    Neuropsychopharmacology 32:1141-58. 2007
    ..The findings of the present study are consistent with a basic prediction of the differential inhibition hypothesis and may be relevant to understanding cocaine addiction...
  100. ncbi request reprint Selective strengthening of conditioned behaviors that occur during periods of amphetamine exposure
    Xun Wan
    Department of Psychology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 32:1346-57. 2007
    ..These findings are relevant to hypotheses regarding the etiology of drug addiction...
  101. ncbi request reprint Initial evidence for the reliability and validity of a "Lite" version of the Addiction Severity Index
    John S Cacciola
    University of Pennsylvania Center for Studies of Addiction, 3440 Market Street, Philadelphia, PA 19104, USA
    Drug Alcohol Depend 87:297-302. 2007
    ..To evaluate the psychometric properties of a shortened version of the baseline ASI-5, the ASI-L-VA...

Research Grants8

  1. FELLOWSHIP IN IV DRUG ABUSE TREATMENT RESEARCH
    CHARLES O BRIEN; Fiscal Year: 2006
    ..The primary facilities are the University of Pennsylvania Addiction Research Center and our clinical affiliates, including the VA Medical Center Substance Abuse Treatment Program. ..
  2. Center for Research on Improving the Treatment of Drug Abuse
    CHARLES O BRIEN; Fiscal Year: 2007
    ..Two proposed pilot projects focus on brain imaging of craving in marijuana and nicotine dependent patients using strategies developed in our prior studies of cocaine and opiate addiction. CENTER CHARACTERISTICS ..
  3. Center for Research Improving Treatment of Drug Abuse
    CHARLES O BRIEN; Fiscal Year: 2007
    ..Core: Introduction, Structure, Educational Functions 2. Core: Research Coordination 3. Core: Biostatistics/Informatics; 4.-7. New Projects (three clinical and one preclinical). ..
  4. Treatment Study Using Depot Naltrexone(1/6)Philadelphia Coord/Data Mgmt Site
    CHARLES P O apos BRIEN; Fiscal Year: 2010
    ..The data from this study can also be used by the FDA to evaluate the benefits of this treatment that could improve the lives of patients suffering from opioid addiction. ..