C P O'Brien

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint A range of research-based pharmacotherapies for addiction
    C P O'Brien
    University of Pennsylvania VA Medical Center, 3900 Chestnut Street, Philadelphia, PA 19104 6178, USA
    Science 278:66-70. 1997
  2. ncbi request reprint Conditioning factors in drug abuse: can they explain compulsion?
    C P O'Brien
    Veterans Affairs Medical Center, University of Pennsylvania, Philadelphia 19104 6178, USA
    J Psychopharmacol 12:15-22. 1998
  3. ncbi request reprint Amantadine in the treatment of cocaine-dependent patients with severe withdrawal symptoms
    K M Kampman
    Department of Psychiatry, University of Pennsylvannia School of Medicine, Philadelphia, 19104, USA
    Am J Psychiatry 157:2052-4. 2000
  4. ncbi request reprint The effect of gamma-vinyl-GABA on the consumption of concurrently available oral cocaine and ethanol in the rat
    M F Stromberg
    Center for Studies of Addiction, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Pharmacol Biochem Behav 68:291-9. 2001
  5. ncbi request reprint 6-beta-naltrexol reduces alcohol consumption in rats
    M R Rukstalis
    Treatment Research Center, University of Pennsylvania, Philadelphia 19104, USA
    Alcohol Clin Exp Res 24:1593-6. 2000
  6. ncbi request reprint A randomized, double-blind, placebo-controlled study of ritanserin pharmacotherapy for cocaine dependence
    J W Cornish
    Treatment Research Center, University of Pennsylvania, 3900 Chestnut Street, Philadelphia, PA 19104 6178, USA
    Drug Alcohol Depend 61:183-9. 2001
  7. ncbi request reprint Comparing levels of cocaine cue reactivity in male and female outpatients
    S J Robbins
    Department of Psychiatry, University of Pennsylvania, Philadelphia, USA
    Drug Alcohol Depend 53:223-30. 1999
  8. doi request reprint Genetic association analyses of PDYN polymorphisms with heroin and cocaine addiction
    T K Clarke
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, 125 South 31st Street, Philadelphia, PA 19104, USA
    Genes Brain Behav 11:415-23. 2012
  9. ncbi request reprint Mood state and recent cocaine use are not associated with levels of cocaine cue reactivity
    S J Robbins
    Treatment Research Center, University of Pennsylvania, 3900 Chestnut Street, Philadelphia, PA 19104, USA
    Drug Alcohol Depend 59:33-42. 2000
  10. ncbi request reprint Cocaine dependence: a disease of the brain's reward centers
    C A Dackis
    Treatment Research Center, University of Pennsylvania, 3900 Chestnut Street, Philadelphia, PA 19104, USA
    J Subst Abuse Treat 21:111-7. 2001

Detail Information

Publications23

  1. ncbi request reprint A range of research-based pharmacotherapies for addiction
    C P O'Brien
    University of Pennsylvania VA Medical Center, 3900 Chestnut Street, Philadelphia, PA 19104 6178, USA
    Science 278:66-70. 1997
    ..In addition, changes in the system for delivery of services have begun to shape the way that addiction is treated...
  2. ncbi request reprint Conditioning factors in drug abuse: can they explain compulsion?
    C P O'Brien
    Veterans Affairs Medical Center, University of Pennsylvania, Philadelphia 19104 6178, USA
    J Psychopharmacol 12:15-22. 1998
    ..We do not yet know the relative importance of learning in the overall phenomenon of relapse, and treatments based on conditioning principles are still under investigation...
  3. ncbi request reprint Amantadine in the treatment of cocaine-dependent patients with severe withdrawal symptoms
    K M Kampman
    Department of Psychiatry, University of Pennsylvannia School of Medicine, Philadelphia, 19104, USA
    Am J Psychiatry 157:2052-4. 2000
    ..The study examined the effectiveness of amantadine in reducing cocaine withdrawal symptoms and improving treatment outcome among cocaine-dependent patients in outpatient treatment...
  4. ncbi request reprint The effect of gamma-vinyl-GABA on the consumption of concurrently available oral cocaine and ethanol in the rat
    M F Stromberg
    Center for Studies of Addiction, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Pharmacol Biochem Behav 68:291-9. 2001
    ..These data suggest that GVG has potential for clinical use in populations that abuse either alcohol or cocaine alone or in combination...
  5. ncbi request reprint 6-beta-naltrexol reduces alcohol consumption in rats
    M R Rukstalis
    Treatment Research Center, University of Pennsylvania, Philadelphia 19104, USA
    Alcohol Clin Exp Res 24:1593-6. 2000
    ..Whether 6-beta-naltrexol is an active metabolite that contributes to the efficacy of naltrexone remains unknown...
  6. ncbi request reprint A randomized, double-blind, placebo-controlled study of ritanserin pharmacotherapy for cocaine dependence
    J W Cornish
    Treatment Research Center, University of Pennsylvania, 3900 Chestnut Street, Philadelphia, PA 19104 6178, USA
    Drug Alcohol Depend 61:183-9. 2001
    ..These results fail to support the use of ritanserin as a complement to outpatient psychosocial therapy for cocaine dependence...
  7. ncbi request reprint Comparing levels of cocaine cue reactivity in male and female outpatients
    S J Robbins
    Department of Psychiatry, University of Pennsylvania, Philadelphia, USA
    Drug Alcohol Depend 53:223-30. 1999
    ..Levels of reactivity in females were comparable to the results of previous studies with all male samples. These results support the use of a constant set of cues in future treatment studies employing gender-balanced patient samples...
  8. doi request reprint Genetic association analyses of PDYN polymorphisms with heroin and cocaine addiction
    T K Clarke
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, 125 South 31st Street, Philadelphia, PA 19104, USA
    Genes Brain Behav 11:415-23. 2012
    ..These data show that polymorphisms in PDYN are associated with opioid addiction in EAs and provide further evidence that these risk variants may be more relevant in females...
  9. ncbi request reprint Mood state and recent cocaine use are not associated with levels of cocaine cue reactivity
    S J Robbins
    Treatment Research Center, University of Pennsylvania, 3900 Chestnut Street, Philadelphia, PA 19104, USA
    Drug Alcohol Depend 59:33-42. 2000
    ..However, negative mood states at the start of a session were associated with higher levels of self-reported craving, high, and withdrawal both before and after cue exposure...
  10. ncbi request reprint Cocaine dependence: a disease of the brain's reward centers
    C A Dackis
    Treatment Research Center, University of Pennsylvania, 3900 Chestnut Street, Philadelphia, PA 19104, USA
    J Subst Abuse Treat 21:111-7. 2001
    ..Treatment principles, including engagement, motivational enhancement, abstinence strategies, and craving reduction are discussed in terms of biological rationales...
  11. ncbi request reprint Three decision-making tasks in cocaine-dependent patients: do they measure the same construct?
    J Monterosso
    Center for the Study of Addictions, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia 19104 6178, USA
    Addiction 96:1825-37. 2001
    ..We examine the interrelationship among these tasks...
  12. ncbi request reprint Gender and psychiatric comorbidity: impact on clinical presentation of alcohol dependence
    H M Pettinati
    Department of Psychiatry, University of Pennsylvania, Philadelphia 19104, USA
    Am J Addict 9:242-52. 2000
    ..All with current comorbidity, irrespective of gender, reported more days of heavy drinking than other groups. When evaluating drinking status, gender and comorbidity should be considered...
  13. ncbi request reprint Effect of acamprosate and naltrexone, alone or in combination, on ethanol consumption
    M F Stromberg
    Center for Studies of Addiction, Department of Psychiatry, University of Pennsylvania, 3900 Chestnut Street, 19104, Philadelphia, PA, USA
    Alcohol 23:109-16. 2001
    ..From these findings, it is suggested that a combination approach of these drugs may not be any more effective than monotherapy...
  14. ncbi request reprint The disabling nature of comorbid depression among older DUI recipients
    D W Oslin
    Center for the Study of Addictions, University of Pennsylvania, Philadelphia 19104, USA
    Am J Addict 8:128-35. 1999
    ..These data support previous studies that suggest greater disability in patients with concurrent mental illnesses...
  15. ncbi request reprint Cocaine withdrawal symptoms and initial urine toxicology results predict treatment attrition in outpatient cocaine dependence treatment
    K M Kampman
    University of Pennsylvania Treatment Research Center, 3900 Chestnut Street, Philadelphia, Pennsylvania 19104, USA
    Psychol Addict Behav 15:52-9. 2001
    ..The presence of cocaine withdrawal symptoms and a positive urine toxicology screen are clinically useful predictors of treatment attrition...
  16. ncbi request reprint Alcoholism treatment after liver transplantation: lessons learned from a clinical trial that failed
    R M Weinrieb
    Department of Psychiatry, The University of Pennsylvania, Philadelphia, USA
    Psychosomatics 42:110-6. 2001
    ..Barriers to posttransplant alcoholism included infirmity, intensive medical management, and denial for alcoholism treatment. Because 30%-50% of alcoholic patients drink after transplant, the authors suggest using MET alone pretransplant...
  17. ncbi request reprint Continuing care for cocaine dependence: comprehensive 2-year outcomes
    J R McKay
    Department of Psychiatry, University of Pennsylvania, Philadelphia 19104, USA
    J Consult Clin Psychol 67:420-7. 1999
    ..In addition, patients with current cocaine or alcohol dependence on entering continuing care who received RP had better cocaine use outcomes in Months 1-6 and better alcohol use outcomes in Months 13-24 than those in STND...
  18. pmc Case-control association analysis of polymorphisms in the delta-opioid receptor, OPRD1, with cocaine and opioid addicted populations
    R C Crist
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Drug Alcohol Depend 127:122-8. 2013
    ..The MOR, however, interacts with and is regulated by many known MOR interacting proteins (MORIPs), including the δ-opioid receptor (DOR)...
  19. ncbi request reprint The effects of naltrexone on alcohol and cocaine use in dually addicted patients
    D W Oslin
    Department of Psychiatry, University of Pennsylvania, Philadelphia, USA
    J Subst Abuse Treat 16:163-7. 1999
    ..The results of this study provide a rationale for a double-blind placebo-controlled study of the efficacy of naltrexone in this difficult to treat but prevalent population...
  20. ncbi request reprint Drug dependence, a chronic medical illness: implications for treatment, insurance, and outcomes evaluation
    A T McLellan
    The Treatment Research Institute, 150 S Independence Mall W, Suite 600, Philadelphia, PA 19106 3475, USA
    JAMA 284:1689-95. 2000
    ..Drug dependence should be insured, treated, and evaluated like other chronic illnesses. JAMA. 2000;284:1689-1695...
  21. ncbi request reprint Psychosocially enhanced treatment for cocaine-dependent mothers: evidence of efficacy
    J R Volpicelli
    Treatment Research Center, University of Pennsylvania, Philadelphia 19104, USA
    J Subst Abuse Treat 18:41-9. 2000
    ..These results show that providing psychosocial enhancement services onsite can improve treatment outcome for cocaine-dependent mothers...
  22. ncbi request reprint Laboratory exposure to cocaine cues does not increase cocaine use by outpatient subjects
    R N Ehrman
    Department of Psychiatry, University of Pennsylvania, Philadelphia 19104, USA
    J Subst Abuse Treat 15:431-5. 1998
    ..These results suggest that with proper clinical protections, cue exposure can be used as a treatment outcome measure and a behavioral intervention in outpatient settings without increasing the risk of drug use...
  23. ncbi request reprint Brain activity during simulated deception: an event-related functional magnetic resonance study
    D D Langleben
    Department of Psychiatry, Treatment Research Center, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuroimage 15:727-32. 2002
    ....