Marygorret Obonyo

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Role of gamma interferon in Helicobacter pylori induction of inflammatory mediators during murine infection
    Marygorret Obonyo
    Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    Infect Immun 70:3295-9. 2002
  2. ncbi request reprint Cultivation at 37 degrees C enhances Borrelia burgdorferi sensu stricto infectivity for hamsters
    Marygorret Obonyo
    Department of Medicine, School of Medicine, University of California, San Diego, La Jolla 92093, USA
    Med Microbiol Immunol 191:33-9. 2002
  3. pmc Antibacterial activities of liposomal linolenic acids against antibiotic-resistant Helicobacter pylori
    Marygorret Obonyo
    Department of Medicine, University of California, San Diego, La Jolla, California 92093, United States
    Mol Pharm 9:2677-85. 2012
  4. pmc Deficiencies of myeloid differentiation factor 88, Toll-like receptor 2 (TLR2), or TLR4 produce specific defects in macrophage cytokine secretion induced by Helicobacter pylori
    Marygorret Obonyo
    School of Medicine, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0640, USA
    Infect Immun 75:2408-14. 2007
  5. ncbi request reprint Evidence for interleukin-1-independent stimulation of interleukin-12 and down-regulation by interleukin-10 in Helicobacter pylori-infected murine dendritic cells deficient in the interleukin-1 receptor
    Marygorret Obonyo
    Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093 0640, USA
    FEMS Immunol Med Microbiol 47:414-9. 2006
  6. pmc Effects of myeloid differentiation primary response gene 88 (MyD88) activation on Helicobacter infection in vivo and induction of a Th17 response
    Marygorret Obonyo
    Department of Medicine, San Diego School of Medicine, University of California, La Jolla, 92093 0640, USA
    Helicobacter 16:398-404. 2011
  7. ncbi request reprint Interactions between inducible nitric oxide and other inflammatory mediators during Helicobacter pylori infection
    Marygorret Obonyo
    Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093 0640, USA
    Helicobacter 8:495-502. 2003
  8. doi request reprint Deficiency of the myeloid differentiation primary response molecule MyD88 leads to an early and rapid development of Helicobacter-induced gastric malignancy
    Anirban Banerjee
    Department of Biology and Center for Microbial Sciences, San Diego State University, San Diego, California, USA
    Infect Immun 82:356-63. 2014
  9. ncbi request reprint Expression of LL-37 by human gastric epithelial cells as a potential host defense mechanism against Helicobacter pylori
    Koji Hase
    Department of Medicine, University of California at San Diego, La Jolla, 92093, USA
    Gastroenterology 125:1613-25. 2003
  10. pmc Bacterial toxin-triggered drug release from gold nanoparticle-stabilized liposomes for the treatment of bacterial infection
    Dissaya Pornpattananangkul
    Department of Bioengineering, University of California San Diego, La Jolla, California 92093, United States
    J Am Chem Soc 133:4132-9. 2011

Research Grants

  1. Immunological Basis for H. Pylori-Related Malignancies
    Marygorret Obonyo; Fiscal Year: 2006

Collaborators

Detail Information

Publications10

  1. pmc Role of gamma interferon in Helicobacter pylori induction of inflammatory mediators during murine infection
    Marygorret Obonyo
    Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    Infect Immun 70:3295-9. 2002
    ..pylori in GSM06 cells. Induction of cyclooxygenase 2 mRNA through IFN-gamma was demonstrated in GSM06 cells. These data indicate that IFN-gamma mediates the induction of MIP-2 and iNOS mRNA expression by H. pylori in mice...
  2. ncbi request reprint Cultivation at 37 degrees C enhances Borrelia burgdorferi sensu stricto infectivity for hamsters
    Marygorret Obonyo
    Department of Medicine, School of Medicine, University of California, San Diego, La Jolla 92093, USA
    Med Microbiol Immunol 191:33-9. 2002
    ..We conclude that cultivation of spirochetes at 37 degrees C enhances their infectivity for hamsters. This study also suggests there is a correlation between enhancement of OspC expression and spirochetal infectivity for hamsters...
  3. pmc Antibacterial activities of liposomal linolenic acids against antibiotic-resistant Helicobacter pylori
    Marygorret Obonyo
    Department of Medicine, University of California, San Diego, La Jolla, California 92093, United States
    Mol Pharm 9:2677-85. 2012
    ..Our findings suggest that LipoLLA is a promising antibacterial nanotherapeutic to treat antibiotic-resistant H. pylori infection...
  4. pmc Deficiencies of myeloid differentiation factor 88, Toll-like receptor 2 (TLR2), or TLR4 produce specific defects in macrophage cytokine secretion induced by Helicobacter pylori
    Marygorret Obonyo
    School of Medicine, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0640, USA
    Infect Immun 75:2408-14. 2007
    ..pylori-related gastric cancer. In conclusion, our study demonstrates that H. pylori activates TLR2 and TLR4, leading to the secretion of distinct cytokines by macrophages...
  5. ncbi request reprint Evidence for interleukin-1-independent stimulation of interleukin-12 and down-regulation by interleukin-10 in Helicobacter pylori-infected murine dendritic cells deficient in the interleukin-1 receptor
    Marygorret Obonyo
    Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093 0640, USA
    FEMS Immunol Med Microbiol 47:414-9. 2006
    ..pylori when the bacterial load is high, allowing for persistent colonization of the gastric mucosa...
  6. pmc Effects of myeloid differentiation primary response gene 88 (MyD88) activation on Helicobacter infection in vivo and induction of a Th17 response
    Marygorret Obonyo
    Department of Medicine, San Diego School of Medicine, University of California, La Jolla, 92093 0640, USA
    Helicobacter 16:398-404. 2011
    ..Several studies have implicated a Th17 response as a key to protective immunity against Helicobacter...
  7. ncbi request reprint Interactions between inducible nitric oxide and other inflammatory mediators during Helicobacter pylori infection
    Marygorret Obonyo
    Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093 0640, USA
    Helicobacter 8:495-502. 2003
    ..Inducible nitric oxide synthase has been shown to be up-regulated in the gastric epithelium during H. pylori gastritis, suggesting a role in inflammation...
  8. doi request reprint Deficiency of the myeloid differentiation primary response molecule MyD88 leads to an early and rapid development of Helicobacter-induced gastric malignancy
    Anirban Banerjee
    Department of Biology and Center for Microbial Sciences, San Diego State University, San Diego, California, USA
    Infect Immun 82:356-63. 2014
    ..This is the first study to show evidence of MyD88 protection in an infection-driven inflammation-associated cancer model. ..
  9. ncbi request reprint Expression of LL-37 by human gastric epithelial cells as a potential host defense mechanism against Helicobacter pylori
    Koji Hase
    Department of Medicine, University of California at San Diego, La Jolla, 92093, USA
    Gastroenterology 125:1613-25. 2003
    ....
  10. pmc Bacterial toxin-triggered drug release from gold nanoparticle-stabilized liposomes for the treatment of bacterial infection
    Dissaya Pornpattananangkul
    Department of Bioengineering, University of California San Diego, La Jolla, California 92093, United States
    J Am Chem Soc 133:4132-9. 2011
    ..This technique can be broadly applied to treat a variety of infections caused by bacteria that secrete pore-forming toxins...

Research Grants1

  1. Immunological Basis for H. Pylori-Related Malignancies
    Marygorret Obonyo; Fiscal Year: 2006
    ..Under this award, the candidate will be able to develop this work into a productive project that will gain independent funding. ..