SCOTT OAKES

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc The adaptor protein CRK is a pro-apoptotic transducer of endoplasmic reticulum stress
    Kathryn Austgen
    Department of Pathology, University of California San Francisco, San Francisco, California 94143 0511, USA
    Nat Cell Biol 14:87-92. 2012
  2. pmc Mitochondria control calcium entry at the immunological synapse
    Scott A Oakes
    Department of Pathology, University of California, San Francisco, CA 94143 0511, USA
    Proc Natl Acad Sci U S A 104:15171-2. 2007
  3. ncbi request reprint The control of endoplasmic reticulum-initiated apoptosis by the BCL-2 family of proteins
    Scott A Oakes
    Department of Pathology, University of California, San Francisco, 94143, USA
    Curr Mol Med 6:99-109. 2006
  4. pmc Caspase-2 cleavage of BID is a critical apoptotic signal downstream of endoplasmic reticulum stress
    John Paul Upton
    Department of Pathology, Medicine, University of California, San Francisco, California 94143, USA
    Mol Cell Biol 28:3943-51. 2008
  5. ncbi request reprint A kinase inhibitor activates the IRE1alpha RNase to confer cytoprotection against ER stress
    Dan Han
    Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 2520, USA
    Biochem Biophys Res Commun 365:777-83. 2008
  6. pmc Blocking the mitochondrial apoptotic pathway preserves motor neuron viability and function in a mouse model of amyotrophic lateral sclerosis
    Nichole A Reyes
    Department of Pathology, University of California, San Francisco, San Francisco, California 94143 0511, USA
    J Clin Invest 120:3673-9. 2010
  7. pmc IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates
    Dan Han
    Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 2520, USA
    Cell 138:562-75. 2009
  8. pmc Phosphorylation of BCL-2 regulates ER Ca2+ homeostasis and apoptosis
    Michael C Bassik
    Department of Pathology and Medicine, Howard Hughes Medical Institute, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    EMBO J 23:1207-16. 2004
  9. ncbi request reprint BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis
    Luca Scorrano
    Howard Hughes Medical Institute, Dana Farber Cancer Institute, Brigham and Women s Hospital, Department of Pathology and Medicine, Harvard Medical School, Boston, MA 02115, USA
    Science 300:135-9. 2003
  10. ncbi request reprint Regulation of endoplasmic reticulum Ca2+ dynamics by proapoptotic BCL-2 family members
    Scott A Oakes
    Howard Hughes Medical Institute, Dana Farber Cancer Institute, Boston, USA
    Biochem Pharmacol 66:1335-40. 2003

Research Grants

Collaborators

  • FEROZ PAPA
  • Tullio Pozzan
  • J T Opferman
  • Dan Han
  • Kathryn Austgen
  • John Paul Upton
  • Luca Scorrano
  • Andrew Hagen
  • Nichole A Reyes
  • Stanley J Korsmeyer
  • Michael C Bassik
  • Tae Ju Park
  • Emily T Johnson
  • Tom Curran
  • Eric J Huang
  • Jill K Fisher
  • Scott Vandenberg
  • Weihong Xu
  • Alana G Lerner
  • Bradley J Backes
  • Lieselotte Vande Walle
  • Kristen M Coakley
  • Mari Nishino
  • Joseph Callahan
  • Mia D Sorcinelli
  • Emily H Cheng
  • Solly Weiler
  • Carmen A Mannella
  • Mona Ashiya
  • Karolyn Buttle

Detail Information

Publications13

  1. pmc The adaptor protein CRK is a pro-apoptotic transducer of endoplasmic reticulum stress
    Kathryn Austgen
    Department of Pathology, University of California San Francisco, San Francisco, California 94143 0511, USA
    Nat Cell Biol 14:87-92. 2012
    ..Together these results identify CRK as a pro-apoptotic protein that signals irremediable ER stress to the mitochondrial execution machinery...
  2. pmc Mitochondria control calcium entry at the immunological synapse
    Scott A Oakes
    Department of Pathology, University of California, San Francisco, CA 94143 0511, USA
    Proc Natl Acad Sci U S A 104:15171-2. 2007
  3. ncbi request reprint The control of endoplasmic reticulum-initiated apoptosis by the BCL-2 family of proteins
    Scott A Oakes
    Department of Pathology, University of California, San Francisco, 94143, USA
    Curr Mol Med 6:99-109. 2006
    ..Recent work has shown that the BCL-2 family of proteins plays a central role in regulating this form of cell death, both locally at the ER and from a distance at the mitochondrial membrane...
  4. pmc Caspase-2 cleavage of BID is a critical apoptotic signal downstream of endoplasmic reticulum stress
    John Paul Upton
    Department of Pathology, Medicine, University of California, San Francisco, California 94143, USA
    Mol Cell Biol 28:3943-51. 2008
    ..Our work defines a novel signaling pathway that couples the ER and mitochondria and establishes a principal apoptotic effector downstream of ER stress...
  5. ncbi request reprint A kinase inhibitor activates the IRE1alpha RNase to confer cytoprotection against ER stress
    Dan Han
    Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 2520, USA
    Biochem Biophys Res Commun 365:777-83. 2008
    ..Thus kinase inhibitors of IRE1alpha are useful for altering the apoptotic outcome to ER stress, and could possibly be developed into drugs to treat ER stress-related diseases...
  6. pmc Blocking the mitochondrial apoptotic pathway preserves motor neuron viability and function in a mouse model of amyotrophic lateral sclerosis
    Nichole A Reyes
    Department of Pathology, University of California, San Francisco, San Francisco, California 94143 0511, USA
    J Clin Invest 120:3673-9. 2010
    ..Hence, inhibiting apoptosis upstream of mitochondrial permeabilization represents a possible therapeutic strategy for preserving functional motor neurons in ALS and other MNDs...
  7. pmc IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates
    Dan Han
    Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 2520, USA
    Cell 138:562-75. 2009
    ..We propose that divergent cell fates during ER stress hinge on a balance between IRE1alpha RNase outputs that can be tilted with kinase inhibitors to favor survival...
  8. pmc Phosphorylation of BCL-2 regulates ER Ca2+ homeostasis and apoptosis
    Michael C Bassik
    Department of Pathology and Medicine, Howard Hughes Medical Institute, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    EMBO J 23:1207-16. 2004
    ..Unexpectedly, the regulation of ER Ca(2+) dynamics is a principal avenue whereby BCL-2 phosphorylation alters susceptibility to apoptosis...
  9. ncbi request reprint BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis
    Luca Scorrano
    Howard Hughes Medical Institute, Dana Farber Cancer Institute, Brigham and Women s Hospital, Department of Pathology and Medicine, Harvard Medical School, Boston, MA 02115, USA
    Science 300:135-9. 2003
    ..Thus, BAX and BAK operate in both the ER and mitochondria as an essential gateway for selected apoptotic signals...
  10. ncbi request reprint Regulation of endoplasmic reticulum Ca2+ dynamics by proapoptotic BCL-2 family members
    Scott A Oakes
    Howard Hughes Medical Institute, Dana Farber Cancer Institute, Boston, USA
    Biochem Pharmacol 66:1335-40. 2003
    ..Thus, BAX and BAK control apoptosis not only at the mitochondria, but also at the ER, an obligate checkpoint for Ca(2+)-dependent apoptotic stimuli...
  11. pmc Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum
    Scott A Oakes
    Howard Hughes Medical Institute, Dana Farber Cancer Institute, Brigham and Women s Hospital, Departments of Pathology and Medicine, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:105-10. 2005
    ..These findings support a model in which BCL-2 family members regulate IP3R-1 phosphorylation to control the rate of ER Ca(2+) leak from intracellular stores...
  12. ncbi request reprint Untangling the web: mitochondrial fission and apoptosis
    Scott A Oakes
    Howard Hughes Medical Institute, Dana Farber Cancer Institute, Brigham and Women s Hospital, Departments of Pathology and Medicine, Harvard Medical School, Boston, MA 02115, USA
    Dev Cell 7:460-2. 2004
    ..A new study by Szabadkai et al. in the October 8th issue of Molecular Cell shows that dynamin-related protein 1 (Drp1)-induced scission hinders the ability of mitochondria to transport calcium across the cell and mediate apoptosis...
  13. ncbi request reprint A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis
    Luca Scorrano
    Howard Hughes Medical Institute, Department of Pathology and Medicine, Harvard Medical School, Dana Farber Cancer Institute, 02115, Boston, MA, USA
    Dev Cell 2:55-67. 2002
    ..This reorganization does not require tBID's BH3 domain and is independent of BAK, but is inhibited by CsA. During this process, individual cristae become fused and the junctions between the cristae and the intermembrane space are opened...

Research Grants3

  1. BAX/BAK control ER-mitochondria apoptotic crosstalk
    SCOTT OAKES; Fiscal Year: 2007
    ..Dr. Scott Oakes, the Principal Investigator, is an M.D...
  2. Signaling Cell Death from the Endoplasmic Reticulum
    SCOTT OAKES; Fiscal Year: 2009
    ..This projects sets out to define how cellular stress normally leads to apoptosis and what goes wrong with this process in cancer-in the hopes of finding new therapeutic targets through which to kill tumor cells. ..
  3. Signaling Cell Death from the Endoplasmic Reticulum
    Scott A Oakes; Fiscal Year: 2010
    ..This projects sets out to define how cellular stress normally leads to apoptosis and what goes wrong with this process in cancer-in the hopes of finding new therapeutic targets through which to kill tumor cells. ..