Arne M Nystuen

Summary

Affiliation: University of Nebraska Medical Center
Country: USA

Publications

  1. ncbi A null mutation in VAMP1/synaptobrevin is associated with neurological defects and prewean mortality in the lethal-wasting mouse mutant
    Arne M Nystuen
    Department of Genetics, Cell Biology and Anatomy, 6008 Durham Research Center, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Neurogenetics 8:1-10. 2007
  2. pmc Nr2e3-directed transcriptional regulation of genes involved in photoreceptor development and cell-type specific phototransduction
    Neena B Haider
    Department of Genetics, Cell Biology, and Anatomy, University of Nebraska Medical Center, 985805 Nebraska Medical Center, Omaha, NE 68198 5805, USA
    Exp Eye Res 89:365-72. 2009
  3. doi A novel mutation in Prph2, a gene regulated by Nr2e3, causes retinal degeneration and outer-segment defects similar to Nr2e3 ( rd7/rd7 ) retinas
    Arne M Nystuen
    The Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE, 68198 5805, USA
    Mamm Genome 19:623-33. 2008
  4. ncbi The mouse mutants recoil wobbler and nmf373 represent a series of Grm1 mutations
    Andrew J Sachs
    Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, Nebraska 68198 5805, USA
    Mamm Genome 18:749-56. 2007
  5. doi Mapping of genetic modifiers of Nr2e3 rd7/rd7 that suppress retinal degeneration and restore blue cone cells to normal quantity
    Neena B Haider
    Department of Genetics, Cell Biology, and Anatomy, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    Mamm Genome 19:145-54. 2008
  6. pmc Patterned neuroprotection in the Inpp4a(wbl) mutant mouse cerebellum correlates with the expression of Eaat4
    Andrew J Sachs
    Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 4:e8270. 2009
  7. pmc Genetic variations strongly influence phenotypic outcome in the mouse retina
    Austin S Jelcick
    Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 6:e21858. 2011
  8. ncbi The transcription factor Nr2e3 functions in retinal progenitors to suppress cone cell generation
    Neena B Haider
    Department of Genetics, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    Vis Neurosci 23:917-29. 2006

Research Grants

Collaborators

Detail Information

Publications8

  1. ncbi A null mutation in VAMP1/synaptobrevin is associated with neurological defects and prewean mortality in the lethal-wasting mouse mutant
    Arne M Nystuen
    Department of Genetics, Cell Biology and Anatomy, 6008 Durham Research Center, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Neurogenetics 8:1-10. 2007
    ..Taken together, these data indicate that VAMP1 has a vital role in a subset of central nervous system tissues...
  2. pmc Nr2e3-directed transcriptional regulation of genes involved in photoreceptor development and cell-type specific phototransduction
    Neena B Haider
    Department of Genetics, Cell Biology, and Anatomy, University of Nebraska Medical Center, 985805 Nebraska Medical Center, Omaha, NE 68198 5805, USA
    Exp Eye Res 89:365-72. 2009
    ..These studies identified novel transcriptional pathways that are potentially targeted by Nr2e3 in the retina and specifically demonstrate a novel role for NR2E3 in regulating genes involved in phototransduction...
  3. doi A novel mutation in Prph2, a gene regulated by Nr2e3, causes retinal degeneration and outer-segment defects similar to Nr2e3 ( rd7/rd7 ) retinas
    Arne M Nystuen
    The Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE, 68198 5805, USA
    Mamm Genome 19:623-33. 2008
    ....
  4. ncbi The mouse mutants recoil wobbler and nmf373 represent a series of Grm1 mutations
    Andrew J Sachs
    Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, Nebraska 68198 5805, USA
    Mamm Genome 18:749-56. 2007
    ..The novel rcw mutants represent a resource that will have utility for further studies of inositol second-messenger-system defects in neurogenetic disorders...
  5. doi Mapping of genetic modifiers of Nr2e3 rd7/rd7 that suppress retinal degeneration and restore blue cone cells to normal quantity
    Neena B Haider
    Department of Genetics, Cell Biology, and Anatomy, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    Mamm Genome 19:145-54. 2008
    ..Our results suggest that there are several genes that are likely to act in the same or parallel pathway as NR2E3 that can rescue the Nr2e3 (rd7/rd7) phenotype and may serve as potential therapeutic targets...
  6. pmc Patterned neuroprotection in the Inpp4a(wbl) mutant mouse cerebellum correlates with the expression of Eaat4
    Andrew J Sachs
    Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 4:e8270. 2009
    ..Our data suggest that Purkinje cell loss in the Inpp4a(wbl) mutant is due to glutamate excitotoxicity initiated by the climbing fiber, and that Eaat4 may exert a protective effect...
  7. pmc Genetic variations strongly influence phenotypic outcome in the mouse retina
    Austin S Jelcick
    Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 6:e21858. 2011
    ..These strain specific genetic variations may also be present in other tissues. In addition, this study will provide valuable insight for the development of more accurate models for human retinal diseases...
  8. ncbi The transcription factor Nr2e3 functions in retinal progenitors to suppress cone cell generation
    Neena B Haider
    Department of Genetics, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    Vis Neurosci 23:917-29. 2006
    ..NR2E3 is thus one of the few genes known to influence the competency of retinal progenitors while simultaneously directing the rod and cone differentiation...

Research Grants1

  1. Inositol defects and neuronal death in the weeble mouse
    Arne Nystuen; Fiscal Year: 2004
    ..Together these aims will provide an understanding of precisely where, when and why neurons are lost due to the loss of Inpp4a function. ..