Sergey V Nuzhdin

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Sex-specific expression of alternative transcripts in Drosophila
    Lauren M McIntyre
    Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL 32611, USA
    Genome Biol 7:R79. 2006
  2. pmc Identification of co-regulated transcripts affecting male body size in Drosophila
    Cynthia J Coffman
    Health Services Research and Development Biostatistics Unit, Durham VA Medical Center 152, Durham, NC 27705, USA
    Genome Biol 6:R53. 2005
  3. ncbi request reprint Common pattern of evolution of gene expression level and protein sequence in Drosophila
    Sergey V Nuzhdin
    Evolution and Ecology, University of California at Davis, CA, USA
    Mol Biol Evol 21:1308-17. 2004
  4. ncbi request reprint Genome-enabled hitchhiking mapping identifies QTLs for stress resistance in natural Drosophila
    S V Nuzhdin
    Department of Evolution and Ecology, University of California at Davis, Davis, CA 95616, USA
    Heredity (Edinb) 99:313-21. 2007
  5. pmc Survival analysis of life span quantitative trait loci in Drosophila melanogaster
    Sergey V Nuzhdin
    Section of Evolution and Ecology, University of California, Davis, 95616, USA
    Genetics 170:719-31. 2005
  6. ncbi request reprint [Heterosis of quantitative trait loci modifying lifespan in Drosophila melanogaster]
    S V Nuzhdin
    Department of Evolution and Ecology, University of California in Davis, Davis, Cal 95616, USA
    Genetika 38:916-21. 2002
  7. ncbi request reprint Sure facts, speculations, and open questions about the evolution of transposable element copy number
    S V Nuzhdin
    Evolution and Ecology, University of California at Davis, CA 95616, USA
    Genetica 107:129-37. 1999
  8. ncbi request reprint Are the same genes responsible for intra- and interspecific variability for sex comb tooth number in Drosophila?
    S V Nuzhdin
    Section of Evolution and Ecology, University of California at Davis, Davis, CA 95616, USA
    Heredity (Edinb) 84:97-102. 2000
  9. ncbi request reprint Mapping quantitative trait loci affecting sternopleural bristle number in Drosophila melanogaster using changes of marker allele frequencies in divergently selected lines
    S V Nuzhdin
    Department of Genetics, North Carolina State University, Raleigh 27695, USA
    Genet Res 72:79-91. 1998
  10. pmc Quantitative genetic analysis of copia retrotransposon activity in inbred Drosophila melanogaster lines
    S V Nuzhdin
    Section of Evolution and Ecology, University of California, Davis, California 95616 5755, USA
    Genetics 150:755-66. 1998

Research Grants

Detail Information

Publications40

  1. pmc Sex-specific expression of alternative transcripts in Drosophila
    Lauren M McIntyre
    Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL 32611, USA
    Genome Biol 7:R79. 2006
    ..Here, we describe a genome-wide analysis of sex-specific expression of alternative transcripts in Drosophila melanogaster...
  2. pmc Identification of co-regulated transcripts affecting male body size in Drosophila
    Cynthia J Coffman
    Health Services Research and Development Biostatistics Unit, Durham VA Medical Center 152, Durham, NC 27705, USA
    Genome Biol 6:R53. 2005
    ..Applied to body size in Drosophila simulans, an evolutionarily important complex trait, a factor was directly associated with body size...
  3. ncbi request reprint Common pattern of evolution of gene expression level and protein sequence in Drosophila
    Sergey V Nuzhdin
    Evolution and Ecology, University of California at Davis, CA, USA
    Mol Biol Evol 21:1308-17. 2004
    ..We hypothesize that as a substantial fraction of nonsynonymous divergence has been shown to be adaptive, much of the observed expression divergence is likewise adaptive...
  4. ncbi request reprint Genome-enabled hitchhiking mapping identifies QTLs for stress resistance in natural Drosophila
    S V Nuzhdin
    Department of Evolution and Ecology, University of California at Davis, Davis, CA 95616, USA
    Heredity (Edinb) 99:313-21. 2007
    ..Our approach can contribute to the fine scale decomposition of the genetics of direct and indirect selection responses, and genotype by environment interactions...
  5. pmc Survival analysis of life span quantitative trait loci in Drosophila melanogaster
    Sergey V Nuzhdin
    Section of Evolution and Ecology, University of California, Davis, 95616, USA
    Genetics 170:719-31. 2005
    ..Our findings are broadly consistent with a mix of transient deleterious mutations and a few polymorphisms maintained by balancing selection, which together contribute to standing genetic variation in life span...
  6. ncbi request reprint [Heterosis of quantitative trait loci modifying lifespan in Drosophila melanogaster]
    S V Nuzhdin
    Department of Evolution and Ecology, University of California in Davis, Davis, Cal 95616, USA
    Genetika 38:916-21. 2002
    ..In Six out of the eight detected QTLs alleles that decreased lifespan were recessive. Heterosis was observed for a of QTL at 33E-38A. Thus, heterosis might contribute to maintaining variation in lifespan in natural populations...
  7. ncbi request reprint Sure facts, speculations, and open questions about the evolution of transposable element copy number
    S V Nuzhdin
    Evolution and Ecology, University of California at Davis, CA 95616, USA
    Genetica 107:129-37. 1999
    ..Thus, evolution of the frequency of permissive alleles of genes controlling transposition must be accounted for to understand evolution of TE copy numbers...
  8. ncbi request reprint Are the same genes responsible for intra- and interspecific variability for sex comb tooth number in Drosophila?
    S V Nuzhdin
    Section of Evolution and Ecology, University of California at Davis, Davis, CA 95616, USA
    Heredity (Edinb) 84:97-102. 2000
    ..One intraspecific QTL mapped to the same interval as the QTL for interspecific differences between D. simulans and D. mauritiana. Whether or not these effects result from the same genes requires further examination...
  9. ncbi request reprint Mapping quantitative trait loci affecting sternopleural bristle number in Drosophila melanogaster using changes of marker allele frequencies in divergently selected lines
    S V Nuzhdin
    Department of Genetics, North Carolina State University, Raleigh 27695, USA
    Genet Res 72:79-91. 1998
    ....
  10. pmc Quantitative genetic analysis of copia retrotransposon activity in inbred Drosophila melanogaster lines
    S V Nuzhdin
    Section of Evolution and Ecology, University of California, Davis, California 95616 5755, USA
    Genetics 150:755-66. 1998
    ..Segregation of modifying genes, rather than mutations, might explain the variability in copia retrotransposon activity between lines...
  11. pmc New candidate genes for sex-comb divergence between Drosophila mauritiana and Drosophila simulans
    Rita M Graze
    Genetics Graduate Group, Center for Genetics and Development, University of California Davis, 1 Shields Avenue, Davis, CA 95616
    Genetics 176:2561-76. 2007
    ..Further supporting the potential involvement of these genes in sex-comb divergence, we found a significant difference in sex-comb tooth number between co-isogenic D. melanogaster lines with and without P-element insertions at CG2791...
  12. ncbi request reprint Cis and trans regulatory effects contribute to natural variation in transcriptome of Drosophila melanogaster
    Anne Genissel
    Section of Evolution and Ecology, University of California, Davis, USA
    Mol Biol Evol 25:101-10. 2008
    ..In addition, we identified 15 genes that have alternative splice variants differentially regulated in cis...
  13. ncbi request reprint Genetic variation for expression of the sex determination pathway genes in Drosophila melanogaster
    Aaron M Tarone
    Evolution and Ecology, University of California at Davis, CA 95616, USA
    Genet Res 86:31-40. 2005
    ....
  14. pmc Naturally segregating quantitative trait loci affecting wing shape of Drosophila melanogaster
    Jason G Mezey
    Center for Population Biology and Section of Evolution and Ecology, University of California, Davis, 95616, USA
    Genetics 169:2101-13. 2005
    ..Naturally segregating variation can therefore act through known signaling pathways to produce variation in vein position...
  15. pmc High-resolution mapping of quantitative trait loci for sternopleural bristle number in Drosophila melanogaster
    M C Gurganus
    Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695, USA
    Genetics 152:1585-604. 1999
    ....
  16. doi request reprint Abundant genetic variation in transcript level during early Drosophila development
    Sergey V Nuzhdin
    Department of Evolution and Ecology, University of California, Davis, CA 95616, USA
    Evol Dev 10:683-9. 2008
    ..Finally, we estimate the dimensionality of gene expression in these two networks and find that-despite large numbers of varying genes-there appear to be only two factors controlling this variation...
  17. ncbi request reprint Quantitative trait locus mapping of fitness-related traits in Drosophila melanogaster
    M L Wayne
    Department of Genetics, Box 7614, North Carolina State University, Raleigh, NC 27695, USA
    Genet Res 77:107-16. 2001
    ..The regions harbouring QTL for female reproductive success and ovariole number were also identified as QTL for longevity in previous studies with these lines...
  18. doi request reprint Population genomic analysis of Tunisian Medicago truncatula reveals candidates for local adaptation
    Maren L Friesen
    Department of Molecular and Computational Biology, University of Southern California, Los Angeles, CA, USA
    Plant J 63:623-35. 2010
    ..These populations provide a strong resource for genome-wide association studies...
  19. doi request reprint Rarity of males in pea aphids results in mutational decay
    Jennifer A Brisson
    Section of Ecology and Evolution, University of California, Davis, CA 95616, USA
    Science 319:58. 2008
    ..We conclude that the ability of females to reproduce asexually without males reduces selection constraints on male-based genes, resulting in their mutational decay...
  20. pmc Natural genetic variation in cuticular hydrocarbon expression in male and female Drosophila melanogaster
    Brad Foley
    School of Integrative Biology, University of Queensland, Brisbane 4072, Queensland, Australia
    Genetics 175:1465-77. 2007
    ..This is consistent with a pattern of divergent sexual and natural selection between the sexes...
  21. pmc Effects of single P-element insertions on bristle number and viability in Drosophila melanogaster
    R F Lyman
    Department of Genetics, North Carolina State University, Raleigh 27695 7614, USA
    Genetics 143:277-92. 1996
    ..Two P-element-induced scabrous alleles and five extramacrochaetae alleles were generated. Single P-element mutagenesis is a powerful method for identifying QTLs at the level of genetic locus...
  22. pmc Nonadditive indirect effects of group genetic diversity on larval viability in Drosophila melanogaster imply key role of maternal decision-making
    Julia B Saltz
    Population Biology Graduate Group, University of California, Davis, Davis, CA, USA
    Mol Ecol 21:2270-81. 2012
    ..melanogaster and that predicting the consequences of genetic diversity at the population level may not be straightforward...
  23. pmc Similar patterns of linkage disequilibrium and nucleotide diversity in native and introduced populations of the pea aphid, Acyrthosiphon pisum
    Jennifer A Brisson
    Section of Ecology and Evolution, University of California at Davis, Davis, CA, USA
    BMC Genet 10:22. 2009
    ..Because introductions can cause population bottlenecks, we hypothesized that U.S. populations harbor lower levels of nucleotide diversity and higher levels of LD than native populations...
  24. ncbi request reprint Fitness costs of Doc expression are insufficient to stabilize its copy number in Drosophila melanogaster
    Hsiao Pei Yang
    Department of Evolution and Ecology, University of California at Davis, USA
    Mol Biol Evol 20:800-4. 2003
    ..Thus, selection against promoter-bearing copies does not appear to be stronger than that of promoter-lacking copies. Our results show that expression is not playing a major role in stabilizing Doc copy numbers...
  25. ncbi request reprint Quantitative trait loci for lifespan of mated Drosophila melanogaster affect both sexes
    Sarah G Reiwitch
    Section of Evolution and Ecology, University of California at Davis, Davis, CA 95616, USA
    Genet Res 80:225-30. 2002
    ..These QTLs have previously been detected in virgin flies surveys and had sex- and/or environment-specific effects...
  26. ncbi request reprint Intracellular battlegrounds: conflict and cooperation between transposable elements
    Teresa E Leonardo
    Center for Population Biology, University of California at Davis, Davis, CA 95616, USA
    Genet Res 80:155-61. 2002
    ..This framework poses new questions requiring conceptual and experimental advances. Considering primarily Drosophila data, we make a case for within host selection on TEs by thinking expansively about the lifecycle of several TE families...
  27. ncbi request reprint QTL mapping of genotype-environment interaction for fitness in Drosophila melanogaster
    J D Fry
    Department of Genetics, North Carolina State University, Raleigh 27695, USA
    Genet Res 71:133-41. 1998
    ....
  28. pmc Genomic islands of speciation in Anopheles gambiae
    Thomas L Turner
    Center for Population Biology, University of California, Davis, California, USA
    PLoS Biol 3:e285. 2005
    ..Concentrating future mapping experiments on these regions should reveal the genes responsible for reproductive isolation between forms...
  29. ncbi request reprint Environment-dependent survival of Drosophila melanogaster: a quantitative genetic analysis
    Mei Hui Wang
    School of Biological Sciences, University of Nebraska Lincoln, Lincoln, NE 68588, USA
    Aging Cell 3:133-40. 2004
    ..One such linkage group on the second chromosome conferred starvation resistance and longevity, supporting the hypothesis of an association between starvation resistance and lifespan...
  30. pmc Quantitative trait loci responsible for variation in sexually dimorphic traits in Drosophila melanogaster
    Artyom Kopp
    Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, Madison, Wisconsin 53706, USA
    Genetics 163:771-87. 2003
    ....
  31. pmc Quantitative trait loci affecting phenotypic plasticity and the allometric relationship of ovariole number and thorax length in Drosophila melanogaster
    Alan O Bergland
    Department of Ecology and Evolutionary Biology, Brown University, Providence, Rhode Island 02912, USA
    Genetics 180:567-82. 2008
    ..The results are discussed in the context of multivariate trait evolution...
  32. pmc Coordinated evolution of co-expressed gene clusters in the Drosophila transcriptome
    Jason G Mezey
    Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, NY 14853, USA
    BMC Evol Biol 8:2. 2008
    ..Clusters where expression evolution of each gene is not independent of their neighbors are important units for understanding transcriptome evolution...
  33. ncbi request reprint Quantitative trait loci for lipid content in Drosophila melanogaster
    Mei Hui Wang
    School of Biological Sciences, University of Nebraska, Lincoln, USA
    Obes Res 13:1891-7. 2005
    ..Candidate genes are discussed in relationship to lipid abundance, lipid proportion, and starvation resistance...
  34. ncbi request reprint A quantitative trait locus analysis of natural genetic variation for Drosophila melanogaster oxidative stress survival
    Yue Wang
    Department of Statistics, University of Nebraska Lincoln, Lincoln, NE 68583 0963, USA
    J Hered 97:355-66. 2006
    ..We also determined early-age egg production and found QTLs for this trait, but there was no support for an association between oxidative stress survival and egg production...
  35. ncbi request reprint Genetic variation for life span, resistance to paraquat, and spontaneous activity in unselected populations of Drosophila melanogaster: implications for transgenic rescue of life span
    Aziz A Khazaeli
    Department of Ecology, Evolution, and Behavior, University of Minnesota, 1987 Buford Circle, St Paul, MN 55108, United States
    Mech Ageing Dev 128:486-93. 2007
    ..Ad hoc observation of spontaneous flying activity 5 days after emergence proved to be a much better predictor of life span than resistance to an exogenous oxidant in these populations...
  36. ncbi request reprint Mutation accumulation and the effect of copia insertions in Drosophila melanogaster
    David Houle
    Department of Biological Science, Florida State University, Tallahassee 32306 1100, USA
    Genet Res 83:7-18. 2004
    ..3% per generation. The element number of copia was a significant predictor of fitness within generations; on average, insertions caused a 0.76% loss in fitness, although the confidence limits on this estimate are wide...
  37. pmc Dominance of mutations affecting viability in Drosophila melanogaster
    James D Fry
    Department of Biology, University of Rochester, Rochester, New York 14627, USA
    Genetics 163:1357-64. 2003
    ....
  38. ncbi request reprint The fixation of malaria refractoriness in mosquitoes
    Matthew W Hahn
    Curr Biol 14:R264-5. 2004
  39. pmc Simpler mode of inheritance of transcriptional variation in male Drosophila melanogaster
    Marta L Wayne
    Department of Zoology, University of Florida, Gainesville, FL 32611 8525, USA
    Proc Natl Acad Sci U S A 104:18577-82. 2007
    ..Consistent with this prediction, genes that are additive in males and nonadditive in females are overrepresented among genes responding to selection for increased mating speed...
  40. pmc Does sex trade with violence among genotypes in Drosophila melanogaster?
    Larry G Cabral
    Department of Biological Sciences, California State University Sacramento, Sacramento, California, United States of America
    PLoS ONE 3:e1986. 2008
    ..Overall patterns of competitive success among males and mating transactions between the sexes are consistent with mechanisms proposed for the maintenance of genetic variation due to nonlinear outcomes of competitive interactions...

Research Grants2

  1. Quantitative genomics of sexual dimorphism
    Sergey Nuzhdin; Fiscal Year: 2005
    ..We expect our results to have a profound impact on our understanding of the evolution of sexual dimorphism, and the role that sexual differentiation plays in the generation of phenotypic diversity. ..
  2. Nucleotide polymorphisms responsible for expression variation in Drosophila
    Sergey Nuzhdin; Fiscal Year: 2007
    ..These studies will contribute to building a pathway-minded description of complex character variation. They will shed light on the genetic architecture of transcript level variation in nature. ..