F Q Nuttall

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. pmc Effect of a LoBAG30 diet on protein metabolism in men with type 2 diabetes. A Randomized Controlled Trial
    Frank Q Nuttall
    Section of Endocrinology, Metabolism and Nutrition, Minneapolis VA Health Care System FQN, MCG, University of Minnesota, Minneapolis St, Paul, Minnesota, USA
    Nutr Metab (Lond) 9:43. 2012
  2. pmc Further decrease in glycated hemoglobin following ingestion of a LoBAG30 diet for 10 weeks compared to 5 weeks in people with untreated type 2 diabetes
    Mary C Gannon
    Metabolic Research Laboratory and Section of Endocrinology, Metabolism and Nutrition, VA Medical Center, Minneapolis, MN, USA
    Nutr Metab (Lond) 7:64. 2010
  3. ncbi request reprint Effect of orally administered phenylalanine with and without glucose on insulin, glucagon and glucose concentrations
    F Q Nuttall
    Section of Endocrinology, Metabolism and Nutrition, VA Medical Center, Minneapolis, Minnesota 55417, USA
    Horm Metab Res 38:518-23. 2006
  4. ncbi request reprint The metabolic response to a high-protein, low-carbohydrate diet in men with type 2 diabetes mellitus
    Frank Q Nuttall
    The Metabolic Research Laboratory, Endocrinology, Metabolism, and Nutrition Section, Department of Veterans Affairs Medical Center, Minneapolis, MN 55417, USA
    Metabolism 55:243-51. 2006
  5. ncbi request reprint Dietary management of type 2 diabetes: a personal odyssey
    Frank Q Nuttall
    Section of Endocrinology, Metabolism and Nutrition, Metabolic Research Laboratory, Department of Veterans Affairs Medical Center, Minneapolis, MN, USA
    J Am Coll Nutr 26:83-94. 2007
  6. ncbi request reprint Effect of the LoBAG30 diet on blood glucose control in people with type 2 diabetes
    Frank Q Nuttall
    Department of Medicine, University of Minnesota, 516 Delaware St SE, Minneapolis, MN 55108, USA
    Br J Nutr 99:511-9. 2008
  7. doi request reprint Regulation of hepatic glucose production and the role of gluconeogenesis in humans: is the rate of gluconeogenesis constant?
    Frank Q Nuttall
    Endocrine, Metabolism and Nutrition Section, VA Medical Center, Minneapolis, Minnesota 55417, USA
    Diabetes Metab Res Rev 24:438-58. 2008
  8. ncbi request reprint Stimulation of insulin secretion by fructose ingested with protein in people with untreated type 2 diabetes
    M C Gannon
    Metabolic Research Laboratory, Minneapolis Veterans Affairs Medical Center, MN 55417, USA
    Diabetes Care 21:16-22. 1998
  9. ncbi request reprint Liver glycogen synthase, phosphorylase, and the glycogen concentration in rats given a glucose load orally: a 24-hour study
    N Ercan
    Metabolic Research Laboratory, Minneapolis Veterans Affairs Medical Center, MN 55417
    Arch Biochem Biophys 315:35-40. 1994
  10. ncbi request reprint Acute metabolic response to high-carbohydrate, high-starch meals compared with moderate-carbohydrate, low-starch meals in subjects with type 2 diabetes
    M C Gannon
    Veterans Affairs Medical Center, and the Department of Food Science and Nutrition, University of Minnesota, Minneapolis 55417, USA
    Diabetes Care 21:1619-26. 1998

Collaborators

Detail Information

Publications44

  1. pmc Effect of a LoBAG30 diet on protein metabolism in men with type 2 diabetes. A Randomized Controlled Trial
    Frank Q Nuttall
    Section of Endocrinology, Metabolism and Nutrition, Minneapolis VA Health Care System FQN, MCG, University of Minnesota, Minneapolis St, Paul, Minnesota, USA
    Nutr Metab (Lond) 9:43. 2012
    ..abstract:..
  2. pmc Further decrease in glycated hemoglobin following ingestion of a LoBAG30 diet for 10 weeks compared to 5 weeks in people with untreated type 2 diabetes
    Mary C Gannon
    Metabolic Research Laboratory and Section of Endocrinology, Metabolism and Nutrition, VA Medical Center, Minneapolis, MN, USA
    Nutr Metab (Lond) 7:64. 2010
    ..In addition, protein balance, and a number of other blood and urine constituents were quantified at 5 and at 10 weeks on the LoBAG30 diet to address metabolic adaptation...
  3. ncbi request reprint Effect of orally administered phenylalanine with and without glucose on insulin, glucagon and glucose concentrations
    F Q Nuttall
    Section of Endocrinology, Metabolism and Nutrition, VA Medical Center, Minneapolis, Minnesota 55417, USA
    Horm Metab Res 38:518-23. 2006
    ....
  4. ncbi request reprint The metabolic response to a high-protein, low-carbohydrate diet in men with type 2 diabetes mellitus
    Frank Q Nuttall
    The Metabolic Research Laboratory, Endocrinology, Metabolism, and Nutrition Section, Department of Veterans Affairs Medical Center, Minneapolis, MN 55417, USA
    Metabolism 55:243-51. 2006
    ..The lack of negative effects, improved glucose control, and a positive nitrogen balance suggest beneficial effects for subjects with type 2 diabetes mellitus at risk for loss of lean body mass...
  5. ncbi request reprint Dietary management of type 2 diabetes: a personal odyssey
    Frank Q Nuttall
    Section of Endocrinology, Metabolism and Nutrition, Metabolic Research Laboratory, Department of Veterans Affairs Medical Center, Minneapolis, MN, USA
    J Am Coll Nutr 26:83-94. 2007
  6. ncbi request reprint Effect of the LoBAG30 diet on blood glucose control in people with type 2 diabetes
    Frank Q Nuttall
    Department of Medicine, University of Minnesota, 516 Delaware St SE, Minneapolis, MN 55108, USA
    Br J Nutr 99:511-9. 2008
    ..Long-term effects and general applicability of this diet remain to be determined...
  7. doi request reprint Regulation of hepatic glucose production and the role of gluconeogenesis in humans: is the rate of gluconeogenesis constant?
    Frank Q Nuttall
    Endocrine, Metabolism and Nutrition Section, VA Medical Center, Minneapolis, Minnesota 55417, USA
    Diabetes Metab Res Rev 24:438-58. 2008
    ..One interesting speculation is that gluconeogenic substrates substitute for each other depending on availability. Thus, the overall rate is either unaffected or only modestly changed. This requires further confirmation...
  8. ncbi request reprint Stimulation of insulin secretion by fructose ingested with protein in people with untreated type 2 diabetes
    M C Gannon
    Metabolic Research Laboratory, Minneapolis Veterans Affairs Medical Center, MN 55417, USA
    Diabetes Care 21:16-22. 1998
    ..Therefore we were interested in determining if ingestion of fructose along with protein would result in an additive, greater than additive, or less than additive effect on circulating insulin, glucagon, and glucose concentrations...
  9. ncbi request reprint Liver glycogen synthase, phosphorylase, and the glycogen concentration in rats given a glucose load orally: a 24-hour study
    N Ercan
    Metabolic Research Laboratory, Minneapolis Veterans Affairs Medical Center, MN 55417
    Arch Biochem Biophys 315:35-40. 1994
    ..In summary, the synthase R, phosphorylase a activities, or changes in the known allosteric modifiers of these enzymes could not explain the changes in glycogen concentration. The reasons for these discrepancies remain to be determined...
  10. ncbi request reprint Acute metabolic response to high-carbohydrate, high-starch meals compared with moderate-carbohydrate, low-starch meals in subjects with type 2 diabetes
    M C Gannon
    Veterans Affairs Medical Center, and the Department of Food Science and Nutrition, University of Minnesota, Minneapolis 55417, USA
    Diabetes Care 21:1619-26. 1998
    ....
  11. ncbi request reprint Glycogen concentration and regulation of synthase activity in rat liver in vivo
    C B Niewoehner
    Endocrine Metabolic Section, Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA
    Arch Biochem Biophys 318:271-8. 1995
    ..These data suggest a more complex mechanism than simply direct inhibition of synthase phosphatase by glycogen...
  12. ncbi request reprint Physiological doses of oral casein affect hepatic glycogen metabolism in normal food-deprived rats
    M C Gannon
    Metabolic Research Laboratory, V A Medical Center, Minneapolis, MN, USA
    J Nutr 125:1159-66. 1995
    ..Protein-induced glycogenolysis is likely to occur when rats ingest a moderate amount of a pure protein meal...
  13. ncbi request reprint Effect of protein ingestion on the glucose appearance rate in people with type 2 diabetes
    M C Gannon
    Section of Endocrinology, Metabolism, and Nutrition, University of Minnesota, Minneapolis, Minnesota 55417, USA
    J Clin Endocrinol Metab 86:1040-7. 2001
    ....
  14. ncbi request reprint The effect of caffeine and caffeine analogs on rat liver phosphorylase a activity
    N Ercan-Fang
    Department of Medicine, University of Minnesota, Minneapolis 55417, USA
    J Pharmacol Exp Ther 280:1312-8. 1997
    ..Xanthine and the other xanthine derivatives all strongly inhibited activity and the inhibition was independent of other effectors...
  15. ncbi request reprint Allosteric regulation of liver phosphorylase a: revisited under approximated physiological conditions
    N Ercan
    Department of Medicine, University of Minnesota, Minneapolis, 55417, USA
    Arch Biochem Biophys 328:255-64. 1996
    ..The present data indicate that the known endogenous allosteric effectors cannot explain the smaller than expected in vivo phosphorylase a activity or the regulation of phosphorylase a activity...
  16. ncbi request reprint Uric acid inhibits liver phosphorylase a activity under simulated in vivo conditions
    N G Ercan-Fang
    Metabolic Research Laboratory and Section of Endocrinology, Metabolism and Nutrition, Minneapolis Veterans Affairs Medical Center, One Veterans Drive 111G, Minneapolis, MN 55417, USA
    Am J Physiol Endocrinol Metab 280:E248-53. 2001
    ..A modest but not statistically significant glucose concentration-dependent inhibition was also present. Thus uric acid may play an important role in regulating phosphorylase a activity in vivo...
  17. ncbi request reprint The human liver Glycogen synthase isozyme gene is located on the short arm of chromosome 12
    F Q Nuttall
    Department of Medicine, University of Minnesota, Minneapolis
    Genomics 19:404-5. 1994
  18. ncbi request reprint Primary structure of human liver glycogen synthase deduced by cDNA cloning
    F Q Nuttall
    Metabolic Research Laboratory, VA Medical Center, Minneapolis, MN 55417
    Arch Biochem Biophys 311:443-9. 1994
    ..These regions include the amino acid sequences from 201 to 400 and 501 to 600. This high conservation suggests that the catalytic site and the glucose-6-P and nucleotide allosteric sites are included in these regions...
  19. ncbi request reprint Glucose appearance rate after the ingestion of galactose
    M C Gannon
    Section of Endocrinology, Metabolism, and Nutrition, Veterans Affairs Medical Center, Minneapolis, MN 55417, USA
    Metabolism 50:93-8. 2001
    ..Nevertheless, the conversion of galactose to glucose in the liver may have been greater than suggested by the increase in glucose appearance in the circulation due to substitution for other gluconeogenic substrates...
  20. ncbi request reprint Comparative characterization of human and rat liver glycogen synthase
    S A Westphal
    Metabolic Research Laboratory, Veterans Administration Medical Center, Minneapolis, Minnesota 55417
    Arch Biochem Biophys 292:479-86. 1992
    ..Since glycogen synthase is an important enzyme in liver glycogen synthesis, the characterization of this enzyme in the human will help provide insight regarding human liver glycogen synthesis...
  21. ncbi request reprint Adult hereditary fructose intolerance
    L A Burmeister
    Department of Medicine, University of Minnesota, Minneapolis
    Arch Intern Med 151:773-6. 1991
    ..The diagnosis can only be suspected by taking a careful dietary history. The prevalence of this condition in adults is unknown. It is rare but is likely to be more common than data in the literature would indicate...
  22. ncbi request reprint Autoimmune hypoglycemia
    J B Redmon
    Department of Medicine, University of Minnesota Medical School, Minneapolis, USA
    Endocrinol Metab Clin North Am 28:603-18, vii. 1999
    ..A correct diagnosis is important to avoid unnecessary surgical intervention in patients who are best treated with conservative support, watchful waiting, or in some cases, immunosuppressive therapy...
  23. ncbi request reprint An increase in dietary protein improves the blood glucose response in persons with type 2 diabetes
    Mary C Gannon
    Metabolic Research Laboratory and the Section of Endocrinology, Metabolism, and Nutrition, Department of Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA
    Am J Clin Nutr 78:734-41. 2003
    ..In single-meal studies, dietary protein does not result in an increase in glucose concentrations in persons with or without type 2 diabetes, even though the resulting amino acids can be used for gluconeogenesis...
  24. ncbi request reprint Protein in optimal health: heart disease and type 2 diabetes
    Donald K Layman
    Department of Food Science and Human Nutrition, University of Illinois, Urbana, IL 61801, USA
    Am J Clin Nutr 87:1571S-1575S. 2008
    ..Additional research is needed to determine specific levels of protein, carbohydrate, and fat for optimum health of individuals who differ in age, physical activity, and metabolic phenotypes...
  25. ncbi request reprint A fasting-induced decrease in plasma glucose concentration does not affect the insulin response to ingested protein in people with type 2 diabetes
    Asad Saeed
    Metabolic Research Laboratory, Section of Endocrinology, Metabolism, and Nutrition, Minneapolis VA Medical Center, Minneapolis, MN 55417, USA
    Metabolism 51:1027-33. 2002
    ..Thus, the greater insulin response to ingested protein is not likely to be due merely to a higher initial glucose concentration...
  26. ncbi request reprint Integrated effects of multiple modulators on human liver glycogen phosphorylase a
    Nacide Ercan-Fang
    Metabolic Research Laboratory and Section of Endocrinology, Metabolism and Nutrition, Minneapolis Veterans Affairs Medical Center and Department of Medicine, University of Minnesota, Minneapolis, Minnesota 55417, USA
    Am J Physiol Endocrinol Metab 283:E29-37. 2002
    ..Of these effectors, only glucose changes greatly in vivo. Thus it may be the major regulator of HLGPa activity...
  27. ncbi request reprint Relationship between GHb concentration and erythrocyte survival determined from breath carbon monoxide concentration
    Mark A Virtue
    Minneapolis Veterans Administration Medical Center, Minneapolis, Minnesota 55417, USA
    Diabetes Care 27:931-5. 2004
    ..Subjects with decreased erythrocyte survival have an unusually low GHb percentage. The goal of this study was to determine whether hyperglycemia, as reflected by GHb percentage, is associated with decreased erythrocyte survival...
  28. ncbi request reprint Metabolic effect of a LoBAG30 diet in men with type 2 diabetes
    Frank Q Nuttall
    Metabolic Research Laboratory, Veterans Affairs Medical Center, University of Minnesota, Minneapolis, MN 55417, USA
    Am J Physiol Endocrinol Metab 291:E786-91. 2006
    ..Nevertheless, the long-term effects and general applicability of the diet remain to be determined...
  29. ncbi request reprint Stability of body weight in type 2 diabetes
    Zoobia W Chaudhry
    Section of Endocrinology, Metabolism, and Nutrition 111G, VA Medical Center One, Veterans Drive, Minneapolis, MN 55417, USA
    Diabetes Care 29:493-7. 2006
    ..In this retrospective study, we tested the hypothesis that the weight gain in a diabetic population is greater than that in the general population...
  30. ncbi request reprint The relationship between 24-hour integrated glucose concentrations and % glycohemoglobin
    Youssef Hassan
    Endocrinology, Metabolism and Nutrition Section, University of Minnesota, Minneapolis, Minnesota, USA
    J Lab Clin Med 147:21-6. 2006
    ....
  31. ncbi request reprint Oral arginine does not stimulate an increase in insulin concentration but delays glucose disposal
    Mary C Gannon
    Metabolic Research Laboratory and the Section of Endocrinology, Metabolism, and Nutrition, Minneapolis Veterans Administration Medical Center, Department of Food Science and Nutrition, University of Minnesota, Minneapolis 55417, USA
    Am J Clin Nutr 76:1016-22. 2002
    ..Several years ago it was also determined that an intravenously administered mixture of 10 essential amino acids stimulated insulin secretion. Of these, arginine was the most potent. The effect was synergistic with administered glucose...
  32. ncbi request reprint The metabolic response to ingestion of proline with and without glucose
    Frank Q Nuttall
    Section of Endocrinology, Metabolism, and Nutrition, Veterans Affairs Medical Center, Minneapolis, USA
    Metabolism 53:241-6. 2004
    ..Ingested proline is readily absorbed. It reduces the glucose-induced increase in glucose concentration in the presence of an unchanged insulin and a decreased glucagon response...
  33. ncbi request reprint Endogenous effectors of human liver glycogen phosphorylase modulate effects of indole-site inhibitors
    Nacide Ercan-Fang
    Metabolic Research Laboratory, Section of Endocrinology, Metabolism, and Nutrition, Minneapolis Veterans Affairs Medical Center, Minneapolis, MN 55417, USA
    Am J Physiol Endocrinol Metab 289:E366-72. 2005
    ..However, at higher concentrations (10-30 microM), the GPI effect was dominant and resulted in inhibition of phosphorylase a activity irrespective of the presence or absence of the other modulators of the enzyme...
  34. ncbi request reprint The metabolic response of subjects with type 2 diabetes to a high-protein, weight-maintenance diet
    Frank Q Nuttall
    Metabolic Research Laboratory and the Section of Endocrinology, Metabolism, and Nutrition, Department of Veterans Affairs Medical Center and the Department of Medicine, University of Minnesota, Minneapolis, Minnesota 55417, USA
    J Clin Endocrinol Metab 88:3577-83. 2003
    ..Serum TSH, total T(3), free T(4), B(12), folate, homocysteine, uric acid, and creatinine concentrations were unchanged...
  35. ncbi request reprint The metabolic response to ingested glycine
    Mary C Gannon
    Metabolic Research Laboratory and the Section of Endocrinology, Metabolism, and Nutrition, Minneapolis VA Medical Center, University of Minnesota, Minneapolis 55417, USA
    Am J Clin Nutr 76:1302-7. 2002
    ..Furthermore, when protein is ingested with glucose, a synergistic effect on insulin secretion is observed. The most potent protein is gelatin, which consists of 30% glycine residues...
  36. ncbi request reprint Effect of a high-protein, low-carbohydrate diet on blood glucose control in people with type 2 diabetes
    Mary C Gannon
    Metabolic Research Laboratory 111G, VA Medical Center, One Veterans Drive, Minneapolis, MN 55417, USA
    Diabetes 53:2375-82. 2004
    ..Potentially, this could be a patient-empowering way to ameliorate hyperglycemia without pharmacological intervention. The long-term effects of such a diet remain to be determined...
  37. ncbi request reprint A case of hereditary xerocytosis diagnosed as a result of suspected hypoglycemia and observed low glycohemoglobin
    Chris H Jokinen
    University of Minnesota Medical School, Minneapolis, Minnesota, USA
    J Lab Clin Med 144:27-30. 2004
    ....
  38. ncbi request reprint Stability over time of glycohemoglobin, glucose, and red blood cell survival in hematologically stable people without diabetes
    Frank Q Nuttall
    Section of endorinology, Metabolism and Nutrition, Veterans Affairs Medical Center, Minneapolis, MN 55417, USA
    Metabolism 53:1399-404. 2004
    ..Nevertheless, this remains to be proven using RBC survival methods that are more precise than those currently available...
  39. ncbi request reprint Total glycohemoglobin or hemoglobin A1C?
    Frank Q Nuttall
    Department of Veterans Affairs Medical Center, University of Minnesota, Minneapolis, Minnesota 55417, USA
    Endocr Pract 13:317-8. 2007
  40. ncbi request reprint Evidence for independent heritability of the glycation gap (glycosylation gap) fraction of HbA1c in nondiabetic twins: response to Cohen et al
    Frank Q Nuttall
    Diabetes Care 30:e14; author reply e15. 2007
  41. ncbi request reprint Stability of body weight in type 2 diabetes: Response to Looker et al
    Zoobia Chaudhry
    Diabetes Care 29:1991. 2006