James Ntambi

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. ncbi request reprint Regulation of stearoyl-CoA desaturases and role in metabolism
    James M Ntambi
    Department of Biochemistry, University of Wisconsin, 433 Babcock Drive, Madison, WI 53706, USA
    Prog Lipid Res 43:91-104. 2004
  2. pmc The role of fatty acid desaturases in epidermal metabolism
    Harini Sampath
    Center for Research on Occupational and Environmental Toxicology Oregon Health and Science University Portland, OR USA
    Dermatoendocrinol 3:62-4. 2011
  3. ncbi request reprint Polyunsaturated fatty acid regulation of gene expression
    J M Ntambi
    Department of Biochemistry, University of Wisconsin Madison, 53706 1544, USA
    J Mol Neurosci 16:273-8; discussion 279-84. 2001
  4. ncbi request reprint Recent insights into stearoyl-CoA desaturase-1
    James M Ntambi
    Departments of Biochemistry and Nutritional Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    Curr Opin Lipidol 14:255-61. 2003
  5. pmc Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity
    James M Ntambi
    Department of Biochemistry, University of Wisconsin, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 99:11482-6. 2002
  6. ncbi request reprint The role of stearoyl-CoA desaturase in body weight regulation
    Agnieszka Dobrzyn
    Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706, USA
    Trends Cardiovasc Med 14:77-81. 2004
  7. ncbi request reprint Regulation of stearoyl-CoA desaturase expression
    James M Ntambi
    Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706, USA
    Lipids 39:1061-5. 2004
  8. pmc Loss of stearoyl-CoA desaturase activity leads to free cholesterol synthesis through increased Xbp-1 splicing
    Chad M Paton
    Department of Biochemistry, University of Wisconsin, Madison, WI, USA
    Am J Physiol Endocrinol Metab 299:E1066-75. 2010
  9. ncbi request reprint Cholestasis and hypercholesterolemia in SCD1-deficient mice fed a low-fat, high-carbohydrate diet
    Matthew T Flowers
    Department of Biochemistry, University of Wisconsin Madison, Madison, WI, USA
    J Lipid Res 47:2668-80. 2006
  10. ncbi request reprint Stearoyl-CoA desaturase 1 gene expression is necessary for fructose-mediated induction of lipogenic gene expression by sterol regulatory element-binding protein-1c-dependent and -independent mechanisms
    Makoto Miyazaki
    Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 279:25164-71. 2004

Research Grants

  1. Role of Stearoyl-CoA Desaturase in Metabolism
    James M Ntambi; Fiscal Year: 2010
  2. Role of Stearoyl-CoA Desaturase in Metabolism
    James M Ntambi; Fiscal Year: 2010
  3. Role of Stearoyl-CoA Desaturase in Metabolism
    James M Ntambi; Fiscal Year: 2010
  4. Role of Stearoyl-CoA Desaturase in Metabolism
    James Ntambi; Fiscal Year: 2009
  5. Role of Stearoyl-CoA Desaturase in Metabolism
    James Ntambi; Fiscal Year: 2009
  6. Role of Stearoyl-CoA Desaturase in Metabolism
    James Ntambi; Fiscal Year: 2007
  7. Role of Stearoyl-CoA Desaturase in Metabolism
    James Ntambi; Fiscal Year: 2006
  8. Role of Stearoyl-CoA Desaturase in Metabolism
    James Ntambi; Fiscal Year: 2005
  9. Role of Stearoyl-CoA Desaturase in Metabolism
    James Ntambi; Fiscal Year: 2004
  10. Role of Stearoyl-CoA Desaturase in Metabolism
    James Ntambi; Fiscal Year: 2003

Collaborators

Detail Information

Publications69

  1. ncbi request reprint Regulation of stearoyl-CoA desaturases and role in metabolism
    James M Ntambi
    Department of Biochemistry, University of Wisconsin, 433 Babcock Drive, Madison, WI 53706, USA
    Prog Lipid Res 43:91-104. 2004
    ....
  2. pmc The role of fatty acid desaturases in epidermal metabolism
    Harini Sampath
    Center for Research on Occupational and Environmental Toxicology Oregon Health and Science University Portland, OR USA
    Dermatoendocrinol 3:62-4. 2011
    ..This review will focus on the role of fatty acid desaturases in maintaining epidermal metabolism...
  3. ncbi request reprint Polyunsaturated fatty acid regulation of gene expression
    J M Ntambi
    Department of Biochemistry, University of Wisconsin Madison, 53706 1544, USA
    J Mol Neurosci 16:273-8; discussion 279-84. 2001
    ....
  4. ncbi request reprint Recent insights into stearoyl-CoA desaturase-1
    James M Ntambi
    Departments of Biochemistry and Nutritional Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    Curr Opin Lipidol 14:255-61. 2003
    ..Why, then, is stearoyl-CoA desaturase a highly regulated enzyme? This review summarizes the recent and timely advances concerning the important role of stearoyl-CoA desaturase in metabolism...
  5. pmc Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity
    James M Ntambi
    Department of Biochemistry, University of Wisconsin, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 99:11482-6. 2002
    ..These observations suggest that a consequence of SCD1 deficiency is an activation of lipid oxidation in addition to reduced triglyceride synthesis and storage...
  6. ncbi request reprint The role of stearoyl-CoA desaturase in body weight regulation
    Agnieszka Dobrzyn
    Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706, USA
    Trends Cardiovasc Med 14:77-81. 2004
    ..SCD therefore appears to be an important metabolic control point, and inhibition of its expression could be of benefit in the treatment of obesity, diabetes, cardiovascular disease, and other metabolic diseases...
  7. ncbi request reprint Regulation of stearoyl-CoA desaturase expression
    James M Ntambi
    Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706, USA
    Lipids 39:1061-5. 2004
    ..By using SCD1-/- mice, which are deficient in tissue oleate, we begin to learn more about the physiological role of SCD gene expression and oleate in normal and disease states...
  8. pmc Loss of stearoyl-CoA desaturase activity leads to free cholesterol synthesis through increased Xbp-1 splicing
    Chad M Paton
    Department of Biochemistry, University of Wisconsin, Madison, WI, USA
    Am J Physiol Endocrinol Metab 299:E1066-75. 2010
    ..It is likely that the accumulation of FC enhances Xbp-1 splicing, induces LXR transcriptional activity, and increases ABCA1 (ATP-binding cassette transporter A1) expression to maintain cholesterol homeostasis...
  9. ncbi request reprint Cholestasis and hypercholesterolemia in SCD1-deficient mice fed a low-fat, high-carbohydrate diet
    Matthew T Flowers
    Department of Biochemistry, University of Wisconsin Madison, Madison, WI, USA
    J Lipid Res 47:2668-80. 2006
    ..Therefore, endogenous MUFA synthesis is essential during dietary unsaturated fat insufficiency and influences the dietary requirement of PUFA...
  10. ncbi request reprint Stearoyl-CoA desaturase 1 gene expression is necessary for fructose-mediated induction of lipogenic gene expression by sterol regulatory element-binding protein-1c-dependent and -independent mechanisms
    Makoto Miyazaki
    Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 279:25164-71. 2004
    ....
  11. ncbi request reprint Reduced adiposity and liver steatosis by stearoyl-CoA desaturase deficiency are independent of peroxisome proliferator-activated receptor-alpha
    Makoto Miyazaki
    Department of Biochemistry, University of Wisconsin, 433 Babcock Drive, Madison, WI 53706, USA
    J Biol Chem 279:35017-24. 2004
    ....
  12. ncbi request reprint Identification and characterization of murine SCD4, a novel heart-specific stearoyl-CoA desaturase isoform regulated by leptin and dietary factors
    Makoto Miyazaki
    Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 278:33904-11. 2003
    ..The current studies identify a novel heart-specific SCD isoform that demonstrates tissue-specific regulation by leptin and dietary factors...
  13. pmc Skin-specific deletion of stearoyl-CoA desaturase-1 alters skin lipid composition and protects mice from high fat diet-induced obesity
    Harini Sampath
    Department of Nutritional Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 284:19961-73. 2009
    ..This results in up-regulation of thermogenic processes for temperature maintenance at the expense of fuel economy, illustrating cross-talk between the skin and peripheral tissues in maintaining energy homeostasis...
  14. ncbi request reprint Dietary cholesterol opposes PUFA-mediated repression of the stearoyl-CoA desaturase-1 gene by SREBP-1 independent mechanism
    Hyoun ju Kim
    Departments of Biochemistry, University of Wisconsin, Madison, Wisconsin, 53706, USA
    J Lipid Res 43:1750-7. 2002
    ..This study demonstrates that cholesterol overrides the PUFA-mediated repression of the SCD1 gene and regulates SCD1 gene expression through a mechanism independent of SREBP-1 maturation...
  15. ncbi request reprint Stearoyl-CoA desaturase deficiency, hypercholesterolaemia, cholestasis and diabetes
    Alan D Attie
    Department of Biochemistry, University of Wisconsin Madison, Madison, WI, USA
    Novartis Found Symp 286:47-53; discussion 54-7, 162-3, 196-203. 2007
    ..But, surprisingly, leptin(ob/ob) Scd1(-/-) mice had worse diabetes than leptin(ob/ob) Scd1(wt/wt) mice. Thus, despite its effects on insulin sensitivity, Scdl deficiency worsens diabetes in leptin-deficient obese mice...
  16. ncbi request reprint Hepatic stearoyl-CoA desaturase-1 deficiency protects mice from carbohydrate-induced adiposity and hepatic steatosis
    Makoto Miyazaki
    Department of Biochemistry, University of Wisconsin Madison, 433 Babcock Drive, Madison, WI 53706, USA
    Cell Metab 6:484-96. 2007
    ....
  17. ncbi request reprint Polyunsaturated fatty acid regulation of gene expression
    Harini Sampath
    Department of Nutritional Sciences, University of Wisconsin, Madison, WI 53706, USA
    Nutr Rev 62:333-9. 2004
    ..The role of transcription factors such as SREBP1c and nuclear receptors such as PPAR-alpha, HNF-4alpha, and LXRalpha in mediating the nuclear effects of PUFAs are addressed...
  18. ncbi request reprint Evidence that the anti-obesity effect of conjugated linoleic acid is independent of effects on stearoyl-CoA desaturase1 expression and enzyme activity
    Kihwa Kang
    Department of Food Microbiology and Toxicology, Food Research Institute, University of Wisconsin Madison, Madison, WI 53706, USA
    Biochem Biophys Res Commun 315:532-7. 2004
    ....
  19. ncbi request reprint Loss of stearoyl-CoA desaturase-1 improves insulin sensitivity in lean mice but worsens diabetes in leptin-deficient obese mice
    Jessica B Flowers
    Department of Nutritional Sciences, University of Wisconsin Madison, Madison, WI 537606, USA
    Diabetes 56:1228-39. 2007
    ..Therefore, although loss of Scd1 has beneficial effects on adiposity, this benefit may come at the expense of beta-cells, resulting in an increased risk of diabetes...
  20. ncbi request reprint The role of stearoyl-CoA desaturase in the control of metabolism
    Agnieszka Dobrzyn
    Department of Biochemistry, University of Wisconsin Madison, Madison, WI 53706, USA
    Prostaglandins Leukot Essent Fatty Acids 73:35-41. 2005
    ..In this review, we examine data from our laboratory and others suggesting that SCD1 is an important component in the regulation of body metabolism...
  21. ncbi request reprint Loss of stearoyl-CoA desaturase 1 inhibits fatty acid oxidation and increases glucose utilization in the heart
    Pawel Dobrzyn
    Department of Biochemistry, University of Wisconsin, 433 Babcock Drive, Madison, WI 53706, USA
    Am J Physiol Endocrinol Metab 294:E357-64. 2008
    ..This increase in cardiac insulin sensitivity and glucose utilization due to SCD1 deficiency could prove therapeutic in pathological conditions such as obesity that are characterized by skewed cardiac substrate utilization...
  22. pmc Probing the role of stearoyl-CoA desaturase-1 in hepatic insulin resistance
    Matthew T Flowers
    Department of Nutritional Sciences, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Clin Invest 116:1478-81. 2006
    ....
  23. ncbi request reprint Polyunsaturated fatty acids do not activate AMP-activated protein kinase in mouse tissues
    Agnieszka Dobrzyn
    Department of Biochemistry, University of Wisconsin Madison, Madison, WI 53706, USA
    Biochem Biophys Res Commun 332:892-6. 2005
    ..The data suggest that PUFA are not involved in AMPK activation in mouse tissues and that the increased activity of AMPK in SCD1-/- mice is probably PUFA-independent...
  24. pmc Stearoyl-coenzyme A desaturase 1 deficiency protects against hypertriglyceridemia and increases plasma high-density lipoprotein cholesterol induced by liver X receptor activation
    Kiki Chu
    Department of Biochemistry, University of Wisconsin Madison, 433 Babcock Drive, Madison, WI 53706, USA
    Mol Cell Biol 26:6786-98. 2006
    ..In addition, SCD1 deficiency also increased plasma high-density lipoprotein cholesterol levels induced by LXR activation...
  25. pmc Loss of Stearoyl-CoA desaturase-1 attenuates adipocyte inflammation: effects of adipocyte-derived oleate
    Xueqing Liu
    Department of Biochemistry, University of Wisconsin, Madison, 433 Babcock Dr, Madison, WI 53706, USA
    Arterioscler Thromb Vasc Biol 30:31-8. 2010
    ..This study aimed at identify the effects of stearoyl-CoA desaturase-1 (SCD1) on the inflammatory response of a paracrine network involving adipocytes, macrophages, and endothelial cells...
  26. ncbi request reprint Stearoyl-CoA desaturase-1 deficiency reduces ceramide synthesis by downregulating serine palmitoyltransferase and increasing beta-oxidation in skeletal muscle
    Agnieszka Dobrzyn
    Dept of Biochemistry, Univ of Wisconsin, 433 Babcock Dr, Madison, WI 53706, USA
    Am J Physiol Endocrinol Metab 288:E599-607. 2005
    ..Taken together, these results indicate that SCD1 deficiency reduces ceramide synthesis by decreasing SPT expression and increasing the rate of beta-oxidation in oxidative muscles...
  27. ncbi request reprint Stearoyl-CoA desaturase-1 mediates the pro-lipogenic effects of dietary saturated fat
    Harini Sampath
    Department of Nutritional Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 282:2483-93. 2007
    ..SCD1 thus serves as a molecular switch in the promotion or prevention of lipid-induced disorders brought on by consumption of excess saturated fat...
  28. pmc Ferrous, but not ferric, iron maintains homeostasis in Histoplasma capsulatum triacylglycerides
    Robert Zarnowski
    Department of Medical Microbiology and Immunology, University of Wisconsin, 416 Service Memorial Institute, 1300 University Avenue, Madison, WI 53705, USA
    Curr Microbiol 57:153-7. 2008
    ..capsulatum to acquire iron in its reduced, more soluble, ferrous form, and therefore, the availability of iron may be the underlying reason for the observed iron-maintained homeostasis in H. capsulatum triacylglycerols...
  29. pmc Stearoyl-CoA desaturase-1 deficiency attenuates obesity and insulin resistance in leptin-resistant obese mice
    Makoto Miyazaki
    Department of Biochemistry, University of Wisconsin Madison, 433, Babcock Drive, Madison, WI 53706, USA
    Biochem Biophys Res Commun 380:818-22. 2009
    ..These data uncouple the effects of SCD1 deficiency on weight loss from those on insulin sensitivity and suggest a beneficial effect of SCD1 inhibition on insulin sensitivity in obese mice that express a functional leptin gene...
  30. pmc Typing of Histoplasma capsulatum strains by fatty acid profile analysis
    Robert Zarnowski
    Department of Medical Microbiology and Immunology, University of Wisconsin, Madison, WI, USA
    J Med Microbiol 56:788-97. 2007
    ..brasiliensis and S. schenckii were shifted away. These data suggest that fatty acid profiling can be used in H. capsulatum strain classification and epidemiological studies that require strain differentiation at the intraspecies level...
  31. ncbi request reprint Stearoyl-CoA desaturase deficiency, hypercholesterolemia, cholestasis, and diabetes
    Alan D Attie
    Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706 1544, USA
    Nutr Rev 65:S35-8. 2007
    ..We also found that the Scd1(-/-) mice on a normal chow diet had dramatically improved insulin sensitivity. However, leptin(ob/ob) Scd1(-/-) mice had worse diabetes than leptin(ob/ob) Scd1(wt/wt) mice...
  32. pmc Neutral storage lipids of Histoplasma capsulatum: effect of culture age
    Robert Zarnowski
    Department of Medical Microbiology and Immunology, University of Wisconsin, 416 Service Memorial Institute, 1300 University Avenue, Madison, WI 53706, USA
    Curr Microbiol 56:110-4. 2008
    ..capsulatum, but also will contribute to better understanding of biology and pathogenesis of this fungus and, consequently, can help in the discovery of more effective antifungal drugs...
  33. ncbi request reprint Lack of stearoyl-CoA desaturase-1 function induces a palmitoyl-CoA Delta6 desaturase and represses the stearoyl-CoA desaturase-3 gene in the preputial glands of the mouse
    Makoto Miyazaki
    Departments of Biochemistry, University of Wisconsin, Madison, Wisconsin Nutritional Sciences, University of Wisconsin, Madison, Wisconsin, USA
    J Lipid Res 43:2146-54. 2002
    ..These observations demonstrate that loss of SCD1 function alters the expression of SCD3 and reveal for the first time the presence and regulation of a palmitoyl-CoA Delta6 desaturase enzyme in mammals...
  34. ncbi request reprint Sterol regulatory element-binding proteins (SREBPs) as regulators of lipid metabolism: polyunsaturated fatty acids oppose cholesterol-mediated induction of SREBP-1 maturation
    Hyoun ju Kim
    Department of Biochemistry, University of Wisconsin, Madison, 53706, USA
    Ann N Y Acad Sci 967:34-42. 2002
    ..The studies also reveal that the induction of SCD1 gene expression by cholesterol occurs through a mechanism independent of SREBP-1 maturation...
  35. doi request reprint Liver gene expression analysis reveals endoplasmic reticulum stress and metabolic dysfunction in SCD1-deficient mice fed a very low-fat diet
    Matthew T Flowers
    Department of Biochemistry, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Physiol Genomics 33:361-72. 2008
    ....
  36. ncbi request reprint Role of stearoyl-coenzyme A desaturase in regulating lipid metabolism
    Matthew T Flowers
    Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706, USA
    Curr Opin Lipidol 19:248-56. 2008
    ..This review evaluates the latest advances in our understanding of the pivotal role of stearoyl-coenzyme A desaturase 1 in health and disease...
  37. pmc Stearoyl-CoA desaturase and its relation to high-carbohydrate diets and obesity
    Matthew T Flowers
    Department of Biochemistry, University of Wisconsin, 433 Babcock Drive, Madison, Wisconsin 53706, USA
    Biochim Biophys Acta 1791:85-91. 2009
    ..In this review, we address the association of high-carbohydrate diets with increased SCD activity and summarize the current literature on the subject of SCD1 and body weight regulation...
  38. ncbi request reprint Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia
    Alan D Attie
    Department of Biochemistry, University of Wisconsin Madison, Madison, WI, USA
    J Lipid Res 43:1899-907. 2002
    ..We propose that many of the factors that influence plasma triglyceride levels do so by converging upon the regulation of SCD activity...
  39. ncbi request reprint Identification of mouse palmitoyl-coenzyme A Delta9-desaturase
    Makoto Miyazaki
    Department of Biochemistry, University of Wisconsin, Madison, WI 53706, USA
    J Lipid Res 47:700-4. 2006
    ..We identify SCD3 as a mammalian palmitotyl-CoA Delta9-desaturase, and its existence in mouse helps explain distinct physiological roles for each SCD isoform...
  40. ncbi request reprint Polyunsaturated fatty acid regulation of genes of lipid metabolism
    Harini Sampath
    Department of Nutritional Sciences, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Annu Rev Nutr 25:317-40. 2005
    ..Working out the mechanisms by which these interactions and consequent effects occur is proving to be complicated but is invaluable to our understanding of the role that dietary fat can play in disease management and prevention...
  41. pmc Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver
    Pawel Dobrzyn
    Department of Biochemistry, University of Wisconsin, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 101:6409-14. 2004
    ..001) thereby stimulating the oxidation of mitochondrial palmitoyl-CoA. Our results identify AMPK as a mediator of increased fatty acid oxidation in liver of SCD1-deficient mice...
  42. ncbi request reprint Stearoyl-CoA desaturase 1 deficiency increases CTP:choline cytidylyltransferase translocation into the membrane and enhances phosphatidylcholine synthesis in liver
    Agnieszka Dobrzyn
    Department of Biochemistry, University of Wisconsin Madison, 53706, USA
    J Biol Chem 280:23356-62. 2005
    ..Our study revealed that SCD1 deficiency specifically increases CCT activity by promoting its translocation into membrane and enhances PC biosynthesis in liver...
  43. ncbi request reprint Two Delta9-stearic acid desaturases are required for Aspergillus nidulans growth and development
    Richard A Wilson
    Department of Plant Pathology, University of Wisconsin Madison, Madison, WI 53706, USA
    Fungal Genet Biol 41:501-9. 2004
    ..Taken together, our results suggest a role for sdeA in growth and development at all temperatures, while sdeB is involved in growth and development at lower temperatures...
  44. pmc Stearoyl-CoA desaturase-2 gene expression is required for lipid synthesis during early skin and liver development
    Makoto Miyazaki
    Department of Biochemistry, University of Wisconsin, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 102:12501-6. 2005
    ....
  45. ncbi request reprint Colocalization of SCD1 and DGAT2: implying preference for endogenous monounsaturated fatty acids in triglyceride synthesis
    Weng Chi Man
    Department of Biochemistry, University of Wisconsin Madison, Madison, WI 53706, USA
    J Lipid Res 47:1928-39. 2006
    ..By performing subcellular fractionation using mouse livers, we also show, for the first time, that SCD is present in the mitochondria-associated membrane...
  46. ncbi request reprint Lack of stearoyl-CoA desaturase 1 upregulates basal thermogenesis but causes hypothermia in a cold environment
    Seong Ho Lee
    Department of Biochemistry, University of Wisconsin, Madison, WI 53706, USA
    J Lipid Res 45:1674-82. 2004
    ..The hypothermia and hypoglycemia in cold-exposed SCD1-/- mice and the compensatory recovery by oleate indicate an important role of SCD1 gene expression in thermoregulation...
  47. ncbi request reprint Stearoyl-coenzyme A desaturase 1, sterol regulatory element binding protein-1c and peroxisome proliferator-activated receptor-alpha: independent and interactive roles in the regulation of lipid metabolism
    Harini Sampath
    Department of Nutritional Sciences, University of Wisconsin, Madison, Wisconsin, USA
    Curr Opin Clin Nutr Metab Care 9:84-8. 2006
    ..Since these conditions share a common factor, aberrations in lipid metabolism, understanding the molecular changes that lead to abnormal lipid partitioning has become key to combating the obesity epidemic...
  48. ncbi request reprint Effects of sterculic acid on stearoyl-CoA desaturase in differentiating 3T3-L1 adipocytes
    F Enrique Gomez
    Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin, Room 415B, 433 Babcock Drive, Madison WI 53706, USA
    Biochem Biophys Res Commun 300:316-26. 2003
    ..These results indicate that sterculic acid directly inhibits SCD activity, possibly by a turnover-dependent reaction, without affecting the processes required for adipocyte differentiation, scd gene expression or SCD protein translation...
  49. ncbi request reprint Membrane topology of mouse stearoyl-CoA desaturase 1
    Weng Chi Man
    Biochemistry andNutritional Sciences, University of Wisconsin Madison, 53706, USA
    J Biol Chem 281:1251-60. 2006
    ....
  50. pmc Stearoyl-CoA desaturase 1 deficiency elevates insulin-signaling components and down-regulates protein-tyrosine phosphatase 1B in muscle
    Shaikh Mizanoor Rahman
    Department of Biochemistry, University of Wisconsin, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 100:11110-5. 2003
    ..We hypothesize that loss of SCD1 function induces increased insulin signaling at least in part by a reduction in the expression of protein-tyrosine phosphatase 1B. SCD1 could be a therapeutic target in the treatment of diabetes...
  51. pmc The role of rapid lipogenesis in insulin secretion: Insulin secretagogues acutely alter lipid composition of INS-1 832/13 cells
    Michael J MacDonald
    Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Room 3459 Medical Science Center, 1300 University Avenue, Madison, WI 53706, USA
    Arch Biochem Biophys 470:153-62. 2008
    ..The results suggest that lipid remodeling and rapid lipogenesis from secretagogue carbon support insulin secretion...
  52. pmc Biochemical and physiological function of stearoyl-CoA desaturase
    Chad M Paton
    Department of Biochemistry, University of Wisconsin, 433 Babcock Dr, Madison, WI 53706, USA
    Am J Physiol Endocrinol Metab 297:E28-37. 2009
    ..In this article, we summarize the recent and timely advances concerning the important role of SCD in the biochemistry and physiology of lipid metabolism...
  53. ncbi request reprint The fate and intermediary metabolism of stearic acid
    Harini Sampath
    Department of Nutritional Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    Lipids 40:1187-91. 2005
    ....
  54. ncbi request reprint Inhibition of stearoyl-CoA desaturase activity by the cis-9,trans-11 isomer and the trans-10,cis-12 isomer of conjugated linoleic acid in MDA-MB-231 and MCF-7 human breast cancer cells
    Youngjin Choi
    Department of Biochemistry, University of Wisconsin Madison, 53706, USA
    Biochem Biophys Res Commun 294:785-90. 2002
    ....
  55. ncbi request reprint Stearoyl-CoA desaturase 1 deficiency increases insulin signaling and glycogen accumulation in brown adipose tissue
    Shaikh Mizanoor Rahman
    Dept of Biochemistry, University of Wisconsin, 433 Babcock Drive, Madison, WI 53706, USA
    Am J Physiol Endocrinol Metab 288:E381-7. 2005
    ..Taken together, these studies illustrate increased insulin signaling and increased glycogen metabolism in BAT of SCD1(-/-) mice...
  56. ncbi request reprint Obesity and gender differences in the risk of type 2 diabetes mellitus in Uganda
    David Lasky
    Department of Biochemistry, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Nutrition 18:417-21. 2002
    ..We assessed the severity of type 2 diabetes in urban and rural communities of Uganda and characterized this disease according to sex, obesity, and hypertension...
  57. ncbi request reprint Role of stearoyl-coenzyme A desaturase in lipid metabolism
    Makoto Miyazaki
    Department of Biochemistry, University of Wisconsin Madison, 433 Babcock Drive, WI 53706, USA
    Prostaglandins Leukot Essent Fatty Acids 68:113-21. 2003
    ..In this review we discuss our current understanding of the physiological role of SCD in lipid synthesis and metabolism...
  58. pmc Genetic control of de novo lipogenesis: role in diet-induced obesity
    Maggie S Strable
    Department of Nutritional Sciences, University of Wisconsin Madison, Madison, WI, USA
    Crit Rev Biochem Mol Biol 45:199-214. 2010
    ....
  59. ncbi request reprint Molecular differences caused by differentiation of 3T3-L1 preadipocytes in the presence of either dehydroepiandrosterone (DHEA) or 7-oxo-DHEA
    F Enrique Gomez
    Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    Biochemistry 41:5473-82. 2002
    ....
  60. ncbi request reprint Effects of conjugated linoleic acid (CLA) on immune responses, body composition and stearoyl-CoA desaturase
    James M Ntambi
    Department of Biochemistry, Food Research Institute, University of Wisconsin Madison, WI, USA
    Can J Appl Physiol 27:617-28. 2002
    ..In this review, we will focus on the effects of CLA on immune responses, body compositional changes and stearoyl-CoA desaturase...
  61. ncbi request reprint Redox reactions of dehydroepiandrosterone and its metabolites in differentiating 3T3-L1 adipocytes: A liquid chromatographic-mass spectrometric study
    Ashok Marwah
    Department of Biochemistry, Enzyme Institute, University of Wisconsin Madison, Wisconsin, USA
    Arch Biochem Biophys 456:1-7. 2006
    ..Androst-5-ene-3beta,17beta-diol has been implicated in prostate cancer. The contribution of adipose cells to the circulating supply of androst-5-ene-3beta,17beta-diol may therefore be considered in managing prostate cancer...
  62. ncbi request reprint Stearoyl-CoA desaturase-1 and the metabolic syndrome
    Paul Cohen
    Laboratory of Molecular Genetics, The Rockefeller University, New York, NY 10021, USA
    Curr Drug Targets Immune Endocr Metabol Disord 3:271-80. 2003
    ..These findings indicate that pharmacologic manipulation of SCD-1 may be of benefit in the treatment of obesity, diabetes, hepatic steatosis, and other components of the Metabolic Syndrome...
  63. pmc Site and mechanism of leptin action in a rodent form of congenital lipodystrophy
    Esra Asilmaz
    Laboratory of Molecular Genetics, The Rockefeller University, New York, New York 10021, USA
    J Clin Invest 113:414-24. 2004
    ..Intracerebroventricular leptin improves glucose homeostasis by improving insulin signal transduction in liver, but in this case the effect appears to be independent of SCD-1...
  64. ncbi request reprint Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss
    Paul Cohen
    Laboratory of Molecular Genetics, Center for Studies in Physics and Biology, Rogosin Institute, Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 297:240-3. 2002
    ..These findings suggest that down-regulation of SCD-1 is an important component of leptin's metabolic actions...
  65. ncbi request reprint Leptin suppresses stearoyl-CoA desaturase 1 by mechanisms independent of insulin and sterol regulatory element-binding protein-1c
    Sudha B Biddinger
    Research Division, Joslin Diabetes Center, One Joslin Pl, Boston, MA 02215, USA
    Diabetes 55:2032-41. 2006
    ..Thus, the effect of leptin on SCD1 in liver is independent of insulin and SREBP-1c, and leptin, rather than insulin, is the major regulator of hepatic MUFA synthesis in obesity-linked diabetes...
  66. pmc Metabolomics reveals that hepatic stearoyl-CoA desaturase 1 downregulation exacerbates inflammation and acute colitis
    Chi Chen
    Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Metab 7:135-47. 2008
    ....
  67. ncbi request reprint Effects of diet and genetic background on sterol regulatory element-binding protein-1c, stearoyl-CoA desaturase 1, and the development of the metabolic syndrome
    Sudha B Biddinger
    Research Division, Joslin Diabetes Center, and Department of Medicine, Harvard Medical School, Boston, MA 02215, USA
    Diabetes 54:1314-23. 2005
    ..Thus, dietary fat and genetic background act through SREBP-1c and SCD1 to affect hepatic lipid metabolism contributing to the development of the metabolic syndrome...
  68. pmc Association of stearoyl-CoA desaturase 1 activity with familial combined hyperlipidemia
    Rebecca Mar-Heyming
    Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Arterioscler Thromb Vasc Biol 28:1193-9. 2008
    ..We used the fatty acid desaturation index (the plasma ratio of 18:1/18:0) as a marker of SCD1 activity to investigate the relationship of SCD1 to familial combined hyperlipidemia (FCHL)...
  69. ncbi request reprint Elevated stearoyl-CoA desaturase-1 expression in skeletal muscle contributes to abnormal fatty acid partitioning in obese humans
    Matthew W Hulver
    Pennington Biomedical Research, Louisiana State University System, Baton Rouge, Louisiana 70808, USA
    Cell Metab 2:251-61. 2005
    ..These results suggest that elevated expression of SCD1 in skeletal muscle contributes to abnormal lipid metabolism and progression of obesity...

Research Grants12

  1. Role of Stearoyl-CoA Desaturase in Metabolism
    James M Ntambi; Fiscal Year: 2010
    ..We have discovered a mechanism that partitions fat away from storage towards its burning in the fed state. Our research will contribute to the treatment of human obesity, diabetes and other metabolic diseases. ..
  2. Role of Stearoyl-CoA Desaturase in Metabolism
    James M Ntambi; Fiscal Year: 2010
    ..We have discovered a mechanism that partitions fat away from storage towards its burning in the fed state. Our research will contribute to the treatment of human obesity, diabetes and other metabolic diseases. ..
  3. Role of Stearoyl-CoA Desaturase in Metabolism
    James M Ntambi; Fiscal Year: 2010
    ..We have discovered a mechanism that partitions fat away from storage towards its burning in the fed state. Our research will contribute to the treatment of human obesity, diabetes and other metabolic diseases. ..
  4. Role of Stearoyl-CoA Desaturase in Metabolism
    James Ntambi; Fiscal Year: 2009
    ..We have discovered a mechanism that partitions fat away from storage towards its burning in the fed state. Our research will contribute to the treatment of human obesity, diabetes and other metabolic diseases. ..
  5. Role of Stearoyl-CoA Desaturase in Metabolism
    James Ntambi; Fiscal Year: 2009
    ..We have discovered a mechanism that partitions fat away from storage towards its burning in the fed state. Our research will contribute to the treatment of human obesity, diabetes and other metabolic diseases. ..
  6. Role of Stearoyl-CoA Desaturase in Metabolism
    James Ntambi; Fiscal Year: 2007
    ..We have discovered a mechanism that partitions fat away from storage towards its burning in the fed state. Our research will contribute to the treatment of human obesity, diabetes and other metabolic diseases. ..
  7. Role of Stearoyl-CoA Desaturase in Metabolism
    James Ntambi; Fiscal Year: 2006
    ..We have discovered a mechanism that partitions fat away from storage towards its burning in the fed state. Our research will contribute to the treatment of human obesity, diabetes and other metabolic diseases. ..
  8. Role of Stearoyl-CoA Desaturase in Metabolism
    James Ntambi; Fiscal Year: 2005
    ..abstract_text> ..
  9. Role of Stearoyl-CoA Desaturase in Metabolism
    James Ntambi; Fiscal Year: 2004
    ..abstract_text> ..
  10. Role of Stearoyl-CoA Desaturase in Metabolism
    James Ntambi; Fiscal Year: 2003
    ..abstract_text> ..
  11. Role of Stearoyl-CoA Desaturase in Metabolism
    James Ntambi; Fiscal Year: 2002
    ..abstract_text> ..