Eva Nozik-Grayck

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. pmc Developmental expression of the receptor for advanced glycation end-products (RAGE) and its response to hyperoxia in the neonatal rat lung
    Pierre Paul Lizotte
    Biology of Breathing Research, Manitoba Institute of Child Health, Winnipeg, MB, Canada
    BMC Dev Biol 7:15. 2007
  2. ncbi S-nitrosoglutathione inhibits alpha1-adrenergic receptor-mediated vasoconstriction and ligand binding in pulmonary artery
    Eva Nozik-Grayck
    Department of Pediatrics, University of Colorado Health Science Center, Denver, CO 80262, USA
    Am J Physiol Lung Cell Mol Physiol 290:L136-43. 2006
  3. pmc Lung EC-SOD overexpression attenuates hypoxic induction of Egr-1 and chronic hypoxic pulmonary vascular remodeling
    Eva Nozik-Grayck
    Department of Pediatrics, Univ of Colorado, Denver, 4200 E 9th Ave, B131, Denver, CO 80262, USA
    Am J Physiol Lung Cell Mol Physiol 295:L422-30. 2008
  4. ncbi Extracellular superoxide dismutase
    Eva Nozik-Grayck
    Pediatric Critical Care, Department of Pediatrics, University of Colorado School of Medicine, 4200 E 9th Ave B131, Denver, CO 80262, USA
    Int J Biochem Cell Biol 37:2466-71. 2005
  5. ncbi Pulmonary vasoconstriction by serotonin is inhibited by S-nitrosoglutathione
    Eva Nozik-Grayck
    Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Physiol Lung Cell Mol Physiol 282:L1057-65. 2002
  6. ncbi Oxidative stress activates anion exchange protein 2 and AP-1 in airway epithelial cells
    Jennifer L Turi
    Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Physiol Lung Cell Mol Physiol 283:L791-8. 2002
  7. pmc Lung extracellular superoxide dismutase overexpression lessens bleomycin-induced pulmonary hypertension and vascular remodeling
    Zachary Van Rheen
    Department of Pediatrics, University of Colorado, Aurora, CO 80045, USA
    Am J Respir Cell Mol Biol 44:500-8. 2011
  8. pmc Sustained lung activity of a novel chimeric protein, SOD2/3, after intratracheal administration
    Margaret B Clarke
    Pediatric Critical Care, Department of Pediatrics, University of Colorado at Denver, Aurora, CO 80045, USA
    Free Radic Biol Med 49:2032-9. 2010
  9. pmc Transgenic extracellular superoxide dismutase protects postnatal alveolar epithelial proliferation and development during hyperoxia
    Richard L Auten
    Neonatal Perinatal Research Institute, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Physiol Lung Cell Mol Physiol 290:L32-40. 2006
  10. ncbi Duodenal cytochrome b: a novel ferrireductase in airway epithelial cells
    Jennifer L Turi
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    Am J Physiol Lung Cell Mol Physiol 291:L272-80. 2006

Collaborators

Detail Information

Publications19

  1. pmc Developmental expression of the receptor for advanced glycation end-products (RAGE) and its response to hyperoxia in the neonatal rat lung
    Pierre Paul Lizotte
    Biology of Breathing Research, Manitoba Institute of Child Health, Winnipeg, MB, Canada
    BMC Dev Biol 7:15. 2007
    ..We sought to determine the regulation of the soluble and membrane isoforms of RAGE in the developing lung, and its expression under hyperoxic conditions in the neonatal lung...
  2. ncbi S-nitrosoglutathione inhibits alpha1-adrenergic receptor-mediated vasoconstriction and ligand binding in pulmonary artery
    Eva Nozik-Grayck
    Department of Pediatrics, University of Colorado Health Science Center, Denver, CO 80262, USA
    Am J Physiol Lung Cell Mol Physiol 290:L136-43. 2006
    ..These data demonstrate a novel cGMP-independent mechanism of reversible alpha1-adrenergic receptor inhibition by S-nitrosothiols...
  3. pmc Lung EC-SOD overexpression attenuates hypoxic induction of Egr-1 and chronic hypoxic pulmonary vascular remodeling
    Eva Nozik-Grayck
    Department of Pediatrics, Univ of Colorado, Denver, 4200 E 9th Ave, B131, Denver, CO 80262, USA
    Am J Physiol Lung Cell Mol Physiol 295:L422-30. 2008
    ..These data provide the first evidence that EC-SOD activity is disrupted in chronic hypoxia, and increased EC-SOD activity can attenuate chronic hypoxic PH by limiting the hypoxic upregulation of redox-sensitive genes...
  4. ncbi Extracellular superoxide dismutase
    Eva Nozik-Grayck
    Pediatric Critical Care, Department of Pediatrics, University of Colorado School of Medicine, 4200 E 9th Ave B131, Denver, CO 80262, USA
    Int J Biochem Cell Biol 37:2466-71. 2005
    ..A thorough understanding of the biological role of EC-SOD will be invaluable for developing novel therapies to prevent stress by extracellular oxidants...
  5. ncbi Pulmonary vasoconstriction by serotonin is inhibited by S-nitrosoglutathione
    Eva Nozik-Grayck
    Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Physiol Lung Cell Mol Physiol 282:L1057-65. 2002
    ..This study demonstrates that GSNO can regulate vascular tone in the intact lung by a reversible mechanism involving inhibition of the response to 5-HT...
  6. ncbi Oxidative stress activates anion exchange protein 2 and AP-1 in airway epithelial cells
    Jennifer L Turi
    Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Physiol Lung Cell Mol Physiol 283:L791-8. 2002
    ..This study demonstrates that AE2 expression is regulated by oxidative stress in airway epithelial cells and that this regulation correlates with activation of AP-1...
  7. pmc Lung extracellular superoxide dismutase overexpression lessens bleomycin-induced pulmonary hypertension and vascular remodeling
    Zachary Van Rheen
    Department of Pediatrics, University of Colorado, Aurora, CO 80045, USA
    Am J Respir Cell Mol Biol 44:500-8. 2011
    ....
  8. pmc Sustained lung activity of a novel chimeric protein, SOD2/3, after intratracheal administration
    Margaret B Clarke
    Pediatric Critical Care, Department of Pediatrics, University of Colorado at Denver, Aurora, CO 80045, USA
    Free Radic Biol Med 49:2032-9. 2010
    ..Further testing in models of chronic lung or pulmonary vascular diseases mediated by excess superoxide should consider the longer tissue half-life of SOD2/3 as well as its potential systemic vascular effects...
  9. pmc Transgenic extracellular superoxide dismutase protects postnatal alveolar epithelial proliferation and development during hyperoxia
    Richard L Auten
    Neonatal Perinatal Research Institute, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Physiol Lung Cell Mol Physiol 290:L32-40. 2006
    ..Reducing the 95% O2-induced impairment of epithelial proliferation at a critical window of lung development was associated with protection against DNA damage and preservation of apical T1alpha expression at P3...
  10. ncbi Duodenal cytochrome b: a novel ferrireductase in airway epithelial cells
    Jennifer L Turi
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    Am J Physiol Lung Cell Mol Physiol 291:L272-80. 2006
    ..production decreased when Dcytb function was blocked. The presence of Dcytb in airway epithelial cells and its regulation by iron therefore may contribute to pulmonary cytoprotection...
  11. pmc A potential role for reactive oxygen species and the HIF-1alpha-VEGF pathway in hypoxia-induced pulmonary vascular leak
    David C Irwin
    University of Colorado Health Science Center, School of Medicine, Denver, CO 80262, USA
    Free Radic Biol Med 47:55-61. 2009
    ..Our data suggest that hypoxia-induced permeability is due, in part, to the ROS-HIF-1alpha-VEGF pathway...
  12. ncbi Role of reactive oxygen species in chronic hypoxia-induced pulmonary hypertension and vascular remodeling
    Eva Nozik-Grayck
    Department of Pediatrics and Developmental Lung Biology Laboratory, University of Colorado at Denver and Health Science Center, Denver, Colorado, USA
    Adv Exp Med Biol 618:101-12. 2007
    ....
  13. pmc The NF-κB inhibitory proteins IκBα and IκBβ mediate disparate responses to inflammation in fetal pulmonary endothelial cells
    Jen Ruey Tang
    Department of Pediatrics, Pediatric Heart Lung Center, University of Colorado School of Medicine, Aurora, CO 80045, USA
    J Immunol 190:2913-23. 2013
    ....
  14. ncbi Discordant extracellular superoxide dismutase expression and activity in neonatal hyperoxic lung
    Lisa B Mamo
    Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, USA
    Am J Respir Crit Care Med 170:313-8. 2004
    ..These data provide the first direct evidence that EC-SOD is itself a target of nitration in hyperoxia, and offer a plausible explanation for low EC-SOD activity despite its increased secretion by O(2)-exposed neonatal lung...
  15. ncbi Bicarbonate-dependent superoxide release and pulmonary artery tone
    Eva Nozik-Grayck
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    Am J Physiol Heart Circ Physiol 285:H2327-35. 2003
    ..These results indicate that O2-* produced by endothelial NOS in normoxia and unidentified sources in hypoxia regulate pulmonary vascular tone via AE2...
  16. ncbi Electrocardiographic response to enzyme replacement therapy for Pompe disease
    Annette K Ansong
    Division of Pediatric Cardiology, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, USA
    Genet Med 8:297-301. 2006
    ..We evaluated the effect of recombinant human GAA (rhGAA) enzyme replacement therapy (ERT) on these ECG parameters in patients with infantile-onset Pompe disease...
  17. ncbi Prenatal hypoxia decreases lung extracellular superoxide dismutase expression and activity
    Brenda Louise Giles
    Department of Pediatrics, University of Manitoba, Winnipeg, Manitoba R3A 1S1
    Am J Physiol Lung Cell Mol Physiol 283:L549-54. 2002
    ..Furthermore, prenatal hypoxia delays secretion of active EC-SOD enzyme. These findings have important implications for the effects of prenatal asphyxia on postnatal response to oxidant stress...
  18. ncbi Extracellular superoxide dismutase protects lung development in hyperoxia-exposed newborn mice
    Mohamed N Ahmed
    Departments of Pediatrics, Medicine, Anesthesiology, Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Respir Crit Care Med 167:400-5. 2003
    ..After 7 days 95% O2 + 14 days 60% O2, lung inflammation measured as myeloperoxidase activity was reduced to control levels in all treatment groups...
  19. ncbi Superoxide-dependent iron uptake: a new role for anion exchange protein 2
    Andrew J Ghio
    P O Box 3315, Duke University Medical Center, Durham, NC 27710, USA
    Am J Respir Cell Mol Biol 29:653-60. 2003
    ..We thus disclose a novel ferri-reductase mechanism of NTBI uptake by human lung cells that employs superoxide exchange for HCO3- by AE2 protein in the plasma membrane...