Research Topics
Genomes and Genes | Eva Nozik-GrayckSummaryAffiliation: University of Colorado Health Sciences Center Country: USA Publications
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Publications
Developmental expression of the receptor for advanced glycation end-products (RAGE) and its response to hyperoxia in the neonatal rat lungPierre Paul Lizotte
Biology of Breathing Research, Manitoba Institute of Child Health, Winnipeg, MB, Canada
BMC Dev Biol 7:15. 2007..We sought to determine the regulation of the soluble and membrane isoforms of RAGE in the developing lung, and its expression under hyperoxic conditions in the neonatal lung...
S-nitrosoglutathione inhibits alpha1-adrenergic receptor-mediated vasoconstriction and ligand binding in pulmonary arteryEva Nozik-Grayck
Department of Pediatrics, University of Colorado Health Science Center, Denver, CO 80262, USA
Am J Physiol Lung Cell Mol Physiol 290:L136-43. 2006..These data demonstrate a novel cGMP-independent mechanism of reversible alpha1-adrenergic receptor inhibition by S-nitrosothiols...- Lung EC-SOD overexpression attenuates hypoxic induction of Egr-1 and chronic hypoxic pulmonary vascular remodelingEva Nozik-Grayck
Department of Pediatrics, Univ of Colorado, Denver, 4200 E 9th Ave, B131, Denver, CO 80262, USA
Am J Physiol Lung Cell Mol Physiol 295:L422-30. 2008..These data provide the first evidence that EC-SOD activity is disrupted in chronic hypoxia, and increased EC-SOD activity can attenuate chronic hypoxic PH by limiting the hypoxic upregulation of redox-sensitive genes... - Extracellular superoxide dismutaseEva Nozik-Grayck
Pediatric Critical Care, Department of Pediatrics, University of Colorado School of Medicine, 4200 E 9th Ave B131, Denver, CO 80262, USA
Int J Biochem Cell Biol 37:2466-71. 2005..A thorough understanding of the biological role of EC-SOD will be invaluable for developing novel therapies to prevent stress by extracellular oxidants... - Pulmonary vasoconstriction by serotonin is inhibited by S-nitrosoglutathioneEva Nozik-Grayck
Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
Am J Physiol Lung Cell Mol Physiol 282:L1057-65. 2002..This study demonstrates that GSNO can regulate vascular tone in the intact lung by a reversible mechanism involving inhibition of the response to 5-HT... - Oxidative stress activates anion exchange protein 2 and AP-1 in airway epithelial cellsJennifer L Turi
Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
Am J Physiol Lung Cell Mol Physiol 283:L791-8. 2002..This study demonstrates that AE2 expression is regulated by oxidative stress in airway epithelial cells and that this regulation correlates with activation of AP-1... - Lung extracellular superoxide dismutase overexpression lessens bleomycin-induced pulmonary hypertension and vascular remodelingZachary Van Rheen
Department of Pediatrics, University of Colorado, Aurora, CO 80045, USA
Am J Respir Cell Mol Biol 44:500-8. 2011.... - Sustained lung activity of a novel chimeric protein, SOD2/3, after intratracheal administrationMargaret B Clarke
Pediatric Critical Care, Department of Pediatrics, University of Colorado at Denver, Aurora, CO 80045, USA
Free Radic Biol Med 49:2032-9. 2010..Further testing in models of chronic lung or pulmonary vascular diseases mediated by excess superoxide should consider the longer tissue half-life of SOD2/3 as well as its potential systemic vascular effects... - Transgenic extracellular superoxide dismutase protects postnatal alveolar epithelial proliferation and development during hyperoxiaRichard L Auten
Neonatal Perinatal Research Institute, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
Am J Physiol Lung Cell Mol Physiol 290:L32-40. 2006..Reducing the 95% O2-induced impairment of epithelial proliferation at a critical window of lung development was associated with protection against DNA damage and preservation of apical T1alpha expression at P3... - Duodenal cytochrome b: a novel ferrireductase in airway epithelial cellsJennifer L Turi
Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
Am J Physiol Lung Cell Mol Physiol 291:L272-80. 2006..production decreased when Dcytb function was blocked. The presence of Dcytb in airway epithelial cells and its regulation by iron therefore may contribute to pulmonary cytoprotection... - A potential role for reactive oxygen species and the HIF-1alpha-VEGF pathway in hypoxia-induced pulmonary vascular leakDavid C Irwin
University of Colorado Health Science Center, School of Medicine, Denver, CO 80262, USA
Free Radic Biol Med 47:55-61. 2009..Our data suggest that hypoxia-induced permeability is due, in part, to the ROS-HIF-1alpha-VEGF pathway... - Role of reactive oxygen species in chronic hypoxia-induced pulmonary hypertension and vascular remodelingEva Nozik Grayck
Department of Pediatrics and Developmental Lung Biology Laboratory, University of Colorado at Denver and Health Science Center, Denver, Colorado, USA
Adv Exp Med Biol 618:101-12. 2007.... - Bicarbonate-dependent superoxide release and pulmonary artery toneEva Nozik-Grayck
Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
Am J Physiol Heart Circ Physiol 285:H2327-35. 2003..These results indicate that O2-* produced by endothelial NOS in normoxia and unidentified sources in hypoxia regulate pulmonary vascular tone via AE2... - Discordant extracellular superoxide dismutase expression and activity in neonatal hyperoxic lungLisa B Mamo
Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, USA
Am J Respir Crit Care Med 170:313-8. 2004..These data provide the first direct evidence that EC-SOD is itself a target of nitration in hyperoxia, and offer a plausible explanation for low EC-SOD activity despite its increased secretion by O(2)-exposed neonatal lung... - Electrocardiographic response to enzyme replacement therapy for Pompe diseaseAnnette K Ansong
Division of Pediatric Cardiology, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, USA
Genet Med 8:297-301. 2006..These results suggest that these ECG parameters may be useful markers of the severity of cardiac disease and the response to ERT treatment in patients with infantile Pompe disease... - Extracellular superoxide dismutase protects lung development in hyperoxia-exposed newborn miceMohamed N Ahmed
Departments of Pediatrics, Medicine, Anesthesiology, Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
Am J Respir Crit Care Med 167:400-5. 2003..After 7 days 95% O2 + 14 days 60% O2, lung inflammation measured as myeloperoxidase activity was reduced to control levels in all treatment groups... - Prenatal hypoxia decreases lung extracellular superoxide dismutase expression and activityBrenda-Louise Giles
Department of Pediatrics, University of Manitoba, Winnipeg, Manitoba R3A 1S1
Am J Physiol Lung Cell Mol Physiol 283:L549-54. 2002..Furthermore, prenatal hypoxia delays secretion of active EC-SOD enzyme. These findings have important implications for the effects of prenatal asphyxia on postnatal response to oxidant stress... - Superoxide-dependent iron uptake: a new role for anion exchange protein 2Andrew J Ghio
P.O. Box 3315, Duke University Medical Center, Durham, NC 27710, USA
Am J Respir Cell Mol Biol 29:653-60. 2003..We thus disclose a novel ferri-reductase mechanism of NTBI uptake by human lung cells that employs superoxide exchange for HCO3- by AE2 protein in the plasma membrane...