P C Nowell
Affiliation: University of Pennsylvania
- Tumor progression: a brief historical perspectivePeter C Nowell
Department of Pathology and Laboratory Medicine, School of Medicine, University of Pennsylvania, M 163 John Morgan Building, 36th and Hamilton Walk, Philadelphia, PA 19104 6082, USA
Semin Cancer Biol 12:261-6. 2002..Multiple types of genes have been identified, and they differ in different tumors, but they provide potential specific targets for important new therapies...
- Discovery of the Philadelphia chromosome: a personal perspectivePeter C Nowell
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6082, USA
J Clin Invest 117:2033-5. 2007....
- Aberrant responses of human lymphocytic neoplasms to cytokine regulationP C Nowell
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA
Immunol Res 17:171-7. 1998..As we define more precisely the specific defects that contribute to the clonal expansion of these neoplasms, the findings may ultimately lead to improved clinical control of these disorders...
- Progress with chronic myelogenous leukemia: a personal perspective over four decadesPeter C Nowell
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Annu Rev Med 53:1-13. 2002..Similar efforts are under way for other human cancers, and although the problem is enormously complex, there is real hope for major improvements in controlling these disorders...
- Fifty years in cancer researchPeter C Nowell
Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19104-6082, USA
Cancer Biol Ther 1:715-7. 2002
- Studies of normal and neoplastic lymphocytesPeter C Nowell
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6082, USA
Immunol Rev 185:220-6. 2002..This career has covered a period of remarkable growth of knowledge concerning both normal and neoplastic lymphocytes, with potential for many important future clinical applications; it has been a privilege to participate...
- Panhandle PCR for cDNA: a rapid method for isolation of MLL fusion transcripts involving unknown partner genesM D Megonigal
Division of Oncology, Joseph Stokes, Jr, Research Institute, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, 19104, USA
Proc Natl Acad Sci U S A 97:9597-602. 2000..cDNA panhandle PCR is useful for identifying MLL translocations and determining unknown partner sequences in the fusion transcripts...
- Association of CYP3A4 genotype with treatment-related leukemiaC A Felix
Division of Oncology, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 95:13176-81. 1998..The variant may decrease production of the epipodophyllotoxin catechol metabolite, which is the precursor of the potentially DNA-damaging quinone...
- Detection of leukemia-associated MLL-GAS7 translocation early during chemotherapy with DNA topoisomerase II inhibitorsM D Megonigal
Division of Oncology, The Children s Hospital of Philadelphia, and Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 97:2814-9. 2000..Although MLL has many partner genes and most have not been characterized, panhandle PCR strategies afford new means for detecting MLL gene translocations early during therapy when the partner gene is unknown...
- Trisomy 8 in an allogeneic stem cell transplant recipient representative of a donor-derived constitutional abnormalityNoelle V Frey
Division of Hematology Oncology and Abramson Cancer Center, Hospital of University of Pennsylvania, Philadelphia, Pennsylvania, USA
Am J Hematol 83:846-9. 2008..The case illustrates the importance of identifying donor-derived constitutional abnormalities to avoid the assumption that these cytogenetic abnormalities after HSCT are representative of malignant disease...
- Variable region gene analysis of pathologic human autoantibodies to the related i and I red blood cell antigensL E Silberstein
Department of Pathology and Laboratory Medicine, University of Pennsylvania, School of Medicine, Philadelphia
Blood 78:2372-86. 1991..21 gene (or a closely related gene). Furthermore, the restricted VH and different VL gene use in anti-i and anti-I CA may reflect the close structural relationship of the i and I antigens...
- Panhandle PCR strategy to amplify MLL genomic breakpoints in treatment-related leukemiasM D Megonigal
Division of Oncology, Jr Research Institute, Department of Pediatrics, Children s Hospital of Philadelphia, Philadelphia, PA 19104 4318, USA
Proc Natl Acad Sci U S A 94:11583-8. 1997..Analysis of additional pediatric cases will determine whether breakpoint distribution deviates from the predilection for 3' distribution in the bcr that has been found in adult cases...
- Oligodeoxynucleotide-mediated inhibition of c-myb gene expression in autografted bone marrow: a pilot studySelina M Luger
Division of Hematology/Oncology and the Stem Cell Biology/Therapeutics Program, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
Blood 99:1150-8. 2002....
- Management of health-care--associated infections in the oncology patientJohn L Guinan
University of Pennsylvania, School of Arts and Science, Young Scholars Program, USA
Oncology (Williston Park) 17:415-20; discussion 423-6. 2003..This paper will review each of these risk factors and discuss preventive steps such as a predictive index, antibiotic therapy, and infection control practices...
- A novel t(3;8)(q27;q24.1) simultaneously involving both the BCL6 and MYC genes in a diffuse large B-cell lymphomaHuan You Wang
Department of Pathology and Laboratory Medicine, School of Medicine, Hospital of the University of Pennsylvania, 7 103 Founders Pavilion, 3400 Spruce Street, Philadelphia, PA 19014 4284, USA
Cancer Genet Cytogenet 172:45-53. 2007..We know of no previous report of this translocation in DLBCL, which simultaneously affects two key genes implicated in lymphomagenesis and may reflect a novel genetic mechanism in neoplastic transformation...
- Low NAD(P)H:quinone oxidoreductase activity is associated with increased risk of leukemia with MLL translocations in infants and childrenMartyn T Smith
Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley 94720 7360, USA
Blood 100:4590-3. 2002..The inactivating NQO1 polymorphism is associated with an increased risk of de novo leukemia with MLL translocations in infants and children...
- Heterogeneous abnormalities of CCND1 and RB1 in primary cutaneous T-Cell lymphomas suggesting impaired cell cycle control in disease pathogenesisXin Mao
Skin Tumour Unit, St John s Institute of Dermatology, St Thomas Hospital, King s College, London, UK
J Invest Dermatol 126:1388-95. 2006..These findings suggest heterogeneous abnormalities of CCND and RB in CTCL, in which dysregulated CCND and RB1 may lead to impaired cell cycle control...