Peter J Novick
Affiliation: University of California
Chen S, Cui Y, Parashar S, Novick P, Ferro Novick S. ER-phagy requires Lnp1, a protein that stabilizes rearrangements of the ER network. Proc Natl Acad Sci U S A. 2018;115:E6237-E6244 pubmed publisher
..This prevents the association of Atg40 with Atg11 and the packaging of the ER into autophagosomes. We propose that Lnp1 is needed to stabilize the actin-dependent remodeling of the ER that is essential for ER-phagy. ..
Chen S, Desai T, McNew J, Gerard P, Novick P, Ferro Novick S. Lunapark stabilizes nascent three-way junctions in the endoplasmic reticulum. Proc Natl Acad Sci U S A. 2015;112:418-23 pubmed publisher
..These findings imply that mLnp1 plays a key role in stabilizing nascent three-way ER junctions. ..
Liu D, Li X, Shen D, Novick P. Two subunits of the exocyst, Sec3p and Exo70p, can function exclusively on the plasma membrane. Mol Biol Cell. 2018;29:736-750 pubmed publisher
..Our results are consistent with a model in which Sec3p and Exo70p can function exclusively on the plasma membrane while the other subunits are brought to them on secretory vesicles. ..
Ling Y, Hayano S, Novick P. Osh4p is needed to reduce the level of phosphatidylinositol-4-phosphate on secretory vesicles as they mature. Mol Biol Cell. 2014;25:3389-400 pubmed publisher
..Spatial regulation of PI4P levels thereby plays an important role in vesicle maturation. ..
Liu D, Novick P. Bem1p contributes to secretory pathway polarization through a direct interaction with Exo70p. J Cell Biol. 2014;207:59-72 pubmed publisher
..Similar to Sec3p, the actin-independent localization of Exo70p requires a synergistic interaction with the phosphoinositide PI(4,5)P2. ..
Stalder D, Novick P. The casein kinases Yck1p and Yck2p act in the secretory pathway, in part, by regulating the Rab exchange factor Sec2p. Mol Biol Cell. 2016;27:686-701 pubmed publisher
..This promotes Sec2p function by stimulating its interaction with Sec15p. Finally, Sec2p is dephosphorylated very late in the exocytic reaction to facilitate recycling. ..
Yuan H, Davis S, Ferro Novick S, Novick P. Rewiring a Rab regulatory network reveals a possible inhibitory role for the vesicle tether, Uso1. Proc Natl Acad Sci U S A. 2017;114:E8637-E8645 pubmed publisher
..This putative inhibitory function could serve to increase the fidelity of vesicle docking. ..