Research Topics
| John NovembreSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
Human population structure and the adaptive response to pathogen-induced selection pressuresJohn Novembre
Department of Ecology and Evolutionary Biology, University of California, Los Angeles, CA, USA
Philos Trans R Soc Lond B Biol Sci 367:878-86. 2012....- Population-genetic comparison of the Sorbian isolate population in Germany with the German KORA population using genome-wide SNP arraysArnd Gross
Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Haertelstrasse 16 18, 04107 Leipzig, Germany
BMC Genet 12:67. 2011..We also aim to separate effects of over-sampling of families in the Sorbs sample from effects of genetic isolation and compare the power of genetic association studies between the samples... 
Perspectives on human population structure at the cusp of the sequencing eraJohn Novembre
Department of Ecology and Evolutionary Biology, University of California, Los Angeles, California 90403, USA
Annu Rev Genomics Hum Genet 12:245-74. 2011..Here we draw on the lessons from these studies to anticipate the directions that will be most fruitful to pursue during the emerging whole-genome sequencing era...- Genes mirror geography within EuropeJohn Novembre
Department of Ecology and Evolutionary Biology, Interdepartmental Program in Bioinformatics, University of California Los Angeles, Los Angeles, California 90095, USA
Nature 456:98-101. 2008..In addition, the results are relevant to the prospects of genetic ancestry testing; an individual's DNA can be used to infer their geographic origin with surprising accuracy-often to within a few hundred kilometres... - Likelihood-based inference in isolation-by-distance models using the spatial distribution of low-frequency allelesJohn Novembre
Department of Ecology and Evolutionary Biology, Interdepartmental Program in Bioinformatics, University of California Los Angeles, Los Angeles, California 90095, USA
Evolution 63:2914-25. 2009..We test the performance of our methods using simulations of new mutations in a lattice model and illustrate its use with a dataset from Arabidopsis thaliana... - Spatial patterns of variation due to natural selection in humansJohn Novembre
Department of Ecology and Evolutionary Biology, Interdepartmental Program in Bioinformatics, University of California Los Angeles, Los Angeles, California 90095 1606, USA
Nat Rev Genet 10:745-55. 2009..Here, we review the challenges of these studies and emerging results, including how human population structure has influenced the response to novel selective pressures... - A genome-wide perspective on the evolutionary history of enigmatic wolf-like canidsBridgett M VonHoldt
Department of Ecology and Evolutionary Biology, University of California, Los Angeles, California 90095, USA
Genome Res 21:1294-305. 2011..Such admixture complicates decisions regarding endangered species restoration and protection... - Fast model-based estimation of ancestry in unrelated individualsDavid H Alexander
Department of Biomathematics, University of California at Los Angeles, Los Angeles, California 90095, USA
Genome Res 19:1655-64. 2009.... - Genome-wide SNP and haplotype analyses reveal a rich history underlying dog domesticationBridgett M VonHoldt
Department of Ecology and Evolutionary Biology, 621 Charles E Young Drive South, University of California, Los Angeles, California 90095, USA
Nature 464:898-902. 2010..More recently, the evolution of modern dog breeds seems to have been an iterative process that drew on a limited genetic toolkit to create remarkable phenotypic diversity... - A model-based approach for analysis of spatial structure in genetic dataWen Yun Yang
Interdepartmental Program in Bioinformatics, University of California, Los Angeles, California, USA
Nat Genet 44:725-31. 2012..These regions include SNPs in the well-characterized LCT region, as well as at loci including FOXP2, OCA2 and LRP1B... - Recombination rates in admixed individuals identified by ancestry-based inferenceDaniel Wegmann
Department of Ecology and Evolutionary Biology, University of California, Los Angeles, California, USA
Nat Genet 43:847-53. 2011..These results suggest that outside of structurally variable regions, admixture does not substantially disrupt the factors controlling recombination rates in humans... 
Ascertainment bias in spatially structured populations: a case study in the eastern fence lizardErica Bree Rosenblum
Museum of Vertebrate Zoology, University of California, Berkeley, CA 94720, USA
J Hered 98:331-6. 2007..Because bias correction methods performed well even when underlying assumptions were violated, our results suggest tools are currently available to analyze SNP data in structured populations...- Finding haplotype block boundaries by using the minimum-description-length principleEric C Anderson
Department of Integrative Biology, University of California, Berkeley, CA, 94720, USA
Am J Hum Genet 73:336-54. 2003..than do other methods. These results suggest that our method may be useful for designing association-based mapping studies that exploit haplotype blocks... - Genetic variation in the Sorbs of eastern Germany in the context of broader European genetic diversityKrishna R Veeramah
Department of Eco and Evo Biol, Interdepartmental Program in Bioinformatics, University of California, Los Angeles, CA, USA
Eur J Hum Genet 19:995-1001. 2011.... - Codon usage patterns in cytochrome oxidase I across multiple insect ordersJoshua T Herbeck
Division of Insect Biology, University of California, Berkeley, Berkeley, CA 94720, USA
J Mol Evol 56:691-701. 2003..These shifts among codons in double-preference models are phylogenetically conservative...