Richard M Novak
Affiliation: University of Illinois at Chicago
- Risk behavior among women enrolled in a randomized controlled efficacy trial of an adenoviral vector vaccine to prevent HIV acquisitionRichard M Novak
Section of Infectious Diseases, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois 60162, USA
AIDS 27:1763-70. 2013..Report of risk behavior, HIV incidence, and pregnancy rates among women participating in the STEP study, which is a phase IIB trial of MRKAd5 HIV-1 gag/pol/nef vaccine in HIV-negative individuals who were at high risk of HIV-1...
- Immune reconstitution inflammatory syndrome: incidence and implications for mortalityRichard M Novak
University of Illinois, Chicago, 60612, USA
AIDS 26:721-30. 2012..To describe incidence of immune reconstitution inflammatory syndrome (IRIS) and its association with mortality in a large multisite US HIV-infected cohort applying an objective, comprehensive definition...
- Cervicovaginal levels of lactoferrin, secretory leukocyte protease inhibitor, and RANTES and the effects of coexisting vaginoses in human immunodeficiency virus (HIV)-seronegative women with a high risk of heterosexual acquisition of HIV infectionRichard M Novak
University of Illinois at Chicago, 808 S Wood St, M C 735, Rm 888, Chicago, IL 60612, USA
Clin Vaccine Immunol 14:1102-7. 2007..However, the increased RANTES levels in a higher-risk subset of high-risk women were reduced after BV treatment...
- Prevalence of antiretroviral drug resistance mutations in chronically HIV-infected, treatment-naive patients: implications for routine resistance screening before initiation of antiretroviral therapyRichard M Novak
University of Illinois, Chicago, IL 60612, USA
Clin Infect Dis 40:468-74. 2005..However, it is unclear to what extent these mutations persist in chronically infected, treatment-naive patients...
- Mucosal HIV-binding antibody and neutralizing activity in high-risk HIV-uninfected female participants in a trial of HIV-vaccine efficacyJohn A Schneider
Department of Medicine, Tufts New England Medical Center, Boston, MA, USA
J Infect Dis 196:1637-44. 2007..This study investigated gp120-binding antibody and neutralizing activity, at the gingival- and cervical-mucosal levels, in response to a bivalent gp120 candidate vaccine...
- Increased mortality among publicly insured participants in the HIV Outpatient Study despite HAART treatmentFrank J Palella
Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
AIDS 25:1865-76. 2011..Understanding mortality differences among HIV-infected patients can focus efforts to improve survival...
- The association of HIV susceptibility testing with survival among HIV-infected patients receiving antiretroviral therapy: a cohort studyFrank J Palella
Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
Ann Intern Med 151:73-84. 2009..HIV-1 genotypic and phenotypic susceptibility testing (GPT) optimizes antiretroviral selection, but its effect on survival is unknown...
- Human cervicovaginal lavage fluid contains an inhibitor of HIV binding to dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrinMeghan A Jendrysik
Section of Infectious Diseases, Department of Medicine, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA
J Infect Dis 192:630-9. 2005..Mechanistic experiments indicate that the inhibitor acts via binding to DC-SIGN. Further study of such inhibitors may help to elucidate the role played by DC-SIGN in HIV transmission...
- Initiation of HAART at higher CD4 cell counts is associated with a lower frequency of antiretroviral drug resistance mutations at virologic failureJonathan Uy
University of Illinois, Chicago, IL, USA
J Acquir Immune Defic Syndr 51:450-3. 2009..There are limited data on the risk of developing HIV drug resistance based on the CD4 cell count at which highly active antiretroviral therapy (HAART) is initiated...
- Induction of tumor necrosis factor- alpha secretion and toll-like receptor 2 and 4 mRNA expression by genital mucosal fluids from women with bacterial vaginosisM Reza Zariffard
Department of Immunology and Microbiology, Rush University, Chicago, Illinois 60612, USA
J Infect Dis 191:1913-21. 2005..Bacterial vaginosis (BV) is associated with complications of pregnancy and increased susceptibility to human immunodeficiency virus (HIV) sexual transmission...
- Factors associated with mortality among persistently viraemic triple-antiretroviral-class-experienced patients receiving antiretroviral therapy in the HIV Outpatient Study (HOPS)Frank J Palella
Northwestern University, Chicago, IL, USA
J Antimicrob Chemother 69:2826-34. 2014..Identifying factors associated with mortality for HIV-infected patients with persistent viraemia despite antiretroviral (ARV) therapy may inform diagnostic and treatment strategies...
- TLR2-mediated cell stimulation in bacterial vaginosisDebra Mares
Department of Immunology Microbiology, Rush University Medical Center, Chicago, IL 60612, USA
J Reprod Immunol 77:91-9. 2008..Thus, these studies show that soluble factor(s) present in the lower genital tract of women with BV activate cells via TLR2, identifying a pathway through which BV may mediate adverse effects...
- Safety and immunogenicity of a replication-incompetent adenovirus type 5 HIV-1 clade B gag/pol/nef vaccine in healthy adultsFrances H Priddy
Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
Clin Infect Dis 46:1769-81. 2008....
- Restoration of the antiviral activity of 3'-azido-3'-deoxythymidine (AZT) against AZT-resistant human immunodeficiency virus by delivery of engineered thymidylate kinase to T cellsArnon Lavie
Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL 60612, USA
J Gen Virol 89:1672-9. 2008..These results provide an experimental basis for the development of new strategies to therapeutically increase the intracellular concentrations of active nucleoside analogue metabolites as a means to overcome emerging drug resistance...
- Disparities in Initiation of Combination Antiretroviral Treatment and in Virologic Suppression Among Patients in the HIV Outpatient Study, 2000-2013Richard M Novak
Department of Medicine, Division of Infectious Diseases, University of Illinois at Chicago, Chicago, IL Cerner Corporation, Vienna, VA Northwestern University Feinberg School of Medicine, Chicago, IL and Division of HIV AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, GA
J Acquir Immune Defic Syndr 70:23-32. 2015..We assessed temporal trends of and disparities in time to combination antiretroviral therapy (cART) initiation and HIV VS in a large demographically diverse cohort of HIV-infected patients...
- Policosanol for managing human immunodeficiency virus-related dyslipidemia in a medically underserved population: a randomized, controlled clinical trialBarbara Swanson
Rush University College of Nursing, Chicago, Illinois, USA
Altern Ther Health Med 17:30-5. 2011..Policosanol is a dietary supplement derived from sugar cane that is widely used as a statin alternative in Latin America...
- In vitro antiretroviral activity and in vivo toxicity of the potential topical microbicide copper phthalocyanine sulfateAshley R Styczynski
Department of Infectious Disease, University of Illinois at Chicago, Chicago, IL, 60612, USA
Virol J 12:132. 2015..Copper complexed within a phthalocyanine ring, forming copper (II) phthalocyanine sulfate (CuPcS), may have a role in microbicide development when used intravaginally...
- T. vaginalis Infection Is Associated with Increased IL-8 and TNFr1 Levels but with the Absence of CD38 and HLADR Activation in the Cervix of ESNOlamide D Jarrett
Section of Infectious Diseases, Department of Medicine, University of Illinois at Chicago School of Medicine, Chicago, Illinois, 60612, United States of America
PLoS ONE 10:e0130146. 2015..It is important to understand possible mechanisms, such as recruitment of activated T cells, by which T. vaginalis could facilitate HIV infection in this population...
- The influence of executive functions, sensation seeking, and HIV serostatus on the risky sexual practices of substance-dependent individualsRaul Gonzalez
University of Illinois Chicago, Department of Psychiatry, M C 912, 1601 W Taylor Street, Room 408, Chicago, IL 60612, USA
J Int Neuropsychol Soc 11:121-31. 2005..Our findings indicate that continued risk behavior among HIV+ drug users may be driven by sensation seeking (a personality trait common among drug users); however, the impact of executive functions is less clear...
- IL-22 levels are associated with Trichomonas vaginalis infection in the lower genital tractHadijat Moradeke Makinde
Department of Immunology Microbiology, Rush University Medical Center, Chicago, IL 60612, USA
Am J Reprod Immunol 70:38-44. 2013..IL-22 has important functions at mucosal surfaces, including the induction of antimicrobial peptides and maintenance of epithelium. However, IL-22 has not been investigated in the genital tract during TV infection...
- Short communication: Apoptosis pathways in HIV-1-infected patients before and after highly active antiretroviral therapy: relevance to immune recoveryDavid L Pitrak
1 Section of Infectious Diseases, Department of Medicine, University of Chicago, Chicago, Illinois
AIDS Res Hum Retroviruses 31:208-16. 2015..66, p=0.038). This suggests that positive selection of naive CD4(+) T cells in the thymus is the major determinant of CD4(+) recovery...
- Viable Mycobacterium avium is required for the majority of human immunodeficiency virus-induced upregulation in monocytoid cellsMahmood Ghassemi
Department of Medicine, University of Illinois, 808 S Wood St, Chicago, IL 60612, USA
J Med Microbiol 52:877-82. 2003....
- Trichomonas vaginalis infection activates cells through toll-like receptor 4M Reza Zariffard
Department of Immunology Microbiology, Rush University, Chicago, IL 60612, USA
Clin Immunol 111:103-7. 2004..These studies show that T. vaginalis infection results in the appearance in the genital tract of substance(s) that stimulate cells through TLR4, suggesting a mechanism for the inflammation caused by this infection...
- Interferon-gamma receptors in HIV-1 infectionJanak Koirala
Division of Infectious Diseases, Southern Illinois University, School of Medicine, Springfield, Illinois 62794 9636, USA
AIDS Res Hum Retroviruses 24:1097-102. 2008..This dysfunction in the interferon-gamma pathway contributes to a further impairment in cellular immune function in patients with advanced HIV-1 infection, which may further increase susceptibility to opportunistic infections...
- Reviews of anti-infective agents: maraviroc: the first of a new class of antiretroviral agentsRodger D MacArthur
Wayne State University, Detroit, Michigan, USA
Clin Infect Dis 47:236-41. 2008..HIV-1 mechanisms of resistance to maraviroc, assays to determine viral coreceptor use (tropism), drug safety, and clinical use of maraviroc are discussed at length...
- The Incidence of HIV drug resistance and its impact on progression of HIV disease among antiretroviral-naïve participants started on three different antiretroviral therapy strategiesMichael J Kozal
Yale University School of Medicine and VA CT Healthcare System, New Haven, Connecticut 06510, USA
HIV Clin Trials 8:357-70. 2007..The strategies were compared for drug resistance at first virologic failure (VF; HIV RNA >1000 copies/mL). The impact of resistance on AIDS or death was determined...
- Mucosal innate immune factors in secretions from high-risk individuals immunized with a bivalent gp120 vaccineJames E Cummins
Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
AIDS Res Hum Retroviruses 23:748-54. 2007..Because of the importance of innate immunity in host defense, evaluation of the mucosal innate immune system should be included in future HIV prevention trials...
- Prevalence and impact of HIV-1 protease codon 33 mutations and polymorphisms in treatment-naive and treatment-experienced patientsMichael J Kozal
Yale University Et VA CT Healthcare System, New Haven, CT, USA
Antivir Ther 11:457-63. 2006..Little is known about the difference in prevalence of codon 33 mutations and polymorphisms between treatment-naive and treatment-experienced patients, and the effect of codon 33F on PI phenotypic resistance patterns...
- HIV sexual risk behavior over 36 months of follow-up in the world's first HIV vaccine efficacy trialBradford N Bartholow
Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
J Acquir Immune Defic Syndr 39:90-101. 2005....
- Stroop performance in drug users classified by HIV and hepatitis C virus serostatusEileen M Martin
J Int Neuropsychol Soc 10:298-300. 2004
- Sex-related differences in the pharmacokinetics of once-daily saquinavir soft-gelatin capsules boosted with low-dose ritonavir in patients infected with human immunodeficiency virus type 1Manjunath P Pai
University of New Mexico Health Sciences Center, Albuquerque, USA
Pharmacotherapy 24:592-9. 2004....
- A comparison of three highly active antiretroviral treatment strategies consisting of non-nucleoside reverse transcriptase inhibitors, protease inhibitors, or both in the presence of nucleoside reverse transcriptase inhibitors as initial therapy (CPCRA 05Rodger D MacArthur
Wayne State University, Detroit, MI, USA
Lancet 368:2125-35. 2006..Here, we report results from the FIRST trial, which compared initial treatment strategies for clinical, immunological, and virological outcomes...
- Rates of hospitalizations and associated diagnoses in a large multisite cohort of HIV patients in the United States, 1994-2005Kate Buchacz
Division of HIV AIDS Prevention, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
AIDS 22:1345-54. 2008..To assess temporal trends in the rates of hospitalizations and associated diagnoses among HIV-infected patients before and during the era of highly active antiretroviral therapy...
- Incidence of types of cancer among HIV-infected persons compared with the general population in the United States, 1992-2003Pragna Patel
Centers for Disease Control and Prevention, Emory University, and Northrop Grumman Information Technology, Atlanta, Georgia 30333, USA
Ann Intern Med 148:728-36. 2008..Persons who are HIV-infected may be at higher risk for certain types of cancer than the general population...