Richard M Novak

Summary

Affiliation: University of Illinois at Chicago
Country: USA

Publications

  1. pmc Risk behavior among women enrolled in a randomized controlled efficacy trial of an adenoviral vector vaccine to prevent HIV acquisition
    Richard M Novak
    Section of Infectious Diseases, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois 60162, USA
    AIDS 27:1763-70. 2013
  2. doi request reprint Immune reconstitution inflammatory syndrome: incidence and implications for mortality
    Richard M Novak
    University of Illinois, Chicago, 60612, USA
    AIDS 26:721-30. 2012
  3. pmc Cervicovaginal levels of lactoferrin, secretory leukocyte protease inhibitor, and RANTES and the effects of coexisting vaginoses in human immunodeficiency virus (HIV)-seronegative women with a high risk of heterosexual acquisition of HIV infection
    Richard M Novak
    University of Illinois at Chicago, 808 S Wood St, M C 735, Rm 888, Chicago, IL 60612, USA
    Clin Vaccine Immunol 14:1102-7. 2007
  4. ncbi request reprint Prevalence of antiretroviral drug resistance mutations in chronically HIV-infected, treatment-naive patients: implications for routine resistance screening before initiation of antiretroviral therapy
    Richard M Novak
    University of Illinois, Chicago, IL 60612, USA
    Clin Infect Dis 40:468-74. 2005
  5. ncbi request reprint Mucosal HIV-binding antibody and neutralizing activity in high-risk HIV-uninfected female participants in a trial of HIV-vaccine efficacy
    John A Schneider
    Department of Medicine, Tufts New England Medical Center, Boston, MA, USA
    J Infect Dis 196:1637-44. 2007
  6. doi request reprint Increased mortality among publicly insured participants in the HIV Outpatient Study despite HAART treatment
    Frank J Palella
    Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    AIDS 25:1865-76. 2011
  7. ncbi request reprint The association of HIV susceptibility testing with survival among HIV-infected patients receiving antiretroviral therapy: a cohort study
    Frank J Palella
    Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Ann Intern Med 151:73-84. 2009
  8. ncbi request reprint Human cervicovaginal lavage fluid contains an inhibitor of HIV binding to dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin
    Meghan A Jendrysik
    Section of Infectious Diseases, Department of Medicine, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA
    J Infect Dis 192:630-9. 2005
  9. doi request reprint Initiation of HAART at higher CD4 cell counts is associated with a lower frequency of antiretroviral drug resistance mutations at virologic failure
    Jonathan Uy
    University of Illinois, Chicago, IL, USA
    J Acquir Immune Defic Syndr 51:450-3. 2009
  10. ncbi request reprint Induction of tumor necrosis factor- alpha secretion and toll-like receptor 2 and 4 mRNA expression by genital mucosal fluids from women with bacterial vaginosis
    M Reza Zariffard
    Department of Immunology and Microbiology, Rush University, Chicago, Illinois 60612, USA
    J Infect Dis 191:1913-21. 2005

Research Grants

Detail Information

Publications29

  1. pmc Risk behavior among women enrolled in a randomized controlled efficacy trial of an adenoviral vector vaccine to prevent HIV acquisition
    Richard M Novak
    Section of Infectious Diseases, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois 60162, USA
    AIDS 27:1763-70. 2013
    ..Report of risk behavior, HIV incidence, and pregnancy rates among women participating in the STEP study, which is a phase IIB trial of MRKAd5 HIV-1 gag/pol/nef vaccine in HIV-negative individuals who were at high risk of HIV-1...
  2. doi request reprint Immune reconstitution inflammatory syndrome: incidence and implications for mortality
    Richard M Novak
    University of Illinois, Chicago, 60612, USA
    AIDS 26:721-30. 2012
    ..To describe incidence of immune reconstitution inflammatory syndrome (IRIS) and its association with mortality in a large multisite US HIV-infected cohort applying an objective, comprehensive definition...
  3. pmc Cervicovaginal levels of lactoferrin, secretory leukocyte protease inhibitor, and RANTES and the effects of coexisting vaginoses in human immunodeficiency virus (HIV)-seronegative women with a high risk of heterosexual acquisition of HIV infection
    Richard M Novak
    University of Illinois at Chicago, 808 S Wood St, M C 735, Rm 888, Chicago, IL 60612, USA
    Clin Vaccine Immunol 14:1102-7. 2007
    ..However, the increased RANTES levels in a higher-risk subset of high-risk women were reduced after BV treatment...
  4. ncbi request reprint Prevalence of antiretroviral drug resistance mutations in chronically HIV-infected, treatment-naive patients: implications for routine resistance screening before initiation of antiretroviral therapy
    Richard M Novak
    University of Illinois, Chicago, IL 60612, USA
    Clin Infect Dis 40:468-74. 2005
    ..However, it is unclear to what extent these mutations persist in chronically infected, treatment-naive patients...
  5. ncbi request reprint Mucosal HIV-binding antibody and neutralizing activity in high-risk HIV-uninfected female participants in a trial of HIV-vaccine efficacy
    John A Schneider
    Department of Medicine, Tufts New England Medical Center, Boston, MA, USA
    J Infect Dis 196:1637-44. 2007
    ..This study investigated gp120-binding antibody and neutralizing activity, at the gingival- and cervical-mucosal levels, in response to a bivalent gp120 candidate vaccine...
  6. doi request reprint Increased mortality among publicly insured participants in the HIV Outpatient Study despite HAART treatment
    Frank J Palella
    Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    AIDS 25:1865-76. 2011
    ..Understanding mortality differences among HIV-infected patients can focus efforts to improve survival...
  7. ncbi request reprint The association of HIV susceptibility testing with survival among HIV-infected patients receiving antiretroviral therapy: a cohort study
    Frank J Palella
    Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Ann Intern Med 151:73-84. 2009
    ..HIV-1 genotypic and phenotypic susceptibility testing (GPT) optimizes antiretroviral selection, but its effect on survival is unknown...
  8. ncbi request reprint Human cervicovaginal lavage fluid contains an inhibitor of HIV binding to dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin
    Meghan A Jendrysik
    Section of Infectious Diseases, Department of Medicine, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA
    J Infect Dis 192:630-9. 2005
    ..Mechanistic experiments indicate that the inhibitor acts via binding to DC-SIGN. Further study of such inhibitors may help to elucidate the role played by DC-SIGN in HIV transmission...
  9. doi request reprint Initiation of HAART at higher CD4 cell counts is associated with a lower frequency of antiretroviral drug resistance mutations at virologic failure
    Jonathan Uy
    University of Illinois, Chicago, IL, USA
    J Acquir Immune Defic Syndr 51:450-3. 2009
    ..There are limited data on the risk of developing HIV drug resistance based on the CD4 cell count at which highly active antiretroviral therapy (HAART) is initiated...
  10. ncbi request reprint Induction of tumor necrosis factor- alpha secretion and toll-like receptor 2 and 4 mRNA expression by genital mucosal fluids from women with bacterial vaginosis
    M Reza Zariffard
    Department of Immunology and Microbiology, Rush University, Chicago, Illinois 60612, USA
    J Infect Dis 191:1913-21. 2005
    ..Bacterial vaginosis (BV) is associated with complications of pregnancy and increased susceptibility to human immunodeficiency virus (HIV) sexual transmission...
  11. pmc TLR2-mediated cell stimulation in bacterial vaginosis
    Debra Mares
    Department of Immunology Microbiology, Rush University Medical Center, Chicago, IL 60612, USA
    J Reprod Immunol 77:91-9. 2008
    ..Thus, these studies show that soluble factor(s) present in the lower genital tract of women with BV activate cells via TLR2, identifying a pathway through which BV may mediate adverse effects...
  12. doi request reprint Safety and immunogenicity of a replication-incompetent adenovirus type 5 HIV-1 clade B gag/pol/nef vaccine in healthy adults
    Frances H Priddy
    Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    Clin Infect Dis 46:1769-81. 2008
    ....
  13. pmc Restoration of the antiviral activity of 3'-azido-3'-deoxythymidine (AZT) against AZT-resistant human immunodeficiency virus by delivery of engineered thymidylate kinase to T cells
    Arnon Lavie
    Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL 60612, USA
    J Gen Virol 89:1672-9. 2008
    ..These results provide an experimental basis for the development of new strategies to therapeutically increase the intracellular concentrations of active nucleoside analogue metabolites as a means to overcome emerging drug resistance...
  14. pmc Policosanol for managing human immunodeficiency virus-related dyslipidemia in a medically underserved population: a randomized, controlled clinical trial
    Barbara Swanson
    Rush University College of Nursing, Chicago, Illinois, USA
    Altern Ther Health Med 17:30-5. 2011
    ..Policosanol is a dietary supplement derived from sugar cane that is widely used as a statin alternative in Latin America...
  15. ncbi request reprint The influence of executive functions, sensation seeking, and HIV serostatus on the risky sexual practices of substance-dependent individuals
    Raul Gonzalez
    University of Illinois Chicago, Department of Psychiatry, M C 912, 1601 W Taylor Street, Room 408, Chicago, IL 60612, USA
    J Int Neuropsychol Soc 11:121-31. 2005
    ..Our findings indicate that continued risk behavior among HIV+ drug users may be driven by sensation seeking (a personality trait common among drug users); however, the impact of executive functions is less clear...
  16. pmc IL-22 levels are associated with Trichomonas vaginalis infection in the lower genital tract
    Hadijat Moradeke Makinde
    Department of Immunology Microbiology, Rush University Medical Center, Chicago, IL 60612, USA
    Am J Reprod Immunol 70:38-44. 2013
    ..IL-22 has important functions at mucosal surfaces, including the induction of antimicrobial peptides and maintenance of epithelium. However, IL-22 has not been investigated in the genital tract during TV infection...
  17. ncbi request reprint Trichomonas vaginalis infection activates cells through toll-like receptor 4
    M Reza Zariffard
    Department of Immunology Microbiology, Rush University, Chicago, IL 60612, USA
    Clin Immunol 111:103-7. 2004
    ..These studies show that T. vaginalis infection results in the appearance in the genital tract of substance(s) that stimulate cells through TLR4, suggesting a mechanism for the inflammation caused by this infection...
  18. ncbi request reprint Viable Mycobacterium avium is required for the majority of human immunodeficiency virus-induced upregulation in monocytoid cells
    Mahmood Ghassemi
    Department of Medicine, University of Illinois, 808 S Wood St, Chicago, IL 60612, USA
    J Med Microbiol 52:877-82. 2003
    ....
  19. ncbi request reprint Interferon-gamma receptors in HIV-1 infection
    Janak Koirala
    Division of Infectious Diseases, Southern Illinois University, School of Medicine, Springfield, Illinois 62794 9636, USA
    AIDS Res Hum Retroviruses 24:1097-102. 2008
    ..This dysfunction in the interferon-gamma pathway contributes to a further impairment in cellular immune function in patients with advanced HIV-1 infection, which may further increase susceptibility to opportunistic infections...
  20. ncbi request reprint Reviews of anti-infective agents: maraviroc: the first of a new class of antiretroviral agents
    Rodger D MacArthur
    Wayne State University, Detroit, Michigan, USA
    Clin Infect Dis 47:236-41. 2008
    ..HIV-1 mechanisms of resistance to maraviroc, assays to determine viral coreceptor use (tropism), drug safety, and clinical use of maraviroc are discussed at length...
  21. ncbi request reprint Prevalence and impact of HIV-1 protease codon 33 mutations and polymorphisms in treatment-naive and treatment-experienced patients
    Michael J Kozal
    Yale University Et VA CT Healthcare System, New Haven, CT, USA
    Antivir Ther 11:457-63. 2006
    ..Little is known about the difference in prevalence of codon 33 mutations and polymorphisms between treatment-naive and treatment-experienced patients, and the effect of codon 33F on PI phenotypic resistance patterns...
  22. ncbi request reprint Mucosal innate immune factors in secretions from high-risk individuals immunized with a bivalent gp120 vaccine
    James E Cummins
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    AIDS Res Hum Retroviruses 23:748-54. 2007
    ..Because of the importance of innate immunity in host defense, evaluation of the mucosal innate immune system should be included in future HIV prevention trials...
  23. ncbi request reprint The Incidence of HIV drug resistance and its impact on progression of HIV disease among antiretroviral-naïve participants started on three different antiretroviral therapy strategies
    Michael J Kozal
    Yale University School of Medicine and VA CT Healthcare System, New Haven, Connecticut 06510, USA
    HIV Clin Trials 8:357-70. 2007
    ..The strategies were compared for drug resistance at first virologic failure (VF; HIV RNA >1000 copies/mL). The impact of resistance on AIDS or death was determined...
  24. ncbi request reprint HIV sexual risk behavior over 36 months of follow-up in the world's first HIV vaccine efficacy trial
    Bradford N Bartholow
    Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Acquir Immune Defic Syndr 39:90-101. 2005
    ....
  25. ncbi request reprint Sex-related differences in the pharmacokinetics of once-daily saquinavir soft-gelatin capsules boosted with low-dose ritonavir in patients infected with human immunodeficiency virus type 1
    Manjunath P Pai
    University of New Mexico Health Sciences Center, Albuquerque, USA
    Pharmacotherapy 24:592-9. 2004
    ....
  26. ncbi request reprint A comparison of three highly active antiretroviral treatment strategies consisting of non-nucleoside reverse transcriptase inhibitors, protease inhibitors, or both in the presence of nucleoside reverse transcriptase inhibitors as initial therapy (CPCRA 05
    Rodger D MacArthur
    Wayne State University, Detroit, MI, USA
    Lancet 368:2125-35. 2006
    ..Here, we report results from the FIRST trial, which compared initial treatment strategies for clinical, immunological, and virological outcomes...
  27. ncbi request reprint Stroop performance in drug users classified by HIV and hepatitis C virus serostatus
    Eileen M Martin
    J Int Neuropsychol Soc 10:298-300. 2004
  28. doi request reprint Rates of hospitalizations and associated diagnoses in a large multisite cohort of HIV patients in the United States, 1994-2005
    Kate Buchacz
    Division of HIV AIDS Prevention, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    AIDS 22:1345-54. 2008
    ..To assess temporal trends in the rates of hospitalizations and associated diagnoses among HIV-infected patients before and during the era of highly active antiretroviral therapy...
  29. ncbi request reprint Incidence of types of cancer among HIV-infected persons compared with the general population in the United States, 1992-2003
    Pragna Patel
    Centers for Disease Control and Prevention, Emory University, and Northrop Grumman Information Technology, Atlanta, Georgia 30333, USA
    Ann Intern Med 148:728-36. 2008
    ..Persons who are HIV-infected may be at higher risk for certain types of cancer than the general population...

Research Grants2

  1. Targeting High-Risk Women for HVTN and Microbicide Trials
    Richard Novak; Fiscal Year: 2007
    ..The Principal Investigator has his own laboratory with hoods and storage facilities that are used for PBMC processing. ADMINISTRATIVE COMPONENT: ..