JAN contact NOVAK

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. ncbi request reprint IgA1-containing immune complexes in IgA nephropathy differentially affect proliferation of mesangial cells
    Jan Novak
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Kidney Int 67:504-13. 2005
  2. doi request reprint Glycosylation of IgA1 and pathogenesis of IgA nephropathy
    Jan Novak
    University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Semin Immunopathol 34:365-82. 2012
  3. doi request reprint Cytokines alter IgA1 O-glycosylation by dysregulating C1GalT1 and ST6GalNAc-II enzymes
    Hitoshi Suzuki
    From the University of Alabama at Birmingham, Birmingham, Alabama 35294
    J Biol Chem 289:5330-9. 2014
  4. ncbi request reprint IgA nephropathy and Henoch-Schoenlein purpura nephritis: aberrant glycosylation of IgA1, formation of IgA1-containing immune complexes, and activation of mesangial cells
    Jan Novak
    University of Alabama at Birmingham, Department of Microbiology, Birmingham, AL 35294, USA
    Contrib Nephrol 157:134-8. 2007
  5. pmc IgA glycosylation and IgA immune complexes in the pathogenesis of IgA nephropathy
    Jan Novak
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Semin Nephrol 28:78-87. 2008
  6. ncbi request reprint Heterogeneity of IgG glycosylation in adult periodontal disease
    J Novak
    Department of Microbiology, University of Alabama at Birmingham, 845 19th Street South, Birmingham, AL 35294 2170, USA
    J Dent Res 84:897-901. 2005
  7. pmc IgA1 immune complexes from pediatric patients with IgA nephropathy activate cultured human mesangial cells
    Jan Novak
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA
    Nephrol Dial Transplant 26:3451-7. 2011
  8. doi request reprint Aberrant glycosylation of IgA1 and anti-glycan antibodies in IgA nephropathy: role of mucosal immune system
    Jan Novak
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Adv Otorhinolaryngol 72:60-3. 2011
  9. ncbi request reprint IgA-containing immune complexes in the urine of IgA nephropathy patients
    Karel Matousovic
    Department of Microbiology, University of Alabama at Birmingham, 845 19th Street South, Birmingham, AL 35294 2170, USA
    Nephrol Dial Transplant 21:2478-84. 2006
  10. pmc Aberrantly glycosylated IgA1 in IgA nephropathy patients is recognized by IgG antibodies with restricted heterogeneity
    Hitoshi Suzuki
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Clin Invest 119:1668-77. 2009

Detail Information

Publications28

  1. ncbi request reprint IgA1-containing immune complexes in IgA nephropathy differentially affect proliferation of mesangial cells
    Jan Novak
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Kidney Int 67:504-13. 2005
    ..Sera of patients with IgA nephropathy (IgAN) contain circulating immune complexes (CIC) composed of galactose-deficient IgA1 complexed with antiglycan antibodies. The role of these CIC in the pathogenesis of IgAN is not known...
  2. doi request reprint Glycosylation of IgA1 and pathogenesis of IgA nephropathy
    Jan Novak
    University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Semin Immunopathol 34:365-82. 2012
    ..Studies of molecular defects of IgA1 can define new biomarkers specific for IgA nephropathy that can be developed into clinical assays to aid in the diagnosis, assessment of prognosis, and monitoring of disease progression...
  3. doi request reprint Cytokines alter IgA1 O-glycosylation by dysregulating C1GalT1 and ST6GalNAc-II enzymes
    Hitoshi Suzuki
    From the University of Alabama at Birmingham, Birmingham, Alabama 35294
    J Biol Chem 289:5330-9. 2014
    ..These data provide a mechanism explaining increased immune-complex formation and disease exacerbation during mucosal infections in IgAN patients. ..
  4. ncbi request reprint IgA nephropathy and Henoch-Schoenlein purpura nephritis: aberrant glycosylation of IgA1, formation of IgA1-containing immune complexes, and activation of mesangial cells
    Jan Novak
    University of Alabama at Birmingham, Department of Microbiology, Birmingham, AL 35294, USA
    Contrib Nephrol 157:134-8. 2007
    ..In summary, we identified the neoepitopes on IgA1 responsible for formation of the pathogenic immune complexes. These studies may lead to development of noninvasive diagnostic assays and future disease-specific therapy...
  5. pmc IgA glycosylation and IgA immune complexes in the pathogenesis of IgA nephropathy
    Jan Novak
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Semin Nephrol 28:78-87. 2008
    ..By using sophisticated analytic methods, it may be possible to define biomarkers for diagnostic purposes and identify new therapeutic targets for a future disease-specific therapy...
  6. ncbi request reprint Heterogeneity of IgG glycosylation in adult periodontal disease
    J Novak
    Department of Microbiology, University of Alabama at Birmingham, 845 19th Street South, Birmingham, AL 35294 2170, USA
    J Dent Res 84:897-901. 2005
    ..Analysis of our data suggests that IgG secreted by B-cells was aberrantly glycosylated, which resulted in the production of pro-inflammatory galactose-deficient IgG...
  7. pmc IgA1 immune complexes from pediatric patients with IgA nephropathy activate cultured human mesangial cells
    Jan Novak
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA
    Nephrol Dial Transplant 26:3451-7. 2011
    ....
  8. doi request reprint Aberrant glycosylation of IgA1 and anti-glycan antibodies in IgA nephropathy: role of mucosal immune system
    Jan Novak
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Adv Otorhinolaryngol 72:60-3. 2011
    ..The aberrant glycosylation of IgA1 may reflect abnormal mucosal immune responses to infections of the upper respiratory tract in genetically predisposed individuals...
  9. ncbi request reprint IgA-containing immune complexes in the urine of IgA nephropathy patients
    Karel Matousovic
    Department of Microbiology, University of Alabama at Birmingham, 845 19th Street South, Birmingham, AL 35294 2170, USA
    Nephrol Dial Transplant 21:2478-84. 2006
    ..Due to damaged sieving properties of the glomerular capillary wall in IgAN, these immune complexes may appear in the urine...
  10. pmc Aberrantly glycosylated IgA1 in IgA nephropathy patients is recognized by IgG antibodies with restricted heterogeneity
    Hitoshi Suzuki
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Clin Invest 119:1668-77. 2009
    ..Collectively, these findings indicate that glycan-specific antibodies are associated with the development of IgAN and may represent a disease-specific marker and potential therapeutic target...
  11. pmc Delivery of DNA HIV-1 vaccine to the liver induces high and long-lasting humoral immune responses
    Milan Raska
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294 2170, USA
    Vaccine 26:1541-51. 2008
    ..7% of CD8(+) splenocytes after in vitro stimulation with HIV-1 envelope peptides. These results demonstrate that DNA vaccines targeted to tissues with high proteosynthetic activity, such as the liver, results in enhanced immune responses...
  12. pmc Antibody-mediated protection and the mucosal immune system of the genital tract: relevance to vaccine design
    Jiri Mestecky
    Department of Microbiology, University of Alabama at Birmingham, AL 35294 2170, USA
    J Reprod Immunol 85:81-5. 2010
    ..The approaches have been explored to a limited extent in humans...
  13. doi request reprint Involvement of envelope-glycoprotein glycans in HIV-1 biology and infection
    Milan Raska
    Department of Immunology, Palacky University in Olomouc, Hnevotinska 3, 772 00 Olomouc, Czech Republic
    Arch Immunol Ther Exp (Warsz) 58:191-208. 2010
    ....
  14. pmc Glycosylation patterns of HIV-1 gp120 depend on the type of expressing cells and affect antibody recognition
    Milan Raska
    Department of Immunology, Palacky University in Olomouc, Olomouc 77100, Czech Republic
    J Biol Chem 285:20860-9. 2010
    ..These results indicate that gp120 glycans contribute to antibody reactivity and should be considered in HIV-1 vaccine design...
  15. ncbi request reprint Electrophoretic methods for analysis of urinary polypeptides in IgA-associated renal diseases
    Bruce A Julian
    Division of Nephrology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Electrophoresis 28:4469-83. 2007
    ....
  16. ncbi request reprint IgA nephropathy: a clinical overview
    Bruce A Julian
    University of Alabama at Birmingham, Department of Medicine, Birmingham, AL 35294, USA
    Contrib Nephrol 157:19-26. 2007
    ..These or other related findings may provide the necessary tools to better classify phenotypes in multiplex pedigrees and to improve monitoring of disease progression or response to therapy...
  17. ncbi request reprint Increased levels of galactose-deficient IgG in sera of HIV-1-infected individuals
    Jennifer S Moore
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    AIDS 19:381-9. 2005
    ..However, this phenomenon has not been investigated at length in human viral infections...
  18. pmc Reactivities of N-acetylgalactosamine-specific lectins with human IgA1 proteins
    Jennifer S Moore
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA
    Mol Immunol 44:2598-604. 2007
    ..Because of the heterogeneity of GalNAc-specific lectins, they should be carefully characterized with appropriate substrates before undertaking any study...
  19. pmc Identification and characterization of CMP-NeuAc:GalNAc-IgA1 alpha2,6-sialyltransferase in IgA1-producing cells
    Milan Raska
    University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Mol Biol 369:69-78. 2007
    ..These data are the first evidence that human cells that lack ST6-GalNAcI can sialylate core 1 GalNAc-Ser/Thr...
  20. ncbi request reprint Interactions of human mesangial cells with IgA and IgA-containing immune complexes
    Jan Novak
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Kidney Int 62:465-75. 2002
    ..The circulating immune complexes (CIC) are composed of galactose- (Gal) deficient IgA1 and IgG or IgA1 antibodies specific for the Gal-deficient IgA1; interactions of these CIC with mesangial cells (MC) were studied...
  21. ncbi request reprint IgA nephropathy: current views of immune complex formation
    Jiri Mestecky
    University of Alabama at Birmingham, Department of Microbiology, Birmingham, AL 35294 2170, USA
    Contrib Nephrol 157:56-63. 2007
    ..Because of the molecular defect in IgA1 glycosylation and its subsequent recognition by naturally-occurring antibodies, experimental approaches that diminish or prevent formation of large immunostimulatory IC should be further explored...
  22. ncbi request reprint IgA nephropathy: characterization of IgG antibodies specific for galactose-deficient IgA1
    Hitoshi Suzuki
    University of Alabama at Birmingham, Department of Microbiology, Birmingham, AL 35294 2170, USA
    Contrib Nephrol 157:129-33. 2007
    ..The immortalized cell lines will provide a stable and convenient source of IgG for molecular studies of antibodies specific to the aberrant O-glycans in IgA1...
  23. ncbi request reprint Urinary biomarkers of IgA nephropathy and other IgA-associated renal diseases
    Bruce A Julian
    Department of Medicine, University of Alabama at Birmingham, 1530 Third Avenue South, Birmingham, AL 35294, USA
    World J Urol 25:467-76. 2007
    ....
  24. ncbi request reprint Analysis of O-glycan heterogeneity in IgA1 myeloma proteins by Fourier transform ion cyclotron resonance mass spectrometry: implications for IgA nephropathy
    Matthew B Renfrow
    UAB Biomedical FT ICR MS Laboratory, Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, MCLM 570 1530 3rd AVE S, Birmingham, AL 35294 0005, USA
    Anal Bioanal Chem 389:1397-407. 2007
    ..These results suggest that future analysis of IgA1 HR from IgAN patients and normal healthy controls should be feasible...
  25. ncbi request reprint IgA nephropathy: an update
    Bruce A Julian
    Department of aMedicine, Division of Nephrology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Curr Opin Nephrol Hypertens 13:171-9. 2004
    ..In the absence of a disease-specific therapy, we discuss current therapeutic approaches...
  26. pmc IgA1-secreting cell lines from patients with IgA nephropathy produce aberrantly glycosylated IgA1
    Hitoshi Suzuki
    University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Clin Invest 118:629-39. 2008
    ..Thus, our data suggest that premature sialylation likely contributes to the aberrant IgA1 glycosylation in IgA nephropathy and may represent a new therapeutic target...
  27. ncbi request reprint The Fap1 fimbrial adhesin is a glycoprotein: antibodies specific for the glycan moiety block the adhesion of Streptococcus parasanguis in an in vitro tooth model
    Aimee E Stephenson
    Department of Microbiology, University of Vermont, Burlington, VT, USA
    Mol Microbiol 43:147-57. 2002
    ..These data suggest that the 'blocking' antibodies are specific for the glycan moiety and that the adhesion of S. parasanguis is mediated by sugar residues associated with Fap1...
  28. ncbi request reprint Isolation of flagellated bacteria implicated in Crohn's disease
    L Wayne Duck
    Division of Gastroenterology and Hepatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 0007, USA
    Inflamm Bowel Dis 13:1191-201. 2007
    ..The present study was done to identify the microbial source of such flagellins...

Research Grants8

  1. Elucidating IgA Nephropathy through Genetic Studies of IgA1 Glycosylation
    Jan Novak; Fiscal Year: 2009
    ....
  2. Molecular Basis of Pathogenicity of 1gA1 - containing Immune Complexes
    Jan Novak; Fiscal Year: 2009
    ..This would represent a major advance in the quality of care for IgAN patients. ..
  3. Molecular Basis of Pathogenicity of 1gA1 - containing Immune Complexes
    Jan Novak; Fiscal Year: 2009
    ..This would represent a major advance in the quality of care for IgAN patients. ..
  4. Elucidating IgA Nephropathy through Genetic Studies of IgA1 Glycosylation
    JAN contact NOVAK; Fiscal Year: 2010
    ....
  5. Molecular Basis of Pathogenicity of 1gA1 - containing Immune Complexes
    Jan Novak; Fiscal Year: 2010
    ..This would represent a major advance in the quality of care for IgAN patients. ..