W B Nothnick

Summary

Affiliation: University of Kansas Medical Center
Country: USA

Publications

  1. ncbi Serum miR-451a Levels Are Significantly Elevated in Women With Endometriosis and Recapitulated in Baboons (Papio anubis) With Experimentally-Induced Disease
    Warren B Nothnick
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, USA
    Reprod Sci . 2016
  2. pmc Non-coding RNAs in Uterine Development, Function and Disease
    Warren B Nothnick
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, USA
    Adv Exp Med Biol 886:171-89. 2016
  3. pmc Circulating Micro-RNAs as Diagnostic Biomarkers for Endometriosis: Privation and Promise
    Warren B Nothnick
    Department of Molecular and Integrative Physiology, Center for Reproductive Sciences, Institute of Reproductive Health and Regenerative Medicine, University of Kansas Medical Center, Kansas City, Kansas Electronic address
    J Minim Invasive Gynecol 22:719-26. 2015
  4. doi The role of micro-RNAs in the female reproductive tract
    Warren B Nothnick
    Departments of Obstetrics and Gynecology and Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Reproduction 143:559-76. 2012
  5. ncbi Novel targets for the treatment of endometriosis
    Warren B Nothnick
    University of Kansas, School of Medicine, Department of Obstetrics and Gynecology, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Expert Opin Ther Targets 8:459-71. 2004
  6. pmc The emerging use of aromatase inhibitors for endometriosis treatment
    Warren B Nothnick
    Department of Obstetrics and Gynecology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Reprod Biol Endocrinol 9:87. 2011
  7. pmc Steroidal regulation of uterine miRNAs is associated with modulation of the miRNA biogenesis components Exportin-5 and Dicer1
    Warren B Nothnick
    Department of Obstetrics and Gynecology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Endocrine 37:265-73. 2010
  8. pmc Estrogen induces distinct patterns of microRNA expression within the mouse uterus
    Warren B Nothnick
    Department of Obstetrics and Gynecology, University of Kansas Medical Center, Kansas City, KS, USA
    Reprod Sci 17:987-94. 2010
  9. ncbi Endometriosis: in search of optimal treatment
    W B Nothnick
    Departments of Obstetrics and Gynecology and Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, USA
    Minerva Ginecol 62:17-31. 2010
  10. ncbi Future targets in endometriosis treatment: targeting the endometriotic implant
    Warren B Nothnick
    Department of Obstetrics and Gynecology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, Kansas 66160, USA
    Mini Rev Med Chem 9:324-8. 2009

Research Grants

Detail Information

Publications31

  1. ncbi Serum miR-451a Levels Are Significantly Elevated in Women With Endometriosis and Recapitulated in Baboons (Papio anubis) With Experimentally-Induced Disease
    Warren B Nothnick
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, USA
    Reprod Sci . 2016
    ..MicroRNA-451a may serve as a serum diagnostic marker for endometriosis...
  2. pmc Non-coding RNAs in Uterine Development, Function and Disease
    Warren B Nothnick
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, USA
    Adv Exp Med Biol 886:171-89. 2016
    ....
  3. pmc Circulating Micro-RNAs as Diagnostic Biomarkers for Endometriosis: Privation and Promise
    Warren B Nothnick
    Department of Molecular and Integrative Physiology, Center for Reproductive Sciences, Institute of Reproductive Health and Regenerative Medicine, University of Kansas Medical Center, Kansas City, Kansas Electronic address
    J Minim Invasive Gynecol 22:719-26. 2015
    ....
  4. doi The role of micro-RNAs in the female reproductive tract
    Warren B Nothnick
    Departments of Obstetrics and Gynecology and Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Reproduction 143:559-76. 2012
    ..When possible, information is presented and discussed with respect to regulation, function, and/or functional targets of these miRNA within each specific organ of the female reproductive tract...
  5. ncbi Novel targets for the treatment of endometriosis
    Warren B Nothnick
    University of Kansas, School of Medicine, Department of Obstetrics and Gynecology, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Expert Opin Ther Targets 8:459-71. 2004
    ..Emphasis is placed upon the emerging research using TNF inhibitors, their potential benefits over current treatment regimens and the development of future potential therapeutic targets...
  6. pmc The emerging use of aromatase inhibitors for endometriosis treatment
    Warren B Nothnick
    Department of Obstetrics and Gynecology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Reprod Biol Endocrinol 9:87. 2011
    ....
  7. pmc Steroidal regulation of uterine miRNAs is associated with modulation of the miRNA biogenesis components Exportin-5 and Dicer1
    Warren B Nothnick
    Department of Obstetrics and Gynecology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Endocrine 37:265-73. 2010
    ....
  8. pmc Estrogen induces distinct patterns of microRNA expression within the mouse uterus
    Warren B Nothnick
    Department of Obstetrics and Gynecology, University of Kansas Medical Center, Kansas City, KS, USA
    Reprod Sci 17:987-94. 2010
    ..This study demonstrates that estrogen regulates specific miRNAs within the murine uterus, which may participate in posttranscriptional regulation of estrogen-regulated genes...
  9. ncbi Endometriosis: in search of optimal treatment
    W B Nothnick
    Departments of Obstetrics and Gynecology and Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, USA
    Minerva Ginecol 62:17-31. 2010
    ..Potential target areas which may be attractive alternatives to current therapies are also reviewed and include aromatase inhibitors, angiogenesis disruptors and anti-tumor necrosis factor-alpha inhibitors...
  10. ncbi Future targets in endometriosis treatment: targeting the endometriotic implant
    Warren B Nothnick
    Department of Obstetrics and Gynecology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, Kansas 66160, USA
    Mini Rev Med Chem 9:324-8. 2009
    ..In this review, current therapies which target the biochemistry of the implant are discussed with emphasis on aromatase inhibitors, anti-angiogenic compounds and vascular-disrupting agents...
  11. pmc Regulation of uterine matrix metalloproteinase-9 and the role of microRNAs
    Warren B Nothnick
    Departments of Obstetrics and Gynecology and Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Semin Reprod Med 26:494-9. 2008
    ....
  12. ncbi Steroidal regulation of uterine edema and tissue inhibitors of metalloproteinase (TIMP)-3 messenger RNA expression is altered in TIMP-1-deficient mice
    Warren B Nothnick
    Departments of Obstetrics and Gynecology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Biol Reprod 70:500-8. 2004
    ..These observations suggest that steroids induce uterine TIMP-1 expression and, in turn, that TIMP-1 influences TIMP-3 mRNA expression and uterine edema...
  13. ncbi Medical management of endometriosis: novel targets and approaches towards the development of future treatment regimes
    Warren B Nothnick
    Department of Obstetrics and Gynecology, University of Kansas School of Medicine, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Gynecol Obstet Invest 55:189-98. 2003
    ..Further, we discuss the advantages of such therapies and offer experimental approaches towards the development and testing of these regimes...
  14. ncbi Disruption of the tissue inhibitor of metalloproteinase-1 gene results in altered reproductive cyclicity and uterine morphology in reproductive-age female mice
    W B Nothnick
    University of Kansas Medical Center, Department of Obstetrics and Gynecology and Molecular and Integrative Physiology, Kansas City, Kansas 66160, USA
    Biol Reprod 63:905-12. 2000
    ..It is concluded from this study that TIMP-1 has a multifaceted role in regulating the murine reproductive cycle, and this control appears to be at the level of both the uterus and the ovary...
  15. ncbi Treating endometriosis as an autoimmune disease
    W B Nothnick
    Department of Obstetrics and Gynecology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Fertil Steril 76:223-31. 2001
    ....
  16. ncbi Disruption of the tissue inhibitor of metalloproteinase-1 gene in reproductive-age female mice is associated with estrous cycle stage-specific increases in stromelysin messenger RNA expression and activity
    W B Nothnick
    Department of Obstetrics and Gynecology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Biol Reprod 65:1780-8. 2001
    ..It is concluded from this study that TIMP-1 plays a pivotal role in regulating uterine stromelysins both at the level of protease activity and the level of transcript expression...
  17. ncbi Reduction in reproductive lifespan of tissue inhibitor of metalloproteinase 1 (TIMP-1)-deficient female mice
    W B Nothnick
    Departments of Obstetrics and Gynecology, and Molecular and Integrative Physiology, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    Reproduction 122:923-7. 2001
    ..These data indicate that the absence of TIMP-1 is associated with a reduction in the reproductive lifespan of female mice, which may be manifested at the ovary, uterus or both organs...
  18. ncbi Tissue inhibitor of metalloproteinase-1 (TIMP-1) deficient mice display reduced serum progesterone levels during corpus luteum development
    Warren B Nothnick
    Department of Obstetrics and Gynecology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Endocrinology 144:5-8. 2003
    ..These observations suggests that expression of TIMP-1 during early luteal development may participate in regulation of progesterone production via its ability to regulate ovarian MMP activity...
  19. ncbi Assessment of the role of tissue inhibitor of metalloproteinase-1 (TIMP-1) during the periovulatory period in female mice lacking a functional TIMP-1 gene
    W B Nothnick
    Department of Obstetrics and Gynecology, University of Kentucky, Lexington 40536 0084, USA
    Biol Reprod 56:1181-8. 1997
    ..In addition, TIMP-1 exhibits steroidogenic activity in vitro, but no evidence was found for regulation of steroidogenesis in vivo...
  20. ncbi Divergent effects of interleukin-1 beta on steroidogenesis and matrix metalloproteinase inhibitor expression and activity in cultured rat granulosa cells
    W B Nothnick
    Department of Obstetrics and Gynecology, University of Kentucky, Lexington 40536 0084, USA
    Endocrinology 137:3784-90. 1996
    ..It is concluded from the current study that IL-1 beta is a mediator of MMPI expression as well as granulosa cell steroidogenesis, and that this cytokine has divergent actions in the presence and absence of LH...
  21. ncbi Collagenase, gelatinase, and proteoglycanase messenger ribonucleic acid expression and activity during luteal development, maintenance, and regression in the pseudopregnant rat ovary
    W B Nothnick
    Department of Obstetrics and Gynecology, University of Kentucky, Lexington 40536, USA
    Biol Reprod 54:616-24. 1996
    ....
  22. ncbi Pattern of messenger ribonucleic acid expression of tissue inhibitors of metalloproteinases (TIMPs) during testicular maturation in male mice lacking a functional TIMP-1 gene
    W B Nothnick
    Department of Obstetrics and Gynecology, University of Kansas, Kansas City, Kansas 66160, USA
    Biol Reprod 59:364-70. 1998
    ....
  23. ncbi Disruption of the TIMP-1 gene product is associated with accelerated endometrial gland formation during early postnatal uterine development
    Han E Zhou
    Department of Obstetrics and Gynecology, Division of Basic and Clinical Women s Research, University of Kansas School of Medicine, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    Biol Reprod 71:534-9. 2004
    ..We conclude that, during early postnatal uterine development, TIMP-1 may be critical for proper endometrial gland development...
  24. ncbi The relevancy of the matrix metalloproteinase system to the pathophysiology of endometriosis
    Han E Zhou
    Department of Obstetrics and Gynecology, University of Kansas School of Medicine, Kansas City, USA
    Front Biosci 10:569-75. 2005
    ..This review will present general knowledge of the MMP system relative to the pathophysiology of the endometriosis as well as address its potential value in relation to the treatment of the disease...
  25. ncbi CD44s expression is reduced in endometriotic lesions compared to eutopic endometrium in women with endometriosis
    W B Nothnick
    Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Int J Gynecol Pathol 20:140-6. 2001
    ..This cyclic pattern of CD44s expression was lost in corresponding endometriotic tissue. Reduced expression of CD44s in endometriotic tissue may provide insight into the pathophysiology of endometriosis...
  26. pmc Estrogen-induced uterine abnormalities in TIMP-1 deficient mice are associated with elevated plasmin activity and reduced expression of the novel uterine plasmin protease inhibitor serpinb7
    Xuan Zhang
    Department of Obstetrics and Gynecology, University of Kansas School of Medicine, Kansas City, Kansas 66160, USA
    Mol Reprod Dev 76:160-72. 2009
    ..We conclude from these studies that in addition to controlling MMP activity, TIMP-1 may also control activity of serine proteases through modulation of serine protease inhibitors such as serpinb7...
  27. ncbi Regulation of MMP-9 expression and activity in the mouse uterus by estrogen
    Xuan Zhang
    Department of Obstetrics and Gynecology, University of Kansas School of Medicine, Kansas City, Kansas 66160, USA
    Mol Reprod Dev 74:321-31. 2007
    ..Collectively, these data suggest that E(2) regulates uterine MMP-9 expression and activity in vivo via a complex mechanism. This estrogen regulation of MMP-9 activity may play an important role in uterine tissue remodeling...
  28. ncbi The role and regulation of the uterine matrix metalloproteinase system in menstruating and non-menstruating species
    Xuan Zhang
    Department of Obstetrics and Gynecology, University of Kansas School of Medicine, Kansas City, USA
    Front Biosci 10:353-66. 2005
    ..The current review focuses on the expression and regulation of the MMP system within the uterus during the menstrual or estrous cycle, and addresses the roles of various MMPs and TIMPs in uterine biology...
  29. ncbi Role of direct contact between spermatozoa and oviductal epithelial cells in maintaining rabbit sperm viability
    T T Smith
    Department of Obstetrics and Gynecology, University of Kentucky, Lexington 40536 0084, USA
    Biol Reprod 56:83-9. 1997
    ..Furthermore, this effect appears to be tissue specific and related to reproductive stage...
  30. pmc Dicer1 is essential for female fertility and normal development of the female reproductive system
    Xiaoman Hong
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, Kansas 66160, USA
    Endocrinology 149:6207-12. 2008
    ..These studies implicate Dicer1/miRNA mediated posttranscriptional gene regulation in reproductive somatic tissues as critical for the normal development and function of these tissues and for female fertility...
  31. ncbi Matrix metalloproteinases and their tissue inhibitors in the developing neonatal mouse uterus
    Jianbo Hu
    Center for Animal Biotechnology and Genomics and Department of Animal Science, Texas A and M University, 442 Kleberg Ceneter, College Station, Texas 77843 2471, USA
    Biol Reprod 71:1598-604. 2004
    ..These results support the hypothesis that MMPs and TIMPs regulate postnatal development of the mouse uterus...

Research Grants2

  1. The Role of TIMP-1 in Uterine Physiology
    Warren Nothnick; Fiscal Year: 2005
    ..These studies will broaden our understanding on the role of TIMP-1 in uterine physiology and may help to develop new strategies to treat uterine disorders such as infertility, endometriosis and uterine cancer. ..
  2. Estrogen regulation of uterine microRNAs: Novel factors in MMP-9 regulation
    Warren Nothnick; Fiscal Year: 2008
    ..Enhancing our understanding on the regulation of MMP-9 expression may lead to the establishment of novel approaches to counteract mis-expression of this protease and the diseases associated with it. [unreadable] [unreadable] [unreadable]..