W B Nothnick


Affiliation: University of Kansas Medical Center
Country: USA


  1. Nothnick W. Regulation of uterine matrix metalloproteinase-9 and the role of microRNAs. Semin Reprod Med. 2008;26:494-9 pubmed publisher
  2. Nothnick W. Endometriosis: in search of optimal treatment. Minerva Ginecol. 2010;62:17-31 pubmed
    ..Potential target areas which may be attractive alternatives to current therapies are also reviewed and include aromatase inhibitors, angiogenesis disruptors and anti-tumor necrosis factor-alpha inhibitors. ..
  3. Nothnick W, Al Hendy A, Lue J. Circulating Micro-RNAs as Diagnostic Biomarkers for Endometriosis: Privation and Promise. J Minim Invasive Gynecol. 2015;22:719-26 pubmed publisher
  4. Nothnick W. Non-coding RNAs in Uterine Development, Function and Disease. Adv Exp Med Biol. 2016;886:171-189 pubmed publisher
  5. Nothnick W. Disruption of the tissue inhibitor of metalloproteinase-1 gene results in altered reproductive cyclicity and uterine morphology in reproductive-age female mice. Biol Reprod. 2000;63:905-12 pubmed
    ..It is concluded from this study that TIMP-1 has a multifaceted role in regulating the murine reproductive cycle, and this control appears to be at the level of both the uterus and the ovary. ..
  6. Nothnick W. Tissue inhibitor of metalloproteinase-1 (TIMP-1) deficient mice display reduced serum progesterone levels during corpus luteum development. Endocrinology. 2003;144:5-8 pubmed
    ..These observations suggests that expression of TIMP-1 during early luteal development may participate in regulation of progesterone production via its ability to regulate ovarian MMP activity. ..
  7. Nothnick W, Zhang X, Zhou H. Steroidal regulation of uterine edema and tissue inhibitors of metalloproteinase (TIMP)-3 messenger RNA expression is altered in TIMP-1-deficient mice. Biol Reprod. 2004;70:500-8 pubmed
    ..These observations suggest that steroids induce uterine TIMP-1 expression and, in turn, that TIMP-1 influences TIMP-3 mRNA expression and uterine edema. ..
  8. Nothnick W, Healy C, Hong X. Steroidal regulation of uterine miRNAs is associated with modulation of the miRNA biogenesis components Exportin-5 and Dicer1. Endocrine. 2010;37:265-73 pubmed publisher
  9. Graham A, Falcone T, Nothnick W. The expression of microRNA-451 in human endometriotic lesions is inversely related to that of macrophage migration inhibitory factor (MIF) and regulates MIF expression and modulation of epithelial cell survival. Hum Reprod. 2015;30:642-52 pubmed publisher
    ..This study was funded by the National Institutes of Health/NICHD by grant NIH HD069043 to W.B.N. The authors have no competing interests. ..