Jeffrey A Norton

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Possible primary lymph node gastrinoma: occurrence, natural history, and predictive factors: a prospective study
    Jeffrey A Norton
    Department of Surgery, University of California San Francisco, 533 Parnassus Avenue, U 371, Box 0790, San Francisco, CA 94143, USA
    Ann Surg 237:650-7; discussion 657-9. 2003
  2. ncbi Morbidity and mortality of aggressive resection in patients with advanced neuroendocrine tumors
    Jeffrey A Norton
    Department of Surgery, University of California, San Francisco, CA 94143, USA
    Arch Surg 138:859-66. 2003
  3. ncbi Hepatic artery embolization for treatment of patients with metastatic carcinoid tumors: a commentary
    Jeffrey A Norton
    Department of Surgery, University of California San Francisco, San Francisco, California 94143, USA
    Cancer J 9:241-3. 2003
  4. doi Pancreatic neuroendocrine tumors: radiographic calcifications correlate with grade and metastasis
    George A Poultsides
    Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA
    Ann Surg Oncol 19:2295-303. 2012
  5. ncbi Surgery for gastrinoma and insulinoma in multiple endocrine neoplasia type 1
    Jeffrey A Norton
    Department of Surgery, Stanford University Medical Center, Room H 3591, 300 Pasteur Drive, Stanford, CA 94305 5641, USA
    J Natl Compr Canc Netw 4:148-53. 2006
  6. pmc Does the use of routine duodenotomy (DUODX) affect rate of cure, development of liver metastases, or survival in patients with Zollinger-Ellison syndrome?
    Jeffrey A Norton
    Surgical Oncology, Department of Surgery, Stanford University Medical Center, Room H 3591, 300 Pasteur Drive, Stanford, CA 94305 5641, USA
    Ann Surg 239:617-25; discussion 626. 2004
  7. ncbi Surgical treatment and prognosis of gastrinoma
    Jeffrey A Norton
    Department of Surgery, Stanford University Medical Center, Room H3591, 300 Pasteur Drive, Stanford, CA 94305 5641, USA
    Best Pract Res Clin Gastroenterol 19:799-805. 2005
  8. pmc Surgery increases survival in patients with gastrinoma
    Jeffrey A Norton
    Department of Surgery, Stanford University Medical Center, Stanford, CA 94305 5641, USA
    Ann Surg 244:410-9. 2006
  9. pmc Lymph nodes and survival in pancreatic neuroendocrine tumors
    Geoffrey W Krampitz
    Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305 5655, USA
    Arch Surg 147:820-7. 2012
  10. ncbi Role of surgery in Zollinger-Ellison syndrome
    Jeffrey A Norton
    Surgical Oncology, Department of Surgery, Stanford University, Palo Alto, California, USA
    J Am Coll Surg 205:S34-7. 2007

Collaborators

Detail Information

Publications47

  1. pmc Possible primary lymph node gastrinoma: occurrence, natural history, and predictive factors: a prospective study
    Jeffrey A Norton
    Department of Surgery, University of California San Francisco, 533 Parnassus Avenue, U 371, Box 0790, San Francisco, CA 94143, USA
    Ann Surg 237:650-7; discussion 657-9. 2003
    ..To analyze the results of a prospective study of 176 patients with Zollinger-Ellison syndrome (ZES) (138 sporadic, 38 MEN1) undergoing 207 operations over a 17-year period...
  2. ncbi Morbidity and mortality of aggressive resection in patients with advanced neuroendocrine tumors
    Jeffrey A Norton
    Department of Surgery, University of California, San Francisco, CA 94143, USA
    Arch Surg 138:859-66. 2003
    ..Aggressive surgery remains a potentially efficacious antitumor therapy but is rarely performed because of its possible morbidity and mortality...
  3. ncbi Hepatic artery embolization for treatment of patients with metastatic carcinoid tumors: a commentary
    Jeffrey A Norton
    Department of Surgery, University of California San Francisco, San Francisco, California 94143, USA
    Cancer J 9:241-3. 2003
  4. doi Pancreatic neuroendocrine tumors: radiographic calcifications correlate with grade and metastasis
    George A Poultsides
    Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA
    Ann Surg Oncol 19:2295-303. 2012
    ..Specifically, the prevalence and prognostic significance of radiographic calcifications in these tumors remains unclear...
  5. ncbi Surgery for gastrinoma and insulinoma in multiple endocrine neoplasia type 1
    Jeffrey A Norton
    Department of Surgery, Stanford University Medical Center, Room H 3591, 300 Pasteur Drive, Stanford, CA 94305 5641, USA
    J Natl Compr Canc Netw 4:148-53. 2006
    ..There is a high likelihood of cure when the insulinoma is excised surgically. However, recurrent hypoglycemia may occur, and careful follow-up is indicated...
  6. pmc Does the use of routine duodenotomy (DUODX) affect rate of cure, development of liver metastases, or survival in patients with Zollinger-Ellison syndrome?
    Jeffrey A Norton
    Surgical Oncology, Department of Surgery, Stanford University Medical Center, Room H 3591, 300 Pasteur Drive, Stanford, CA 94305 5641, USA
    Ann Surg 239:617-25; discussion 626. 2004
    ..To determine whether routine use of duodenotomy (DUODX) alters cure rate, survival, or development of liver metastases in 143 patients (162 operations) with Zollinger-Ellison syndrome (ZES) without MEN1...
  7. ncbi Surgical treatment and prognosis of gastrinoma
    Jeffrey A Norton
    Department of Surgery, Stanford University Medical Center, Room H3591, 300 Pasteur Drive, Stanford, CA 94305 5641, USA
    Best Pract Res Clin Gastroenterol 19:799-805. 2005
    ..However, the excellent long-term survival of these patients with lesser operations and the increased operative mortality and long-term morbidity of Whipple make its current role unclear until further studies are done...
  8. pmc Surgery increases survival in patients with gastrinoma
    Jeffrey A Norton
    Department of Surgery, Stanford University Medical Center, Stanford, CA 94305 5641, USA
    Ann Surg 244:410-9. 2006
    ..To determine whether the routine use of surgical exploration for gastrinoma resection/cure in 160 patients with Zollinger-Ellison syndrome (ZES) altered survival compared with 35 ZES patients who did not undergo surgery...
  9. pmc Lymph nodes and survival in pancreatic neuroendocrine tumors
    Geoffrey W Krampitz
    Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305 5655, USA
    Arch Surg 147:820-7. 2012
    ..Lymph node metastases decrease survival in patients with pancreatic neuroendocrine tumors (pNETs)...
  10. ncbi Role of surgery in Zollinger-Ellison syndrome
    Jeffrey A Norton
    Surgical Oncology, Department of Surgery, Stanford University, Palo Alto, California, USA
    J Am Coll Surg 205:S34-7. 2007
  11. pmc Prospective study of surgery for primary hyperparathyroidism (HPT) in multiple endocrine neoplasia-type 1 and Zollinger-Ellison syndrome: long-term outcome of a more virulent form of HPT
    Jeffrey A Norton
    Department of Surgery, Stanford University Medical Center, Stanford, CA 94305, USA
    Ann Surg 247:501-10. 2008
    ..Surgery for parathyroid hyperplasia is tricky and difficult. Long-term outcome in ZES/MEN1/HPT is not well known...
  12. pmc Resolved and unresolved controversies in the surgical management of patients with Zollinger-Ellison syndrome
    Jeffrey A Norton
    Department of Surgery, Stanford University Medical Center, Stanford, California 94305 5641, USA
    Ann Surg 240:757-73. 2004
    ..Highlight unresolved controversies in the management of Zollinger-Ellison syndrome (ZES)...
  13. ncbi Gastric carcinoid tumors in multiple endocrine neoplasia-1 patients with Zollinger-Ellison syndrome can be symptomatic, demonstrate aggressive growth, and require surgical treatment
    Jeffrey A Norton
    Department of Surgery, Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305 5651, USA
    Surgery 136:1267-74. 2004
    ..We report 5 patients with MEN-1/ZES with symptomatic, aggressive gastric carcinoid tumors that required surgical procedures...
  14. pmc Hospital readmission after a pancreaticoduodenectomy: an emerging quality metric?
    Zachary J Kastenberg
    Department of Surgery, Stanford University Medical Center, Stanford, CA 94305 5641, USA
    HPB (Oxford) 15:142-8. 2013
    ..The aim of the study was to evaluate the frequency and patterns of rehospitalization after a pancreaticoduodenectomy (PD)...
  15. pmc Failure to comply with NCCN guidelines for the management of pancreatic cancer compromises outcomes
    Brendan C Visser
    Department of Surgery, Stanford University Medical Center, CA 94305 5641, USA
    HPB (Oxford) 14:539-47. 2012
    ..We investigated variation in the management of pancreatic cancer (PC) among large hospitals in California, USA, specifically to evaluate whether compliance with NCCN guidelines correlates with patient outcomes...
  16. pmc CDH1 truncating mutations in the E-cadherin gene: an indication for total gastrectomy to treat hereditary diffuse gastric cancer
    Jeffrey A Norton
    Department of Surgery, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94035, USA
    Ann Surg 245:873-9. 2007
    ....
  17. doi Hereditary diffuse gastric cancer: surgery, surveillance and unanswered questions
    Robin M Cisco
    Stanford University School of Medicine, Department of Surgery, Stanford, CA 94305, USA
    Future Oncol 4:553-9. 2008
    ....
  18. doi Hereditary diffuse gastric cancer: implications of genetic testing for screening and prophylactic surgery
    Robin M Cisco
    Department of Surgery, Stanford University School of Medicine, Stanford, California, USA
    Cancer 113:1850-6. 2008
    ..Because of the emergence of gene-directed gastrectomy for HDGC, today, a previously lethal disease is detected by molecular techniques, allowing curative surgery at an early stage...
  19. pmc Pancreatic neuroendocrine tumours: hypoenhancement on arterial phase computed tomography predicts biological aggressiveness
    David J Worhunsky
    Department of Surgery, Division of Oncology, Stanford University Medical Center, Stanford, CA, USA
    HPB (Oxford) 16:304-11. 2014
    ..However, a subset of these tumours can be hypoenhancing. The prognostic significance of the CT appearance of these tumors remains unclear...
  20. ncbi Surgery and prognosis of duodenal gastrinoma as a duodenal neuroendocrine tumor
    Jeffrey A Norton
    Department of Surgery, Stanford University Medical Center, 300 Pasteur Drive, Room H3651, Stanford, CA 94305 5641, USA
    Best Pract Res Clin Gastroenterol 19:699-704. 2005
    ..However, it has not affected the rate of development of liver metastases. Duodenotomy is a critical method to find duodenal gastrinomas. It should be routinely performed in all surgery to find and remove gastrinoma for cure of ZES...
  21. ncbi Surgical management of neuroendocrine tumors of the gastrointestinal tract
    Lyen C Huang
    Department of Surgery, Stanford University School of Medicine, Stanford, California 94305 5641, USA
    Oncology (Williston Park) 25:794-803. 2011
    ....
  22. pmc Pancreatic endocrine tumors with major vascular abutment, involvement, or encasement and indication for resection
    Jeffrey A Norton
    Department of Surgery, Stanford University Medical Center, Stanford, CA 94305 5641, USA
    Arch Surg 146:724-32. 2011
    ..Surgery for pancreatic endocrine tumors (PETs) with blood vessel involvement is controversial...
  23. ncbi Production of interferon-gamma by tumor-sensitized T cells is essential for interleukin-12-induced complete tumor eradication
    Natalie C Lee
    Department of Surgery, University of California, San Francisco, USA
    Surgery 132:365-8. 2002
    ..Adoptive transfer of T cells into T cell-deficient mice allows for evaluation of the role of T cells and T cell production of IFN-gamma in the antitumor immune response...
  24. ncbi The role of IFN-gamma in rejection of established tumors by IL-12 : source of production and target
    Jennifer Gillary Segal
    Department of Surgery, University of California, VA Medical Center, San Francisco, California 94121, USA
    Cancer Res 62:4696-703. 2002
    ..Our results indicate that the rejection of established tumors by IL-12/Cy+IL-12 is dependent on the induction of a Th1 response producing IFN-gamma that acts on host cells...
  25. ncbi Laparoscopic spleen-preserving distal pancreatectomy: the technique must suit the lesion
    David J Worhunsky
    Division of Surgical Oncology, Department of Surgery, Stanford University Medical Center, 300 Pasteur Drive, Suite H3680C, Stanford, CA, 94305, USA
    J Gastrointest Surg 18:1445-51. 2014
    ..We found no advantage to either technique with respect to outcomes and splenic preservation. Operative approach should reflect technical considerations including location in the pancreas. ..
  26. ncbi Aggressive surgery for metastatic liver neuroendocrine tumors
    Jeffrey A Norton
    Department of Surgery, University of California San Francisco, San Francisco, CA, USA
    Surgery 134:1057-63; discussion 1063-5. 2003
    ..Neuroendocrine tumors of the gastrointestinal tract (carcinoids, pancreatic endocrine tumors) have low malignant potential but can decrease survival rates if they spread to the liver (LNET)...
  27. ncbi Antitumor immunity induced by dendritic cell-based vaccination is dependent on interferon-gamma and interleukin-12
    Jade S Hiramoto
    Department of Surgery, University of California, San Francisco, California 94143 0780, USA
    J Surg Res 116:64-9. 2004
    ..This study was conducted to determine whether dendritic cells (DCs) pulsed with a tumor cell lysate can effectively vaccinate against tumor cells and to establish which cytokines are necessary...
  28. ncbi Macrophages as effector cells in interleukin 12-induced T cell-dependent tumor rejection
    Kangla Tsung
    Department of Surgery, University of California, San Francisco, San Francisco Veterans Affairs Medical Center, San Francisco, California 94121, USA
    Cancer Res 62:5069-75. 2002
    ....
  29. doi Postoperative serum amylase predicts pancreatic fistula formation following pancreaticoduodenectomy
    Jordan M Cloyd
    Department of Surgery, Stanford University, 300 Pasteur Dr, H3591, Stanford, CA, 94305, USA
    J Gastrointest Surg 18:348-53. 2014
    ..Early identification of patients at risk for developing pancreatic fistula (PF) after pancreaticoduodenectomy (PD) may facilitate prevention or treatment strategies aimed at reducing its associated morbidity...
  30. doi Preexisting antitumor immunity augments the antitumor effects of chemotherapy
    Lingbing Zhang
    Department of Surgery, Stanford University School of Medicine, 300 Pasteur Drive, H3591, Stanford, CA 94305 5641, USA
    Cancer Immunol Immunother 62:1061-71. 2013
    ..Further, our results show that timely immune modification of chemotherapy-activated antitumor immunity can result in enhanced antitumor-immune response and complete tumor eradication...
  31. ncbi Computed tomography, endoscopic, laparoscopic, and intra-operative sonography for assessing resectability of pancreatic cancer
    Eliza E Long
    Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA
    Surg Oncol 14:105-13. 2005
    ..With these modern imaging modalities, it is now possible to avoid major operations that only determine an inoperable tumor. With proper preoperative selection, surgery is able to remove tumor in the majority of patients...
  32. ncbi Surgical management of Zollinger-Ellison syndrome; state of the art
    Ellen H Morrow
    Division of General Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305 5641, USA
    Surg Clin North Am 89:1091-103. 2009
    ..The role of Whipple procedure, especially for MEN-1 cases, should be explored further. Laparoscopic and endoscopic treatments are more experimental, but may have a role...
  33. ncbi Surgery for gastrinoma
    Robin M Cisco
    Department of Surgery, Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305 5641, USA
    Adv Surg 41:165-76. 2007
    ..More research also is needed to define the appropriate indications for pancreaticoduodenectomy in ZES and to determine whether proximal vagotomy should be performed at the time of surgical exploration...
  34. ncbi Current management of the Zollinger-Ellison syndrome
    Geoffrey W Krampitz
    Stanford University School of Medicine, Department of Surgery, 300 Pasteur Drive, H3591, Stanford, CA 94305 5655, USA
    Adv Surg 47:59-79. 2013
    ..In patients with liver metastases, surgery should be considered if all identifiable tumor can be safely removed. A multidisciplinary approach including surgical and nonsurgical therapies should be taken in patients with advanced disease...
  35. ncbi Lessons from Coley's Toxin
    Kangla Tsung
    Department of Surgery, Stanford University School of Medicine, Room H3591, 300 Pasteur Drive, Stanford, CA 94025, USA
    Surg Oncol 15:25-8. 2006
    ..The active molecule in Coley's Toxin is not tumor necrosis factor (TNF) or endotoxin (LPS), but interleukin-12 (IL-12). IL-12 holds the key to improved anti-tumor immuns response...
  36. ncbi Current surgical management of Zollinger-Ellison syndrome (ZES) in patients without multiple endocrine neoplasia-type 1 (MEN1)
    Jeffrey A Norton
    Department of Surgery, University of California San Francisco, 533 Parnassus Avenue, Room U 372, San Francisco, CA 94143 0790, USA
    Surg Oncol 12:145-51. 2003
    ..Postoperative evaluation should include secretin test because it is the most sensitive method to document cure and detect tumor recurrence...
  37. pmc Role of factor VII in correcting dilutional coagulopathy and reducing re-operations for bleeding following non-traumatic major gastrointestinal and abdominal surgery
    Thomas C Tsai
    Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA
    J Gastrointest Surg 14:1311-8. 2010
    ..The objective of this study is to evaluate the effectiveness of rfVIIa in reducing blood product requirements and re-operation for postoperative bleeding after major abdominal surgery...
  38. doi Effect of preoperative intravenous pantoprazole in elective-surgery patients: a pilot study
    Joseph R Pisegna
    CURE Digestive Diseases Research Center, University of California, Los Angeles, CA, USA
    Dig Dis Sci 54:1041-9. 2009
    ..This study evaluated the effects of intravenous pantoprazole on gastric volume and acid output in elective-surgical patients...
  39. ncbi Inhibition of host signal transducer and activator of transcription factor 6 results in cure with cyclophosphamide and interleukin 12 immunotherapy
    Jeffrey A Norton
    Department of Surgery, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California, 94305 5641, USA
    Ann Surg Oncol 13:118-24. 2006
    ..It is not known whether this lack of a preexisting host antitumor immune response is a limiting factor for the lack of response to IL-12 therapy by nonimmunogenic tumors...
  40. ncbi A national comparison of surgical versus percutaneous drainage of pancreatic pseudocysts: 1997-2001
    John M Morton
    Department of Surgery, Stanford School of Medicine, Stanford, California 94305 5655, USA
    J Gastrointest Surg 9:15-20; discussion 20-1. 2005
    ....
  41. ncbi Cure of an established nonimmunogenic tumor, SCC VII, with a novel interleukin 12-based immunotherapy regimen in C3H mice
    Aditi H Mandpe
    Department of Otolaryngology Head and Neck Surgery, University of California, San Francisco, and the Surgical Service Veterans Affairs Medical Center, San Francisco, 94143 0342, USA
    Arch Otolaryngol Head Neck Surg 129:786-92. 2003
    ..To develop a murine model of effective treatment with immunotherapy for established head and neck squamous cell carcinoma...
  42. pmc Management and outcome of patients with sporadic gastrinoma arising in the duodenum
    Theresa G Zogakis
    Surgery Branch, Center for Cancer Research, National Cancer Institute National Institutes of Health, Building 10, Room 2B07, 10 Center Drive, Bethesda, MD 20892 1502, USA
    Ann Surg 238:42-8. 2003
    ....
  43. ncbi Surgery for primary pancreatic neuroendocrine tumors
    Jeffrey A Norton
    Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California, USA
    J Gastrointest Surg 10:327-31. 2006
  44. ncbi Endocrine tumours of the gastrointestinal tract. Surgical treatment of neuroendocrine metastases
    Jeffrey A Norton
    Stanford University Medical Center, CA 94305 5641, USA
    Best Pract Res Clin Gastroenterol 19:577-83. 2005
    ..Surgical resection appears to result in outstanding long-term survival and amelioration of symptoms. It should be the first-line therapy for patients with liver neuroendocrine tumors in whom the tumor can be completely removed...
  45. ncbi Results of initial operation for hyperparathyroidism in patients with multiple endocrine neoplasia type 1
    Dina M Elaraj
    Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Surgery 134:858-64; discussion 864-5. 2003
    ..This study analyzes outcomes of a cohort of MEN1 patients undergoing initial PTx at one institution...
  46. pmc Inherited pancreatic endocrine tumor syndromes: advances in molecular pathogenesis, diagnosis, management, and controversies
    Robert T Jensen
    Digestive Diseases Branch, National Institutes of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Cancer 113:1807-43. 2008
    ..In this article, these areas are reviewed briefly along with the current state of knowledge of the PETs in these disorders, and the controversies that exist in their management are summarized briefly and discussed...
  47. ncbi A carrier of both MEN1 and BRCA2 mutations: case report and review of the literature
    Pavandeep Ghataorhe
    School of Medicine, Oxford University, South Parks Road, Oxford OX1 3PL, UK
    Cancer Genet Cytogenet 179:89-92. 2007
    ..To our knowledge, this is the first report of a patient with both MEN1 and BRCA2 mutations and with a personal history of hyperparathyroidism and pancreatic neuroendocrine tumors...