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Genomes and GenesSpecies | Kari NorthSummaryAffiliation: University of North Carolina Country: USA Publications
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The transcription factor 7-like 2 (TCF7L2) polymorphism may be associated with focal arteriolar narrowing in Caucasians with hypertension or without diabetes: the ARIC StudyYu Yan
Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA
BMC Endocr Disord 10:9. 2010..We therefore aimed to investigate the association between the transcription factor 7-like 2 (TCF7L2) rs7903146 polymorphism and retinal microvascular phenotypes in the Atherosclerosis Risk in Communities (ARIC) Study (1993-1995)...
Heritability of carotid artery structure and function: the Strong Heart Family StudyKari E North
Department of Epidemiology, University of North Carolina, Chapel Hill, USA
Arterioscler Thromb Vasc Biol 22:1698-703. 2002..23), and the augmentation index (h2<0.18). CONCLUSIONS: These results suggest that the additive effects of genes explain a moderate proportion of the variability of carotid artery structure and function...- Admixture mapping of obesity-related traits in African Americans: the Atherosclerosis Risk in Communities (ARIC) StudyChing Yu Cheng
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
Obesity (Silver Spring) 18:563-72. 2010..92 kg/m(2) (P = 2.9 x 10(-5)). Further mapping in this region on chromosome 2 may be able to uncover causative variants underlying obesity, which may offer insights into the control of energy homeostasis... - NOS3 polymorphisms, cigarette smoking, and cardiovascular disease risk: the Atherosclerosis Risk in Communities studyCraig R Lee
Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27709, USA
Pharmacogenet Genomics 16:891-9. 2006..We sought to determine whether cigarette smoking modified the association between NOS3 polymorphisms and risk of coronary heart disease or stroke... - Transcription factor 7-like 2 (TCF7L2) polymorphism and context-specific risk of impaired fasting glucose in African American and Caucasian adults: the atherosclerosis risk in communities (ARIC) studyYu Yan
Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599 8050, USA
Diabetes Metab Res Rev 26:371-7. 2010..Moreover, few studies have investigated the effects of TCF7L2 on IFG in the context of metabolic risk factors for diabetes... - Transcription factor 7-like 2 (TCF7L2) polymorphism and context-specific risk of type 2 diabetes in African American and Caucasian adults: the Atherosclerosis Risk in Communities studyYu Yan
Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA
Diabetes 58:285-9. 2009..Moreover, few studies have investigated the effects of TCF7L2 on type 2 diabetes in the context of metabolic risk factors of type 2 diabetes... - NPHS2 gene, nephrotic syndrome and focal segmental glomerulosclerosis: a HuGE reviewNora Franceschini
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC 27514 3628, USA
Genet Med 8:63-75. 2006..Nevertheless, the available data suggest that large epidemiological case-control studies to examine the association between NPHS2 variants and nephrotic syndrome are warranted... - Genetic epidemiology of BMI and body mass change from adolescence to young adulthoodKari E North
Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA
Obesity (Silver Spring) 18:1474-6. 2010..61 +/- 0.03) and young adulthood (rho(G) = 0.23 +/- 0.06). Our findings support a complex etiology of BMI and BMI change... - Linkage analysis of factors underlying insulin resistance: Strong Heart Family StudyKari E North
Department of Epidemiology, University of North Carolina, Chapel Hill, Bank of America Center, 137 E Franklin Street, Suite 306, NC 27514, USA
Obes Res 13:1877-84. 2005..The corroboration of existing QTLs will bring us closer to the identification of the functional genes that predispose to IR... - Variation in the checkpoint kinase 2 gene is associated with type 2 diabetes in multiple populationsKari E North
Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA
Acta Diabetol 47:199-207. 2010..These results may suggest a new pathway in the pathogenesis of type 2 diabetes that involves pancreatic beta-cell damage and apoptosis... - Genome-wide linkage analysis of pulse pressure in American Indians: the Strong Heart StudyNora Franceschini
Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA
Am J Hypertens 21:194-9. 2008..Pulse pressure, a measure of central arterial stiffness and a predictor of cardiovascular mortality, has known genetic components... - Linkage analysis of albuminuriaAmy K Mottl
UNC Kidney Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7155, USA
J Am Soc Nephrol 20:1597-606. 2009..4) and 10q25.1 using model 2 (logarithm of odds = 3.3). These loci replicate findings from multiple other genome scans of kidney disease phenotypes with distinct populations and are worthy of further study... - Diabetes-specific genetic effects on obesity traits in American Indian populations: the Strong Heart Family StudyNora Franceschini
Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA
BMC Med Genet 9:90. 2008..1.4)... - A quantitative trait loci-specific gene-by-sex interaction on systolic blood pressure among American Indians: the Strong Heart Family StudyNora Franceschini
Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Bank of America Center, Chapel Hill, NC 27514 3628, USA
Hypertension 48:266-70. 2006..8 in women). Accounting for interaction with sex improved our ability to detect QTLs and demonstrated the importance of considering genotype-by-sex interaction in our search for blood pressure genes... - Longitudinal impact of physical activity on lipid profiles in middle-aged adults: the Atherosclerosis Risk in Communities StudyKeri L Monda
Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA
J Lipid Res 50:1685-91. 2009..Overall our results highlight the importance of physical activity on plasma lipid profiles and provide evidence for novel differential associations... - Genotype-by-sex interaction on fasting insulin concentration: the HyperGEN studyKari E North
Department of Epidemiology, University of North Carolina Chapel Hill, Bank of America Center, 137 E Franklin St, Suite 306, Chapel Hill, NC 27514, USA
Diabetes 56:137-42. 2007..2) female subjects. Our findings overlap with several other linkage reports of insulin-related traits and demonstrate the importance of considering complex context-dependent interactions in the search for insulin-related genes... - The association of cell cycle checkpoint 2 variants and kidney function: findings of the Family Blood Pressure Program and the Atherosclerosis Risk In Communities studyNora Franceschini
Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Am J Hypertens 22:552-8. 2009..The checkpoint 2 gene (CHEK2) is an important transducer in DNA damage signaling pathways in response to injury, and therefore, CHEK2 variants may affect susceptibility to kidney disease... - Body mass, DRD4, physical activity, sedentary behavior, and family socioeconomic status: the add health studyGuang Guo
Carolina Population Center, University of North Carolina, Chapel Hill, NC 27599 3210, USA
Obesity (Silver Spring) 15:1199-206. 2007..To investigate the joint role of the 48-base pair repeat polymorphism of the dopamine receptor 4 gene (DRD4) and environmental factors in body mass variation among an ethnically diverse sample of U.S. adolescents and young adults... - Val153Met polymorphism of catechol-O-methyltransferase and prevalence of uterine leiomyomataKyna M Gooden
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
Reprod Sci 14:117-20. 2007..This study suggests that variation in this polymorphism alone does not affect fibroid prevalence. Additional research is needed to examine other variations and haplotypes within the COMT gene... - The association of the MYH9 gene and kidney outcomes in American Indians: the Strong Heart Family StudyNora Franceschini
Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27514, USA
Hum Genet 127:295-301. 2010..Identification of the actual functional genetic variation responsible for the associations seen in African-Americans will likely help to clarify the lack of replication of this gene in our population of American Indians... - Genetic association studies and the effect of misclassification and selection bias in putative confoundersChristy L Avery
Department of Epidemiology, University of North Carolina, 137 East Franklin Street, CB 8050, Suite 306, Chapel Hill, North Carolina 27514 USA
BMC Proc 3:S48. 2009..These results support careful consideration of how well a study population represents the target population because selection bias may result even when associations are modest... - Genetic and environmental contributions to cardiovascular disease risk in American Indians: the strong heart family studyKari E North
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX, USA
Am J Epidemiol 157:303-14. 2003..34)). These results suggest that heredity explains a substantial proportion of the variability of CVD risk factors and that these heritabilities are large enough to warrant a search for major risk factor genes... 
Angiotensin II type 1 receptor polymorphisms and susceptibility to hypertension: a HuGE reviewAmy K Mottl
Division of Nephrology and Hypertension, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA
Genet Med 10:560-74. 2008..In conclusion, there is insufficient evidence that polymorphisms in the AGTR1 gene are risk factors for hypertension. However, most studies are inadequately powered, and larger well-designed studies of haplotypes are warranted...- Evidence for distinct genetic effects on obesity and lipid-related CVD risk factors in diabetic compared to nondiabetic American Indians: the Strong Heart Family StudyKari E North
Department of Epidemiology, University of North Carolina, Chapel Hill, Bank of America Center, North Carolina 27514 3628, USA
Diabetes Metab Res Rev 19:140-7. 2003..The purpose of the present paper is to determine whether the genetic effects on CVD risk factors in the SHFS are different in diabetic and nondiabetic individuals... - Association of adolescent obesity with risk of severe obesity in adulthoodNatalie S The
Departments of Nutrition, Carolina Population Center, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27516 3997, USA
JAMA 304:2042-7. 2010.... - Obesity and diabetes genetic variants associated with gestational weight gainAlison M Stuebe
Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, NC, USA
Am J Obstet Gynecol 203:283.e1-17. 2010..We sought to determine whether genetic variants associated with diabetes and obesity predict gestational weight gain... - Evidence for genetic factors underlying the insulin resistance syndrome in american indiansKari E North
Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Obes Res 11:1444-8. 2003..These results suggest that heredity explains a substantial proportion of the variability of the factors that underlie the insulin resistance syndrome in American Indians and that these factors are genetically independent... - Longitudinal age-dependent effect on systolic blood pressureBonnie R Joubert
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, 2101 McGavran Greenberg Hall, CB 7435, Chapel Hill, North Carolina 27599, USA
BMC Proc 3:S87. 2009..The value of the 2-df test for screening genetic interaction effects could not be established in this study... - Evidence for a gene on chromosome 13 influencing postural systolic blood pressure change and body mass indexKari E North
Department of Epidemiology, University of North Carolina Chapel Hill, Bank of America Center, 137 E Franklin St, Suite 306, Chapel Hill, NC 27514, USA
Hypertension 43:780-4. 2004..4 and 0.9, respectively). These findings suggest that a gene(s) on chromosome 13q jointly regulates the SBP response to postural change and BMI... - Evidence for a gene influencing fasting LDL cholesterol and triglyceride levels on chromosome 21qKari E North
Department of Epidemiology, University of North Carolina, Bank of America Center, 137 E Franklin St, Suite 306, Chapel Hill, NC 27514, USA
Atherosclerosis 179:119-25. 2005.... - Accuracy of haplotype estimation in a region of low linkage disequilibriumChristy L Avery
Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA
BMC Genet 6:S80. 2005.... - Social- and behavioral-specific genetic effects on blood pressure traits: the Strong Heart Family StudyNora Franceschini
Department of Epidemiology, University of North Carolina Chapel Hill, 137 E Franklin St, Suite 306 CB 8050, Chapel Hill, NC 27514, USA
Circ Cardiovasc Genet 2:396-401. 2009..Accounting for the genetic interaction of these factors may help to identify common BP susceptibility alleles... - The genetics of obesity and the metabolic syndromeKeri L Monda
Department of Epidemiology, University of North Carolina at Chapel Hill, USA
Endocr Metab Immune Disord Drug Targets 10:86-108. 2010..We provide also a gene network analysis of recent variants related to obesity and metabolic syndrome discovered through genome-wide association studies, and 4 gene networks based on searching the NCBI database... - Comparison of strategies for identification of regulatory quantitative trait loci of transcript expression traitsNora Franceschini
Department of Epidemiology, University of North Carolina Chapel Hill, Bank of America Center, 137 East Franklin Street, Suite 306, CB 8050, Chapel Hill, North Carolina 27514, USA
BMC Proc 1:S85. 2007..Similar results were found in analysis of 12 transcripts, that had co-localized QTLs in the 13q34 region. Principal-component analyses did not improve the ability to identify chromosomal regions of co-localized gene expressions... - HDL cholesterol in females in the Framingham Heart Study is linked to a region of chromosome 2qKari E North
Department of Epidemiology, University of North Carolina, Chapel Hill 27514 USA
BMC Genet 4:S98. 2003..Although the QTL could be detected in the combined sample of males and females at the first time point, the linkage was not significant at subsequent time points... - Linkage analysis of glomerular filtration rate in American IndiansAmy K Mottl
UNC Kidney Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7155, USA
Kidney Int 74:1185-91. 2008..This evidence for linkage of a quantitative trait locus influencing estimated glomerular filtration rate to a region of chromosome 12p in a large cohort of American Indians will be worth studying in more detail in the future... - Quantitative effects of common genetic variations in the 3'UTR of the human LDL-receptor gene and their associations with plasma lipid levels in the Atherosclerosis Risk in Communities studyHind Muallem
Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599 7525, USA
Hum Genet 121:421-31. 2007.... - Regulation of CCR5 expression in human placenta: insights from a study of mother-to-child transmission of HIV in MalawiBonnie R Joubert
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, United States of America
PLoS ONE 5:e9212. 2010..Placental expression of CCR5 may be influenced by such polymorphisms as well as other in vivo regulatory factors... - Comparison of genome-wide variation between Malawians and African ancestry HapMap populationsBonnie R Joubert
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599, USA
J Hum Genet 55:366-74. 2010..Five SNPs within the lactase gene (LCT) had substantially different allele frequencies between the Malawi population and Maasai in Kenyawa, Kenya (rs3769013, rs730005, rs3769012, rs2304370; P-values <1 x 10(-33))... - DNA repair polymorphisms XRCC1 and MGMT and risk of adult gliomasMartha J Felini
Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA
Neuroepidemiology 29:55-8. 2007..26; CI 0.90-1.75) and the MGMT Ile143Val polymorphism (Ile or Val/Val versus Ile/Ile: adjusted OR = 1.20; CI 0.85-1.71)... - Peroxisome proliferator-activated receptor-alpha (PPARA) genetic polymorphisms and breast cancer risk: a Long Island ancillary studyAmanda K Golembesky
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC 27599, USA
Carcinogenesis 29:1944-9. 2008..Our results are the first to evaluate the relationship between PPARA and breast cancer incidence and suggest that replication in an independent cohort is warranted... - Linkage analysis of diabetes status among hypertensive families: the Hypertension Genetic Epidemiology Network studyChristy L Avery
Department of Epidemiology, University of North Carolina Chapel Hill, Chapel Hill, NC 27514, USA
Diabetes 53:3307-12. 2004..The identification and replication of type 2 diabetes QTLs will bring us closer to the detection of functional genes that influence diabetes susceptibility... - The DRD3 rs6280 polymorphism and prevalence of tardive dyskinesia: a meta-analysisHuei Ting Tsai
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Am J Med Genet B Neuropsychiatr Genet 153:57-66. 2010..Under the recessive model, the summary estimate was POR = 0.93 (95% confidence interval: 0.70-1.23). We conclude that there is no or little association between DRD3 rs6280 polymorphisms and prevalence of TD... - Genetic polymorphisms and the progression of liver fibrosis: a critical appraisalRamon Bataller
Department of Medicine, Biochemistry and Biophysics, University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, NC 27599, USA
Hepatology 37:493-503. 2003..Large-scale, well-designed studies are required to clarify the actual role of this factor and other genetic variants in liver fibrosis... - Prospective analysis of mannose-binding lectin genotypes and coronary artery disease in American Indians: the Strong Heart StudyLyle G Best
Missouri Breaks Industries Research Inc, Timber Lake, SD, USA
Circulation 109:471-5. 2004..After a preliminary report associating these variations with coronary artery disease (CAD), we determined MBL genotypes in 3 American Indian communities experiencing an increased mortality and morbidity from CAD... - TCF7L2 variants associate with CKD progression and renal function in population-based cohortsAnna Kottgen
Department of Epidemiology and Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, Maryland, USA
J Am Soc Nephrol 19:1989-99. 2008..In conclusion, several population-based samples suggest that variants in the TCF7L2 gene are associated with reduced kidney function or CKD progression, overall and specifically among participants without diabetes... - Linkage study of fibrinogen levels: the Strong Heart Family StudyLyle G Best
Missouri Breaks Industries Research Inc, Timber Lake, SD, USA
BMC Med Genet 9:77. 2008..The Strong Heart Study has demonstrated an increased incidence of cardiovascular disease in the American Indian population, and therefore represents an important source for genetic-epidemiological investigations... - Factor relationships of metabolic syndrome and echocardiographic phenotypes in the HyperGEN studyPinchia Huang
Division of Biostatistics, Washington University School of Medicine, Saint Louis, MO 63110, USA
J Hypertens 26:1360-6. 2008..Metabolic syndrome and its risk factors are predictors of cardiovascular events. Metabolic syndrome is also directly associated with echocardiographic phenotypes... - A population association study of angiotensinogen polymorphisms and haplotypes with left ventricular phenotypesLaura J Rasmussen-Torvik
Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA
Hypertension 46:1294-9. 2005..The single SNP association was driven by a large group of SNPs in high linkage disequilibrium that includes the promoter SNP rs5051... - Use of nonsteroidal antiinflammatory drugs and risk of colon cancer in a population-based, case-control study of African Americans and WhitesLeah B Sansbury
Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 8325, USA
Am J Epidemiol 162:548-58. 2005..These results add new knowledge suggesting that the protective effect of NSAIDs against colon cancer is similar among African Americans and Whites... - Pleiotropic QTL on chromosome 19q13 for triglycerides and adiposity: the HERITAGE Family StudyMary F Feitosa
Division of Biostatistics, Washington University School of Medicine, Campus Box 8067, 660 S Euclid, St Louis, MO 63110 1093, USA
Atherosclerosis 185:426-32. 2006..Polymorphisms in the APOE gene, and possibly LIPE gene, appear to be strong candidates for the source of this pleiotropic QTL... - Hysterectomy prevalence and cardiovascular disease risk factors in American Indian womenYing Zhang
Center for American Indian Health Research, University of Oklahoma Health Sciences Center, P O Box 26901, Oklahoma City, OK 73190, USA
Maturitas 52:328-36. 2005..We investigated hysterectomy prevalence and associated demographic and reproductive factors among American Indian women. The association between hysterectomy and cardiovascular disease (CVD) risk factors was also examined... - Genetic influences on aortic root size in American Indians: the Strong Heart Study Jonathan N Bella
Department of Medicine, Weill Medical College of Cornell University, New York, NY, USA
Arterioscler Thromb Vasc Biol 22:1008-11. 2002..Echocardiographic screening of family members with aortic root dilatation may identify other individuals predisposed to aortic dissection or rupture... - Genome-wide linkage analysis replicates susceptibility locus for fasting plasma triglycerides: NHLBI Family Heart StudyDonna K Arnett
Division of Epidemiology, University of Minnesota, 1300 South Second Street, Suite 300, Minneapolis, MN 55454, USA
Hum Genet 115:468-74. 2004..Chromosome 15 likely harbors a susceptibility locus with an influence on triglycerides and HDL. Regions on chromosomes 6 and 8 may also contain loci contributing to inter-individual variation in plasma triglycerides... - Phenotypic, genetic, and genome-wide structure in the metabolic syndromeLisa J Martin
Center for Epidemiology and Biostatistics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, 45229, USA
BMC Genet 4:S95. 2003..We next applied factor analysis to summarize the relationship between these phenotypes... - Analysis of metabolic syndrome phenotypes in Framingham Heart Study families from Genetic Analysis Workshop 13Lynn R Goldin
Genetic Epidemiology Branch, DCEG, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 7236, USA
Genet Epidemiol 25:S78-89. 2003..Over 40 genome-wide linkage analyses were conducted. Despite the broad range of approaches, several regions of the genome were repeatedly identified across multiple analyses... - Meta-analysis of genome-wide linkage studies for quantitative lipid traits in African AmericansAlka Malhotra
Diabetes and Obesity Research Unit, Translational Genomics Research Institute, Phoenix, AZ 85004, USA
Hum Mol Genet 14:3955-62. 2005..0429) for TG. Statistically significant evidence for linkage and low heterogeneity on chromosome 1q therefore suggest that this region may harbor a gene underlying the inheritance of LDL in African Americans... - Genetic variation in soluble epoxide hydrolase (EPHX2) and risk of coronary heart disease: The Atherosclerosis Risk in Communities (ARIC) studyCraig R Lee
Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health Research, Triangle Park, NC 27709, USA
Hum Mol Genet 15:1640-9. 2006..315). Genetic variation in EPHX2 was significantly associated with risk of incident CHD in Caucasians, implicating EPHX2 as a potential cardiovascular disease-susceptibility gene... - Linkage analysis of a composite factor for the multiple metabolic syndrome: the National Heart, Lung, and Blood Institute Family Heart StudyWeihong Tang
Division of Epidemiology, University of Minnesota, Minneapolis 55454, USA
Diabetes 52:2840-7. 2003..34 at 240 cM. Suggestive linkage was also observed for regions on chromosomes 7, 12, 14, and 15. In summary, a genomic region on chromosome 2 may contain a pleiotropic locus contributing to the clustering of MMS-related phenotypes... - GSTM1 and GSTT1 polymorphisms, cigarette smoking, and risk of colon cancer: a population-based case-control study in North Carolina (United States)Kui Huang
Global Epidemiology, Pfizer Inc, Mail stop 150 3 80, 235 East 42nd Street, New York City, NY 10017 575, USA
Cancer Causes Control 17:385-94. 2006..GSTT1 and GSTM1 polymorphisms may be weakly related to colon cancer risk and there may be racial differences in gene-smoking interactions... - Body mass index gain, fast food, and physical activity: effects of shared environments over timeMelissa C Nelson
Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, USA
Obesity (Silver Spring) 14:701-9. 2006..Household and physical environments play an important role in establishing long-term behavior patterns... - Genome scan of glomerular filtration rate and albuminuria: the HyperGEN studyJoanlise M Leon
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, USA
Nephrol Dial Transplant 22:763-71. 2007..We performed genome-wide scans to detect loci impacting these parameters in 1251 African American (AAs) and 1129 European American (EAs) hypertensive siblings from the Hypertension Genetic Epidemiology Network study... - CYP2J2 and CYP2C8 polymorphisms and coronary heart disease risk: the Atherosclerosis Risk in Communities (ARIC) studyCraig R Lee
Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
Pharmacogenet Genomics 17:349-58. 2007..The cytochromes P450 epoxygenases CYP2J2 and CYP2C8 synthesize epoxyeicosatrienoic acids, which regulate endothelial function. We sought to determine if genetic variation in CYP2J2 and CYP2C8 was associated with coronary heart disease risk... - Sex-specific effects of ACE I/D and AGT-M235T on pulse pressure: the HyperGEN StudyAmy I Lynch
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA
Hum Genet 122:33-40. 2007..This evidence for a genotype-by-sex interaction helps our understanding of the complex genetic underpinnings of blood pressure phenotypes... - Genome-wide admixture mapping for coronary artery calcification in African Americans: the NHLBI Family Heart StudyQunyuan Zhang
Division of Statistical Genomics, Washington University School of Medicine, St Louis, Missouri 63108, USA
Genet Epidemiol 32:264-72. 2008..On the basis of the results from this and other independent studies, the location of D6S1053 at 80cM on chromosome 6 (6q12) seems to harbor a highly promising quantitative trait loci for atherosclerosis... - Relation of albuminuria to left ventricular mass (from the HyperGEN Study)Luc Djousse
Division of Aging, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
Am J Cardiol 101:212-6. 2008..In conclusion, these results suggest that albuminuria is positively associated with LV mass in normotensive subjects as it is in hypertensive subjects... - Heritability of left ventricular dimensions and mass in American Indians: The Strong Heart StudyJonathan N Bella
Weill Medical College of Cornell University, New York, New York, USA
J Hypertens 22:281-6. 2004..We sought to determine the heritability of left ventricular dimensions and mass in adult American Indians... - Multiple testing in the genomics era: findings from Genetic Analysis Workshop 15, Group 15Lisa J Martin
Department of Pediatrics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Genet Epidemiol 31:S124-31. 2007..We show that while each approach may have certain advantages, adequate error control is largely dependent upon the question under consideration and often requires the use of multiple analytic strategies... - Genetic determination of acute phase reactant levels: the strong heart studyLyle G Best
Missouri Breaks Industries Research Inc, Timber Lake, SD, USA
Hum Hered 58:112-6. 2004..We sought to determine the relative contributions of genetic and environmental factors influencing basal serum levels of APRs... - Association of sICAM-1 and MCP-1 with coronary artery calcification in families enriched for coronary heart disease or hypertension: the NHLBI Family Heart StudyWeihong Tang
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA
BMC Cardiovasc Disord 7:30. 2007..In the follow-up exam of the NHLBI Family Heart Study, we evaluated whether plasma levels of sICAM-1 and MCP-1 were associated with coronary artery calcification (CAC), a measure of the burden of coronary atherosclerosis... - COX-2 polymorphism, use of nonsteroidal anti-inflammatory drugs, and risk of colon cancer in African Americans (United States)Leah B Sansbury
Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892 8325, USA
Cancer Causes Control 17:257-66. 2006..We explored the association between the COX-2 Val511Ala SNP and risk of colon cancer among 240 African American cases and 326 African American controls in a population-based, case-control study in North Carolina...
Research Grants
- HYPERGEN-NCKari North; Fiscal Year: 2004..The resulting synthesis of ideas and amassed data permits rigorous hypothesis testing not otherwise possible and will hasten understanding of the previously elusive genetic variation responsible for disease risk. ..
- Gene-by-Smoking Interaction and Risk of AtherosclerosisKari North; Fiscal Year: 2005..The findings are expected to be of clinical and public health significance. ..
- Comprehensive Mapping of a Blood Pressure QTL on Chromosome 17Kari E North; Fiscal Year: 2010..The proposed study may expand our understanding of the impact of the genes on the natural history of hypertension and mechanisms of blood pressure control. ..