Kari North

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi request reprint Heritability of carotid artery structure and function: the Strong Heart Family Study
    Kari E North
    Department of Epidemiology, University of North Carolina, Chapel Hill, USA
    Arterioscler Thromb Vasc Biol 22:1698-703. 2002
  2. pmc Investigation of gene-by-sex interactions for lipid traits in diverse populations from the population architecture using genomics and epidemiology study
    Kira C Taylor
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    BMC Genet 14:33. 2013
  3. pmc The transcription factor 7-like 2 (TCF7L2) polymorphism may be associated with focal arteriolar narrowing in Caucasians with hypertension or without diabetes: the ARIC Study
    Yu Yan
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA
    BMC Endocr Disord 10:9. 2010
  4. pmc Admixture mapping of obesity-related traits in African Americans: the Atherosclerosis Risk in Communities (ARIC) Study
    Ching Yu Cheng
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Obesity (Silver Spring) 18:563-72. 2010
  5. pmc NOS3 polymorphisms, cigarette smoking, and cardiovascular disease risk: the Atherosclerosis Risk in Communities study
    Craig R Lee
    Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27709, USA
    Pharmacogenet Genomics 16:891-9. 2006
  6. pmc Transcription factor 7-like 2 (TCF7L2) polymorphism and context-specific risk of impaired fasting glucose in African American and Caucasian adults: the atherosclerosis risk in communities (ARIC) study
    Yu Yan
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599 8050, USA
    Diabetes Metab Res Rev 26:371-7. 2010
  7. pmc Transcription factor 7-like 2 (TCF7L2) polymorphism and context-specific risk of type 2 diabetes in African American and Caucasian adults: the Atherosclerosis Risk in Communities study
    Yu Yan
    Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA
    Diabetes 58:285-9. 2009
  8. ncbi request reprint NPHS2 gene, nephrotic syndrome and focal segmental glomerulosclerosis: a HuGE review
    Nora Franceschini
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC 27514 3628, USA
    Genet Med 8:63-75. 2006
  9. pmc Genetic epidemiology of BMI and body mass change from adolescence to young adulthood
    Kari E North
    Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA
    Obesity (Silver Spring) 18:1474-6. 2010
  10. ncbi request reprint Body mass, DRD4, physical activity, sedentary behavior, and family socioeconomic status: the add health study
    Guang Guo
    Carolina Population Center, University of North Carolina, Chapel Hill, NC 27599 3210, USA
    Obesity (Silver Spring) 15:1199-206. 2007

Research Grants

  1. HYPERGEN-NC
    Kari North; Fiscal Year: 2004
  2. Gene-by-Smoking Interaction and Risk of Atherosclerosis
    Kari North; Fiscal Year: 2005
  3. Comprehensive Mapping of a Blood Pressure QTL on Chromosome 17
    Kari E North; Fiscal Year: 2010

Detail Information

Publications72

  1. ncbi request reprint Heritability of carotid artery structure and function: the Strong Heart Family Study
    Kari E North
    Department of Epidemiology, University of North Carolina, Chapel Hill, USA
    Arterioscler Thromb Vasc Biol 22:1698-703. 2002
    ..The purpose of this study was to examine the genetic and environmental contributions to carotid artery structure and function in 3 large groups of American Indians...
  2. pmc Investigation of gene-by-sex interactions for lipid traits in diverse populations from the population architecture using genomics and epidemiology study
    Kira C Taylor
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    BMC Genet 14:33. 2013
    ..Here, we investigated whether GWAS-identified SNPs for lipid traits exhibited heterogeneity by sex in the Population Architecture using Genomics and Epidemiology (PAGE) study...
  3. pmc The transcription factor 7-like 2 (TCF7L2) polymorphism may be associated with focal arteriolar narrowing in Caucasians with hypertension or without diabetes: the ARIC Study
    Yu Yan
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA
    BMC Endocr Disord 10:9. 2010
    ..We therefore aimed to investigate the association between the transcription factor 7-like 2 (TCF7L2) rs7903146 polymorphism and retinal microvascular phenotypes in the Atherosclerosis Risk in Communities (ARIC) Study (1993-1995)...
  4. pmc Admixture mapping of obesity-related traits in African Americans: the Atherosclerosis Risk in Communities (ARIC) Study
    Ching Yu Cheng
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Obesity (Silver Spring) 18:563-72. 2010
    ..92 kg/m(2) (P = 2.9 x 10(-5)). Further mapping in this region on chromosome 2 may be able to uncover causative variants underlying obesity, which may offer insights into the control of energy homeostasis...
  5. pmc NOS3 polymorphisms, cigarette smoking, and cardiovascular disease risk: the Atherosclerosis Risk in Communities study
    Craig R Lee
    Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27709, USA
    Pharmacogenet Genomics 16:891-9. 2006
    ..We sought to determine whether cigarette smoking modified the association between NOS3 polymorphisms and risk of coronary heart disease or stroke...
  6. pmc Transcription factor 7-like 2 (TCF7L2) polymorphism and context-specific risk of impaired fasting glucose in African American and Caucasian adults: the atherosclerosis risk in communities (ARIC) study
    Yu Yan
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599 8050, USA
    Diabetes Metab Res Rev 26:371-7. 2010
    ..Moreover, few studies have investigated the effects of TCF7L2 on IFG in the context of metabolic risk factors for diabetes...
  7. pmc Transcription factor 7-like 2 (TCF7L2) polymorphism and context-specific risk of type 2 diabetes in African American and Caucasian adults: the Atherosclerosis Risk in Communities study
    Yu Yan
    Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA
    Diabetes 58:285-9. 2009
    ..Moreover, few studies have investigated the effects of TCF7L2 on type 2 diabetes in the context of metabolic risk factors of type 2 diabetes...
  8. ncbi request reprint NPHS2 gene, nephrotic syndrome and focal segmental glomerulosclerosis: a HuGE review
    Nora Franceschini
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC 27514 3628, USA
    Genet Med 8:63-75. 2006
    ..Nevertheless, the available data suggest that large epidemiological case-control studies to examine the association between NPHS2 variants and nephrotic syndrome are warranted...
  9. pmc Genetic epidemiology of BMI and body mass change from adolescence to young adulthood
    Kari E North
    Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA
    Obesity (Silver Spring) 18:1474-6. 2010
    ..61 +/- 0.03) and young adulthood (rho(G) = 0.23 +/- 0.06). Our findings support a complex etiology of BMI and BMI change...
  10. ncbi request reprint Body mass, DRD4, physical activity, sedentary behavior, and family socioeconomic status: the add health study
    Guang Guo
    Carolina Population Center, University of North Carolina, Chapel Hill, NC 27599 3210, USA
    Obesity (Silver Spring) 15:1199-206. 2007
    ..To investigate the joint role of the 48-base pair repeat polymorphism of the dopamine receptor 4 gene (DRD4) and environmental factors in body mass variation among an ethnically diverse sample of U.S. adolescents and young adults...
  11. pmc Variation in the checkpoint kinase 2 gene is associated with type 2 diabetes in multiple populations
    Kari E North
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA
    Acta Diabetol 47:199-207. 2010
    ..These results may suggest a new pathway in the pathogenesis of type 2 diabetes that involves pancreatic beta-cell damage and apoptosis...
  12. ncbi request reprint A quantitative trait loci-specific gene-by-sex interaction on systolic blood pressure among American Indians: the Strong Heart Family Study
    Nora Franceschini
    Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Bank of America Center, Chapel Hill, NC 27514 3628, USA
    Hypertension 48:266-70. 2006
    ..8 in women). Accounting for interaction with sex improved our ability to detect QTLs and demonstrated the importance of considering genotype-by-sex interaction in our search for blood pressure genes...
  13. pmc Social- and behavioral-specific genetic effects on blood pressure traits: the Strong Heart Family Study
    Nora Franceschini
    Department of Epidemiology, University of North Carolina Chapel Hill, 137 E Franklin St, Suite 306 CB 8050, Chapel Hill, NC 27514, USA
    Circ Cardiovasc Genet 2:396-401. 2009
    ..Accounting for the genetic interaction of these factors may help to identify common BP susceptibility alleles...
  14. doi request reprint Angiotensin II type 1 receptor polymorphisms and susceptibility to hypertension: a HuGE review
    Amy K Mottl
    Division of Nephrology and Hypertension, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA
    Genet Med 10:560-74. 2008
    ..In conclusion, there is insufficient evidence that polymorphisms in the AGTR1 gene are risk factors for hypertension. However, most studies are inadequately powered, and larger well-designed studies of haplotypes are warranted...
  15. pmc Linkage analysis of albuminuria
    Amy K Mottl
    UNC Kidney Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7155, USA
    J Am Soc Nephrol 20:1597-606. 2009
    ..4) and 10q25.1 using model 2 (logarithm of odds = 3.3). These loci replicate findings from multiple other genome scans of kidney disease phenotypes with distinct populations and are worthy of further study...
  16. ncbi request reprint Genotype-by-sex interaction on fasting insulin concentration: the HyperGEN study
    Kari E North
    Department of Epidemiology, University of North Carolina Chapel Hill, Bank of America Center, 137 E Franklin St, Suite 306, Chapel Hill, NC 27514, USA
    Diabetes 56:137-42. 2007
    ..2) female subjects. Our findings overlap with several other linkage reports of insulin-related traits and demonstrate the importance of considering complex context-dependent interactions in the search for insulin-related genes...
  17. pmc Longitudinal impact of physical activity on lipid profiles in middle-aged adults: the Atherosclerosis Risk in Communities Study
    Keri L Monda
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA
    J Lipid Res 50:1685-91. 2009
    ..Overall our results highlight the importance of physical activity on plasma lipid profiles and provide evidence for novel differential associations...
  18. ncbi request reprint Val153Met polymorphism of catechol-O-methyltransferase and prevalence of uterine leiomyomata
    Kyna M Gooden
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
    Reprod Sci 14:117-20. 2007
    ..This study suggests that variation in this polymorphism alone does not affect fibroid prevalence. Additional research is needed to examine other variations and haplotypes within the COMT gene...
  19. pmc Linkage analysis of glomerular filtration rate in American Indians
    Amy K Mottl
    UNC Kidney Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7155, USA
    Kidney Int 74:1185-91. 2008
    ..This evidence for linkage of a quantitative trait locus influencing estimated glomerular filtration rate to a region of chromosome 12p in a large cohort of American Indians will be worth studying in more detail in the future...
  20. pmc Diabetes-specific genetic effects on obesity traits in American Indian populations: the Strong Heart Family Study
    Nora Franceschini
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA
    BMC Med Genet 9:90. 2008
    ..1.4)...
  21. pmc Genome-wide linkage analysis of pulse pressure in American Indians: the Strong Heart Study
    Nora Franceschini
    Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA
    Am J Hypertens 21:194-9. 2008
    ..Pulse pressure, a measure of central arterial stiffness and a predictor of cardiovascular mortality, has known genetic components...
  22. pmc Comparison of strategies for identification of regulatory quantitative trait loci of transcript expression traits
    Nora Franceschini
    Department of Epidemiology, University of North Carolina Chapel Hill, Bank of America Center, 137 East Franklin Street, Suite 306, CB 8050, Chapel Hill, North Carolina 27514, USA
    BMC Proc 1:S85. 2007
    ..Similar results were found in analysis of 12 transcripts, that had co-localized QTLs in the 13q34 region. Principal-component analyses did not improve the ability to identify chromosomal regions of co-localized gene expressions...
  23. pmc Association of adolescent obesity with risk of severe obesity in adulthood
    Natalie S The
    Departments of Nutrition, Carolina Population Center, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27516 3997, USA
    JAMA 304:2042-7. 2010
    ....
  24. pmc Accuracy of haplotype estimation in a region of low linkage disequilibrium
    Christy L Avery
    Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA
    BMC Genet 6:S80. 2005
    ....
  25. ncbi request reprint Linkage analysis of factors underlying insulin resistance: Strong Heart Family Study
    Kari E North
    Department of Epidemiology, University of North Carolina, Chapel Hill, Bank of America Center, 137 E Franklin Street, Suite 306, NC 27514, USA
    Obes Res 13:1877-84. 2005
    ..The corroboration of existing QTLs will bring us closer to the identification of the functional genes that predispose to IR...
  26. ncbi request reprint Genetic and environmental contributions to cardiovascular disease risk in American Indians: the strong heart family study
    Kari E North
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX, USA
    Am J Epidemiol 157:303-14. 2003
    ..34)). These results suggest that heredity explains a substantial proportion of the variability of CVD risk factors and that these heritabilities are large enough to warrant a search for major risk factor genes...
  27. ncbi request reprint Evidence for distinct genetic effects on obesity and lipid-related CVD risk factors in diabetic compared to nondiabetic American Indians: the Strong Heart Family Study
    Kari E North
    Department of Epidemiology, University of North Carolina, Chapel Hill, Bank of America Center, North Carolina 27514 3628, USA
    Diabetes Metab Res Rev 19:140-7. 2003
    ..The purpose of the present paper is to determine whether the genetic effects on CVD risk factors in the SHFS are different in diabetic and nondiabetic individuals...
  28. pmc The association of cell cycle checkpoint 2 variants and kidney function: findings of the Family Blood Pressure Program and the Atherosclerosis Risk In Communities study
    Nora Franceschini
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Am J Hypertens 22:552-8. 2009
    ..The checkpoint 2 gene (CHEK2) is an important transducer in DNA damage signaling pathways in response to injury, and therefore, CHEK2 variants may affect susceptibility to kidney disease...
  29. ncbi request reprint Evidence for genetic factors underlying the insulin resistance syndrome in american indians
    Kari E North
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Obes Res 11:1444-8. 2003
    ..These results suggest that heredity explains a substantial proportion of the variability of the factors that underlie the insulin resistance syndrome in American Indians and that these factors are genetically independent...
  30. pmc Obesity and diabetes genetic variants associated with gestational weight gain
    Alison M Stuebe
    Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, NC, USA
    Am J Obstet Gynecol 203:283.e1-17. 2010
    ..We sought to determine whether genetic variants associated with diabetes and obesity predict gestational weight gain...
  31. pmc Longitudinal age-dependent effect on systolic blood pressure
    Bonnie R Joubert
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, 2101 McGavran Greenberg Hall, CB 7435, Chapel Hill, North Carolina 27599, USA
    BMC Proc 3:S87. 2009
    ..The value of the 2-df test for screening genetic interaction effects could not be established in this study...
  32. pmc HDL cholesterol in females in the Framingham Heart Study is linked to a region of chromosome 2q
    Kari E North
    Department of Epidemiology, University of North Carolina, Chapel Hill 27514 USA
    BMC Genet 4:S98. 2003
    ....
  33. ncbi request reprint Evidence for a gene on chromosome 13 influencing postural systolic blood pressure change and body mass index
    Kari E North
    Department of Epidemiology, University of North Carolina Chapel Hill, Bank of America Center, 137 E Franklin St, Suite 306, Chapel Hill, NC 27514, USA
    Hypertension 43:780-4. 2004
    ..4 and 0.9, respectively). These findings suggest that a gene(s) on chromosome 13q jointly regulates the SBP response to postural change and BMI...
  34. pmc The association of the MYH9 gene and kidney outcomes in American Indians: the Strong Heart Family Study
    Nora Franceschini
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27514, USA
    Hum Genet 127:295-301. 2010
    ..Identification of the actual functional genetic variation responsible for the associations seen in African-Americans will likely help to clarify the lack of replication of this gene in our population of American Indians...
  35. pmc Genetic association studies and the effect of misclassification and selection bias in putative confounders
    Christy L Avery
    Department of Epidemiology, University of North Carolina, 137 East Franklin Street, CB 8050, Suite 306, Chapel Hill, North Carolina 27514 USA
    BMC Proc 3:S48. 2009
    ..These results support careful consideration of how well a study population represents the target population because selection bias may result even when associations are modest...
  36. ncbi request reprint The genetics of obesity and the metabolic syndrome
    Keri L Monda
    Department of Epidemiology, University of North Carolina at Chapel Hill, USA
    Endocr Metab Immune Disord Drug Targets 10:86-108. 2010
    ..We provide also a gene network analysis of recent variants related to obesity and metabolic syndrome discovered through genome-wide association studies, and 4 gene networks based on searching the NCBI database...
  37. ncbi request reprint Evidence for a gene influencing fasting LDL cholesterol and triglyceride levels on chromosome 21q
    Kari E North
    Department of Epidemiology, University of North Carolina, Bank of America Center, 137 E Franklin St, Suite 306, Chapel Hill, NC 27514, USA
    Atherosclerosis 179:119-25. 2005
    ....
  38. pmc Comparison of genome-wide variation between Malawians and African ancestry HapMap populations
    Bonnie R Joubert
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599, USA
    J Hum Genet 55:366-74. 2010
    ..Five SNPs within the lactase gene (LCT) had substantially different allele frequencies between the Malawi population and Maasai in Kenyawa, Kenya (rs3769013, rs730005, rs3769012, rs2304370; P-values <1 x 10(-33))...
  39. pmc Regulation of CCR5 expression in human placenta: insights from a study of mother-to-child transmission of HIV in Malawi
    Bonnie R Joubert
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, United States of America
    PLoS ONE 5:e9212. 2010
    ..Placental expression of CCR5 may be influenced by such polymorphisms as well as other in vivo regulatory factors...
  40. ncbi request reprint DNA repair polymorphisms XRCC1 and MGMT and risk of adult gliomas
    Martha J Felini
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA
    Neuroepidemiology 29:55-8. 2007
    ..26; CI 0.90-1.75) and the MGMT Ile143Val polymorphism (Ile or Val/Val versus Ile/Ile: adjusted OR = 1.20; CI 0.85-1.71)...
  41. ncbi request reprint Quantitative effects of common genetic variations in the 3'UTR of the human LDL-receptor gene and their associations with plasma lipid levels in the Atherosclerosis Risk in Communities study
    Hind Muallem
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599 7525, USA
    Hum Genet 121:421-31. 2007
    ....
  42. ncbi request reprint Linkage analysis of diabetes status among hypertensive families: the Hypertension Genetic Epidemiology Network study
    Christy L Avery
    Department of Epidemiology, University of North Carolina Chapel Hill, Chapel Hill, NC 27514, USA
    Diabetes 53:3307-12. 2004
    ..The identification and replication of type 2 diabetes QTLs will bring us closer to the detection of functional genes that influence diabetes susceptibility...
  43. pmc Peroxisome proliferator-activated receptor-alpha (PPARA) genetic polymorphisms and breast cancer risk: a Long Island ancillary study
    Amanda K Golembesky
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC 27599, USA
    Carcinogenesis 29:1944-9. 2008
    ..Our results are the first to evaluate the relationship between PPARA and breast cancer incidence and suggest that replication in an independent cohort is warranted...
  44. doi request reprint The DRD3 rs6280 polymorphism and prevalence of tardive dyskinesia: a meta-analysis
    Huei Ting Tsai
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Am J Med Genet B Neuropsychiatr Genet 153:57-66. 2010
    ..Under the recessive model, the summary estimate was POR = 0.93 (95% confidence interval: 0.70-1.23). We conclude that there is no or little association between DRD3 rs6280 polymorphisms and prevalence of TD...
  45. ncbi request reprint Genetic polymorphisms and the progression of liver fibrosis: a critical appraisal
    Ramon Bataller
    Department of Medicine, Biochemistry and Biophysics, University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, NC 27599, USA
    Hepatology 37:493-503. 2003
    ..Large-scale, well-designed studies are required to clarify the actual role of this factor and other genetic variants in liver fibrosis...
  46. pmc Linkage study of fibrinogen levels: the Strong Heart Family Study
    Lyle G Best
    Missouri Breaks Industries Research Inc, Timber Lake, SD, USA
    BMC Med Genet 9:77. 2008
    ..The Strong Heart Study has demonstrated an increased incidence of cardiovascular disease in the American Indian population, and therefore represents an important source for genetic-epidemiological investigations...
  47. pmc TCF7L2 variants associate with CKD progression and renal function in population-based cohorts
    Anna Kottgen
    Department of Epidemiology and Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, Maryland, USA
    J Am Soc Nephrol 19:1989-99. 2008
    ..In conclusion, several population-based samples suggest that variants in the TCF7L2 gene are associated with reduced kidney function or CKD progression, overall and specifically among participants without diabetes...
  48. ncbi request reprint Genetic influences on aortic root size in American Indians: the Strong Heart Study
    Jonathan N Bella
    Department of Medicine, Weill Medical College of Cornell University, New York, NY, USA
    Arterioscler Thromb Vasc Biol 22:1008-11. 2002
    ..Echocardiographic screening of family members with aortic root dilatation may identify other individuals predisposed to aortic dissection or rupture...
  49. pmc Factor relationships of metabolic syndrome and echocardiographic phenotypes in the HyperGEN study
    Pinchia Huang
    Division of Biostatistics, Washington University School of Medicine, Saint Louis, MO 63110, USA
    J Hypertens 26:1360-6. 2008
    ..Metabolic syndrome and its risk factors are predictors of cardiovascular events. Metabolic syndrome is also directly associated with echocardiographic phenotypes...
  50. ncbi request reprint A population association study of angiotensinogen polymorphisms and haplotypes with left ventricular phenotypes
    Laura J Rasmussen-Torvik
    Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA
    Hypertension 46:1294-9. 2005
    ..The single SNP association was driven by a large group of SNPs in high linkage disequilibrium that includes the promoter SNP rs5051...
  51. ncbi request reprint Use of nonsteroidal antiinflammatory drugs and risk of colon cancer in a population-based, case-control study of African Americans and Whites
    Leah B Sansbury
    Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 8325, USA
    Am J Epidemiol 162:548-58. 2005
    ..These results add new knowledge suggesting that the protective effect of NSAIDs against colon cancer is similar among African Americans and Whites...
  52. ncbi request reprint Pleiotropic QTL on chromosome 19q13 for triglycerides and adiposity: the HERITAGE Family Study
    Mary F Feitosa
    Division of Biostatistics, Washington University School of Medicine, Campus Box 8067, 660 S Euclid, St Louis, MO 63110 1093, USA
    Atherosclerosis 185:426-32. 2006
    ..Polymorphisms in the APOE gene, and possibly LIPE gene, appear to be strong candidates for the source of this pleiotropic QTL...
  53. ncbi request reprint Hysterectomy prevalence and cardiovascular disease risk factors in American Indian women
    Ying Zhang
    Center for American Indian Health Research, University of Oklahoma Health Sciences Center, P O Box 26901, Oklahoma City, OK 73190, USA
    Maturitas 52:328-36. 2005
    ..We investigated hysterectomy prevalence and associated demographic and reproductive factors among American Indian women. The association between hysterectomy and cardiovascular disease (CVD) risk factors was also examined...
  54. ncbi request reprint Genome-wide linkage analysis replicates susceptibility locus for fasting plasma triglycerides: NHLBI Family Heart Study
    Donna K Arnett
    Division of Epidemiology, University of Minnesota, 1300 South Second Street, Suite 300, Minneapolis, MN 55454, USA
    Hum Genet 115:468-74. 2004
    ..Chromosome 15 likely harbors a susceptibility locus with an influence on triglycerides and HDL. Regions on chromosomes 6 and 8 may also contain loci contributing to inter-individual variation in plasma triglycerides...
  55. pmc Phenotypic, genetic, and genome-wide structure in the metabolic syndrome
    Lisa J Martin
    Center for Epidemiology and Biostatistics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, 45229, USA
    BMC Genet 4:S95. 2003
    ..We next applied factor analysis to summarize the relationship between these phenotypes...
  56. ncbi request reprint Prospective analysis of mannose-binding lectin genotypes and coronary artery disease in American Indians: the Strong Heart Study
    Lyle G Best
    Missouri Breaks Industries Research Inc, Timber Lake, SD, USA
    Circulation 109:471-5. 2004
    ..After a preliminary report associating these variations with coronary artery disease (CAD), we determined MBL genotypes in 3 American Indian communities experiencing an increased mortality and morbidity from CAD...
  57. ncbi request reprint Analysis of metabolic syndrome phenotypes in Framingham Heart Study families from Genetic Analysis Workshop 13
    Lynn R Goldin
    Genetic Epidemiology Branch, DCEG, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 7236, USA
    Genet Epidemiol 25:S78-89. 2003
    ..Over 40 genome-wide linkage analyses were conducted. Despite the broad range of approaches, several regions of the genome were repeatedly identified across multiple analyses...
  58. ncbi request reprint Meta-analysis of genome-wide linkage studies for quantitative lipid traits in African Americans
    Alka Malhotra
    Diabetes and Obesity Research Unit, Translational Genomics Research Institute, Phoenix, AZ 85004, USA
    Hum Mol Genet 14:3955-62. 2005
    ..0429) for TG. Statistically significant evidence for linkage and low heterogeneity on chromosome 1q therefore suggest that this region may harbor a gene underlying the inheritance of LDL in African Americans...
  59. pmc Genetic variation in soluble epoxide hydrolase (EPHX2) and risk of coronary heart disease: The Atherosclerosis Risk in Communities (ARIC) study
    Craig R Lee
    Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health Research, Triangle Park, NC 27709, USA
    Hum Mol Genet 15:1640-9. 2006
    ..315). Genetic variation in EPHX2 was significantly associated with risk of incident CHD in Caucasians, implicating EPHX2 as a potential cardiovascular disease-susceptibility gene...
  60. ncbi request reprint Linkage analysis of a composite factor for the multiple metabolic syndrome: the National Heart, Lung, and Blood Institute Family Heart Study
    Weihong Tang
    Division of Epidemiology, University of Minnesota, Minneapolis 55454, USA
    Diabetes 52:2840-7. 2003
    ..34 at 240 cM. Suggestive linkage was also observed for regions on chromosomes 7, 12, 14, and 15. In summary, a genomic region on chromosome 2 may contain a pleiotropic locus contributing to the clustering of MMS-related phenotypes...
  61. ncbi request reprint Body mass index gain, fast food, and physical activity: effects of shared environments over time
    Melissa C Nelson
    Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, USA
    Obesity (Silver Spring) 14:701-9. 2006
    ....
  62. ncbi request reprint Genome scan of glomerular filtration rate and albuminuria: the HyperGEN study
    Joanlise M Leon
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, USA
    Nephrol Dial Transplant 22:763-71. 2007
    ..We performed genome-wide scans to detect loci impacting these parameters in 1251 African American (AAs) and 1129 European American (EAs) hypertensive siblings from the Hypertension Genetic Epidemiology Network study...
  63. pmc CYP2J2 and CYP2C8 polymorphisms and coronary heart disease risk: the Atherosclerosis Risk in Communities (ARIC) study
    Craig R Lee
    Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Pharmacogenet Genomics 17:349-58. 2007
    ..The cytochromes P450 epoxygenases CYP2J2 and CYP2C8 synthesize epoxyeicosatrienoic acids, which regulate endothelial function. We sought to determine if genetic variation in CYP2J2 and CYP2C8 was associated with coronary heart disease risk...
  64. ncbi request reprint Sex-specific effects of ACE I/D and AGT-M235T on pulse pressure: the HyperGEN Study
    Amy I Lynch
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA
    Hum Genet 122:33-40. 2007
    ..This evidence for a genotype-by-sex interaction helps our understanding of the complex genetic underpinnings of blood pressure phenotypes...
  65. ncbi request reprint GSTM1 and GSTT1 polymorphisms, cigarette smoking, and risk of colon cancer: a population-based case-control study in North Carolina (United States)
    Kui Huang
    Global Epidemiology, Pfizer Inc, Mail stop 150 3 80, 235 East 42nd Street, New York City, NY 10017 575, USA
    Cancer Causes Control 17:385-94. 2006
    ..GSTT1 and GSTM1 polymorphisms may be weakly related to colon cancer risk and there may be racial differences in gene-smoking interactions...
  66. doi request reprint Genome-wide admixture mapping for coronary artery calcification in African Americans: the NHLBI Family Heart Study
    Qunyuan Zhang
    Division of Statistical Genomics, Washington University School of Medicine, St Louis, Missouri 63108, USA
    Genet Epidemiol 32:264-72. 2008
    ..On the basis of the results from this and other independent studies, the location of D6S1053 at 80cM on chromosome 6 (6q12) seems to harbor a highly promising quantitative trait loci for atherosclerosis...
  67. doi request reprint Relation of albuminuria to left ventricular mass (from the HyperGEN Study)
    Luc Djousse
    Division of Aging, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Am J Cardiol 101:212-6. 2008
    ..In conclusion, these results suggest that albuminuria is positively associated with LV mass in normotensive subjects as it is in hypertensive subjects...
  68. ncbi request reprint Multiple testing in the genomics era: findings from Genetic Analysis Workshop 15, Group 15
    Lisa J Martin
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Genet Epidemiol 31:S124-31. 2007
    ..We show that while each approach may have certain advantages, adequate error control is largely dependent upon the question under consideration and often requires the use of multiple analytic strategies...
  69. ncbi request reprint Heritability of left ventricular dimensions and mass in American Indians: The Strong Heart Study
    Jonathan N Bella
    Weill Medical College of Cornell University, New York, New York, USA
    J Hypertens 22:281-6. 2004
    ..We sought to determine the heritability of left ventricular dimensions and mass in adult American Indians...
  70. pmc Association of sICAM-1 and MCP-1 with coronary artery calcification in families enriched for coronary heart disease or hypertension: the NHLBI Family Heart Study
    Weihong Tang
    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA
    BMC Cardiovasc Disord 7:30. 2007
    ..In the follow-up exam of the NHLBI Family Heart Study, we evaluated whether plasma levels of sICAM-1 and MCP-1 were associated with coronary artery calcification (CAC), a measure of the burden of coronary atherosclerosis...
  71. ncbi request reprint Genetic determination of acute phase reactant levels: the strong heart study
    Lyle G Best
    Missouri Breaks Industries Research Inc, Timber Lake, SD, USA
    Hum Hered 58:112-6. 2004
    ..We sought to determine the relative contributions of genetic and environmental factors influencing basal serum levels of APRs...
  72. ncbi request reprint COX-2 polymorphism, use of nonsteroidal anti-inflammatory drugs, and risk of colon cancer in African Americans (United States)
    Leah B Sansbury
    Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892 8325, USA
    Cancer Causes Control 17:257-66. 2006
    ..We explored the association between the COX-2 Val511Ala SNP and risk of colon cancer among 240 African American cases and 326 African American controls in a population-based, case-control study in North Carolina...

Research Grants7

  1. HYPERGEN-NC
    Kari North; Fiscal Year: 2004
    ..The resulting synthesis of ideas and amassed data permits rigorous hypothesis testing not otherwise possible and will hasten understanding of the previously elusive genetic variation responsible for disease risk. ..
  2. Gene-by-Smoking Interaction and Risk of Atherosclerosis
    Kari North; Fiscal Year: 2005
    ..The findings are expected to be of clinical and public health significance. ..
  3. Comprehensive Mapping of a Blood Pressure QTL on Chromosome 17
    Kari E North; Fiscal Year: 2010
    ..The proposed study may expand our understanding of the impact of the genes on the natural history of hypertension and mechanisms of blood pressure control. ..