Jill Norris

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. pmc Genome scan linkage results for longitudinal systolic blood pressure phenotypes in subjects from the Framingham Heart Study
    Katherine James
    Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, Colorado, USA
    BMC Genet 4:S83. 2003
  2. pmc Comparison between two analytic strategies to detect linkage to obesity with genetically determined age of onset: the Framingham Heart Study
    Corinne D Engelman
    Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, Colorado, USA
    BMC Genet 4:S90. 2003
  3. ncbi Risk of celiac disease autoimmunity and timing of gluten introduction in the diet of infants at increased risk of disease
    Jill M Norris
    Department of Preventive Medicine and Biometrics, University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA
    JAMA 293:2343-51. 2005
  4. ncbi Timing of initial exposure to cereal grains and the risk of wheat allergy
    Jill A Poole
    Division of Allergy and Clinical Immunology, Department of Medicine and Pediatrics, National Jewish Medical and Research Center, Denver, Colorado, USA
    Pediatrics 117:2175-82. 2006
  5. ncbi Quantitative trait loci for abdominal fat and BMI in Hispanic-Americans and African-Americans: the IRAS Family study
    J M Norris
    Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Int J Obes (Lond) 29:67-77. 2005
  6. ncbi Omega-3 polyunsaturated fatty acid intake and islet autoimmunity in children at increased risk for type 1 diabetes
    Jill M Norris
    Department of Preventive Medicine and Biostatistics, University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA
    JAMA 298:1420-8. 2007
  7. ncbi Timing of initial cereal exposure in infancy and risk of islet autoimmunity
    Jill M Norris
    Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver 80262, USA
    JAMA 290:1713-20. 2003
  8. ncbi Elevated C-reactive protein levels in the development of type 1 diabetes
    H Peter Chase
    Department of Pediatrics, The Barbara Davis Center for Childhood Diabetes, Denver, Colorado, USA
    Diabetes 53:2569-73. 2004
  9. ncbi Rapid mass spectrometric analysis for ascorbate and related organic acids in small volumes of plasma for use in pediatric subjects
    J C Deutsch
    Department of Medicine, Denver Veterans Affairs Hospital and University of Colorado Health Sciences Center, 80220, USA
    J Chromatogr B Biomed Sci Appl 726:79-84. 1999
  10. ncbi Lack of association between early childhood immunizations and beta-cell autoimmunity
    P M Graves
    Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver 80262, USA
    Diabetes Care 22:1694-7. 1999

Detail Information

Publications67

  1. pmc Genome scan linkage results for longitudinal systolic blood pressure phenotypes in subjects from the Framingham Heart Study
    Katherine James
    Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, Colorado, USA
    BMC Genet 4:S83. 2003
    ....
  2. pmc Comparison between two analytic strategies to detect linkage to obesity with genetically determined age of onset: the Framingham Heart Study
    Corinne D Engelman
    Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, Colorado, USA
    BMC Genet 4:S90. 2003
    ..The first is to consider a person affected if they possess the trait before a certain age (an early age of onset phenotype). The second is to define the phenotype based on the residual from a survival analysis...
  3. ncbi Risk of celiac disease autoimmunity and timing of gluten introduction in the diet of infants at increased risk of disease
    Jill M Norris
    Department of Preventive Medicine and Biometrics, University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA
    JAMA 293:2343-51. 2005
    ..While gluten ingestion is responsible for the signs and symptoms of celiac disease, it is not known what factors are associated with initial appearance of the disease...
  4. ncbi Timing of initial exposure to cereal grains and the risk of wheat allergy
    Jill A Poole
    Division of Allergy and Clinical Immunology, Department of Medicine and Pediatrics, National Jewish Medical and Research Center, Denver, Colorado, USA
    Pediatrics 117:2175-82. 2006
    ..The aim of this study was to examine the association between cereal-grain exposures (wheat, barley, rye, oats) in the infant diet and development of wheat allergy...
  5. ncbi Quantitative trait loci for abdominal fat and BMI in Hispanic-Americans and African-Americans: the IRAS Family study
    J M Norris
    Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Int J Obes (Lond) 29:67-77. 2005
    ..To conduct linkage analysis for body mass index (BMI, kg/m2), waist-to-hip ratio (WHR), visceral adipose tissue mass (VAT, cm2) and subcutaneous adipose tissue mass (SAT, cm2) using a whole genome scan...
  6. ncbi Omega-3 polyunsaturated fatty acid intake and islet autoimmunity in children at increased risk for type 1 diabetes
    Jill M Norris
    Department of Preventive Medicine and Biostatistics, University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA
    JAMA 298:1420-8. 2007
    ..Cod liver oil supplements in infancy have been associated with a decreased risk of type 1 diabetes mellitus in a retrospective study...
  7. ncbi Timing of initial cereal exposure in infancy and risk of islet autoimmunity
    Jill M Norris
    Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver 80262, USA
    JAMA 290:1713-20. 2003
    ..Dietary exposures in infancy have been implicated, albeit inconsistently, in the etiology of type 1 diabetes mellitus (DM)...
  8. ncbi Elevated C-reactive protein levels in the development of type 1 diabetes
    H Peter Chase
    Department of Pediatrics, The Barbara Davis Center for Childhood Diabetes, Denver, Colorado, USA
    Diabetes 53:2569-73. 2004
    ..The elevated CRP levels may provide an additional marker for risk of progression to type 1 diabetes...
  9. ncbi Rapid mass spectrometric analysis for ascorbate and related organic acids in small volumes of plasma for use in pediatric subjects
    J C Deutsch
    Department of Medicine, Denver Veterans Affairs Hospital and University of Colorado Health Sciences Center, 80220, USA
    J Chromatogr B Biomed Sci Appl 726:79-84. 1999
    ..Analysis on 28 subjects fell within the expected range for plasma ascorbate 68+/-29 microm (11.9+/-5.0 microg/ml) and established a normal range for plasma threonate of 28.1+/-2.4 microm (3.8+/-0.4 microg/ml)...
  10. ncbi Lack of association between early childhood immunizations and beta-cell autoimmunity
    P M Graves
    Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver 80262, USA
    Diabetes Care 22:1694-7. 1999
    ..To determine whether early childhood immunization history affects the risk of developing the beta-cell autoimmunity that precedes type 1 diabetes...
  11. ncbi Epidemiology of type 1 Diabetes Mellitus
    Marian Rewers
    Barbara Davis Center for Childhood Diabetes, University of Colorado, Health Sciences Center, Denver, USA
    Adv Exp Med Biol 552:219-46. 2004
    ..Current research effort is focused on identification of the genetic and environmental determinants of this process and the ways they interact...
  12. pmc An exploration of Glo-3A antibody levels in children at increased risk for type 1 diabetes mellitus
    M Simpson
    Department of Epidemiology, Colorado School of Public Health, Colorado, USA
    Pediatr Diabetes 10:563-72. 2009
    ....
  13. ncbi Investigation of a candidate gene, environment, and G x E interaction using case-control and case-parent study designs
    J M Norris
    Univ. of Colorado Health Sci. Center, Department of Preventive Medicine and Biometrics, 4200 East Ninth Ave, Box C245, Denver, CO 80262, USA
    Genet Epidemiol 21:S843-8. 2001
    ..Using the case-parent study design in the same population, we detected association between SNPs within CG1 and disease, but no G x E interaction was detected...
  14. pmc Comparison between omega-3 and omega-6 polyunsaturated fatty acid intakes as assessed by a food frequency questionnaire and erythrocyte membrane fatty acid composition in young children
    H D Orton
    Department of Preventive Medicine and Biometrics, University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA
    Eur J Clin Nutr 62:733-8. 2008
    ....
  15. ncbi Maternal risk factors for term neonatal seizures: population-based study in Colorado, 1989-2003
    Deborah A Hall
    Department of Neurology, University of Colorado at Denver and Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    J Child Neurol 21:795-8. 2006
    ..Maternal diabetic vasculopathy can also be a contributing factor...
  16. pmc Extreme genetic risk for type 1A diabetes
    Theresa A Aly
    Barbara Davis Center for Childhood Diabetes and Human Medical Genetics Program, University Colorado Health Sciences Center, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 103:14074-9. 2006
    ..A subset of siblings at extremely high risk for T1D can now be identified at birth for trials to prevent islet autoimmunity...
  17. pmc Genetic and environmental determinants of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels in Hispanic and African Americans
    Corinne D Engelman
    Department of Population Health Sciences, University of Wisconsin School of Medicine and Public Health, 610 Walnut Street, 1007A WARF, Madison, Wisconsin 53726 2397, USA
    J Clin Endocrinol Metab 93:3381-8. 2008
    ..Vitamin D deficiency is associated with many adverse health outcomes, yet little is known about the genetic epidemiology of vitamin D or its metabolites...
  18. pmc Rheumatoid factor seropositivity is inversely associated with oral contraceptive use in women without rheumatoid arthritis
    Shailaja S Bhatia
    Department of Preventive Medicine and Biometrics, University of Colorado at Denver and Health Sciences Center, Denver, 4200 East Ninth Avenue, Box B119, Denver, CO 80262, USA
    Ann Rheum Dis 66:267-9. 2007
    ..To examine whether oral contraceptive use is associated with the presence of serum rheumatoid factor in women of reproductive age without rheumatoid arthritis...
  19. ncbi Increasing incidence of type 1 diabetes in 0- to 17-year-old Colorado youth
    Kendra Vehik
    University of Colorado School of Medicine, Denver, Colorado, USA
    Diabetes Care 30:503-9. 2007
    ....
  20. doi Maternal diet during pregnancy and islet autoimmunity in offspring
    Molly M Lamb
    Department of Preventive Medicine and Biometrics, University of Colorado at Denver and Health Sciences Center, Denver, CO, USA
    Pediatr Diabetes 9:135-41. 2008
    ..The role of prenatal nutritional exposures has not been thoroughly investigated...
  21. ncbi Genome-wide linkage of plasma adiponectin reveals a major locus on chromosome 3q distinct from the adiponectin structural gene: the IRAS family study
    Xiuqing Guo
    Medical Genetics Institutes, Cedars Sinai Medical Center, 8700 Beverly Blvd, 665W, Los Angeles, CA 90048, USA
    Diabetes 55:1723-30. 2006
    ..Therefore, a quantitative trait locus at 3q27, likely distinct from the APM1 gene, contributes to the variation of plasma adiponectin levels in the Hispanic-American population...
  22. ncbi Genetic mapping of disposition index and acute insulin response loci on chromosome 11q. The Insulin Resistance Atherosclerosis Study (IRAS) Family Study
    Nicholette D Palmer
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Diabetes 55:911-8. 2006
    ..These detailed genetic analyses provide strong evidence of a DI locus on 11q in African-American pedigrees, with additional suggestive evidence of independent AIR loci in the same region...
  23. ncbi Genetic prediction of autoimmunity: initial oligogenic prediction of anti-islet autoimmunity amongst DR3/DR4-DQ8 relatives of patients with type 1A diabetes
    Theresa A Aly
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Avenue B 140, Denver, CO 80262, USA
    J Autoimmun 25:40-5. 2005
    ..These results highlight the multiplicative risk of combined high-risk genotypes at different loci in terms of time to autoantibody and autoimmune disease development...
  24. ncbi Rotavirus infection frequency and risk of celiac disease autoimmunity in early childhood: a longitudinal study
    Lars C Stene
    Barbara Davis Center for Childhood Diabetes, University of Colorado School of Medicine, Aurora, Colorado 80045 6511, USA
    Am J Gastroenterol 101:2333-40. 2006
    ..We investigated whether increased frequency of rotavirus infection, a common cause of gastrointestinal infection and inflammation, predicts increased risk of celiac disease autoimmunity...
  25. ncbi Normal but increasing hemoglobin A1c levels predict progression from islet autoimmunity to overt type 1 diabetes: Diabetes Autoimmunity Study in the Young (DAISY)
    Lars C Stene
    Barbara Davis Center for Childhood Diabetes, University of Colorado School of Medicine, Aurora, CO 80045 6511, USA
    Pediatr Diabetes 7:247-53. 2006
    ..The aim of this study was to assess the utility of hemoglobin A1c (HbA1c) measurements in the early detection of clinical type 1 diabetes during prospective follow-up of children with islet autoimmunity...
  26. ncbi Genome-wide association: which do you want first: the good news, the bad news, or the good news?
    Kent D Taylor
    Medical Genetics Institute, Cedars Sinai Medical Center, 8700 Beverly Blvd, Suite 665, West Los Angeles, California 90048 1804, USA
    Diabetes 56:2844-8. 2007
  27. pmc Association of TCF7L2 gene polymorphisms with reduced acute insulin response in Hispanic Americans
    Nicholette D Palmer
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Clin Endocrinol Metab 93:304-9. 2008
    ..Genetic variation at the transcription factor 7-like 2 locus has been linked to type 2 diabetes in predominantly European-derived populations. The biological basis of these associations remains to be determined...
  28. ncbi Genetic epidemiology of insulin resistance and visceral adiposity. The IRAS Family Study design and methods
    Leora Henkin
    Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Ann Epidemiol 13:211-7. 2003
    ..In this report, we describe the methods of the IRAS Family Study, which was designed to identify the genetic and environmental risk factors for insulin resistance and visceral adiposity...
  29. ncbi The PPARgamma Pro12Ala polymorphism is not associated with body mass index or waist circumference among Hispanics from Colorado
    Tracy L Nelson
    Department of Health and Exercise Science, Colorado State University, Fort Collins, CO 80523, USA
    Ann Nutr Metab 51:252-7. 2007
    ....
  30. ncbi HLA-DPB1*0402 protects against type 1A diabetes autoimmunity in the highest risk DR3-DQB1*0201/DR4-DQB1*0302 DAISY population
    Erin E Baschal
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, CO 80045 6511, USA
    Diabetes 56:2405-9. 2007
    ....
  31. ncbi Mortality from pulmonary fibrosis increased in the United States from 1992 to 2003
    Amy L Olson
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver Colorado 80262, USA
    Am J Respir Crit Care Med 176:277-84. 2007
    ..From the late 1970s to the early 1990s, studies found that mortality rates for pulmonary fibrosis were increasing. Recent data for mortality from pulmonary fibrosis are unavailable...
  32. doi Quantitative trait analysis of type 2 diabetes susceptibility loci identified from whole genome association studies in the Insulin Resistance Atherosclerosis Family Study
    Nicholette D Palmer
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Diabetes 57:1093-100. 2008
    ....
  33. pmc Trends in high-risk HLA susceptibility genes among Colorado youth with type 1 diabetes
    Kendra Vehik
    University of Colorado Denver, School of Medicine, Denver, Colorado, USA
    Diabetes Care 31:1392-6. 2008
    ....
  34. ncbi Associations of adiponectin with body fat distribution and insulin sensitivity in nondiabetic Hispanics and African-Americans
    Anthony J G Hanley
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada M5S 3E2
    J Clin Endocrinol Metab 92:2665-71. 2007
    ....
  35. doi VDR and SRD5A2 polymorphisms combine to increase risk for prostate cancer in both non-Hispanic White and Hispanic White men
    Kathleen C Torkko
    Department of Pathology, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado 80045, USA
    Clin Cancer Res 14:3223-9. 2008
    ..This study tested the interactions of VDR (CDX2, FokI) and SRD5A2 (V89L, A49T) polymorphisms, and their associations with prostate cancer...
  36. pmc Perinatal and early childhood risk factors associated with rheumatoid factor positivity in a healthy paediatric population
    Kendra A Young
    Department of Preventive Medicine and Biometrics, University of Colorado at Denver and Health Sciences Center, 4200 East Ninth Avenue, Box B119, Denver, CO 80262, USA
    Ann Rheum Dis 66:179-83. 2007
    ..To examine perinatal and childhood risk factors for the presence of rheumatoid factor in healthy children...
  37. ncbi Association of proopiomelanocortin gene polymorphisms with obesity in the IRAS family study
    Beth S Sutton
    Department of Biochemistry, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Obes Res 13:1491-8. 2005
    ..These results support the hypothesis that POMC contributes genetically to the development of obesity...
  38. pmc Newborn HLA-DR,DQ genotype screening: age- and ethnicity-specific type 1 diabetes risk estimates
    Lisa M Emery
    Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, CO, USA
    Pediatr Diabetes 6:136-44. 2005
    ..To characterize the role of the HLA-DR,DQ genotype and ethnicity on the onset age of T1DM, we analyzed these factors in patients with T1DM and the general population...
  39. ncbi Association of non-HLA genes with type 1 diabetes autoimmunity
    Andrea K Steck
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Mail Stop A140, P O Box 6511, Aurora, CO 80045 6511, USA
    Diabetes 54:2482-6. 2005
    ..Genes involved in the IL-4 regulatory pathway (IL-4, IL-4R, IL-13) may confer susceptibility or protection to type 1 diabetes depending on individual SNPs or specific haplotypes...
  40. ncbi Clinical features of children with screening-identified evidence of celiac disease
    Edward J Hoffenberg
    Department of Pediatrics, Children s Hospital, and the University of Colorado School of Medicine, Denver, Colorado, USA
    Pediatrics 113:1254-9. 2004
    ..However, the clinical significance of a positive test remains uncertain. The objective of this study was to evaluate growth and clinical features of children who test positive for an autoantibody associated with CD...
  41. ncbi Linkage of the metabolic syndrome to 1q23-q31 in Hispanic families: the Insulin Resistance Atherosclerosis Study Family Study
    Carl D Langefeld
    Department of Public Health Sciences, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157 1063, USA
    Diabetes 53:1170-4. 2004
    ..These results contribute to the growing evidence that chromosome 1q harbors at least one locus related to the metabolic precursors of diabetes...
  42. ncbi Is presence of islet autoantibodies at birth associated with development of persistent islet autoimmunity? The Diabetes Autoimmunity Study in the Young (DAISY)
    Heather M Stanley
    Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Diabetes Care 27:497-502. 2004
    ..To determine whether the presence of islet autoantibodies in the umbilical cord blood is predictive of subsequent development of islet autoimmunity...
  43. ncbi In utero dietary exposures and risk of islet autoimmunity in children
    Carolyn M Fronczak
    Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Diabetes Care 26:3237-42. 2003
    ..The goal of this study was to examine whether maternal dietary intake of vitamin D, omega-3 fatty acids, and omega-6 fatty acids during pregnancy is associated with the appearance of islet autoimmunity (IA) in offspring...
  44. ncbi Symptoms of common maternal infections in pregnancy and risk of islet autoimmunity in early childhood
    Lars C Stene
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Diabetes Care 26:3136-41. 2003
    ..The aim of this study was to test whether symptoms of maternal infections during pregnancy and indicators of postnatal infections predict development of islet autoimmunity in children at genetically increased risk of type 1 diabetes...
  45. ncbi A prospective study of the incidence of childhood celiac disease
    Edward J Hoffenberg
    Department of Pediatrics, Barbara Davis Center for Childhood Diabetes, University of Colorado, Denver, USA
    J Pediatr 143:308-14. 2003
    ..To estimate the frequency of celiac disease (CD) in children in the general population of Denver, Colorado...
  46. ncbi Insulin sensitivity, insulin secretion, and abdominal fat: the Insulin Resistance Atherosclerosis Study (IRAS) Family Study
    Lynne E Wagenknecht
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Diabetes 52:2490-6. 2003
    ..The fat measures explained 27% of the model R2 for SI, 16% for AIR, and 16% for DI. Thus, fat distribution is an important determinant of both insulin resistance and insulin secretion...
  47. ncbi Minimal model-based insulin sensitivity has greater heritability and a different genetic basis than homeostasis model assessment or fasting insulin
    Richard N Bergman
    Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Diabetes 52:2168-74. 2003
    ..Thus S(I), a direct measure of insulin sensitivity, is determined more by genetic factors rather than measures such as HOMA, which reflect fasting insulin...
  48. ncbi Risk factors for initial acquisition of Pseudomonas aeruginosa in children with cystic fibrosis identified by newborn screening
    Judith H Maselli
    Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, Colorado 80218, USA
    Pediatr Pulmonol 35:257-62. 2003
    ..We conclude that female gender, homozygous DeltaF508 mutation, and S. aureus isolations are important risk factors for early P. aeruginosa detection in children with CF identified through newborn screening...
  49. ncbi Prospective study of enteroviral infections and development of beta-cell autoimmunity. Diabetes autoimmunity study in the young (DAISY)
    Patricia M Graves
    Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Diabetes Res Clin Pract 59:51-61. 2003
    ..To determine whether there is association between infection with enteroviruses and beta-cell autoimmunity in children at elevated risk of developing type 1 diabetes...
  50. ncbi Millennium award recipient contribution. Identification of children with early onset and high incidence of anti-islet autoantibodies
    David T Robles
    Barbara Davis Center, Department of Immunology, University of Colorado, Denver, Colorado 80262, USA
    Clin Immunol 102:217-24. 2002
    ..These results suggest that a high incidence and early appearance of islet autoantibodies for siblings of patients with type 1A diabetes are associated with DR3/4, DQB1*0302 and potentially increased with HLA-A genotype A1, A2...
  51. ncbi Clinical characteristics of children diagnosed with type 1 diabetes through intensive screening and follow-up
    Jennifer M Barker
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East Ninth Ave, Box B140, Denver, CO 80262
    Diabetes Care 27:1399-404. 2004
    ..The objective of this study was to determine whether earlier diagnosis of diabetes in prospectively followed autoantibody-positive children lowered onset morbidity and improved the clinical course after diagnosis...
  52. ncbi A genome scan for fasting insulin and fasting glucose identifies a quantitative trait locus on chromosome 17p: the insulin resistance atherosclerosis study (IRAS) family study
    Stephen S Rich
    Department of Public Health Sciences, Wake Forest University School of Medicine, 3rd Floor MRI Center, Winston Salem, NC 27157, USA
    Diabetes 54:290-5. 2005
    ..Identifying genes in these regions should provide insight into the nature of genetic factors regulating plasma glucose and insulin concentrations...
  53. ncbi Genetic analysis of adiponectin and obesity in Hispanic families: the IRAS Family Study
    Beth S Sutton
    Department of Biochemistry, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Hum Genet 117:107-18. 2005
    ..Additional studies are needed to confirm our findings and determine which polymorphism causes the functional effect...
  54. ncbi Association of protein tyrosine phosphatase 1B gene polymorphisms with measures of glucose homeostasis in Hispanic Americans: the insulin resistance atherosclerosis study (IRAS) family study
    Nicholette D Palmer
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Diabetes 53:3013-9. 2004
    ..001) fasting glucose, respectively, in the IRASFS. This comprehensive genetic analysis of PTPN1 reveals significant association with metabolic traits consistent with the proposed in vivo role for the PTP-1B protein...
  55. ncbi Association analysis of the plasminogen activator inhibitor-1 4G/5G polymorphism in Hispanics and African Americans: the IRAS family study
    Jeannette T Bensen
    Center for Human Genomics, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Hum Hered 57:128-37. 2004
    ..In addition, we explore whether transforming growth factor (TGF-beta1), a key regulator of PAI-1 expression, modifies the influence of the PAI-1 4G/5G polymorphism on these traits...
  56. ncbi Prediction of autoantibody positivity and progression to type 1 diabetes: Diabetes Autoimmunity Study in the Young (DAISY)
    Jennifer M Barker
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Clin Endocrinol Metab 89:3896-902. 2004
    ..Predictive value of autoantibodies increases with blinded duplicate and independent sample retesting and incorporation of the level of autoantibody in the predictive algorithm...
  57. ncbi Perinatal factors and development of islet autoimmunity in early childhood: the diabetes autoimmunity study in the young
    Lars C Stene
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Am J Epidemiol 160:3-10. 2004
    ..008. Other factors evaluated were not related to risk of islet autoimmunity. In conclusion, influences in utero or during delivery may affect the fetal immune system...
  58. ncbi Insulin sensitivity, body fat distribution, and family diabetes history: the IRAS Family Study
    Braxton D Mitchell
    University of Maryland School of Medicine, Division of Endocrinology, Diabetes, and Nutrition, 660 W Redwood Street, Room 492, Baltimore, MD 21201, USA
    Obes Res 12:831-9. 2004
    ..Whether diabetes family history (FH) also predicts visceral fat accumulation and, if so, whether the increased insulin resistance in relatives of diabetic subjects occurs independently of visceral fat accumulation are not known...
  59. ncbi Cosegregation of albuminuria and blood pressure: the Insulin Resistance Atherosclerosis (IRAS) family study
    Xiuqing Guo
    Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Am J Hypertens 18:823-7. 2005
    ..Our aim in this study was to examine the familial aggregation of albuminuria and its phenotypic, genetic, and environmental correlations with BP in nondiabetic individuals of Hispanic (HA) and African American (AA) ethnicity...
  60. ncbi Antibodies against cyclic citrullinated peptide are associated with HLA-DR4 in simplex and multiplex polyarticular-onset juvenile rheumatoid arthritis
    Elizabeth D Ferucci
    Division of Rheumatology, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Arthritis Rheum 52:239-46. 2005
    ....
  61. ncbi Validation of a food frequency questionnaire in preschool children
    Lezlie A Parrish
    Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver 80262, USA
    Epidemiology 14:213-7. 2003
    ..Support for the validity of food frequency questionnaires (FFQ) in preschool children using parental report is limited...
  62. ncbi Does accounting for gene-environment (GxE) interaction increase the power to detect the effect of a gene in a multifactorial disease?
    Hana Selinger-Leneman
    INSERM U535, Le Kremlin Bicetre, France
    Genet Epidemiol 24:200-7. 2003
    ..1, accounting for GxE interaction increases the power to detect the gene effect in 200 trios by 10%; alternatively, when the exposure frequency is 0.9, it decreases the power by 15%...
  63. ncbi Urinary F2-isoprostanes in young healthy children at risk for type 1 diabetes mellitus
    Laura D Kauffman
    Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Free Radic Biol Med 35:551-7. 2003
    ..Normal values in this healthy population can be used as the basis for future studies of disease mechanisms involving oxidative stress...
  64. ncbi Comparison of children's diets as reported by the child via the Youth/Adolescent Questionnaire and the parent via the Willett food-frequency questionnaire
    Molly M Lamb
    University of Colorado at Denver and Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262, USA
    Public Health Nutr 10:663-70. 2007
    ..A comparison of a parent-completed Willett food-frequency questionnaire (FFQ) and a self-completed Youth/Adolescent Questionnaire (YAQ) has not yet been conducted...
  65. ncbi Identification of quantitative trait loci for glucose homeostasis: the Insulin Resistance Atherosclerosis Study (IRAS) Family Study
    Stephen S Rich
    Department of Public Health Sciences, Wake Forest University School of Medicine, 3rd Floor, MRI Center, Winston Salem, NC 27157, USA
    Diabetes 53:1866-75. 2004
    ....
  66. ncbi Association of the peroxisome proliferator-activated receptor gamma gene with type 2 diabetes mellitus varies by physical activity among non-Hispanic whites from Colorado
    Tracy L Nelson
    Department of Health and Exercise Science, Colorado State University, Fort Collins, CO 80523, USA
    Metabolism 56:388-93. 2007
    ..37; 95% confidence interval, 1.14-4.94). There may be a gene-environment interaction between the Pro12 allele of the PPAR-gamma gene and physical activity that results in increased risk of T2DM in NHWs...
  67. ncbi Plasma micronutrients are associated with dietary intake and environmental tobacco smoke exposure in a paediatric population
    Heather Brady
    Department of Preventive Medicine and Biometrics, University of Colorado Denver and Health Sciences Center UCDHSC, and Section of Pediatric Gastroenterology, Hepatology, and Nutrition, The Children s Hospital, Denver, CO 80262, USA
    Public Health Nutr 10:712-8. 2007
    ..While adult populations have been well described in terms of nutritional status, such as the concentration of nutrient biomarkers, little work has been done in healthy paediatric populations...

Research Grants26

  1. Nutritional Etiology of Pre-Diabetic Autoimmunity
    Jill Norris; Fiscal Year: 2005
    ..In addition, we propose to examine the role of n-3 and n-6 PUFA, prostaglandins, erythrocyte membrane fatty acids, and prostaglandin synthase 2 (PGS2 ) expression in the remission of beta cell autoimmunity. ..
  2. NUTRITIONAL ETIOLOGY OF PREDIABETIC AUTOIMMUNITY
    Jill Norris; Fiscal Year: 2007
    ....
  3. GENETICS OF ADIPOSITY AND GLUCOSE HOMEOSTASIS
    Jill Norris; Fiscal Year: 2009
    ....
  4. RA-Related Autoantibodies in Healthy FDR of RA Patients
    Jill Norris; Fiscal Year: 2009
    ....
  5. NUTRITIONAL ETIOLOGY OF PREDIABETIC AUTOIMMUNITY
    Jill Norris; Fiscal Year: 2009
    ....
  6. IRAS FAMILY STUDY--GENETICS OF INSULIN RESISTANCE
    Jill Norris; Fiscal Year: 2003
    ..This project will contribute substantially to our understanding of the genetic determinants of insulin sensitivity, and consequently to risk of atherosclerosis. ..
  7. NUTRITIONAL ETIOLOGY OF PREDIABETIC AUTOIMMUNITY
    Jill Norris; Fiscal Year: 2000
    ....
  8. GENE ENVIRONMENT STUDY OF TYPE 2 DIABETES IN FAMILIES
    Jill Norris; Fiscal Year: 2002
    ....
  9. NUTRITIONAL ETIOLOGY OF PREDIABETIC AUTOIMMUNITY
    Jill M Norris; Fiscal Year: 2010
    ....